{"id":"https://openalex.org/W2111506773","doi":"https://doi.org/10.1158/0008-5472.can-07-0941","title":"Combined Natural Killer T-Cell\u2013Based Immunotherapy Eradicates Established Tumors in Mice","display_name":"Combined Natural Killer T-Cell\u2013Based Immunotherapy Eradicates Established Tumors in Mice","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W2111506773","doi":"https://doi.org/10.1158/0008-5472.can-07-0941","mag":"2111506773","pmid":"https://pubmed.ncbi.nlm.nih.gov/17671220"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-07-0941","doi":"https://doi.org/10.1158/0008-5472.can-07-0941","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-07-0941","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007330428","display_name":"Michele W.L. Teng","orcid":"https://orcid.org/0000-0003-1886-9145","observed_orcids":["https://orcid.org/0000-0003-1886-9145"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michele W.L. Teng","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036088140","display_name":"Jennifer A. Westwood","orcid":"https://orcid.org/0000-0003-2957-5767","observed_orcids":["https://orcid.org/0000-0003-2957-5767"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer A. Westwood","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055053148","display_name":"Phillip Kevin Darcy","orcid":"https://orcid.org/0000-0002-5303-9561","observed_orcids":["https://orcid.org/0000-0002-5303-9561"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Phillip K. Darcy","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069017947","display_name":"Janelle Sharkey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Janelle Sharkey","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070087777","display_name":"Moriya Tsuji","orcid":"https://orcid.org/0000-0001-8587-277X","observed_orcids":["https://orcid.org/0000-0001-8587-277X"]},"institutions":[{"id":"https://openalex.org/I157122930","display_name":"Aaron Diamond AIDS Research Center","ror":"https://ror.org/04jdq2t93","country_code":"US","type":"facility","lineage":["https://openalex.org/I157122930"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moriya Tsuji","raw_affiliation_strings":["2HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University;","institution_ids":["https://openalex.org/I157122930","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110471080","display_name":"Richard W. Franck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Franck","raw_affiliation_strings":["3Hunter College, City University of New York, New York, New York;","CITY UNIVERSITY OF NEW YORK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Hunter College, City University of New York, New York, New York;","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]},{"raw_affiliation_string":"CITY UNIVERSITY OF NEW YORK","institution_ids":["https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016158429","display_name":"Steven Anthony Porcelli","orcid":"https://orcid.org/0000-0002-4441-9888","observed_orcids":["https://orcid.org/0000-0002-4441-9888"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Porcelli","raw_affiliation_strings":["4Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016293777","display_name":"Gurdyal Singh Besra","orcid":"https://orcid.org/0000-0002-5605-0395","observed_orcids":["https://orcid.org/0000-0002-5605-0395"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gurdyal S. Besra","raw_affiliation_strings":["5School of Biosciences, University of Birmingham, Birmingham, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5School of Biosciences, University of Birmingham, Birmingham, United Kingdom;","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074513079","display_name":"Kazuyoshi Takeda","orcid":"https://orcid.org/0000-0002-5539-310X","observed_orcids":["https://orcid.org/0000-0002-5539-310X"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Takeda","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494006","display_name":"Hideo Yagita\u2225","orcid":"https://orcid.org/0000-0003-4279-9343","observed_orcids":["https://orcid.org/0000-0003-4279-9343"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Yagita","raw_affiliation_strings":["6Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan; and","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026944433","display_name":"Michael H. Kershaw","orcid":"https://orcid.org/0000-0002-2697-487X","observed_orcids":["https://orcid.org/0000-0002-2697-487X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael H. Kershaw","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061575707","display_name":"Mark John Smyth","orcid":"https://orcid.org/0000-0001-7098-7240","observed_orcids":["https://orcid.org/0000-0001-7098-7240"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark J. Smyth","raw_affiliation_strings":["1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"7Department of Pathology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2161,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.92781763,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"15","first_page":"7495","last_page":"7504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glycolipid-ligands","display_name":"glycolipid ligands","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alpha-galactosylceramide","display_name":"alpha-galactosylceramide","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cd1d","display_name":"CD1d","score":0.734000027179718},{"id":"https://openalex.org/keywords/anti-cd40-antibody","display_name":"anti-CD40 antibody","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.4259999990463257},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5820000171661377},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.5460000038146973},{"id":"https://openalex.org/keywords/immunotherapy-toxicity","display_name":"immunotherapy toxicity","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5961248278617859},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5368623733520508},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.5160908102989197},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5160312652587891},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4843936562538147},{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.4417099356651306},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4370659291744232},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43618693947792053},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43011558055877686},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4013637900352478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4008256494998932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3774931728839874},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32116347551345825},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.27726274728775024},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2513328194618225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13758835196495056},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.116708904504776}],"mesh":[{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005699","descriptor_name":"Galactosylceramides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053220","descriptor_name":"Receptors, TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-07-0941","doi":"https://doi.org/10.1158/0008-5472.can-07-0941","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-07-0941","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:17671220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17671220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/66f43c38-226f-4971-ade0-45586efacbfe","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/66f43c38-226f-4971-ade0-45586efacbfe","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Teng, MW, Westwood, JA, Darcy, PK, Sharkey, J, Tsuji, M, Franck, RW, Porcelli, SA, Besra, G, Takeda, K, Yagita, H, Kershaw, MH & Smyth, MJ 2007, 'Combined Natural Killer T-Cell Based Immunotherapy Eradicates Established Tumors in Mice', Cancer Research, vol. 67, no. 15, pp. 7495-7504. https://doi.org/10.1158/0008-5472.CAN-07-0941","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1527985047","https://openalex.org/W1528349069","https://openalex.org/W1594509286","https://openalex.org/W1653749361","https://openalex.org/W1876800744","https://openalex.org/W1933185076","https://openalex.org/W1954055770","https://openalex.org/W1975582036","https://openalex.org/W1978354618","https://openalex.org/W1996952962","https://openalex.org/W1998006783","https://openalex.org/W2016548343","https://openalex.org/W2026555862","https://openalex.org/W2026578316","https://openalex.org/W2044729019","https://openalex.org/W2045278228","https://openalex.org/W2049916014","https://openalex.org/W2050809964","https://openalex.org/W2052414561","https://openalex.org/W2059313909","https://openalex.org/W2064718707","https://openalex.org/W2067754261","https://openalex.org/W2082219820","https://openalex.org/W2096158777","https://openalex.org/W2097790514","https://openalex.org/W2099712864","https://openalex.org/W2100495456","https://openalex.org/W2116556475","https://openalex.org/W2119695630","https://openalex.org/W2120943145","https://openalex.org/W2122582242","https://openalex.org/W2124465622","https://openalex.org/W2125536112","https://openalex.org/W2142656879","https://openalex.org/W2143193187","https://openalex.org/W2144037068","https://openalex.org/W2144821901","https://openalex.org/W2146983958","https://openalex.org/W2150888484","https://openalex.org/W2155672162","https://openalex.org/W2159312193","https://openalex.org/W2160186045","https://openalex.org/W2161888789","https://openalex.org/W2162601620","https://openalex.org/W2163270673","https://openalex.org/W2164617193","https://openalex.org/W2165107917","https://openalex.org/W2170417753","https://openalex.org/W2170640588","https://openalex.org/W4237081104"],"related_works":["https://openalex.org/W1947552363","https://openalex.org/W2618250791","https://openalex.org/W1978354618","https://openalex.org/W1972884449","https://openalex.org/W3022575231","https://openalex.org/W2811357073","https://openalex.org/W2766991138","https://openalex.org/W3042402624","https://openalex.org/W2104578054","https://openalex.org/W2903043017"],"abstract_inverted_index":{"A":[0],"rational":[1],"monoclonal":[2],"antibody":[3],"(mAb)-based":[4],"antitumor":[5,199],"therapy":[6,26,150],"approach":[7,237],"has":[8],"previously":[9],"been":[10,67],"shown":[11],"to":[12,48,57],"eradicate":[13],"various":[14],"established":[15,112],"experimental":[16,113],"and":[17,52,110,116,125,139,145,207,222,235],"carcinogen-induced":[18],"tumors":[19,118],"in":[20,69,74,121,167,203],"a":[21,211],"majority":[22],"of":[23,64,164,177,184,193,224],"mice.":[24],"This":[25],"comprised":[27],"an":[28,44,53,233],"agonistic":[29,45,54],"mAb":[30,47,56,77,109],"reactive":[31],"with":[32,78,123,205],"tumor":[33,42,133,165,219],"necrosis":[34],"factor-related":[35],"apoptosis-inducing":[36],"ligand":[37],"receptor":[38],"(DR5),":[39],"expressed":[40],"by":[41,88,228],"cells,":[43,51,142,144],"anti-CD40":[46,76,108],"mature":[49],"dendritic":[50,80,225],"anti-4-1BB":[55,126],"costimulate":[58],"CD8(+)":[59,140],"T":[60,92,141],"cells.":[61,94],"Because":[62],"agonists":[63,231],"CD40":[65],"have":[66],"toxic":[68],"patients,":[70],"we":[71,96],"were":[72],"interested":[73],"substituting":[75],"other":[79],"cell-maturing":[81],"agents,":[82],"such":[83],"as":[84],"glycolipid":[85,100],"ligands":[86,101],"recognized":[87],"invariant":[89],"natural":[90],"killer":[91],"(iNKT)":[93],"Here,":[95],"show":[97],"that":[98],"CD1d-restricted":[99],"for":[102,107,238],"iNKT":[103],"cells":[104],"effectively":[105],"substitute":[106],"reject":[111],"mouse":[114],"breast":[115],"renal":[117],"when":[119,201],"used":[120,202],"combination":[122,204],"anti-DR5":[124],"mAbs":[127],"(termed":[128],"\"NKTMab\"":[129],"therapy).":[130],"NKTMab":[131,149],"therapy-induced":[132],"rejection":[134,166],"was":[135,171],"dependent":[136],"on":[137],"CD4(+)":[138],"NKT":[143,229],"the":[146,174,182],"cytokine":[147],"IFN-gamma.":[148],"containing":[151],"either":[152],"alpha-galactosylceramide":[153],"(alpha-GC)":[154],"or":[155],"alpha-C-galactosylceramide":[156],"(alpha-c-GC)":[157],"at":[158,173],"high":[159],"concentrations":[160],"induced":[161],"similar":[162],"rates":[163],"mice;":[168],"however,":[169],"toxicity":[170],"observed":[172],"highest":[175],"doses":[176,192],"alpha-GC":[178],"(>250":[179],"ng/injection),":[180],"limiting":[181],"use":[183],"this":[185],"glycolipid.":[186],"By":[187],"contrast,":[188],"even":[189],"very":[190],"low":[191],"alpha-c-GC":[194,209],"(25":[195],"ng/injection)":[196],"retained":[197],"considerable":[198],"activity":[200],"anti-DR5/anti-4-1BB,":[206],"thus,":[208],"showed":[210],"considerably":[212],"greater":[213],"therapeutic":[214],"index.":[215],"In":[216],"summary,":[217],"sequential":[218],"cell":[220,226,230],"apoptosis":[221],"amplification":[223],"function":[227],"represents":[232],"exciting":[234],"novel":[236],"cancer":[239],"treatment.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}