{"id":"https://openalex.org/W2111352166","doi":null,"title":"Energy availability and alcohol-related liver pathology.","display_name":"Energy availability and alcohol-related liver pathology.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2111352166","mag":"2111352166","pmid":"https://pubmed.ncbi.nlm.nih.gov/15540800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5627711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109652677","display_name":"CAROL C. CUNNINGHAM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol C Cunningham","raw_affiliation_strings":["Department ofBiochemistry at Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofBiochemistry at Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076368599","display_name":"Cynthia G. Van Horn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia G Van Horn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4372,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.67257651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"4","first_page":"291","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/energy-availability","display_name":"energy availability","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxygen-deficit","display_name":"oxygen deficit","score":0.7409999966621399},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.5630000233650208},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.968999981880188},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.906000018119812},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6179999709129333},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6776206493377686},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6617939472198486},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6017160415649414},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.596184253692627},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.555618166923523},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5325077772140503},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.5155777335166931},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.500410795211792},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4964459538459778},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4784267544746399},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.43792420625686646},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4342220723628998},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43099847435951233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4278488755226135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3526408076286316},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.34476566314697266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34287896752357483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33779653906822205},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3107364773750305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2976188659667969},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.154087632894516},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019973","descriptor_name":"Alcohol-Related Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019973","descriptor_name":"Alcohol-Related Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:5627711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6668872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol Res Health","raw_type":"Text"},{"id":"pmid:15540800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15540800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.576.3832","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.576.3832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://pubs.niaaa.nih.gov/publications/arh27-4/291-299.pdf","raw_type":"text"},{"id":"mag:2111352166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15540800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5627711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668872","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000899266","display_name":"Multidisciplinary Training in the Biology of Alcohol Addiction","funder_award_id":"T32AA007565","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W12142967","https://openalex.org/W82978742","https://openalex.org/W188004913","https://openalex.org/W1565212514","https://openalex.org/W1584832175","https://openalex.org/W1778687422","https://openalex.org/W1800399702","https://openalex.org/W1976428870","https://openalex.org/W1979874273","https://openalex.org/W1991259391","https://openalex.org/W2011122017","https://openalex.org/W2017052034","https://openalex.org/W2043335917","https://openalex.org/W2086099320","https://openalex.org/W2133362207","https://openalex.org/W2137724456","https://openalex.org/W2275889189"],"related_works":["https://openalex.org/W2201852530","https://openalex.org/W2127215398","https://openalex.org/W4235638781","https://openalex.org/W2111919147","https://openalex.org/W2043654531","https://openalex.org/W7098838386","https://openalex.org/W2009399532","https://openalex.org/W958410617","https://openalex.org/W2053521594","https://openalex.org/W4293201560"],"abstract_inverted_index":{"Alcohol":[0,139],"consumption":[1,140],"alters":[2],"the":[3,6,14,16,23,26,36,55,64,73,80,114,124,134,160,168],"metabolism":[4],"of":[5,10,20,85,118,126,129,145,148,157,170],"most":[7],"common":[8],"type":[9],"cell":[11,107,172,179],"found":[12],"in":[13,22,41,46,51,100],"liver,":[15],"hepatocyte.":[17],"The":[18,88],"presence":[19],"alcohol":[21],"body":[24],"causes":[25,43],"liver":[27,86,183],"to":[28,63,82,163,178],"use":[29],"more":[30],"oxygen-for":[31],"example,":[32,110],"when":[33],"breaking":[34],"down":[35],"alcohol.":[37],"Increased":[38],"oxygen":[39,44,92],"use,":[40],"turn,":[42],"deficits":[45,93,99],"several":[47,152],"key":[48],"cells,":[49],"particularly":[50],"hepatocytes":[52],"located":[53],"near":[54],"small":[56],"hepatic":[57],"veins.":[58],"These":[59],"veins":[60,78],"return":[61],"blood":[62],"heart":[65],"for":[66,106],"re-oxygenation":[67],"after":[68],"it":[69],"has":[70],"passed":[71],"through":[72,151],"liver.":[74],"Hepatocytes":[75],"surrounding":[76],"these":[77,146],"are":[79,104],"first":[81],"show":[83],"signs":[84],"disease.":[87,184],"damage":[89],"induced":[90],"by":[91,97],"may":[94,141,175],"be":[95],"exacerbated":[96],"alcohol-induced":[98,171],"other":[101],"components":[102],"that":[103],"essential":[105],"survival.":[108],"For":[109],"adenosine":[111],"triphosphate":[112],"(ATP),":[113],"cell's":[115,161],"main":[116],"source":[117],"energy,":[119],"is":[120],"generated":[121],"primarily":[122],"during":[123],"course":[125],"two":[127],"sets":[128],"metabolic":[130],"reactions:":[131],"glycolysis":[132],"and":[133,174,181],"mitochondrial":[135],"oxidative":[136],"phosphorylation":[137],"process.":[138],"interfere":[142],"with":[143],"both":[144],"pathways":[147],"ATP":[149,158],"production":[150],"mechanisms.":[153],"An":[154],"inadequate":[155],"supply":[156],"impairs":[159],"ability":[162],"perform":[164],"critical":[165],"functions,":[166],"including":[167],"repair":[169],"damage,":[173],"therefore":[176],"contribute":[177],"death":[180],"alcoholic":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
