{"id":"https://openalex.org/W2111963583","doi":null,"title":"Elucidation of the aerobic respiratory chains in mycobacteria","display_name":"Elucidation of the aerobic respiratory chains in mycobacteria","publication_year":2006,"publication_date":"2006-10-27","ids":{"openalex":"https://openalex.org/W2111963583","mag":"2111963583"},"language":"en","primary_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/1486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/1486","pdf_url":"http://hdl.handle.net/10539/1486","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10539/1486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015494216","display_name":"Limenako G. Matsoso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Limenako G. Matsoso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015494216"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aerobic-respiratory-chain","display_name":"aerobic respiratory chain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mycobacteria","display_name":"mycobacteria","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cytochrome-bd-oxidase","display_name":"cytochrome bd oxidase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hypoxia-adaptation","display_name":"hypoxia adaptation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5457179546356201},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.48787784576416016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3840218186378479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3251008987426758},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14179742336273193}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:wiredspace.wits.ac.za:10539/1486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/1486","pdf_url":"http://hdl.handle.net/10539/1486","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2111963583","doi":null,"is_oa":false,"landing_page_url":"https://wiredspace.wits.ac.za/bitstream/10539/1486/1/PhD%20Thesis_Limenako%20G%20Matsoso%209602685E.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/1486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/1486","pdf_url":"http://hdl.handle.net/10539/1486","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111963583.pdf","grobid_xml":"https://content.openalex.org/works/W2111963583.grobid-xml"},"referenced_works_count":165,"referenced_works":["https://openalex.org/W219883212","https://openalex.org/W1484179725","https://openalex.org/W1504627965","https://openalex.org/W1513899899","https://openalex.org/W1514631861","https://openalex.org/W1515987373","https://openalex.org/W1531259103","https://openalex.org/W1546213590","https://openalex.org/W1547863599","https://openalex.org/W1552054481","https://openalex.org/W1566042048","https://openalex.org/W1597808424","https://openalex.org/W1600329457","https://openalex.org/W1657643071","https://openalex.org/W1784295017","https://openalex.org/W1831303753","https://openalex.org/W1851138068","https://openalex.org/W1910583010","https://openalex.org/W1966849007","https://openalex.org/W1967457339","https://openalex.org/W1973722927","https://openalex.org/W1973789730","https://openalex.org/W1976293911","https://openalex.org/W1977671952","https://openalex.org/W1979690034","https://openalex.org/W1980789643","https://openalex.org/W1981931219","https://openalex.org/W1982753455","https://openalex.org/W1984474061","https://openalex.org/W1984523365","https://openalex.org/W1986111503","https://openalex.org/W1987604802","https://openalex.org/W1990902683","https://openalex.org/W1990909752","https://openalex.org/W1996638297","https://openalex.org/W1998686777","https://openalex.org/W2004361822","https://openalex.org/W2005175892","https://openalex.org/W2007097682","https://openalex.org/W2008186432","https://openalex.org/W2010279277","https://openalex.org/W2011261850","https://openalex.org/W2014578355","https://openalex.org/W2014960917","https://openalex.org/W2015937582","https://openalex.org/W2020110672","https://openalex.org/W2020214471","https://openalex.org/W2022911857","https://openalex.org/W2030657489","https://openalex.org/W2032564365","https://openalex.org/W2034090964","https://openalex.org/W2039590408","https://openalex.org/W2039808886","https://openalex.org/W2043952643","https://openalex.org/W2044357547","https://openalex.org/W2045706309","https://openalex.org/W2048281093","https://openalex.org/W2049328674","https://openalex.org/W2050714483","https://openalex.org/W2051543845","https://openalex.org/W2051869814","https://openalex.org/W2052481735","https://openalex.org/W2053700342","https://openalex.org/W2055043387","https://openalex.org/W2058927231","https://openalex.org/W2060104088","https://openalex.org/W2060248414","https://openalex.org/W2063091433","https://openalex.org/W2065216540","https://openalex.org/W2066363284","https://openalex.org/W2067045966","https://openalex.org/W2068035031","https://openalex.org/W2069030760","https://openalex.org/W2074507716","https://openalex.org/W2078034003","https://openalex.org/W2078290231","https://openalex.org/W2079534946","https://openalex.org/W2080354196","https://openalex.org/W2081098333","https://openalex.org/W2082520438","https://openalex.org/W2082573007","https://openalex.org/W2083660727","https://openalex.org/W2085763693","https://openalex.org/W2086227247","https://openalex.org/W2086498493","https://openalex.org/W2088931841","https://openalex.org/W2090680389","https://openalex.org/W2090902470","https://openalex.org/W2091298198","https://openalex.org/W2094094557","https://openalex.org/W2096762497","https://openalex.org/W2097421503","https://openalex.org/W2098475709","https://openalex.org/W2098732312","https://openalex.org/W2099087776","https://openalex.org/W2099183065","https://openalex.org/W2102604764","https://openalex.org/W2103412135","https://openalex.org/W2106810153","https://openalex.org/W2106942635","https://openalex.org/W2107872590","https://openalex.org/W2109817270","https://openalex.org/W2110739147","https://openalex.org/W2112509478","https://openalex.org/W2114161394","https://openalex.org/W2114685191","https://openalex.org/W2114902148","https://openalex.org/W2115438934","https://openalex.org/W2117936351","https://openalex.org/W2118978296","https://openalex.org/W2119028507","https://openalex.org/W2119387381","https://openalex.org/W2120842435","https://openalex.org/W2123084649","https://openalex.org/W2124258222","https://openalex.org/W2125112523","https://openalex.org/W2126996122","https://openalex.org/W2128482141","https://openalex.org/W2128918222","https://openalex.org/W2129957930","https://openalex.org/W2130834666","https://openalex.org/W2130986751","https://openalex.org/W2131731929","https://openalex.org/W2132001120","https://openalex.org/W2132417094","https://openalex.org/W2133199321","https://openalex.org/W2135038276","https://openalex.org/W2135414906","https://openalex.org/W2136871901","https://openalex.org/W2138457121","https://openalex.org/W2138517628","https://openalex.org/W2140981202","https://openalex.org/W2141091718","https://openalex.org/W2141891741","https://openalex.org/W2142415307","https://openalex.org/W2143061508","https://openalex.org/W2144010669","https://openalex.org/W2145072890","https://openalex.org/W2145412238","https://openalex.org/W2148959908","https://openalex.org/W2151444479","https://openalex.org/W2151636105","https://openalex.org/W2153547633","https://openalex.org/W2154158126","https://openalex.org/W2154694614","https://openalex.org/W2154733823","https://openalex.org/W2158023121","https://openalex.org/W2158036571","https://openalex.org/W2158268887","https://openalex.org/W2158658436","https://openalex.org/W2159760322","https://openalex.org/W2160110449","https://openalex.org/W2161881247","https://openalex.org/W2162192550","https://openalex.org/W2163369626","https://openalex.org/W2164217177","https://openalex.org/W2164416050","https://openalex.org/W2165576393","https://openalex.org/W2166076738","https://openalex.org/W2168009569","https://openalex.org/W2168306675","https://openalex.org/W2170149552","https://openalex.org/W2171646475","https://openalex.org/W2280997219","https://openalex.org/W4232468224"],"related_works":["https://openalex.org/W2119028507","https://openalex.org/W1600329457","https://openalex.org/W4417192117","https://openalex.org/W3161583162","https://openalex.org/W2139719418","https://openalex.org/W2263444363","https://openalex.org/W2995039415","https://openalex.org/W2080329944","https://openalex.org/W7096177083","https://openalex.org/W2802469892"],"abstract_inverted_index":{"The":[0,32,204,251],"aerobic":[1,263],"respiratory":[2,124],"chain":[3],"of":[4,7,36,66,78,115,122,133,153,163,181,195,206,230,259,274],"mycobacteria":[5],"consists":[6],"at":[8],"least":[9],"two":[10],"branches,":[11],"a":[12,24,130,192,228],"\\ncytochrome":[13,143],"c":[14,21,56,82],"branch":[15,169,254],"terminating":[16,27,51,170],"in":[17,28,52,60,69,75,119,171,201,210,215,241,269],"an":[18,120],"aa3-type":[19,54,80],"cytochrome":[20,29,47,55,252,275],"oxidase,":[22,57],"and":[23,34,74,87,91,98,140,185,218,227,245,249,265,272],"quinol":[25],"\\nbranch":[26],"bd":[30,276],"oxidase.":[31,277],"structure":[33],"function":[35],"the":[37,42,46,53,70,79,123,137,151,164,172,182,211],"former":[38],"\\nbranch,":[39],"leading":[40],"from":[41],"menaquinone-menaquinol":[43],"pool":[44],"to":[45,109,161,236],"bc1":[48,71],"complex":[49],"\\nand":[50],"was":[58],"characterized":[59,128],"\\nMycobacterium":[61],"smegmatis.":[62],"Allelic":[63],"exchange":[64],"mutants":[65,106],"M.":[67,154,196,242,246,260],"smegmatis":[68,155,197,243,261],"\\ncomplex":[72],"(\u0394qcrCAB::hyg)":[73],"subunit":[76],"II":[77],"cytochome":[81],"oxidase":[83,146,174],"\\n(\u0394ctaC::hyg)":[84],"were":[85,107,175,222,233],"constructed":[86],"analyzed":[88],"for":[89,150,257],"growth,":[90],"gene":[92],"expression":[93,100,179],"using":[94,191],"lacZ":[95],"\\nreporter":[96],"assays":[97],"genome":[99],"profiling":[101],"by":[102,129,177,239],"DNA":[103],"microarray.":[104],"Both":[105],"\\nfound":[108],"be":[110,237],"profoundly":[111],"growth":[112,152,258],"impaired.":[113],"Disruption":[114],"this":[116],"pathway":[117],"resulted":[118],"\\nadaptation":[121],"network":[125],"that":[126,147,198],"is":[127,148,199,255],"marked":[131],"up-regulation":[132,273],"\\ncydAB,":[134],"which":[135,232],"encodes":[136],"bioenergetically":[138],"less-efficient":[139],"microaerobically":[141],"induced":[142,221],"bd-type":[144,173],"menaquinol":[145],"required":[149],"\\nunder":[156],"O2-limiting":[157],"conditions.":[158],"Other":[159],"adaptations":[160],"re-routing":[162],"electron":[165],"flux":[166],"through":[167],"\\nthe":[168,207],"revealed":[176],"comparative":[178],"\\nprofiling":[180],"bc1-deficient":[183],"mutant":[184,212],"its":[186,266],"parental":[187],"wild":[188],"type":[189],"strain":[190],"partialgenome":[193],"\\nmicroarray":[194],"enriched":[200],"essential":[202],"genes.":[203],"majority":[205],"genes":[208,224],"up-regulated":[209,238],"are":[213],"involved":[214],"intermediary":[216],"metabolism":[217],"\\nrespiration.":[219],"Also":[220],"several":[223],"including,":[225],"uspL":[226],"homologue":[229],"\\nRv1592c,":[231],"previously":[234],"shown":[235],"hypoxia":[240],"\\n(uspL)":[244],"tuberculosis":[247],"(uspL":[248],"Rv1592).":[250],"bc1-aa3":[253],"\\nrequired":[256],"under":[262],"conditions":[264],"disruption":[267],"results":[268],"\\ngrowth":[270],"attenuation":[271]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
