{"id":"https://openalex.org/W2111037779","doi":null,"title":"Inflammation and behavior following irradiation-induced injury in the developing brain","display_name":"Inflammation and behavior following irradiation-induced injury in the developing brain","publication_year":2009,"publication_date":"2009-08-28","ids":{"openalex":"https://openalex.org/W2111037779","mag":"2111037779"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/20440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/20440","pdf_url":"http://hdl.handle.net/2077/20440","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/20440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003281286","display_name":"Marie Kalm","orcid":"https://orcid.org/0000-0002-0680-5040","observed_orcids":["https://orcid.org/0000-0002-0680-5040"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marie Kalm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0680-5040","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003281286"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-brain-injury","display_name":"radiation-induced brain injury","score":0.8429999947547913},{"id":"https://openalex.org/keywords/irradiation","display_name":"irradiation","score":0.492000013589859},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.8730000257492065},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.7360000014305115},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/neural-progenitor-differentiation","display_name":"neural progenitor differentiation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6430000066757202},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.6480000019073486},{"id":"https://openalex.org/keywords/place-learning","display_name":"place learning","score":0.753000020980835},{"id":"https://openalex.org/keywords/reversal-learning","display_name":"reversal learning","score":0.984000027179718},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.6399999856948853},{"id":"https://openalex.org/keywords/radiotherapy-late-effects","display_name":"radiotherapy late effects","score":0.8830000162124634},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8670220375061035},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7402922511100769},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7393403053283691},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.7029364109039307},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.535315752029419},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4865981340408325},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.45934659242630005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4569145143032074},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4470304846763611},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4120384156703949},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.410483717918396},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3866424560546875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3679770827293396},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3293108344078064},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27845489978790283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.264782190322876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2228974997997284},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14233943819999695},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0715702474117279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0676622986793518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/20440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/20440","pdf_url":"http://hdl.handle.net/2077/20440","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2111037779","doi":null,"is_oa":false,"landing_page_url":"http://gupea.ub.gu.se/bitstream/2077/20440/1/gupea_2077_20440_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/20440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/20440","pdf_url":"http://hdl.handle.net/2077/20440","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322125","display_name":"Stiftelserna Wilhelm och Martina Lundgrens","ror":"https://ror.org/00f08y308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111037779.pdf","grobid_xml":"https://content.openalex.org/works/W2111037779.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W45468463","https://openalex.org/W798758106","https://openalex.org/W1515564094","https://openalex.org/W1534406272","https://openalex.org/W1541080002","https://openalex.org/W1587419561","https://openalex.org/W1594425991","https://openalex.org/W1607819524","https://openalex.org/W1636672661","https://openalex.org/W1903287340","https://openalex.org/W1927523013","https://openalex.org/W1933483841","https://openalex.org/W1963536800","https://openalex.org/W1963634739","https://openalex.org/W1971747664","https://openalex.org/W1974182280","https://openalex.org/W1981279518","https://openalex.org/W1983148583","https://openalex.org/W1984948341","https://openalex.org/W1986791919","https://openalex.org/W1989449291","https://openalex.org/W1990646544","https://openalex.org/W1991805788","https://openalex.org/W1993472781","https://openalex.org/W1997684569","https://openalex.org/W1999831755","https://openalex.org/W1999927211","https://openalex.org/W2001193614","https://openalex.org/W2003425662","https://openalex.org/W2005038717","https://openalex.org/W2006900071","https://openalex.org/W2007369689","https://openalex.org/W2007542786","https://openalex.org/W2008226573","https://openalex.org/W2008274227","https://openalex.org/W2010097112","https://openalex.org/W2014012364","https://openalex.org/W2015040450","https://openalex.org/W2015213990","https://openalex.org/W2015670274","https://openalex.org/W2016803105","https://openalex.org/W2018292685","https://openalex.org/W2018743597","https://openalex.org/W2020266918","https://openalex.org/W2025604203","https://openalex.org/W2027608872","https://openalex.org/W2030439112","https://openalex.org/W2031087975","https://openalex.org/W2034279215","https://openalex.org/W2035572268","https://openalex.org/W2037218186","https://openalex.org/W2038438278","https://openalex.org/W2040881358","https://openalex.org/W2041243237","https://openalex.org/W2043375002","https://openalex.org/W2050178809","https://openalex.org/W2053721606","https://openalex.org/W2053790038","https://openalex.org/W2055301723","https://openalex.org/W2057608998","https://openalex.org/W2063355012","https://openalex.org/W2063827358","https://openalex.org/W2064017800","https://openalex.org/W2064264280","https://openalex.org/W2067856703","https://openalex.org/W2068387575","https://openalex.org/W2070444599","https://openalex.org/W2071181288","https://openalex.org/W2071683156","https://openalex.org/W2076621516","https://openalex.org/W2076733450","https://openalex.org/W2077892030","https://openalex.org/W2078243391","https://openalex.org/W2078253393","https://openalex.org/W2080131125","https://openalex.org/W2080772875","https://openalex.org/W2081700879","https://openalex.org/W2090300105","https://openalex.org/W2090562728","https://openalex.org/W2091320827","https://openalex.org/W2091543295","https://openalex.org/W2091676080","https://openalex.org/W2092527190","https://openalex.org/W2094606090","https://openalex.org/W2094660330","https://openalex.org/W2096327192","https://openalex.org/W2096395078","https://openalex.org/W2097802875","https://openalex.org/W2098137179","https://openalex.org/W2099250398","https://openalex.org/W2099713879","https://openalex.org/W2103046674","https://openalex.org/W2104886236","https://openalex.org/W2108189835","https://openalex.org/W2109759840","https://openalex.org/W2112019903","https://openalex.org/W2112880160","https://openalex.org/W2113546972","https://openalex.org/W2113805610","https://openalex.org/W2116014397","https://openalex.org/W2118177585","https://openalex.org/W2125691088","https://openalex.org/W2127038160","https://openalex.org/W2129209876","https://openalex.org/W2132845838","https://openalex.org/W2133726754","https://openalex.org/W2135437310","https://openalex.org/W2136454105","https://openalex.org/W2141868358","https://openalex.org/W2148842308","https://openalex.org/W2149615516","https://openalex.org/W2150813685","https://openalex.org/W2151400960","https://openalex.org/W2152794331","https://openalex.org/W2153533547","https://openalex.org/W2156066294","https://openalex.org/W2157886885","https://openalex.org/W2158647606","https://openalex.org/W2162020808","https://openalex.org/W2168136532","https://openalex.org/W2410446460"],"related_works":["https://openalex.org/W2315454789","https://openalex.org/W3112281857","https://openalex.org/W2015040450","https://openalex.org/W1967832961","https://openalex.org/W3140224894","https://openalex.org/W2994910635","https://openalex.org/W2132521760","https://openalex.org/W2048851366","https://openalex.org/W2160995151","https://openalex.org/W4327745352"],"abstract_inverted_index":{"Radiotherapy":[0],"is":[1,11,59,135,140,171],"used":[2],"in":[3,23,230,238,308,321,346],"the":[4,24,63,80,101,129,154,159,176,202,214,231,247,257,271,282,298,335,347],"treatment":[5,72],"of":[6,37,77,121,156,175,204,223,234,246,268,279],"pediatric":[7],"brain":[8,25,83,103,164,285],"tumors":[9],"and":[10,35,163,196,221,293,324,342],"often":[12],"associated":[13],"with":[14],"debilitating":[15],"late":[16],"effects,":[17],"such":[18],"as":[19,218,228,237],"intellectual":[20],"impairment.":[21],"Areas":[22],"harboring":[26],"stem":[27],"cells":[28,39],"are":[29,149],"particularly":[30],"sensitive":[31],"to":[32,42,61,66,69,79,100,132,143,151,161,182,191,200,255,270,281,339],"irradiation":[33],"(IR)":[34],"loss":[36,124,155,220],"these":[38],"may":[40],"contribute":[41],"cognitive":[43],"deficits.":[44],"It":[45],"has":[46,188],"been":[47,189],"demonstrated":[48],"that":[49,86,98,113,128,138,244,276,289,334],"IR-induced":[50,122,215,261,344],"inflammation":[51],"negatively":[52],"affects":[53,158],"neural":[54],"progenitor":[55],"differentiation.":[56],"Therefore,":[57],"it":[58],"necessary":[60],"investigate":[62,201],"inflammatory":[64,107],"mechanism":[65],"be":[67,127,183,192,251],"able":[68],"find":[70],"potential":[71],"strategies.":[73],"One":[74],"moderate":[75],"dose":[76,278],"IR":[78,99,162,208,269,280,315],"young":[81,283,348],"rodent":[82,284],"caused":[84,286],"injuries":[85],"were":[87,290],"detectable":[88,291],"after":[89,117,185,207,297,314],"several":[90],"months,":[91],"including":[92],"impaired":[93],"growth.":[94],"We":[95,274],"have":[96,264],"shown":[97,190],"developing":[102],"induces":[104],"an":[105],"acute":[106],"response.":[108],"An":[109],"unexpected":[110],"finding":[111],"was":[112,226],"microglia":[114,123,157],"died":[115],"shortly":[116],"treatment.":[118,299],"The":[119],"consequences":[120,267],"can":[125],"either":[126],"injury,":[130,216],"due":[131,142],"pronounced":[133,229],"inflammation,":[134],"decreased,":[136],"or":[137],"injury":[139,345],"enhanced":[141],"weakened":[144],"repair":[145],"mechanisms.":[146],"Further":[147],"investigations":[148],"needed":[150],"elucidate":[152],"how":[153],"response":[160],"development.":[165],"\\n\\nThe":[166],"third":[167],"complement":[168,177,205,248,336],"component":[169],"(C3)":[170],"a":[172,252],"key":[173],"protein":[174],"system":[178,249,337],"which":[179],"we":[180,198],"found":[181],"upregulated":[184],"IR.":[186],"C3":[187],"important":[193],"for":[194],"neurogenesis,":[195],"therefore":[197],"wanted":[199],"role":[203],"activation":[206],"by":[209],"using":[210],"C3-deficient":[211,235,316],"mice.":[212,241,330],"Interestingly,":[213],"measured":[217],"tissue":[219],"decrease":[222],"proliferating":[224],"cells,":[225],"not":[227],"dentate":[232],"gyrus":[233],"mice":[236,317],"wild":[239],"type":[240],"This":[242],"indicates":[243],"manipulation":[245],"could":[250],"fruitful":[253],"strategy":[254],"protect":[256],"neurogenic":[258],"areas":[259],"from":[260],"injuries.":[262],"\\n\\nWe":[263],"studied":[265],"functional":[266,343],"growing":[272],"brain.":[273,349],"saw":[275],"one":[277,295],"behavioral":[287],"changes":[288],"months":[292,313],"even":[294],"year":[296],"Furthermore,":[300],"non-irradiated":[301],"animals":[302],"performed":[303],"better":[304],"than":[305,328],"irradiated":[306],"ones":[307],"different":[309],"learning":[310,323,326],"tasks.":[311],"Importantly,":[312],"made":[318],"fewer":[319],"errors":[320],"place":[322],"reversal":[325],"tests":[327],"WT":[329],"These":[331],"results":[332],"indicate":[333],"contributes":[338],"both":[340],"morphological":[341]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
