{"id":"https://openalex.org/W2111494027","doi":null,"title":"p53 alterations are associated with improved prognosis in distal colonic carcinomas.","display_name":"p53 alterations are associated with improved prognosis in distal colonic carcinomas.","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2111494027","mag":"2111494027","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815825"},"language":"en","primary_location":{"id":"pmid:9815825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052071706","display_name":"Richie Soong","orcid":"https://orcid.org/0000-0002-0152-1225","observed_orcids":["https://orcid.org/0000-0002-0152-1225"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"R Soong","raw_affiliation_strings":["Departments of Surgery and Public Health, University of Western Australia, Nedlands 6907, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Public Health, University of Western Australia, Nedlands 6907, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111901369","display_name":"Fabienne Grieu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Grieu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Robbins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Robbins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016813934","display_name":"Brett R. Dix","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Dix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084896609","display_name":"D. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082690187","display_name":"Ramon E. Parsons","orcid":"https://orcid.org/0000-0002-6656-3514","observed_orcids":["https://orcid.org/0000-0002-6656-3514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Parsons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108487265","display_name":"A. K. House","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A House","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041995242","display_name":"Bianca M. Iacopetta","orcid":"https://orcid.org/0009-0003-7510-5261","observed_orcids":["https://orcid.org/0009-0003-7510-5261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Iacopetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8249,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.9046238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"8","first_page":"1405","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1931000053882599,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/p53-overexpression","display_name":"p53 overexpression","score":0.9440000057220459},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dukes-stage","display_name":"Dukes stage","score":0.7570000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6329240798950195},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.630404531955719},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5574227571487427},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5256822109222412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5031759142875671},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.47231313586235046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4639297127723694},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.44868385791778564},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4258890151977539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42481160163879395},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42397361993789673},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4217492938041687},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40859290957450867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3850295841693878},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3802652955055237},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3719552159309387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3309789001941681},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.30946987867355347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05691990256309509},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:9815825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/8fa3e4c7-e118-4879-922b-50f4e1c38a85","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/8fa3e4c7-e118-4879-922b-50f4e1c38a85","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Soong, R, Grieu, F, Robbins, P, Dix, B, Chen, D, Parsons, R, House, A & Iacopetta, B 1997, 'p53 Alterations Are Associated with Improved Prognosis in Distal Colonic Carcinomas1', Clinical Cancer Research, vol. 3, pp. 1405-1411.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2111494027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1552426876","https://openalex.org/W1841077963","https://openalex.org/W1847864430","https://openalex.org/W1906462579","https://openalex.org/W1921565175","https://openalex.org/W1964120169","https://openalex.org/W1966268185","https://openalex.org/W1982619204","https://openalex.org/W1995819860","https://openalex.org/W2004072274","https://openalex.org/W2012053348","https://openalex.org/W2029359666","https://openalex.org/W2030283142","https://openalex.org/W2047350045","https://openalex.org/W2052193554","https://openalex.org/W2054224954","https://openalex.org/W2059909963","https://openalex.org/W2065031458","https://openalex.org/W2065730711","https://openalex.org/W2067568391","https://openalex.org/W2073114196","https://openalex.org/W2081661161","https://openalex.org/W2084954009","https://openalex.org/W2088098884","https://openalex.org/W2094616662","https://openalex.org/W2159021709","https://openalex.org/W2166594730","https://openalex.org/W2403452898","https://openalex.org/W2417518862","https://openalex.org/W2421234360","https://openalex.org/W2428861015"],"related_works":["https://openalex.org/W1973715178","https://openalex.org/W2267421534","https://openalex.org/W1975718492","https://openalex.org/W2002678771","https://openalex.org/W2080636165","https://openalex.org/W2072027648","https://openalex.org/W1977109930","https://openalex.org/W2054014807","https://openalex.org/W2164170534","https://openalex.org/W2885038346"],"abstract_inverted_index":{"Alterations":[0],"of":[1,15,59,63,74,90,101,117,133,143,167,183,228,255],"the":[2,6,50,60,108,115,165,168,173,181,197,203,229,242,253],"p53":[3,7,22,26,64,102,118,134,184,219,230,256],"gene":[4,23,68,119,231],"and":[5,67,186,221],"protein":[8,27,65,135],"are":[9],"common":[10],"in":[11,52,70,121,172,202,241,249],"a":[12,31,71,177,235],"wide":[13],"spectrum":[14],"human":[16],"malignancies.":[17],"In":[18],"several":[19],"tumor":[20,144,251],"types,":[21,252],"mutation":[24,69,120],"and/or":[25],"overexpression":[28],"correlate":[29,259],"with":[30,80,107,138,234,260],"more":[32],"clinically":[33],"aggressive":[34],"phenotype":[35],"as":[36],"judged":[37],"by":[38,105],"worse":[39],"patient":[40,82,140,188],"survival.":[41],"This":[42],"has":[43],"not":[44,196,211],"been":[45],"clearly":[46],"demonstrated":[47],"to":[48],"be":[49],"case":[51,198],"colorectal":[53,75],"cancer.":[54],"Herein,":[55],"we":[56],"report":[57],"results":[58,246],"prognostic":[61],"significance":[62],"accumulation":[66,103,185,220],"large":[72,88],"series":[73],"cancers":[76],"(n":[77],"=":[78,156,191,225],"541)":[79],"long":[81],"follow-up":[83],"(mean,":[84],"87":[85],"months).":[86],"The":[87,99],"majority":[89],"patients":[91],"(95%)":[92],"received":[93],"no":[94],"postoperative":[95],"systemic":[96],"adjuvant":[97],"therapy.":[98],"incidence":[100,116],"detected":[104,124],"immunohistochemistry":[106],"monoclonal":[109],"antibody":[110],"DO-7":[111],"was":[112,130,136,161,195,232],"30%,":[113],"whereas":[114],"exons":[122],"5-8":[123],"using":[125],"PCR-single":[126],"strand":[127],"conformation":[128],"polymorphism":[129],"36%.":[131],"Accumulation":[132],"associated":[137,233],"improved":[139,187,238],"survival":[141,189],"independent":[142],"stage":[145,207,212],"or":[146],"grade":[147],"(hazard":[148],"ratio,":[149],"0.66;":[150],"95%":[151],"confidence":[152],"interval,":[153],"0.47-0.93;":[154],"P":[155],"0.017).":[157],"A":[158],"marked":[159],"difference":[160],"observed":[162],"depending":[163],"on":[164],"location":[166],"tumor:":[169],"tumors":[170],"originating":[171],"distal":[174,243],"colon":[175],"showed":[176,215],"strong":[178],"association":[179,217],"between":[180,218],"presence":[182,254],"(P":[190,224],"0.003),":[192],"but":[193,210],"this":[194],"for":[199],"those":[200],"located":[201],"proximal":[204],"colon.":[205],"Dukes'":[206],"C":[208],"tumors,":[209],"B,":[213],"also":[214],"an":[216],"better":[222,261],"outcome":[223],"0.013).":[226],"Mutation":[227],"trend":[236],"toward":[237],"survival,":[239],"particularly":[240],"tumors.":[244],"Our":[245],"demonstrate":[247],"that":[248],"some":[250],"abnormalities":[257],"can":[258],"prognosis.":[262]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}