{"id":"https://openalex.org/W2111237653","doi":null,"title":"CD8+ T CELLS IN THE DEVELOPMENT OF ALLOGRAFT VASCULOPATHY AND DE NOVO ALLOSPECIFIC MEMORY FORMATION","display_name":"CD8+ T CELLS IN THE DEVELOPMENT OF ALLOGRAFT VASCULOPATHY AND DE NOVO ALLOSPECIFIC MEMORY FORMATION","publication_year":2014,"publication_date":"2014-01-24","ids":{"openalex":"https://openalex.org/W2111237653","mag":"2111237653"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1017.1740","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1017.1740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dalspace.library.dal.ca:8080/xmlui/bitstream/handle/10222/43957/Hart-Matyas-Michael-PhD-PATH-January-2014.pdf%3Bjsessionid%3DEDE3C7F6A76BA17FBC9585F65DC9FE90?sequence%3D3","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003369935","display_name":"Michael Hart-Matyas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Hart-Matyas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003369935"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allograft-vasculopathy","display_name":"allograft vasculopathy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/chronic-rejection","display_name":"chronic rejection","score":0.7670000195503235},{"id":"https://openalex.org/keywords/calcineurin-inhibitor-immunosuppression","display_name":"calcineurin inhibitor immunosuppression","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neointimal-lesion","display_name":"neointimal lesion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/immunosuppression-timing","display_name":"immunosuppression timing","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3648325800895691},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3558219075202942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31092196702957153}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1017.1740","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1017.1740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dalspace.library.dal.ca:8080/xmlui/bitstream/handle/10222/43957/Hart-Matyas-Michael-PhD-PATH-January-2014.pdf%3Bjsessionid%3DEDE3C7F6A76BA17FBC9585F65DC9FE90?sequence%3D3","raw_type":"text"},{"id":"pmh:oai:collectionscanada.gc.ca:NSHD.ca#10222/43957","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10222/43957","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:dal.scholaris.ca:10222/43957","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10222/43957","pdf_url":null,"source":{"id":"https://openalex.org/S7407064432","display_name":"DalSpace (Dalhousie University)","issn_l":"2041-2096","issn":["2041-2096"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/I129902397","host_organization_name":"Dalhousie University","host_organization_lineage":["https://openalex.org/I129902397"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2111237653","doi":null,"is_oa":false,"landing_page_url":"https://dalspace.library.dal.ca/bitstream/handle/10222/43957/Hart-Matyas-Michael-PhD-PATH-January-2014.pdf?sequence=3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":297,"referenced_works":["https://openalex.org/W23408998","https://openalex.org/W26420099","https://openalex.org/W28981592","https://openalex.org/W45859881","https://openalex.org/W54684436","https://openalex.org/W69496016","https://openalex.org/W111178072","https://openalex.org/W139683219","https://openalex.org/W171893929","https://openalex.org/W250791542","https://openalex.org/W1466598573","https://openalex.org/W1480410314","https://openalex.org/W1482570752","https://openalex.org/W1486436163","https://openalex.org/W1495605389","https://openalex.org/W1500281207","https://openalex.org/W1508800859","https://openalex.org/W1513619062","https://openalex.org/W1520723865","https://openalex.org/W1523840697","https://openalex.org/W1533596330","https://openalex.org/W1535969196","https://openalex.org/W1540477117","https://openalex.org/W1542488102","https://openalex.org/W1548963416","https://openalex.org/W1556405737","https://openalex.org/W1563797570","https://openalex.org/W1564196191","https://openalex.org/W1593482304","https://openalex.org/W1606417387","https://openalex.org/W1648537547","https://openalex.org/W1697418081","https://openalex.org/W1796142965","https://openalex.org/W1859810431","https://openalex.org/W1942735408","https://openalex.org/W1946807613","https://openalex.org/W1964100060","https://openalex.org/W1966025802","https://openalex.org/W1966073897","https://openalex.org/W1966271780","https://openalex.org/W1966628387","https://openalex.org/W1967676521","https://openalex.org/W1968640534","https://openalex.org/W1970237823","https://openalex.org/W1972258694","https://openalex.org/W1973175840","https://openalex.org/W1973335643","https://openalex.org/W1973386385","https://openalex.org/W1973390559","https://openalex.org/W1973505502","https://openalex.org/W1973586733","https://openalex.org/W1975398457","https://openalex.org/W1975682095","https://openalex.org/W1976355501","https://openalex.org/W1976553783","https://openalex.org/W1976726113","https://openalex.org/W1977322584","https://openalex.org/W1977427723","https://openalex.org/W1977685314","https://openalex.org/W1977703774","https://openalex.org/W1978765918","https://openalex.org/W1979129340","https://openalex.org/W1979674588","https://openalex.org/W1981298448","https://openalex.org/W1981480494","https://openalex.org/W1981568036","https://openalex.org/W1981723348","https://openalex.org/W1982707127","https://openalex.org/W1983315434","https://openalex.org/W1983698019","https://openalex.org/W1983974142","https://openalex.org/W1984908915","https://openalex.org/W1984911228","https://openalex.org/W1985202241","https://openalex.org/W1985253103","https://openalex.org/W1986445400","https://openalex.org/W1987445307","https://openalex.org/W1989684369","https://openalex.org/W1989880720","https://openalex.org/W1990264127","https://openalex.org/W1991210089","https://openalex.org/W1994121614","https://openalex.org/W1994362040","https://openalex.org/W1995181168","https://openalex.org/W1996004092","https://openalex.org/W1996235865","https://openalex.org/W1997780004","https://openalex.org/W1998318400","https://openalex.org/W1999931163","https://openalex.org/W2000779612","https://openalex.org/W2001849346","https://openalex.org/W2002131722","https://openalex.org/W2002989725","https://openalex.org/W2003075471","https://openalex.org/W2003413758","https://openalex.org/W2005154465","https://openalex.org/W2005981959","https://openalex.org/W2007013204","https://openalex.org/W2008184737","https://openalex.org/W2008464410","https://openalex.org/W2008667095","https://openalex.org/W2011387593","https://openalex.org/W2012110635","https://openalex.org/W2013468804","https://openalex.org/W2014752904","https://openalex.org/W2015878807","https://openalex.org/W2016525911","https://openalex.org/W2018628082","https://openalex.org/W2018798721","https://openalex.org/W2019664914","https://openalex.org/W2019967722","https://openalex.org/W2020684972","https://openalex.org/W2020850832","https://openalex.org/W2020955187","https://openalex.org/W2021046976","https://openalex.org/W2021428880","https://openalex.org/W2023037704","https://openalex.org/W2023038954","https://openalex.org/W2025200618","https://openalex.org/W2026933758","https://openalex.org/W2027357824","https://openalex.org/W2027434623","https://openalex.org/W2028208800","https://openalex.org/W2029330507","https://openalex.org/W2029785503","https://openalex.org/W2029889841","https://openalex.org/W2030146228","https://openalex.org/W2033808892","https://openalex.org/W2036807791","https://openalex.org/W2037024992","https://openalex.org/W2038289042","https://openalex.org/W2039688361","https://openalex.org/W2039822378","https://openalex.org/W2040318571","https://openalex.org/W2041658172","https://openalex.org/W2041951312","https://openalex.org/W2041977741","https://openalex.org/W2042594873","https://openalex.org/W2043202072","https://openalex.org/W2043250502","https://openalex.org/W2044271501","https://openalex.org/W2045224955","https://openalex.org/W2045720771","https://openalex.org/W2046842585","https://openalex.org/W2047151970","https://openalex.org/W2048020812","https://openalex.org/W2048044026","https://openalex.org/W2049325121","https://openalex.org/W2049345643","https://openalex.org/W2051893458","https://openalex.org/W2053280933","https://openalex.org/W2054554990","https://openalex.org/W2055248228","https://openalex.org/W2055543492","https://openalex.org/W2058291419","https://openalex.org/W2058430303","https://openalex.org/W2059113040","https://openalex.org/W2059243323","https://openalex.org/W2061904336","https://openalex.org/W2062303998","https://openalex.org/W2062643000","https://openalex.org/W2062924985","https://openalex.org/W2063559371","https://openalex.org/W2063592505","https://openalex.org/W2064876347","https://openalex.org/W2065638217","https://openalex.org/W2065746760","https://openalex.org/W2066300055","https://openalex.org/W2066754455","https://openalex.org/W2066892124","https://openalex.org/W2067000451","https://openalex.org/W2067385303","https://openalex.org/W2067511487","https://openalex.org/W2067679957","https://openalex.org/W2070672630","https://openalex.org/W2071171621","https://openalex.org/W2071246977","https://openalex.org/W2071307134","https://openalex.org/W2073290833","https://openalex.org/W2073580835","https://openalex.org/W2076125315","https://openalex.org/W2076534074","https://openalex.org/W2077483701","https://openalex.org/W2077619366","https://openalex.org/W2077855603","https://openalex.org/W2078307057","https://openalex.org/W2079830501","https://openalex.org/W2081097093","https://openalex.org/W2081903402","https://openalex.org/W2083948182","https://openalex.org/W2084388859","https://openalex.org/W2084493378","https://openalex.org/W2088247886","https://openalex.org/W2088465176","https://openalex.org/W2088732359","https://openalex.org/W2089539530","https://openalex.org/W2089560185","https://openalex.org/W2089688349","https://openalex.org/W2089882531","https://openalex.org/W2090326997","https://openalex.org/W2091649591","https://openalex.org/W2092180284","https://openalex.org/W2093364772","https://openalex.org/W2093848988","https://openalex.org/W2094407359","https://openalex.org/W2094499949","https://openalex.org/W2095733508","https://openalex.org/W2096370504","https://openalex.org/W2098408784","https://openalex.org/W2100359443","https://openalex.org/W2100412095","https://openalex.org/W2105086997","https://openalex.org/W2106531897","https://openalex.org/W2108767527","https://openalex.org/W2109454572","https://openalex.org/W2109673921","https://openalex.org/W2110360170","https://openalex.org/W2112079575","https://openalex.org/W2112506009","https://openalex.org/W2113485611","https://openalex.org/W2113847305","https://openalex.org/W2115655550","https://openalex.org/W2115903325","https://openalex.org/W2116811386","https://openalex.org/W2116891319","https://openalex.org/W2118393858","https://openalex.org/W2118767515","https://openalex.org/W2119502441","https://openalex.org/W2121816244","https://openalex.org/W2122783053","https://openalex.org/W2123052625","https://openalex.org/W2123481422","https://openalex.org/W2124386367","https://openalex.org/W2126222686","https://openalex.org/W2127323719","https://openalex.org/W2127622386","https://openalex.org/W2128392734","https://openalex.org/W2130473166","https://openalex.org/W2130638031","https://openalex.org/W2130939890","https://openalex.org/W2132220648","https://openalex.org/W2132809216","https://openalex.org/W2133190342","https://openalex.org/W2134768631","https://openalex.org/W2136618778","https://openalex.org/W2136992496","https://openalex.org/W2137469857","https://openalex.org/W2137579433","https://openalex.org/W2137780217","https://openalex.org/W2138581811","https://openalex.org/W2138637141","https://openalex.org/W2139277639","https://openalex.org/W2139418412","https://openalex.org/W2139847529","https://openalex.org/W2140813750","https://openalex.org/W2140965118","https://openalex.org/W2144609248","https://openalex.org/W2144890743","https://openalex.org/W2147632178","https://openalex.org/W2148817537","https://openalex.org/W2149142511","https://openalex.org/W2150419780","https://openalex.org/W2150545218","https://openalex.org/W2152027636","https://openalex.org/W2153142861","https://openalex.org/W2153511402","https://openalex.org/W2154724678","https://openalex.org/W2154991712","https://openalex.org/W2155759076","https://openalex.org/W2157388012","https://openalex.org/W2160821944","https://openalex.org/W2160985360","https://openalex.org/W2162098634","https://openalex.org/W2162251532","https://openalex.org/W2162602127","https://openalex.org/W2164351607","https://openalex.org/W2166685519","https://openalex.org/W2168084973","https://openalex.org/W2168662912","https://openalex.org/W2168901087","https://openalex.org/W2169933347","https://openalex.org/W2170476119","https://openalex.org/W2170509997","https://openalex.org/W2178917950","https://openalex.org/W2279448607","https://openalex.org/W2297350747","https://openalex.org/W2312675724","https://openalex.org/W2314230416","https://openalex.org/W2320423786","https://openalex.org/W2322384767","https://openalex.org/W2327490126","https://openalex.org/W2329573625","https://openalex.org/W2333823110","https://openalex.org/W2417865593","https://openalex.org/W2427567590","https://openalex.org/W2521467817","https://openalex.org/W4313422306"],"related_works":["https://openalex.org/W2094407359","https://openalex.org/W2013468804","https://openalex.org/W1974285339","https://openalex.org/W2049325121","https://openalex.org/W2086027010","https://openalex.org/W2058417899","https://openalex.org/W2137579433","https://openalex.org/W1989369192","https://openalex.org/W1970195118","https://openalex.org/W1968276715"],"abstract_inverted_index":{"Long-term":[0],"survival":[1],"of":[2,14,36,57,70,78,87,134,153,197,214,224,237,245,273,281,298,318,345],"cardiac":[3,82,208],"transplant":[4,65,209,230],"recipients":[5,210],"continues":[6],"to":[7,26,150,207,294,308,334],"be":[8,27],"severely":[9],"limited":[10],"by":[11,188],"the":[12,28,34,46,55,76,85,132,138,151,185,200,212,222,235,243,270,279,296,316,343],"development":[13,86,133,236,280,297,317],"a":[15,61,88,109,119,218,310],"pathological,":[16],"chronic":[17],"rejection":[18],"process,":[19],"termed":[20],"allograft":[21],"vasculopathy":[22],"(AV).":[23],"This":[24,73,182],"remains":[25],"case":[29],"despite":[30],"dramatic":[31],"improvements":[32],"in":[33,60,80,96,111,131,175,192,211,229,242,342],"areas":[35],"surgical":[37],"techniques,":[38],"pre-":[39],"and":[40,43,179,217,289],"post-operative":[41],"care,":[42],"immunosuppression.\\nTo":[44],"model":[45,66,74,98],"clinical":[47,271],"setting":[48],"we":[49,141,232,267],"used":[50],"calcineurin":[51],"inhibitor":[52],"(CNI)":[53],"immunosuppression,":[54,59,216],"cornerstone":[56],"post-transplant":[58,276],"murine":[62],"aortic":[63],"interposition":[64],"for":[67,122],"our":[68],"analysis":[69,326],"AV":[71,79,198],"development.":[72],"mimics":[75],"presentation":[77],"human":[81],"transplants":[83],"through":[84],"progressively":[89],"occlusive":[90],"neointimal":[91,112,176],"lesion.":[92],"Our":[93,325],"previous":[94],"work":[95,183],"this":[97,329],"has":[99],"demonstrated":[100,331],"that":[101,143,202,251,269,328],"CD8+,":[102],"but":[103],"not":[104,257],"CD4+,":[105],"T":[106,125,145,190,204,227,240,254,286,303,323,339],"cells":[107,191,205,228,241,255,340],"play":[108],"role":[110,194],"lesion":[113,135,164,177],"formation.":[114,136,165],"Further":[115],"investigation":[116],"also":[117,148,172],"highlighted":[118],"specific":[120],"requirement":[121],"either":[123],"CD8+":[124,144,189,203,239,253,285,302,322,338],"cell-derived":[126,146],"IFN-\u03b3":[127,147],"or":[128],"direct":[129,168],"cytotoxicity":[130],"In":[137],"current":[139],"study":[140],"confirmed":[142],"leads":[149],"loss":[152],"medial":[154,180],"smooth":[155],"muscle":[156],"cells,":[157],"an":[158],"event":[159],"which":[160],"inversely":[161],"correlates":[162],"with":[163,221],"The":[166],"Fas/FasL":[167],"cytotoxic":[169],"pathway":[170],"was":[171,262,292],"significantly":[173],"involved":[174],"formation":[178],"remodeling.":[181],"clarified":[184],"pathways":[186],"utilized":[187],"their":[193],"as":[195],"mediators":[196],"development.\\nRecognizing":[199],"threat":[201],"pose":[206],"presence":[213,223,244],"CNI":[215,246,260,274,346],"growing":[219],"concern":[220],"anti-donor":[225],"memory":[226,238,252,284,301,321,337],"recipients,":[231],"next":[233],"explored":[234],"immunosuppression.":[247,347],"We":[248],"first":[249],"established":[250],"could":[256],"develop":[258],"when":[259],"immunosuppression":[261],"initiated":[263],"immediately":[264],"post-challenge.":[265],"Next,":[266],"hypothesized":[268],"practice":[272],"delay":[275,307],"would":[277],"permit":[278,315],"de":[282,299,319,335],"novo":[283,300,320,336],"cells.":[287,304,324],"Immediate":[288],"early":[290],"initiation":[291],"sufficient":[293],"prevent":[295],"However,":[305],"later":[306],"within":[309],"clinically":[311],"practiced":[312],"timeframe":[313],"did":[314],"revealed":[327],"population":[330],"equivalent":[332],"functionality":[333],"generated":[341],"absence":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}