{"id":"https://openalex.org/W2111591622","doi":"https://doi.org/10.1136/bmjopen-2014-006468","title":"Interaction analysis of the new pooled cohort equations for 10-year atherosclerotic cardiovascular disease risk estimation: a simulation analysis","display_name":"Interaction analysis of the new pooled cohort equations for 10-year atherosclerotic cardiovascular disease risk estimation: a simulation analysis","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2111591622","doi":"https://doi.org/10.1136/bmjopen-2014-006468","mag":"2111591622","pmid":"https://pubmed.ncbi.nlm.nih.gov/25941176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420957"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2014-006468","doi":"https://doi.org/10.1136/bmjopen-2014-006468","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2014-006468","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/5/4/e006468.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/5/4/e006468.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015042407","display_name":"Chun G. Schiros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun G Schiros","raw_affiliation_strings":["Department of Medicine, Cardiovascular Disease, University of Alabama, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Disease, University of Alabama, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022480407","display_name":"Thomas S. Denney","orcid":"https://orcid.org/0000-0002-6695-4777","observed_orcids":["https://orcid.org/0000-0002-6695-4777"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S Denney","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Auburn University, Auburn, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Auburn University, Auburn, Alabama, USA","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"last","author":{"id":null,"display_name":"Himanshu Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Himanshu Gupta","raw_affiliation_strings":["Department of Medicine, Cardiovascular Disease, University of Alabama, Birmingham, Alabama, USA","VA Medical Center, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Disease, University of Alabama, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"VA Medical Center, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I4210115616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.918,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.77962336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"4","first_page":"e006468","last_page":"e006468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.35030001401901245,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pooled-cohort-equations","display_name":"Pooled Cohort Equations","score":0.8100000023841858},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/african-american-women","display_name":"African American women","score":0.6110000014305115},{"id":"https://openalex.org/keywords/white-women","display_name":"white women","score":0.6909999847412109},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8248845338821411},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.722636342048645},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.615471601486206},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5029096007347107},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5013918876647949},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.42605292797088623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4188322424888611},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4117029905319214},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3948819041252136},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3502306044101715},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32843562960624695},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14862465858459473},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/bmjopen-2014-006468","doi":"https://doi.org/10.1136/bmjopen-2014-006468","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2014-006468","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/5/4/e006468.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4420957","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420957","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:25941176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25941176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2014-006468","doi":"https://doi.org/10.1136/bmjopen-2014-006468","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2014-006468","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/5/4/e006468.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111591622.pdf","grobid_xml":"https://content.openalex.org/works/W2111591622.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1580788756","https://openalex.org/W1975897418","https://openalex.org/W2019071303","https://openalex.org/W2111186986","https://openalex.org/W2119340816","https://openalex.org/W2160812379","https://openalex.org/W2168536722","https://openalex.org/W3001764054","https://openalex.org/W3147894994"],"related_works":["https://openalex.org/W7100764622","https://openalex.org/W2513485226","https://openalex.org/W2035971228","https://openalex.org/W2006634243","https://openalex.org/W6977357428","https://openalex.org/W6958708305","https://openalex.org/W2551615700","https://openalex.org/W2921091794","https://openalex.org/W3155999985","https://openalex.org/W2730119562"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"the":[3,9,34,58,62,67,78,105,131,152,178,180,193,233,236,247,254],"individual":[4],"and":[5,20,31,75,101,122,139,206,267],"interacting":[6],"impacts":[7],"of":[8,36,42,61,104,112,133,173,197,204,235,260],"continuous":[10,68,237],"variables":[11,69,116,238],"(age,":[12],"total":[13],"cholesterol":[14,18],"(total-C),":[15],"high-density":[16],"lipoprotein":[17],"(HDL-C)":[19],"systolic":[21],"blood":[22],"pressure(BP))":[23],"on":[24,73],"10-year":[25,38,81,148,162,218,241,249],"atherosclerotic":[26],"cardiovascular":[27],"disease":[28],"(ASCVD)":[29],"risk":[30,39,82,163,250],"better":[32],"understand":[33],"pattern":[35],"predicted":[37,217],"with":[40,114,135,187],"change":[41],"each":[43],"variable":[44,96],"using":[45,94,119],"recently":[46],"published":[47],"new":[48,222],"pooled":[49,79,223],"cohort":[50,80,224],"equations.":[51,83],"DESIGN:":[52],"Simulation":[53],"analysis":[54],"was":[55],"performed":[56],"across":[57],"whole":[59],"range":[60,196,203],"boundary":[63],"limits":[64],"suggested":[65],"for":[66,70,164,200,281],"groupings":[71],"based":[72],"race":[74],"gender":[76],"in":[77,151,160,177,215,239,278],"SETTING:":[84],"Computer-based":[85],"simulation":[86,93,100],"analysis.":[87,107,124],"PARTICIPANTS:":[88],"Data":[89,99],"were":[90,117],"generated":[91],"by":[92],"prespecified":[95],"ranges.":[97],"INTERVENTION:":[98],"visual":[102],"display":[103],"hazard":[106,123],"MAIN":[108],"OUTCOME":[109],"MEASURES:":[110],"Interactions":[111],"age":[113,134,143,195,210],"other":[115],"analysed":[118],"multidimensional":[120],"visualisation":[121],"RESULTS:":[125],"In":[126],"African-American":[127],"females,":[128,169],"due":[129,170],"to":[130,171],"interaction":[132],"HDL-C,":[136,207],"treated":[137],"BP":[138],"untreated":[140],"BP,":[141],"increasing":[142,155],"may":[144,158,211,264],"not":[145,184,212,252],"always":[146,213],"increase":[147,186],"risk.":[149,219,242],"Furthermore,":[150],"same":[153],"cohort,":[154],"HDL-C":[156],"level":[157],"result":[159,214],"higher":[161],"older":[165],"individuals.":[166],"For":[167],"Caucasian":[168],"square":[172],"Ln":[174],"(age)":[175],"term":[176],"equation,":[179],"age-risk":[181],"curve":[182],"does":[183,251],"monotonically":[185],"age.":[188],"The":[189,221,258],"vertex":[190],"is":[191,271],"within":[192],"given":[194],"40-79":[198],"years":[199],"a":[201],"certain":[202],"total-C":[205],"indicating":[208],"that":[209],"increased":[216],"CONCLUSIONS:":[220],"equations":[225],"are":[226],"sophisticated":[227],"as":[228,273],"they":[229],"take":[230],"into":[231],"account":[232],"interactions":[234],"predicting":[240],"We":[243],"find":[244],"situations":[245],"where":[246],"estimated":[248],"follow":[253],"general":[255],"secular":[256],"trends.":[257],"impact":[259],"such":[261],"interesting":[262],"patterns":[263],"be":[265],"substantial":[266],"therefore":[268],"further":[269],"exploration":[270],"needed":[272],"it":[274],"has":[275],"direct":[276],"implications":[277],"clinical":[279],"management":[280],"primary":[282],"prevention.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}