{"id":"https://openalex.org/W2111809136","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1380","title":"Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas","display_name":"Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas","publication_year":2012,"publication_date":"2012-09-11","ids":{"openalex":"https://openalex.org/W2111809136","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1380","mag":"2111809136","pmid":"https://pubmed.ncbi.nlm.nih.gov/22966016"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-12-1380","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1380","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-1380","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077482284","display_name":"Jana Sly\u0161kov\u00e1","orcid":"https://orcid.org/0000-0003-3474-4799","observed_orcids":["https://orcid.org/0000-0003-3474-4799"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Jana Slyskova","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013548626","display_name":"Vlasta Korenkov\u00e1","orcid":"https://orcid.org/0000-0002-6289-5175","observed_orcids":["https://orcid.org/0000-0002-6289-5175"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Vlasta Korenkova","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069045085","display_name":"Andrew Richard Collins","orcid":"https://orcid.org/0000-0001-5916-6871","observed_orcids":["https://orcid.org/0000-0001-5916-6871","https://orcid.org/0000-0001-7108-0771"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Andrew R. Collins","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102974778","display_name":"Pavel Proch\u00e1zka","orcid":"https://orcid.org/0000-0001-7456-3322","observed_orcids":["https://orcid.org/0000-0001-7456-3322"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Pavel Prochazka","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037749737","display_name":"\u013dudmila Vodi\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-8277-539X","observed_orcids":["https://orcid.org/0000-0002-8277-539X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Ludmila Vodickova","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023782138","display_name":"Ji\u0159\u00ed \u0160vec","orcid":"https://orcid.org/0000-0003-4701-9625","observed_orcids":["https://orcid.org/0000-0003-4701-9625"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Jiri Svec","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035392232","display_name":"Ludmila Lipsk\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Ludmila Lipska","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074797573","display_name":"Miroslav Lev\u00fd","orcid":"https://orcid.org/0000-0003-3321-6644","observed_orcids":["https://orcid.org/0000-0003-3321-6644"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Miroslav Levy","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018683556","display_name":"Michaela Schneiderov\u00e1","orcid":"https://orcid.org/0000-0002-3357-0072","observed_orcids":["https://orcid.org/0000-0002-3357-0072"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Michaela Schneiderova","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016595123","display_name":"V\u00e1clav Li\u0161ka","orcid":"https://orcid.org/0000-0002-5226-0280","observed_orcids":["https://orcid.org/0000-0002-5226-0280"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Vaclav Liska","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045913361","display_name":"L Holubec","orcid":"https://orcid.org/0000-0002-8566-0512","observed_orcids":["https://orcid.org/0000-0002-8566-0512"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Lubos Holubec","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404594","display_name":"Rajiv Kumar","orcid":"https://orcid.org/0000-0002-6093-0395","observed_orcids":["https://orcid.org/0000-0002-6093-0395"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Rajiv Kumar","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090756163","display_name":"Pavel Sou\u010dek","orcid":"https://orcid.org/0000-0002-4294-6799","observed_orcids":["https://orcid.org/0000-0002-4294-6799"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Pavel Soucek","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068376010","display_name":"Alessio Naccarati","orcid":"https://orcid.org/0000-0001-5774-0905","observed_orcids":["https://orcid.org/0000-0001-5774-0905"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Alessio Naccarati","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004651940","display_name":"Pavel Vodi\u010dka","orcid":"https://orcid.org/0000-0003-2376-1243","observed_orcids":["https://orcid.org/0000-0003-2376-1243"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210123319","display_name":"Italian institute for Genomic Medicine","ror":"https://ror.org/036054d36","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210123319"]},{"id":"https://openalex.org/I4210133092","display_name":"Czech Academy of Sciences, Institute of Experimental Medicine","ror":"https://ror.org/03hjekm25","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210133092"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ","DE","IT","NO"],"is_corresponding":false,"raw_author_name":"Pavel Vodicka","raw_affiliation_strings":["Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Institute of Experimental Medicine, and 2Institute of Biotechnology, Academy of Sciences of the Czech Republic; 3Faculty of Science, and 4Institute of Biology and Medical Genetics, First Faculty of Medicine, and 5Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 6Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; 7National Institute of Public Health; 8Department of Surgery, Thomayer Hospital; 9Department of Surgery, General University Hospital in Prague; 10Department of Surgery, Teaching Hospital and Medical School in Pilsen, Charles University, Prague, Czech Republic; 11Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; and 12Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Torino, Italy","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I184942183","https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210123319","https://openalex.org/I4210133092","https://openalex.org/I4210162037"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6247,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.91373325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"21","first_page":"5878","last_page":"5887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.21089999377727509,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-repair-capacity","display_name":"DNA repair capacity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6499999761581421},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/csb","display_name":"CSB","score":0.7429999709129333},{"id":"https://openalex.org/keywords/xpa","display_name":"XPA","score":0.6610000133514404},{"id":"https://openalex.org/keywords/ercc2","display_name":"XPD","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apex1","display_name":"APEX1","score":0.753000020980835},{"id":"https://openalex.org/keywords/ogg1","display_name":"OGG1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neil1","display_name":"NEIL1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-versus-adjacent-tissue","display_name":"tumor versus adjacent tissue","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6822423934936523},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.6326164603233337},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.5299621224403381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5172779560089111},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.5012948513031006},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4456539452075958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4317166209220886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4182162880897522},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4095761477947235},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3970981240272522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2892274260520935},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.176588773727417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16799089312553406}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-12-1380","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1380","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-1380","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:22966016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22966016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0385619","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0007411","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1591524401","https://openalex.org/W1758248157","https://openalex.org/W1964212603","https://openalex.org/W1969314275","https://openalex.org/W1975657891","https://openalex.org/W1977382129","https://openalex.org/W1981989535","https://openalex.org/W1986711815","https://openalex.org/W1990754540","https://openalex.org/W2002472122","https://openalex.org/W2004326614","https://openalex.org/W2005356916","https://openalex.org/W2008594900","https://openalex.org/W2008793163","https://openalex.org/W2012071848","https://openalex.org/W2016493248","https://openalex.org/W2023418017","https://openalex.org/W2026621373","https://openalex.org/W2028243884","https://openalex.org/W2056590589","https://openalex.org/W2062150992","https://openalex.org/W2064108451","https://openalex.org/W2071728859","https://openalex.org/W2073593459","https://openalex.org/W2074730941","https://openalex.org/W2083580464","https://openalex.org/W2085971602","https://openalex.org/W2088380487","https://openalex.org/W2089708226","https://openalex.org/W2095692554","https://openalex.org/W2095727314","https://openalex.org/W2099009743","https://openalex.org/W2110262618","https://openalex.org/W2121245276","https://openalex.org/W2130375644","https://openalex.org/W2137462740","https://openalex.org/W2139097459","https://openalex.org/W2139122477","https://openalex.org/W2140686633","https://openalex.org/W2147329127","https://openalex.org/W2147923982","https://openalex.org/W2150368211","https://openalex.org/W2151110250","https://openalex.org/W2151227837","https://openalex.org/W2159212221","https://openalex.org/W2160824600","https://openalex.org/W2164683263","https://openalex.org/W2167501549","https://openalex.org/W2170454539"],"related_works":["https://openalex.org/W2150368211","https://openalex.org/W2562553453","https://openalex.org/W2784033834","https://openalex.org/W2093847914","https://openalex.org/W7127059244","https://openalex.org/W2894961621","https://openalex.org/W2016493248","https://openalex.org/W2226586012","https://openalex.org/W2583875323","https://openalex.org/W2126202399"],"abstract_inverted_index":{"PURPOSE:":[0],"DNA":[1,250],"repair":[2,26,49,82,222,251],"capacity":[3],"(DRC)":[4],"is":[5,224],"a":[6,80,93,110,126,155,226,245],"determinant":[7],"not":[8,119,173,181,199,225],"only":[9],"of":[10,15,35,66,92,95,113,120,186,220,237,248],"cancer":[11],"development":[12],"but":[13,118,205],"also":[14],"individual":[16,212],"response":[17],"to":[18,55,157],"therapy.":[19],"Previously,":[20],"altered":[21],"base":[22],"and":[23,28,68,76,98,146,178,203,213],"nucleotide":[24],"excision":[25,48,221],"(BER":[27],"NER)":[29],"have":[30],"been":[31],"described":[32],"in":[33,51,59,122,161,163,201,229,240],"lymphocytes":[34],"patients":[36],"with":[37,175,216],"sporadic":[38],"colorectal":[39,60,230],"cancer.":[40],"We,":[41],"for":[42,74,89,132,210],"the":[43,187,235],"first":[44],"time,":[45],"evaluate":[46],"both":[47,130],"capacities":[50],"human":[52,241],"colon":[53],"biopsies":[54],"study":[56,233],"their":[57,103],"participation":[58],"tumorigenesis.":[61],"EXPERIMENTAL":[62],"DESIGN:":[63],"Seventy":[64],"pairs":[65,85],"tumor":[67,196],"adjacent":[69,217],"healthy":[70],"tissues":[71,131],"were":[72,86],"analyzed":[73],"BER-":[75],"NER-specific":[77],"DRC":[78,238],"by":[79,102],"comet":[81],"assay.":[83],"Tissue":[84],"further":[87],"compared":[88],"expression":[90,162,170],"levels":[91,171],"panel":[94],"25":[96],"BER":[97,148,202],"NER":[99,141],"genes":[100,153],"complemented":[101],"promoter":[104],"methylation":[105,185],"status.":[106],"RESULTS:":[107],"We":[108],"observed":[109],"moderate":[111],"increase":[112],"NER-DRC":[114],"(P":[115,136,165],"=":[116],"0.019),":[117],"BER-DRC":[121],"tumors.":[123],"There":[124],"was":[125],"strong":[127],"correlation":[128],"between":[129],"all":[133],"investigated":[134,188],"parameters":[135],"<":[137,166],"0.001).":[138],"However,":[139],"4":[140,147],"(CSB,":[142],"CCNH,":[143],"XPA,":[144],"XPD)":[145],"(NEIL1,":[149],"APEX1,":[150],"OGG1,":[151],"PARP1)":[152],"showed":[154,194],"1.08-":[156],"1.28-fold":[158],"change":[159],"difference":[160],"tumors":[164],"0.05).":[167],"Individual":[168],"gene":[169],"did":[172,180],"correlate":[174],"overall":[176],"DRC,":[177],"we":[179],"detect":[182],"any":[183],"aberrant":[184],"genes.":[189],"CONCLUSIONS:":[190],"Our":[191],"complex":[192,246],"analysis":[193],"that":[195],"cells":[197],"are":[198,214],"deficient":[200],"NER,":[204],"rather":[206],"follow":[207],"patterns":[208],"characteristic":[209],"each":[211],"comparable":[215],"tissue.":[218],"Alteration":[219],"pathways":[223],"pronounced":[227],"event":[228],"carcinogenesis.":[231],"This":[232],"shows":[234],"feasibility":[236],"evaluation":[239],"solid":[242],"tissues,":[243],"representing":[244],"marker":[247],"multigene":[249],"processes.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}