{"id":"https://openalex.org/W2111045845","doi":"https://doi.org/10.1161/01.atv.20.2.556","title":"HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells","display_name":"HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2111045845","doi":"https://doi.org/10.1161/01.atv.20.2.556","mag":"2111045845","pmid":"https://pubmed.ncbi.nlm.nih.gov/10669656"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.20.2.556","doi":"https://doi.org/10.1161/01.atv.20.2.556","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.20.2.556","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.20.2.556","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.20.2.556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068344835","display_name":"T. Bourcier","orcid":"https://orcid.org/0000-0002-4267-5685","observed_orcids":["https://orcid.org/0000-0002-4267-5685"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Bourcier","raw_affiliation_strings":["From Brigham &amp; Women\u2019s Hospital and Harvard Medical School, Department of Medicine, Vascular Medicine and Atherosclerosis Unit, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Brigham &amp; Women\u2019s Hospital and Harvard Medical School, Department of Medicine, Vascular Medicine and Atherosclerosis Unit, Boston, Mass","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043201732","display_name":"Peter Libby","orcid":"https://orcid.org/0000-0002-1502-502X","observed_orcids":["https://orcid.org/0000-0002-1502-502X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Libby","raw_affiliation_strings":["From Brigham &amp; Women\u2019s Hospital and Harvard Medical School, Department of Medicine, Vascular Medicine and Atherosclerosis Unit, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Brigham &amp; Women\u2019s Hospital and Harvard Medical School, Department of Medicine, Vascular Medicine and Atherosclerosis Unit, Boston, Mass","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8273,"has_fulltext":true,"cited_by_count":277,"citation_normalized_percentile":{"value":0.99344837,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"556","last_page":"562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.949999988079071},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":1.0},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/geranylgeranylation","display_name":"geranylgeranylation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/geranylgeranyl-pyrophosphate","display_name":"geranylgeranyl pyrophosphate","score":0.9120000004768372},{"id":"https://openalex.org/keywords/c3-exoenzyme","display_name":"C3 exoenzyme","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pai-1-promoter","display_name":"PAI-1 promoter","score":0.8799999952316284},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9779999852180481},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2778827360","wikidata":"https://www.wikidata.org/wiki/Q774795","display_name":"Geranylgeranyl pyrophosphate","level":4,"score":0.8617035150527954},{"id":"https://openalex.org/C2776990775","wikidata":"https://www.wikidata.org/wiki/Q2699676","display_name":"Farnesyl pyrophosphate","level":4,"score":0.8402450084686279},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.8137398958206177},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6855616569519043},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.6656476855278015},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6052967309951782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5663729310035706},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.47838082909584045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4763217866420746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4609018564224243},{"id":"https://openalex.org/C2777320049","wikidata":"https://www.wikidata.org/wiki/Q2989497","display_name":"Hydroxymethylglutaryl-CoA reductase","level":5,"score":0.4548337161540985},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.44219234585762024},{"id":"https://openalex.org/C2909373784","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"T-plasminogen activator","level":3,"score":0.4264291226863861},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4215329885482788},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.3898933529853821},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.3472956120967865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33496302366256714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3002973198890686},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25755950808525085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1845252811908722},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.08032891154289246},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.07697060704231262},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07388481497764587}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011106","descriptor_name":"Polyisoprenyl Phosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.atv.20.2.556","doi":"https://doi.org/10.1161/01.atv.20.2.556","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.20.2.556","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.20.2.556","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:10669656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10669656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/12760261","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12760261","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"mag:2887225365","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atvb.20.2.556?legid=atvbaha%3B20%2F2%2F556&cited-by=yes&keytype2=tf_ipsecsha&ijkey=19829a07d716c4be5c513a8c0266ce28b569afe9","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis Thrombosis and Vascular Biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.atv.20.2.556","doi":"https://doi.org/10.1161/01.atv.20.2.556","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.20.2.556","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.20.2.556","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2045210848","display_name":"CONTROL OF GROWTH OF VASCULAR WALL CELLS","funder_award_id":"R37HL034636","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5007819849","display_name":"NFKB IN VASCULAR SMOOTH MUSCLE CELL ACTIVATION/GROWTH","funder_award_id":"F32HL009483","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5185384556","display_name":null,"funder_award_id":"HL09483-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8239363792","display_name":null,"funder_award_id":"R37 HL34636-13","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111045845.pdf","grobid_xml":"https://content.openalex.org/works/W2111045845.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W125668925","https://openalex.org/W1489573122","https://openalex.org/W1585344925","https://openalex.org/W1933212546","https://openalex.org/W1971849142","https://openalex.org/W1990655990","https://openalex.org/W2004797123","https://openalex.org/W2005336665","https://openalex.org/W2015273569","https://openalex.org/W2020690650","https://openalex.org/W2032890774","https://openalex.org/W2052803306","https://openalex.org/W2055323243","https://openalex.org/W2063992063","https://openalex.org/W2070013537","https://openalex.org/W2070627144","https://openalex.org/W2072308694","https://openalex.org/W2076400202","https://openalex.org/W2088237907","https://openalex.org/W2092067196","https://openalex.org/W2096791952","https://openalex.org/W2100233089","https://openalex.org/W2100918102","https://openalex.org/W2135565172","https://openalex.org/W2145448066","https://openalex.org/W2153435788","https://openalex.org/W2155598961","https://openalex.org/W2159633079","https://openalex.org/W2164615751","https://openalex.org/W2169667471","https://openalex.org/W2322095705","https://openalex.org/W2339031854","https://openalex.org/W2417843828","https://openalex.org/W4246764494"],"related_works":["https://openalex.org/W2051235001","https://openalex.org/W1970807871","https://openalex.org/W2157245535","https://openalex.org/W2373889183","https://openalex.org/W2353283622","https://openalex.org/W6990262014","https://openalex.org/W2145448066","https://openalex.org/W2359224432","https://openalex.org/W1945914689","https://openalex.org/W2027865808"],"abstract_inverted_index":{"The":[0],"clinical":[1],"benefit":[2],"of":[3,32,36,61,83,92,97,120,134,141,150],"3-hydroxy-3-methylglutaryl":[4],"coenzyme":[5],"A":[6],"reductase":[7],"inhibitors":[8],"(statins)":[9],"may":[10,155],"derive":[11],"from":[12,65,143,152],"a":[13],"qualitative,":[14],"functional":[15],"change":[16],"in":[17,20,48,170],"atherosclerotic":[18],"lesions":[19],"addition":[21],"to":[22],"their":[23],"lipid-lowering":[24],"properties.":[25],"We":[26],"examined":[27],"whether":[28],"statins":[29],"altered":[30],"expression":[31,140,149],"the":[33,89,118,135,157,162],"major":[34],"determinants":[35],"fibrinolytic":[37,159,167],"balance,":[38],"plasminogen":[39,45],"activator":[40,46],"inhibitor-1":[41],"(PAI-1),":[42],"and":[43,54,67,107,132,145],"tissue-type":[44],"(tPA)":[47],"human":[49],"vascular":[50],"smooth":[51],"muscle":[52],"(SMC)":[53],"endothelial":[55],"(EC)":[56],"cells.":[57],"Simvastatin":[58],"reduced":[59,129],"levels":[60],"PAI-1":[62,124,136,142],"antigen":[63,125],"released":[64],"SMCs":[66,144],"ECs":[68,146],"stimulated":[69],"with":[70,128],"platelet-derived":[71],"growth":[72,76],"factor":[73],"or":[74],"transforming":[75],"factor-beta":[77],"(IC(50)":[78],"approximately":[79],"1":[80],"micromol/L).":[81],"Levels":[82],"EC-derived":[84],"tPA":[85,151],"increased":[86,166],"2-fold":[87],"over":[88],"same":[90],"concentrations":[91],"simvastatin":[93,154],"that":[94],"inhibited":[95],"release":[96],"PAI-1.":[98],"Simvastatin's":[99],"inhibitory":[100],"effect":[101],"was":[102,126],"mimicked":[103],"by":[104,109,114],"C3":[105],"exoenzyme":[106],"prevented":[108],"geranylgeranyl":[110],"pyrophosphate,":[111,116],"but":[112],"not":[113],"farnesyl":[115],"suggesting":[117],"involvement":[119],"geranylgeranyl-modified":[121],"intermediates.":[122],"Decreased":[123],"correlated":[127],"mRNA":[130],"transcription":[131],"activity":[133],"promoter.":[137],"By":[138],"inhibiting":[139],"while":[147],"increasing":[148],"ECs,":[153],"alter":[156],"local":[158],"balance":[160],"within":[161],"vessel":[163],"wall":[164],"toward":[165],"capacity":[168],"that,":[169],"turn,":[171],"would":[172],"reduce":[173],"thrombotic":[174],"risk":[175],"after":[176],"plaque":[177],"rupture.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}
