{"id":"https://openalex.org/W2111707331","doi":"https://doi.org/10.3748/wjg.v16.i46.5801","title":"Leptin in hepatocellular carcinoma","display_name":"Leptin in hepatocellular carcinoma","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2111707331","doi":"https://doi.org/10.3748/wjg.v16.i46.5801","mag":"2111707331","pmid":"https://pubmed.ncbi.nlm.nih.gov/21155000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001970"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v16.i46.5801","doi":"https://doi.org/10.3748/wjg.v16.i46.5801","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v16.i46.5801","pdf_url":"https://www.wjgnet.com/1007-9327/full/v16/i46/5801.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v16/i46/5801.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025870465","display_name":"Shen\u2010Nien Wang","orcid":"https://orcid.org/0000-0002-4394-5608","observed_orcids":["https://orcid.org/0000-0002-4394-5608","https://orcid.org/0000-0003-4052-360X"]},"institutions":[{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shen-Nien Wang","raw_affiliation_strings":["Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, San-Ming District, Kaohsiung 807, Taiwan, China. snwang@kmu.edu.tw","Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, San-Ming District, Kaohsiung 807, Taiwan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, San-Ming District, Kaohsiung 807, Taiwan, China. snwang@kmu.edu.tw","institution_ids":["https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, San-Ming District, Kaohsiung 807, Taiwan, China","institution_ids":["https://openalex.org/I2802587341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025870465"],"corresponding_institution_ids":["https://openalex.org/I2802587341"],"apc_list":null,"apc_paid":null,"fwci":0.7099,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.57820856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"46","first_page":"5801","last_page":"5801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.09300000220537186,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9129999876022339},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8607711791992188},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.7985185384750366},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6681041717529297},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6266680359840393},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.5588718056678772},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5418376326560974},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4954181909561157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4903145134449005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48753687739372253},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.46436449885368347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45870742201805115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44239795207977295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42386507987976074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28070998191833496},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22457614541053772},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2075228989124298}],"mesh":[{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3748/wjg.v16.i46.5801","doi":"https://doi.org/10.3748/wjg.v16.i46.5801","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v16.i46.5801","pdf_url":"https://www.wjgnet.com/1007-9327/full/v16/i46/5801.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3001970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:21155000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21155000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:3142749363","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/201046/1003602888.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v16.i46.5801","doi":"https://doi.org/10.3748/wjg.v16.i46.5801","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v16.i46.5801","pdf_url":"https://www.wjgnet.com/1007-9327/full/v16/i46/5801.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111707331.pdf","grobid_xml":"https://content.openalex.org/works/W2111707331.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W117557844","https://openalex.org/W169476524","https://openalex.org/W1504864998","https://openalex.org/W1522687886","https://openalex.org/W1805877675","https://openalex.org/W1827435162","https://openalex.org/W1963739832","https://openalex.org/W1966893246","https://openalex.org/W1967347203","https://openalex.org/W1969363259","https://openalex.org/W1972709924","https://openalex.org/W1972750645","https://openalex.org/W1975077708","https://openalex.org/W1979243279","https://openalex.org/W1979269668","https://openalex.org/W1984180526","https://openalex.org/W1984865862","https://openalex.org/W1986244637","https://openalex.org/W1986978777","https://openalex.org/W1988208946","https://openalex.org/W1990034749","https://openalex.org/W1990884838","https://openalex.org/W1992357919","https://openalex.org/W1993850076","https://openalex.org/W1994621482","https://openalex.org/W1995333955","https://openalex.org/W1996713062","https://openalex.org/W1996788067","https://openalex.org/W1996958355","https://openalex.org/W2001671445","https://openalex.org/W2007461756","https://openalex.org/W2013438978","https://openalex.org/W2014163208","https://openalex.org/W2016387434","https://openalex.org/W2021199098","https://openalex.org/W2025653346","https://openalex.org/W2028799125","https://openalex.org/W2030316166","https://openalex.org/W2038659028","https://openalex.org/W2040109162","https://openalex.org/W2042753075","https://openalex.org/W2044788354","https://openalex.org/W2045159219","https://openalex.org/W2049713116","https://openalex.org/W2055355179","https://openalex.org/W2056728315","https://openalex.org/W2056767166","https://openalex.org/W2062570379","https://openalex.org/W2064431177","https://openalex.org/W2066528365","https://openalex.org/W2067123933","https://openalex.org/W2068186755","https://openalex.org/W2070800430","https://openalex.org/W2071019693","https://openalex.org/W2072435523","https://openalex.org/W2076014158","https://openalex.org/W2080325240","https://openalex.org/W2081738005","https://openalex.org/W2084942467","https://openalex.org/W2089783561","https://openalex.org/W2091484157","https://openalex.org/W2091484442","https://openalex.org/W2092413619","https://openalex.org/W2092509345","https://openalex.org/W2096098978","https://openalex.org/W2096486173","https://openalex.org/W2103637700","https://openalex.org/W2109128406","https://openalex.org/W2111288662","https://openalex.org/W2111406940","https://openalex.org/W2113621567","https://openalex.org/W2113979297","https://openalex.org/W2115940051","https://openalex.org/W2124200900","https://openalex.org/W2127151069","https://openalex.org/W2129802081","https://openalex.org/W2130837075","https://openalex.org/W2138791600","https://openalex.org/W2141662760","https://openalex.org/W2144178804","https://openalex.org/W2149166783","https://openalex.org/W2151106782","https://openalex.org/W2155770413","https://openalex.org/W2158089810","https://openalex.org/W2160566428","https://openalex.org/W2163505977","https://openalex.org/W2164118055","https://openalex.org/W2165503944","https://openalex.org/W2166604740","https://openalex.org/W2168692939","https://openalex.org/W2169077516","https://openalex.org/W2170666112","https://openalex.org/W2172281772","https://openalex.org/W2182416413","https://openalex.org/W2312345770","https://openalex.org/W2339941599","https://openalex.org/W2964947239","https://openalex.org/W3138780921","https://openalex.org/W4247961163","https://openalex.org/W4251240516","https://openalex.org/W4253624534","https://openalex.org/W6641013180","https://openalex.org/W6673588209","https://openalex.org/W7073868935"],"related_works":["https://openalex.org/W117557844","https://openalex.org/W1604179718","https://openalex.org/W4411257587","https://openalex.org/W7096800901","https://openalex.org/W2588535030","https://openalex.org/W2051277632","https://openalex.org/W2143829302","https://openalex.org/W2377355470","https://openalex.org/W1985519814","https://openalex.org/W2568438813"],"abstract_inverted_index":{"The":[0],"risk":[1,35],"factors":[2],"for":[3],"hepatocellular":[4],"carcinoma":[5],"(HCC)":[6],"development":[7,68,241],"have":[8,164,183],"been":[9,39,76,184,223],"established,":[10],"and":[11,16,21,146,180,217],"include":[12],"chronic":[13],"hepatitis":[14],"B":[15],"C,":[17],"heavy":[18],"alcohol":[19],"consumption,":[20],"aflatoxins.":[22],"In":[23,150],"fact,":[24],"5%-30%":[25],"of":[26,44,58,69,83,90,102,125,131,143,157,169,178,192,210,215,219,237,242],"patients":[27],"with":[28,66,189],"HCC":[29,46,221],"still":[30],"lack":[31],"a":[32,88,141,190,251],"readily":[33],"identifiable":[34],"factor.":[36],"It":[37],"has":[38,75,121,222],"reported":[40],"that":[41],"the":[42,55,59,67,70,97,100,103,123,154,166,172,175,205,213,234,240],"majority":[43],"''cryptogenic''":[45],"may":[47],"be":[48,187],"attributed":[49],"to":[50,86,136,152,186,229],"nonalcoholic":[51],"fatty":[52],"liver":[53],"disease,":[54],"hepatic":[56],"presentation":[57],"metabolic":[60,193],"syndrome":[61],"(MS).":[62],"Obesity":[63],"is":[64,106],"associated":[65,188],"MS.":[71],"Recently,":[72],"adipose":[73,110],"tissue":[74],"considered":[77],"as":[78,96,195,197],"an":[79],"endocrine":[80],"organ":[81],"because":[82],"its":[84,137,181],"capacity":[85],"secrete":[87],"variety":[89,191],"cytokines,":[91],"which":[92],"are":[93],"collectively":[94],"known":[95],"adipokines.":[98],"Leptin,":[99],"product":[101],"obese":[104],"gene,":[105],"mainly":[107],"produced":[108],"by":[109],"tissue.":[111],"Since":[112],"leptin":[113,139,170,179,211,238],"was":[114],"first":[115],"characterized":[116],"in":[117,128,161,171,212,239,255],"1994,":[118],"accumulated":[119],"literature":[120],"demonstrated":[122,165,185],"involvement":[124],"this":[126],"adipokine":[127],"several":[129,160],"areas":[130],"human":[132,198,220],"physiology.":[133],"After":[134],"binding":[135],"receptor,":[138],"initiates":[140],"cascade":[142],"signaling":[144],"events":[145],"subsequent":[147],"cellular":[148],"effects.":[149],"addition":[151],"being":[153],"regulatory":[155],"mediator":[156],"energy":[158],"homeostasis,":[159],"vitro":[162],"studies":[163],"fibrogenic":[167],"role":[168,209],"liver.":[173],"Furthermore,":[174],"deregulated":[176],"expression":[177],"receptor":[182],"disorders":[194],"well":[196],"cancers.":[199],"Most":[200],"importantly,":[201],"direct":[202],"evidence":[203],"supporting":[204],"inhibitory":[206],"and/or":[207],"activating":[208],"process":[214],"carcinogenesis":[216],"progression":[218],"accumulating":[224],"rapidly.":[225],"This":[226],"review":[227],"aims":[228],"provide":[230],"important":[231],"insights":[232],"into":[233],"potential":[235],"mechanisms":[236],"HCC.":[243,256],"Hopefully,":[244],"further":[245],"investigations":[246],"will":[247],"shed":[248],"light":[249],"on":[250],"new":[252],"therapeutic":[253],"target":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
