{"id":"https://openalex.org/W2111429331","doi":"https://doi.org/10.1097/00003246-200207000-00001","title":"Increasing respiratory rate to improve CO2 clearance during mechanical ventilation is not a panacea in acute respiratory failure*","display_name":"Increasing respiratory rate to improve CO2 clearance during mechanical ventilation is not a panacea in acute respiratory failure*","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2111429331","doi":"https://doi.org/10.1097/00003246-200207000-00001","mag":"2111429331","pmid":"https://pubmed.ncbi.nlm.nih.gov/12130953"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-200207000-00001","doi":"https://doi.org/10.1097/00003246-200207000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200207000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086939755","display_name":"Antoine Vieillard\u2010Baron","orcid":"https://orcid.org/0000-0002-4179-3583","observed_orcids":["https://orcid.org/0000-0002-4179-3583"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Vieillard-Baron","raw_affiliation_strings":["Medical Intensive Care Unit, University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Intensive Care Unit, University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]},{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023244652","display_name":"S\u00e9bastien Prin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Prin","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041627553","display_name":"Roch Augarde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roch Augarde","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043170349","display_name":"P Desfonds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Desfonds","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113560083","display_name":"Bernard Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Page","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081205053","display_name":"Alain Beauchet","orcid":"https://orcid.org/0000-0001-6339-982X","observed_orcids":["https://orcid.org/0000-0001-6339-982X"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Beauchet","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113591506","display_name":"Fran\u00e7ois Jardin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Jardin","raw_affiliation_strings":["A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A respiratory strategy including a high respiratory rate to increase minute ventilation in patients with acute respiratory failure, when not accompanied by instrumental deadspace reduction and a major change in inspiratory flow, was inefficient in improving CO2 elimination and produced a substantial intrinsic positive end-expiratory pressure","institution_ids":[]},{"raw_affiliation_string":"the Medical Intensive Care Unit (AVB, SP, RA, BP, FJ), the Department of Clinical Physiology (PD), and the Department of Biostatistics (AB), University Hospital Ambroise Par\u00e9, Assistance Publique H\u00f4pitaux de Paris, Boulogne Cedex, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5288,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.95957021,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"30","issue":"7","first_page":"1407","last_page":"1412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-failure","display_name":"acute respiratory failure","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/co2-clearance","display_name":"CO2 clearance","score":0.953000009059906},{"id":"https://openalex.org/keywords/dynamic-hyperinflation","display_name":"dynamic hyperinflation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/intrinsic-positive-end-expiratory-pressure","display_name":"intrinsic positive end-expiratory pressure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/right-ventricular-function","display_name":"right ventricular function","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cardiac-index","display_name":"cardiac index","score":0.675000011920929},{"id":"https://openalex.org/keywords/pao2","display_name":"PaO2","score":0.5600000023841858},{"id":"https://openalex.org/keywords/paco2","display_name":"PaCO2","score":0.6970000267028809},{"id":"https://openalex.org/keywords/volume-controlled-ventilation","display_name":"volume-controlled ventilation","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8682650327682495},{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.7297199368476868},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.58615642786026},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.563715934753418},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.547732949256897},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5252261161804199},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.5220087170600891},{"id":"https://openalex.org/C2777311218","wikidata":"https://www.wikidata.org/wiki/Q7202231","display_name":"Plateau pressure","level":4,"score":0.5125391483306885},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.506777822971344},{"id":"https://openalex.org/C2778917391","wikidata":"https://www.wikidata.org/wiki/Q352381","display_name":"Positive end-expiratory pressure","level":3,"score":0.49807095527648926},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3977227509021759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2643461227416992},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2557079493999481},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.23691809177398682},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016278","descriptor_name":"Ventricular Function, Right","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-200207000-00001","doi":"https://doi.org/10.1097/00003246-200207000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200207000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:12130953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12130953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1911299581","https://openalex.org/W1964723140","https://openalex.org/W1974349191","https://openalex.org/W2017114258","https://openalex.org/W2028613288","https://openalex.org/W2031180695","https://openalex.org/W2046575947","https://openalex.org/W2047833061","https://openalex.org/W2051877516","https://openalex.org/W2068400171","https://openalex.org/W2092204085","https://openalex.org/W2093952348","https://openalex.org/W2111453635","https://openalex.org/W2134224532","https://openalex.org/W2147279870","https://openalex.org/W2161328469","https://openalex.org/W2239119540","https://openalex.org/W2333922183","https://openalex.org/W2597070792","https://openalex.org/W2897229054"],"related_works":["https://openalex.org/W2356632944","https://openalex.org/W7163179657","https://openalex.org/W2600753217","https://openalex.org/W2037474989","https://openalex.org/W2088877985","https://openalex.org/W3090915748","https://openalex.org/W4239705096","https://openalex.org/W6902820546","https://openalex.org/W2068400171","https://openalex.org/W2108203508"],"abstract_inverted_index":{"BACKGROUND:":[0],"Increasing":[1],"respiratory":[2,16,62,96,106,120,138,142,153,271,281],"rate":[3,97,143,154,272],"has":[4],"recently":[5],"been":[6],"proposed":[7],"to":[8,43,206],"improve":[9,285],"CO2":[10,286],"clearance":[11],"in":[12,77,226,245,249,277],"patients":[13,59,278],"with":[14,60,122,140,151,160,180,197,217,261,279],"acute":[15,61,280],"failure":[17,63,282],"who":[18],"are":[19],"receiving":[20],"mechanical":[21,75,275],"ventilation.":[22],"However,":[23],"the":[24,65,71,83,123,161,164,181,198,218,250,262],"efficacy":[25],"of":[26,51,67,74,98,111,144,155],"this":[27],"strategy":[28,139,150,166,273],"may":[29],"be":[30],"limited":[31],"by":[32,116],"deadspace":[33,205],"ventilation,":[34],"and":[35,108,147,221,291],"it":[36],"might":[37],"induce":[38],"adverse":[39],"hemodynamic":[40],"effects":[41],"related":[42],"dynamic":[44,223,289],"hyperinflation.":[45],"SETTING:":[46],"An":[47],"intensive":[48],"care":[49],"unit":[50],"a":[52,95,135,141,148,152,227,246,269],"university":[53],"hospital.":[54],"PATIENTS:":[55],"We":[56,266],"studied":[57],"14":[58],"during":[64,274],"adjustment":[66],"ventilator":[68],"settings":[69],"on":[70],"first":[72],"day":[73],"ventilation":[76,276],"volume-controlled":[78],"mode.":[79],"MEASUREMENTS:":[80],"After":[81],"determining":[82],"positive":[84,91,230],"end-expiratory":[85,92,231],"pressure":[86,93,126,232],"that":[87,268],"suppresses":[88],"any":[89],"intrinsic":[90,229],"at":[94],"15":[99,145],"breaths/min,":[100,146],"we":[101],"compared":[102],"blood":[103],"gas":[104],"analysis,":[105],"measurements,":[107],"Doppler":[109],"evaluation":[110],"right":[112,293],"ventricular":[113,239,294],"systolic":[114],"function":[115],"using":[117],"two":[118],"different":[119],"strategies":[121],"same":[124],"airway":[125],"limitation":[127],"(plateau":[128],"pressure,":[129],"<":[130],"or":[131],"=25":[132],"cm":[133,236],"H2O),":[134],"low-rate":[136,162,182,199,219,263],"conventional":[137],"high-rate":[149,165],"30":[156],"breaths/min.":[157],"RESULTS:":[158],"Compared":[159],"strategy,":[163],"neither":[167],"significantly":[168,185,202],"reduced":[169],"PaCO2":[170],"(47":[171],"+/-":[172,176,189,193,211,215,234,254,258],"8":[173],"vs.":[174,191,213,256],"51":[175],"7":[177],"mm":[178,195],"Hg":[179,196],"strategy)":[183,220],"nor":[184],"improved":[186],"PaO2":[187],"(99":[188],"40":[190],"95":[192],"35":[194],"strategy).":[200,264],"It":[201],"increased":[203],"alveolar":[204],"tidal":[207],"volume":[208],"ratio":[209],"(21%":[210],"8%,":[212],"14%":[214],"6%":[216],"produced":[222,288],"hyperinflation,":[224,290],"resulting":[225,244],"substantial":[228],"(6.4":[233],"2.7":[235],"H2O).":[237],"Right":[238],"outflow":[240],"impedance":[241],"was":[242],"increased,":[243],"significant":[247],"drop":[248],"cardiac":[251],"index":[252],"(2.9":[253],"0.6":[255],"3.3":[257],"0.7":[259],"L/min/m":[260],"CONCLUSION:":[265],"conclude":[267],"high":[270],"did":[283],"not":[284],"clearance,":[287],"impaired":[292],"ejection.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
