{"id":"https://openalex.org/W2111699652","doi":"https://doi.org/10.1021/bp060261y","title":"Alignment\u2010Based Approach for Durable Data Storage into Living Organisms","display_name":"Alignment\u2010Based Approach for Durable Data Storage into Living Organisms","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2111699652","doi":"https://doi.org/10.1021/bp060261y","mag":"2111699652","pmid":"https://pubmed.ncbi.nlm.nih.gov/17253725"},"language":"en","primary_location":{"id":"doi:10.1021/bp060261y","doi":"https://doi.org/10.1021/bp060261y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp060261y","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033505756","display_name":"Nozomu Yachie","orcid":"https://orcid.org/0000-0003-1582-6027","observed_orcids":["https://orcid.org/0000-0003-1582-6027"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nozomu Yachie","raw_affiliation_strings":["Institute for Advanced Biosciences, Keio University, 403-1 Nipponkoku, Daihoji, Tsuruoka, 997-0017 Yamagata, Japan","Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, 403-1 Nipponkoku, Daihoji, Tsuruoka, 997-0017 Yamagata, Japan","institution_ids":["https://openalex.org/I4405286215"]},{"raw_affiliation_string":"Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005710596","display_name":"Kazuhide Sekiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhide Sekiyama","raw_affiliation_strings":["Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan","institution_ids":["https://openalex.org/I4405286215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070186990","display_name":"Junichi Sugahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Sugahara","raw_affiliation_strings":["Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan","institution_ids":["https://openalex.org/I4405286215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034807411","display_name":"Yoshiaki Ohashi","orcid":"https://orcid.org/0000-0003-2093-5519","observed_orcids":["https://orcid.org/0000-0003-2093-5519"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiaki Ohashi","raw_affiliation_strings":["Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan","institution_ids":["https://openalex.org/I4405286215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015575713","display_name":"Masaru Tomita","orcid":"https://orcid.org/0000-0003-3423-377X","observed_orcids":["https://orcid.org/0000-0003-3423-377X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405265437","display_name":"Human Metabolome Technologies, Inc. (Japan)","ror":"https://ror.org/04t4rvp17","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265437"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Tomita","raw_affiliation_strings":["Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","Human Metabolome Technologies, Inc., 246\u20132 Mizukami, Kakuganji, Tsuruoka, 997\u20130052 Yamagata, Japan","Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252\u20138520 Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Human Metabolome Technologies, Inc., 246\u20132 Mizukami, Kakuganji, Tsuruoka, 997\u20130052 Yamagata, Japan","institution_ids":["https://openalex.org/I4405265437"]},{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, 403\u20131 Nipponkoku, Daihoji, Tsuruoka, 997\u20130017 Yamagata, Japan","institution_ids":["https://openalex.org/I4405286215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034807411"],"corresponding_institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4405286215"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":3.1366,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.91221608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"501","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11269","display_name":"Algorithms and Data Compression","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-storage","display_name":"DNA data storage","score":0.996999979019165},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"sequence alignment","score":0.847000002861023},{"id":"https://openalex.org/keywords/genomic-dna","display_name":"genomic DNA","score":0.7310000061988831},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oligonucleotide-sequences","display_name":"oligonucleotide sequences","score":0.7699999809265137},{"id":"https://openalex.org/keywords/data-retrieval","display_name":"data retrieval","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mutation-tolerance","display_name":"mutation tolerance","score":0.4050000011920929},{"id":"https://openalex.org/keywords/data-durability","display_name":"data durability","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4064602255821228}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bp060261y","doi":"https://doi.org/10.1021/bp060261y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp060261y","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmid:17253725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17253725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W280994533","https://openalex.org/W1496987857","https://openalex.org/W1598985695","https://openalex.org/W1643629030","https://openalex.org/W1964604871","https://openalex.org/W1974178918","https://openalex.org/W1981994435","https://openalex.org/W2014680464","https://openalex.org/W2035327151","https://openalex.org/W2055043387","https://openalex.org/W2074880981","https://openalex.org/W2118390049","https://openalex.org/W2133290100","https://openalex.org/W2145304961","https://openalex.org/W2147504831","https://openalex.org/W4248578633"],"related_works":["https://openalex.org/W2050200641","https://openalex.org/W7095218262","https://openalex.org/W3185653573","https://openalex.org/W2923697975","https://openalex.org/W7139963377","https://openalex.org/W2788257106","https://openalex.org/W1964604871","https://openalex.org/W4393352721","https://openalex.org/W4403683261","https://openalex.org/W3209368052"],"abstract_inverted_index":{"The":[0],"practical":[1,99],"realization":[2],"of":[3,29,33,49,56,70,91,101],"DNA":[4,32],"data":[5,20,37,59,74,92],"storage":[6,21],"is":[7,105],"a":[8,15,98],"major":[9],"scientific":[10],"goal.":[11],"Here":[12],"we":[13],"introduce":[14],"simple,":[16],"flexible,":[17],"and":[18,22,72],"robust":[19],"retrieval":[23,69,93],"method":[24,104],"based":[25],"on":[26],"sequence":[27],"alignment":[28,55],"the":[30,50,57,68,76,88],"genomic":[31],"living":[34],"organisms.":[35],"Duplicated":[36],"encoded":[38],"by":[39,62],"different":[40],"oligonucleotide":[41],"sequences":[42,60,66],"was":[43],"inserted":[44],"redundantly":[45],"into":[46],"multiple":[47],"loci":[48],"Bacillus":[51],"subtilis":[52,64],"genome.":[53],"Multiple":[54],"bit":[58],"decoded":[61],"B.":[63],"genome":[65],"enabled":[67],"stable":[71],"compact":[73],"without":[75],"need":[77],"for":[78],"template":[79],"DNA,":[80,97],"parity":[81],"checks,":[82],"or":[83],"error-correcting":[84],"algorithms.":[85],"Combined":[86],"with":[87],"computational":[89],"simulation":[90],"from":[94],"mutated":[95],"message":[96],"use":[100],"this":[102],"alignment-based":[103],"discussed.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}