{"id":"https://openalex.org/W2111790746","doi":"https://doi.org/10.1109/nebc.2010.5458127","title":"Evaluation of the cell-penetrating peptide TAT as a trans-blood-brain barrier delivery vehicle","display_name":"Evaluation of the cell-penetrating peptide TAT as a trans-blood-brain barrier delivery vehicle","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2111790746","doi":"https://doi.org/10.1109/nebc.2010.5458127","mag":"2111790746"},"language":"en","primary_location":{"id":"doi:10.1109/nebc.2010.5458127","doi":"https://doi.org/10.1109/nebc.2010.5458127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2010.5458127","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082657329","display_name":"Melissa J. Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa J. Simon","raw_affiliation_strings":["Columbia University, New York, NY, USA","Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021369430","display_name":"Woo Hyeun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woo Hyeun Kang","raw_affiliation_strings":["Columbia University, New York, NY, USA","Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666597","display_name":"Shan Gao","orcid":"https://orcid.org/0000-0001-9529-589X","observed_orcids":["https://orcid.org/0000-0001-9529-589X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Gao","raw_affiliation_strings":["Columbia University, New York, NY, USA","Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063109716","display_name":"Scott A. Banta","orcid":"https://orcid.org/0000-0001-7885-0150","observed_orcids":["https://orcid.org/0000-0001-7885-0150"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Banta","raw_affiliation_strings":["Columbia University, New York, NY, USA","Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019039663","display_name":"Barclay Morrison","orcid":"https://orcid.org/0000-0001-7676-0864","observed_orcids":["https://orcid.org/0000-0001-7676-0864"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barclay Morrison","raw_affiliation_strings":["Columbia University, New York, NY, USA","Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University 351 Engineering Terrace 1210 Amsterdam Avenue New York, New York 10027","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.11965812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tat-peptide","display_name":"TAT peptide","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":1.0},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9929999709129333},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7519919276237488},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.6323661804199219},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.6126202344894409},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5676241517066956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.538154661655426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5368972420692444},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.5324692726135254},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.49063029885292053},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4770169258117676},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.47126030921936035},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4432508945465088},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.43452104926109314},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.41927570104599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2943064570426941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22060340642929077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1171255111694336},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11632084846496582},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10369366407394409},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nebc.2010.5458127","doi":"https://doi.org/10.1109/nebc.2010.5458127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2010.5458127","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1982514381","https://openalex.org/W2001582257","https://openalex.org/W2008576706","https://openalex.org/W2013760630","https://openalex.org/W2053754060","https://openalex.org/W2094458858","https://openalex.org/W2105668301","https://openalex.org/W2124628016","https://openalex.org/W2138053088"],"related_works":["https://openalex.org/W1967561034","https://openalex.org/W2020247754","https://openalex.org/W2288013959","https://openalex.org/W3209456322","https://openalex.org/W4387526438","https://openalex.org/W2200232771","https://openalex.org/W2111303385","https://openalex.org/W4318000499","https://openalex.org/W2805451949","https://openalex.org/W2026755460"],"abstract_inverted_index":{"Therapeutic":[0],"delivery":[1,165],"into":[2,68,130],"the":[3,10,13,40,63,71,79,82,103,106,133,137,146,167],"brain":[4],"parenchyma":[5],"is":[6,20,52],"difficult":[7],"due":[8],"to":[9,21,42,49,85,125,148,166],"presence":[11],"of":[12,32,81,128,136],"blood-brain":[14],"barrier":[15],"(BBB).":[16],"One":[17],"potential":[18],"solution":[19],"use":[22],"cell-penetrating":[23],"peptides":[24,29],"(CPPs).":[25],"CPPs":[26,56],"are":[27],"short":[28],"made":[30],"up":[31],"primarily":[33],"positively":[34],"charged":[35],"amino":[36],"acids":[37],"that":[38,141],"have":[39,145],"ability":[41,80,147],"transduce":[43],"cell":[44,59],"membranes":[45],"and":[46,65,105,155],"deliver":[47,66,86,149],"cargoes":[48,67,150],"cells.":[50],"It":[51],"unclear,":[53],"however,":[54],"whether":[55],"can":[57],"penetrate":[58],"barriers,":[60],"such":[61],"as":[62],"BBB,":[64,154],"cells":[69],"on":[70,132],"other":[72,115,134],"side.":[73],"In":[74],"this":[75,120],"study,":[76],"we":[77],"examined":[78],"CPP":[83],"TAT":[84,142],"a":[87,160],"green":[88],"fluorescent":[89],"protein":[90],"(GFP)":[91],"cargo":[92],"across":[93,102,151],"an":[94,152],"endothelial":[95],"monolayer.":[96,138],"GFP-TAT":[97,129],"had":[98],"only":[99],"minimal":[100],"permeability":[101,121],"monolayer,":[104],"rate":[107],"was":[108,122],"no":[109],"different":[110],"from":[111],"GFP":[112],"alone":[113],"or":[114],"similarly":[116],"sized":[117],"dextrans.":[118],"Furthermore,":[119],"too":[123],"small":[124],"detect":[126],"transduction":[127],"astrocytes":[131],"side":[135],"We":[139],"conclude":[140],"does":[143],"not":[144,158],"intact":[153],"therefore":[156],"may":[157],"be":[159],"suitable":[161],"vehicle":[162],"for":[163],"therapeutic":[164],"brain.":[168]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}