{"id":"https://openalex.org/W2111109989","doi":null,"title":"Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.","display_name":"Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2111109989","mag":"2111109989","pmid":"https://pubmed.ncbi.nlm.nih.gov/11309338"},"language":"en","primary_location":{"id":"pmid:11309338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11309338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075582483","display_name":"Yasunobu Kanamori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Kanamori","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago 683-8504, Japan. kanamori@grape.med.tottori-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago 683-8504, Japan. kanamori@grape.med.tottori-u.ac.jp","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068198123","display_name":"Junzo Kigawa","orcid":"https://orcid.org/0000-0002-6206-8292","observed_orcids":["https://orcid.org/0000-0002-6206-8292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kigawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062644470","display_name":"Hiroaki Itamochi","orcid":"https://orcid.org/0000-0002-7417-8595","observed_orcids":["https://orcid.org/0000-0002-7417-8595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Itamochi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Shimada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Shimada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001436135","display_name":"Mina Takahashi","orcid":"https://orcid.org/0009-0006-6247-9645","observed_orcids":["https://orcid.org/0009-0006-6247-9645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034562499","display_name":"Shunji Kamazawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kamazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020477987","display_name":"Shinya Sato","orcid":"https://orcid.org/0000-0001-7707-8533","observed_orcids":["https://orcid.org/0000-0001-7707-8533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111612089","display_name":"Ryouji Akeshima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Akeshima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049926214","display_name":"Naoki Terakawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Terakawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6928,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.90892722,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"7","issue":"4","first_page":"892","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9769999980926514},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bad","display_name":"Bad","score":0.3499999940395355},{"id":"https://openalex.org/keywords/protein-expression-correlation","display_name":"protein expression correlation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9906514883041382},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7539819478988647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6641604900360107},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6544999480247498},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5732230544090271},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5403497815132141},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5384964346885681},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5263396501541138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4701195955276489},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.42289048433303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3550277054309845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.343031108379364},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32359278202056885},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.304598331451416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21570435166358948},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.18777430057525635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11917468905448914}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11309338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11309338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2111109989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11309338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1551696649","https://openalex.org/W1565532031","https://openalex.org/W1593108703","https://openalex.org/W1614313922","https://openalex.org/W1973577899","https://openalex.org/W1973653888","https://openalex.org/W1998038367","https://openalex.org/W2024220711","https://openalex.org/W2030573603","https://openalex.org/W2068427129","https://openalex.org/W2070942270","https://openalex.org/W2091403769","https://openalex.org/W2095804402","https://openalex.org/W2097767970","https://openalex.org/W2111125738","https://openalex.org/W2128635872","https://openalex.org/W2141607880"],"related_works":["https://openalex.org/W1975022926","https://openalex.org/W1968942801","https://openalex.org/W2188909999","https://openalex.org/W7051728074","https://openalex.org/W2008463032","https://openalex.org/W2393355524","https://openalex.org/W2362562470","https://openalex.org/W2397967824","https://openalex.org/W2374086065","https://openalex.org/W2379481974"],"abstract_inverted_index":{"The":[0,121,139],"tumor":[1],"suppressor":[2],"PTEN":[3,26,44,85,115,152],"acts":[4],"as":[5],"a":[6,31,110,135],"lipid":[7],"phosphatase,":[8],"regulates":[9],"the":[10,46,55,82,143,149],"phosphatidylinositol":[11],"3-kinase":[12],"(PI3K)/Akt-signaling":[13],"pathway,":[14],"and":[15,20,42,45,116],"modulates":[16],"cell":[17,21],"cycle":[18],"progression":[19],"survival.":[22],"Somatic":[23],"mutations":[24],"of":[25,33,57,76,84,123,145,151,156],"have":[27],"been":[28],"reported":[29],"in":[30,36,61,86,95,102,127,153],"variety":[32],"cancers,":[34],"especially":[35],"endometrial":[37,51,64,68,157],"carcinoma.":[38,65],"To":[39],"clarify":[40],"whether":[41],"how":[43],"PI3K/Akt":[47],"pathway":[48],"relates":[49],"to":[50],"carcinoma,":[52],"we":[53],"examined":[54],"expression":[56,83,122],"those":[58],"pathway-related":[59],"proteins":[60],"patients":[62],"with":[63,93],"Of":[66],"103":[67],"carcinomas,":[69],"37":[70],"(36%)":[71],"showed":[72],"negative":[73,103,128],"immunohistochemical":[74],"staining":[75],"PTEN.":[77],"Western":[78],"blotting":[79],"revealed":[80],"that":[81,94,131],"PTEN-negative":[87],"cases":[88,104],"was":[89,105,125],"significantly":[90,106],"lower":[91],"compared":[92],"positive":[96],"cases.":[97],"In":[98],"contrast,":[99],"phospho-Akt":[100,117],"level":[101],"higher.":[107],"We":[108],"found":[109],"significant":[111],"inverse":[112],"correlation":[113],"between":[114],"(r":[118],"=":[119],"-0.796).":[120],"phospho-Bad":[124],"greater":[126],"cases,":[129],"suggesting":[130],"Bad":[132],"might":[133],"be":[134],"target":[136],"for":[137],"AKT:":[138],"present":[140],"study":[141],"demonstrates":[142],"phosphorylation":[144],"Akt":[146],"accompanied":[147],"by":[148],"loss":[150],"clinical":[154],"specimens":[155],"carcinomas.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}