{"id":"https://openalex.org/W2111244541","doi":null,"title":"THE USE OF INFRARED SPECTROSCOPY FOR FOLLOWING DRUG-MEMBRANE INTERACTIONS: PROBING PACLITAXEL (TAXOL)-CELL PHOSPHOLIPID SURFACE RECOGNITION","display_name":"THE USE OF INFRARED SPECTROSCOPY FOR FOLLOWING DRUG-MEMBRANE INTERACTIONS: PROBING PACLITAXEL (TAXOL)-CELL PHOSPHOLIPID SURFACE RECOGNITION","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2111244541","mag":"2111244541"},"language":"en","primary_location":{"id":"mag:2111244541","doi":null,"is_oa":false,"landing_page_url":"https://biomed.uninet.edu/2009/n3/erhan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111993333","display_name":"Comit\u00e9 Cient\u00edfico","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Comit\u00e9 Cient\u00edfico","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090238632","display_name":"Erhan S\u00fcleymano\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erhan S\u00fcleymano\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059948983","display_name":"Electron J Biomed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Electron J Biomed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.43630000948905945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-membrane-interactions","display_name":"drug-membrane interactions","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-membrane-phospholipids","display_name":"cell membrane phospholipids","score":0.8109999895095825},{"id":"https://openalex.org/keywords/surface-recognition","display_name":"surface recognition","score":0.5529999732971191},{"id":"https://openalex.org/keywords/infrared-spectroscopy","display_name":"infrared spectroscopy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6610000133514404},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7768361568450928},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.500483512878418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49078139662742615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47909027338027954},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.47697052359580994},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46831876039505005},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4451867938041687},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4381859600543976},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43601012229919434},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4351118803024292},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.40770161151885986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39643073081970215},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38002529740333557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3720579147338867},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3663814067840576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21035811305046082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18990135192871094},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.09202304482460022}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2111244541","doi":null,"is_oa":false,"landing_page_url":"https://biomed.uninet.edu/2009/n3/erhan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W131371615","https://openalex.org/W201490378","https://openalex.org/W564189437","https://openalex.org/W590955347","https://openalex.org/W651447696","https://openalex.org/W1433665766","https://openalex.org/W1486096206","https://openalex.org/W1503388768","https://openalex.org/W1504172295","https://openalex.org/W1568104635","https://openalex.org/W1572819095","https://openalex.org/W1587963872","https://openalex.org/W1650906623","https://openalex.org/W1826954337","https://openalex.org/W1924206975","https://openalex.org/W1967950972","https://openalex.org/W1969788761","https://openalex.org/W1974938825","https://openalex.org/W1977340713","https://openalex.org/W1978278349","https://openalex.org/W1981280471","https://openalex.org/W1981748085","https://openalex.org/W1984552603","https://openalex.org/W1985774086","https://openalex.org/W1986650764","https://openalex.org/W1995963317","https://openalex.org/W1996365673","https://openalex.org/W1997041762","https://openalex.org/W1998858180","https://openalex.org/W1999032092","https://openalex.org/W2001099356","https://openalex.org/W2003418017","https://openalex.org/W2004042700","https://openalex.org/W2005575116","https://openalex.org/W2005623678","https://openalex.org/W2005753373","https://openalex.org/W2006221512","https://openalex.org/W2008091140","https://openalex.org/W2010420767","https://openalex.org/W2018576697","https://openalex.org/W2023933505","https://openalex.org/W2024372419","https://openalex.org/W2028691524","https://openalex.org/W2029704126","https://openalex.org/W2030845694","https://openalex.org/W2032736075","https://openalex.org/W2033346155","https://openalex.org/W2033557562","https://openalex.org/W2039877763","https://openalex.org/W2042190518","https://openalex.org/W2043061492","https://openalex.org/W2043288164","https://openalex.org/W2044647958","https://openalex.org/W2048751065","https://openalex.org/W2048997359","https://openalex.org/W2049114455","https://openalex.org/W2051831178","https://openalex.org/W2056775926","https://openalex.org/W2059654151","https://openalex.org/W2060013956","https://openalex.org/W2060331797","https://openalex.org/W2067361016","https://openalex.org/W2068548171","https://openalex.org/W2069031289","https://openalex.org/W2069243797","https://openalex.org/W2070805871","https://openalex.org/W2071500473","https://openalex.org/W2074388242","https://openalex.org/W2076672515","https://openalex.org/W2081771865","https://openalex.org/W2089217892","https://openalex.org/W2095177417","https://openalex.org/W2097388066","https://openalex.org/W2098649843","https://openalex.org/W2101256833","https://openalex.org/W2107433400","https://openalex.org/W2112604698","https://openalex.org/W2122522737","https://openalex.org/W2123281294","https://openalex.org/W2125872855","https://openalex.org/W2127957413","https://openalex.org/W2136447069","https://openalex.org/W2140744545","https://openalex.org/W2147114673","https://openalex.org/W2148478985","https://openalex.org/W2148943471","https://openalex.org/W2150974219","https://openalex.org/W2151606546","https://openalex.org/W2152126170","https://openalex.org/W2153043838","https://openalex.org/W2155966056","https://openalex.org/W2164778107","https://openalex.org/W2165911934","https://openalex.org/W2169542233","https://openalex.org/W2211100999","https://openalex.org/W2315747402","https://openalex.org/W2406664710","https://openalex.org/W2409430697","https://openalex.org/W2416600647","https://openalex.org/W2417196901","https://openalex.org/W2417505768","https://openalex.org/W2471968876","https://openalex.org/W2484543306","https://openalex.org/W2489644807","https://openalex.org/W2489851715","https://openalex.org/W2501923200","https://openalex.org/W2605015606","https://openalex.org/W2950309033","https://openalex.org/W3023376463","https://openalex.org/W3165931875","https://openalex.org/W4310822345"],"related_works":["https://openalex.org/W7099226718","https://openalex.org/W6992886286","https://openalex.org/W2501213027","https://openalex.org/W4385399683","https://openalex.org/W2133662220","https://openalex.org/W2010609867","https://openalex.org/W2019974662","https://openalex.org/W2086148809","https://openalex.org/W2583402758","https://openalex.org/W2107436374"],"abstract_inverted_index":{"SUMMARY:":[0],"Over":[1],"the":[2,7,20,28,82,90],"past":[3],"two":[4],"decades,":[5],"of":[6,22,27,46,65,69,84,92],"several":[8],"new":[9],"chemotherapeutic":[10],"agents,":[11],"taxol":[12],"(Paclitaxel)":[13],"has":[14],"played":[15],"a":[16],"crucial":[17],"role":[18],"in":[19],"treatment":[21],"various":[23],"malignancies,":[24],"including":[25],"those":[26],"ovary,":[29],"breast,":[30],"lung,":[31],"head":[32],"and":[33,52],"neck,":[34],"esophagus,":[35],"as":[36,38,72,102],"well":[37,43,78],"Kaposi's":[39],"sarcoma.":[40],"Despite":[41],"its":[42],"documented":[44],"mechanisms":[45,83],"action":[47],"causing":[48],"cell":[49],"cycle":[50],"arrest":[51],"apoptosis":[53],"following":[54],"microtubule":[55],"stabilization,":[56],"further":[57],"details":[58],"still":[59],"remain":[60],"to":[61],"be":[62],"clarified.":[63],"Alterations":[64],"lipid":[66],"membrane":[67,98],"composition":[68],"cancer":[70,93],"cells":[71,76],"compared":[73],"with":[74],"normal":[75],"are":[77,95],"established.":[79],"In":[80],"addition,":[81],"drug":[85],"resistance,":[86],"which":[87],"severely":[88],"limit":[89],"effectiveness":[91],"chemotherapy":[94],"undertaken":[96],"by":[97],"located":[99],"proteins":[100],"such":[101],"multidrug":[103],"resistance":[104],"(MDR-1)":[105],"or":[106],"P-glycoprotein":[107],"(Pgp).":[108]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
