{"id":"https://openalex.org/W2111819969","doi":"https://doi.org/10.1093/jmcb/mjp031","title":"Identity Crisis When Telomeres Left Unprotected","display_name":"Identity Crisis When Telomeres Left Unprotected","publication_year":2009,"publication_date":"2009-10-04","ids":{"openalex":"https://openalex.org/W2111819969","doi":"https://doi.org/10.1093/jmcb/mjp031","mag":"2111819969","pmid":"https://pubmed.ncbi.nlm.nih.gov/19805416","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3003554"},"language":"en","primary_location":{"id":"doi:10.1093/jmcb/mjp031","doi":"https://doi.org/10.1093/jmcb/mjp031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjp031","pdf_url":"https://academic.oup.com/jmcb/article-pdf/2/1/14/2550506/mjp031.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jmcb/article-pdf/2/1/14/2550506/mjp031.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102021749","display_name":"Yunyun Wu","orcid":"https://orcid.org/0000-0002-7237-2554","observed_orcids":["https://orcid.org/0000-0002-7237-2554"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. Wu","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. yunwu@princeton.edu","Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. yunwu@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006524357","display_name":"Virginia A. Zakian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. A. Zakian","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006524357","https://openalex.org/A5102021749"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":0.1989,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.48722888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"1","first_page":"14","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-uncapping","display_name":"telomere uncapping","score":0.7950000166893005},{"id":"https://openalex.org/keywords/shelterin","display_name":"shelterin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mre11","display_name":"MRE11","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9449999928474426},{"id":"https://openalex.org/keywords/atm-signaling","display_name":"ATM signaling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7020000219345093},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7739194631576538},{"id":"https://openalex.org/C2780714602","wikidata":"https://www.wikidata.org/wiki/Q3354876","display_name":"Identity crisis","level":3,"score":0.6471251249313354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48972252011299133},{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.48617023229599},{"id":"https://openalex.org/C3019544756","wikidata":"https://www.wikidata.org/wiki/Q1027525","display_name":"Left behind","level":3,"score":0.4241065979003906},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4213337302207947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3949087858200073},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3708330988883972},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.24285367131233215},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17781683802604675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1685798168182373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1595047116279602},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10270866751670837},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.09755954146385193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08684107661247253},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.08301243185997009},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.08095639944076538},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2779304628","wikidata":"https://www.wikidata.org/wiki/Q3503480","display_name":"Face (sociological concept)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/jmcb/mjp031","doi":"https://doi.org/10.1093/jmcb/mjp031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjp031","pdf_url":"https://academic.oup.com/jmcb/article-pdf/2/1/14/2550506/mjp031.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmid:19805416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19805416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3003554","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3003554/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.550.3102","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.550.3102","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jmcb.oxfordjournals.org/content/early/2009/10/04/jmcb.mjp031.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.927.3457","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.927.3457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jmcb.oxfordjournals.org/content/2/1/14.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:jmcb:2/1/14","doi":null,"is_oa":false,"landing_page_url":"http://jmcb.oxfordjournals.org/cgi/content/short/2/1/14","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"mag:2183193506","doi":null,"is_oa":false,"landing_page_url":"http://jmcb.oxfordjournals.org/content/2/1/14.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/jmcb/mjp031","doi":"https://doi.org/10.1093/jmcb/mjp031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jmcb/mjp031","pdf_url":"https://academic.oup.com/jmcb/article-pdf/2/1/14/2550506/mjp031.pdf","source":{"id":"https://openalex.org/S14311075","display_name":"Journal of Molecular Cell Biology","issn_l":"1674-2788","issn":["1674-2788","1759-4685"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7841207189","display_name":"Structure and Behavior of Yeast Telomeres","funder_award_id":"R01GM043265","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111819969.pdf","grobid_xml":"https://content.openalex.org/works/W2111819969.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1980636468","https://openalex.org/W1982199027","https://openalex.org/W1985964699","https://openalex.org/W2004317394","https://openalex.org/W2013225037","https://openalex.org/W2015924792","https://openalex.org/W2022873453","https://openalex.org/W2032407757","https://openalex.org/W2040392790","https://openalex.org/W2086095857","https://openalex.org/W2150490516"],"related_works":["https://openalex.org/W2183193506","https://openalex.org/W7098123047","https://openalex.org/W3175590603","https://openalex.org/W1965889900","https://openalex.org/W2142743663","https://openalex.org/W1982199027","https://openalex.org/W2604996055","https://openalex.org/W2050302428","https://openalex.org/W4238933967","https://openalex.org/W6948498123"],"abstract_inverted_index":{"Loss":[0],"of":[1,51],"shelterin":[2],"components":[3],"TRF2":[4],"or":[5],"POT1a-TPP1":[6],"complex":[7],"from":[8],"the":[9,32,42,52],"chromosome":[10],"end":[11],"triggers":[12],"DNA":[13,19,33],"damage":[14],"response":[15],"(DDR)":[16],"and":[17,28,55],"aberrant":[18],"repair":[20,34],"events.":[21],"In":[22],"a":[23],"recent":[24],"Nature":[25],"paper,":[26],"Chang":[27],"colleagues":[29],"reported":[30],"that":[31],"protein":[35],"Mre11":[36],"contributes":[37],"to":[38],"multiple":[39],"events":[40],"at":[41],"uncapped":[43],"telomere,":[44],"including":[45],"ataxia":[46],"telangiectasia-mutated":[47],"(ATM)-dependent":[48],"signaling,":[49],"processing":[50],"telomeric":[53],"G-tail":[54],"homologous":[56],"recombination":[57],"(HR).":[58]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}