{"id":"https://openalex.org/W2110244470","doi":"https://doi.org/10.1186/s13075-015-0553-1","title":"Haptoglobin-\u03b11, -\u03b12, vitamin D-binding protein and apolipoprotein C-III as predictors of etanercept drug response in rheumatoid arthritis","display_name":"Haptoglobin-\u03b11, -\u03b12, vitamin D-binding protein and apolipoprotein C-III as predictors of etanercept drug response in rheumatoid arthritis","publication_year":2015,"publication_date":"2015-03-04","ids":{"openalex":"https://openalex.org/W2110244470","doi":"https://doi.org/10.1186/s13075-015-0553-1","mag":"2110244470","pmid":"https://pubmed.ncbi.nlm.nih.gov/25884688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4383078"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-015-0553-1","doi":"https://doi.org/10.1186/s13075-015-0553-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0553-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0553-1.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0553-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013358717","display_name":"Sabine Blaschke","orcid":"https://orcid.org/0000-0001-8800-7554","observed_orcids":["https://orcid.org/0000-0001-8800-7554"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sabine Blaschke","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. sblasch@gwdg.de","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. sblasch@gwdg.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098442713","display_name":"Kathinka Rinke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathinka Rinke","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. kathinka.rinke@med.uni-goettingen.de","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. kathinka.rinke@med.uni-goettingen.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007422682","display_name":"Michael Maring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Maring","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. michael.maring@stud.uni-goettingen.de","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. michael.maring@stud.uni-goettingen.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108462530","display_name":"Thomas Flad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Flad","raw_affiliation_strings":["PANATecs GmbH, Inselwiesenstr. 10, 74076, Heilbronn, Germany. tflad@panatecs.com","PANATecs GmbH, Heilbronn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PANATecs GmbH, Inselwiesenstr. 10, 74076, Heilbronn, Germany. tflad@panatecs.com","institution_ids":[]},{"raw_affiliation_string":"PANATecs GmbH, Heilbronn, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035843496","display_name":"Susann A. Patschan","orcid":"https://orcid.org/0000-0002-2286-7356","observed_orcids":["https://orcid.org/0000-0002-2286-7356"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susann Patschan","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. spatschan@gmail.com","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. spatschan@gmail.com","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064614134","display_name":"Olaf Jahn","orcid":"https://orcid.org/0000-0002-3397-8924","observed_orcids":["https://orcid.org/0000-0002-3397-8924"]},"institutions":[{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Jahn","raw_affiliation_strings":["Proteomics Group, Max-Planck-Institute of Experimental Medicine, Hermann-Rein Str. 3, 37075, G\u00f6ttingen, Germany. Jahn@em.mpg.de","Proteomics Group, Max-Planck-Institute of Experimental Medicine, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Group, Max-Planck-Institute of Experimental Medicine, Hermann-Rein Str. 3, 37075, G\u00f6ttingen, Germany. Jahn@em.mpg.de","institution_ids":["https://openalex.org/I4210137682"]},{"raw_affiliation_string":"Proteomics Group, Max-Planck-Institute of Experimental Medicine, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210137682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419349","display_name":"Claudia A. Mu\u0308ller","orcid":"https://orcid.org/0000-0002-0689-3431","observed_orcids":["https://orcid.org/0000-0002-0689-3431"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia A Mueller","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, Waldh\u00f6rnlestr. 22, 72072, T\u00fcbingen, Germany. prof.cmueller@gmail.com","Section for Transplantation Immunology and Immunohematology, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, Waldh\u00f6rnlestr. 22, 72072, T\u00fcbingen, Germany. prof.cmueller@gmail.com","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112395966","display_name":"Gerhard Anton Muller","orcid":"https://orcid.org/0000-0001-9889-1638","observed_orcids":["https://orcid.org/0000-0001-9889-1638"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard A Mueller","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. gmueller@med.uni-goettingen.de","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. gmueller@med.uni-goettingen.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017541498","display_name":"Hassan Dihazi","orcid":"https://orcid.org/0000-0003-3417-0385","observed_orcids":["https://orcid.org/0000-0003-3417-0385"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hassan Dihazi","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. dihazi@med.uni-goettingen.de","Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, Robert-Koch Stra\u00dfe 40, 37075, G\u00f6ttingen, Germany. dihazi@med.uni-goettingen.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013358717"],"corresponding_institution_ids":["https://openalex.org/I4210116730"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":1508,"currency":"EUR","value_usd":1626},"fwci":2.3089,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8698135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vitamin-d-binding-protein","display_name":"vitamin D binding protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-a-ii","display_name":"apolipoprotein A-II","score":0.9290000200271606},{"id":"https://openalex.org/keywords/serum-proteome","display_name":"serum proteome","score":0.8999999761581421},{"id":"https://openalex.org/keywords/clinical-proteomics","display_name":"clinical proteomics","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.916212797164917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8270667195320129},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.7908743619918823},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7372082471847534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6311519145965576},{"id":"https://openalex.org/C2776465410","wikidata":"https://www.wikidata.org/wiki/Q14911599","display_name":"Retinol binding protein 4","level":5,"score":0.6284036040306091},{"id":"https://openalex.org/C153639570","wikidata":"https://www.wikidata.org/wiki/Q906435","display_name":"Vitamin D-binding protein","level":3,"score":0.5794001817703247},{"id":"https://openalex.org/C2776474381","wikidata":"https://www.wikidata.org/wiki/Q409414","display_name":"Hemopexin","level":4,"score":0.5260291695594788},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.49882030487060547},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.49148356914520264},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4616256058216095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4424678087234497},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42862600088119507},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.4183216392993927},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.3968755304813385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14947155117988586},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.08008244633674622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07773518562316895},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014809","descriptor_name":"Vitamin D-Binding Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053305","descriptor_name":"Apolipoprotein C-III","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1186/s13075-015-0553-1","doi":"https://doi.org/10.1186/s13075-015-0553-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0553-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0553-1.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3348767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4383078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4383078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4383078","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:25884688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25884688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Clinical Study"},{"id":"pmh:oai:edoc.mpg.de:702096","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/702096","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis Research &amp; Therapy (2015)","raw_type":"Article"},{"id":"pmh:oai:goescholar:1/13467","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/13467","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/37661","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/37661","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2186490","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0029-6C59-A","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13075-015-0553-1","doi":"https://doi.org/10.1186/s13075-015-0553-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0553-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0553-1.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110244470.pdf","grobid_xml":"https://content.openalex.org/works/W2110244470.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W143401915","https://openalex.org/W1793650522","https://openalex.org/W1926159205","https://openalex.org/W1934799805","https://openalex.org/W1940316087","https://openalex.org/W1964694806","https://openalex.org/W1977222719","https://openalex.org/W1978576762","https://openalex.org/W1995999188","https://openalex.org/W2000190640","https://openalex.org/W2008281569","https://openalex.org/W2018062154","https://openalex.org/W2035973303","https://openalex.org/W2043709854","https://openalex.org/W2044310665","https://openalex.org/W2048436941","https://openalex.org/W2058670939","https://openalex.org/W2061244704","https://openalex.org/W2065419533","https://openalex.org/W2066170238","https://openalex.org/W2067387741","https://openalex.org/W2068372391","https://openalex.org/W2069359258","https://openalex.org/W2072567581","https://openalex.org/W2079590652","https://openalex.org/W2080118830","https://openalex.org/W2080708975","https://openalex.org/W2084201099","https://openalex.org/W2088328480","https://openalex.org/W2098919737","https://openalex.org/W2103310388","https://openalex.org/W2116033495","https://openalex.org/W2116843833","https://openalex.org/W2117692612","https://openalex.org/W2120200846","https://openalex.org/W2126269412","https://openalex.org/W2128635872","https://openalex.org/W2130631271","https://openalex.org/W2131882149","https://openalex.org/W2138061818","https://openalex.org/W2139348148","https://openalex.org/W2144164915","https://openalex.org/W2152348310","https://openalex.org/W2154716537","https://openalex.org/W2156996668","https://openalex.org/W2157948156","https://openalex.org/W2162098545","https://openalex.org/W2162370292","https://openalex.org/W2336588424","https://openalex.org/W2340084730","https://openalex.org/W2615604523","https://openalex.org/W4241917186"],"related_works":["https://openalex.org/W4220780259","https://openalex.org/W1966066948","https://openalex.org/W4231982973","https://openalex.org/W2092829005","https://openalex.org/W2099204441","https://openalex.org/W1977222719","https://openalex.org/W4366831683","https://openalex.org/W2403967715","https://openalex.org/W2971209575","https://openalex.org/W2326004449"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,91],"introduction":[2],"of":[3,24,38,117,122,156,161,225,250],"tumor":[4],"necrosis":[5],"factor-alpha":[6],"(TNF-\u03b1)":[7],"antagonists":[8],"has":[9],"substantially":[10],"improved":[11],"patient's":[12],"clinical":[13,74,226],"outcome":[14],"in":[15,42,66,182,198,219,228,254],"rheumatoid":[16],"arthritis":[17],"(RA).":[18],"However,":[19],"nearly":[20],"20%":[21],"to":[22,30,53,82,98,111,178,211],"40%":[23],"RA":[25,77,162],"patients":[26,78,163],"do":[27],"not":[28],"respond":[29],"anti-TNF-\u03b1":[31],"treatment":[32,158],"strategies.":[33],"To":[34],"identify":[35,233],"valid":[36],"predictors":[37],"TNF-\u03b1":[39,58],"antagonist":[40],"response":[41,81,96,253],"RA,":[43],"serum":[44],"proteome":[45],"profiles":[46],"from":[47],"responders":[48],"(R)":[49],"and":[50,87,113,139,168,171,207,234,243],"non-responders":[51,199],"(NR)":[52],"etanercept,":[54],"a":[55,67],"soluble":[56],"recombinant":[57],"receptor/IgG":[59],"Fc":[60],"fusion":[61],"protein":[62,174],"receptor,":[63],"were":[64,85,120,146,176,209],"compared":[65],"prospective":[68],"cohort":[69],"study.":[70],"METHODS:":[71],"In":[72,189],"this":[73],"study":[75,187,202],"50":[76],"with":[79,89],"inadequate":[80],"conventional":[83],"DMARDs":[84],"included":[86],"treated":[88],"etanercept.":[90],"primary":[92],"efficacy":[93],"endpoint":[94],"was":[95],"according":[97],"the":[99,123,237],"European":[100],"League":[101],"against":[102],"Rheumatism":[103],"(EULAR)":[104],"improvement":[105],"criteria.":[106],"Serum":[107],"samples":[108],"collected":[109],"prior":[110],"initiation":[112],"after":[114],"six":[115,154],"months":[116,155],"etanercept":[118,157,251],"therapy":[119],"cleared":[121],"most":[124],"abundant":[125],"major":[126],"proteins":[127],"by":[128,133,141,148],"immunoaffinity":[129],"chromatography.":[130],"After":[131,153],"separation":[132],"two-dimensional":[134],"differential":[135],"gel":[136],"electrophoresis":[137],"(2D-DIGE)":[138],"identification":[140],"mass":[142],"spectrometry":[143],"(MS)":[144],"data":[145],"validated":[147],"Western":[149],"blot":[150],"analysis.":[151],"RESULTS:":[152],"62%":[159],"(n=31)":[160],"achieved":[164],"response.":[165],"Haptoglobin-\u03b11":[166],"(Hp-\u03b11)":[167],"-\u03b12":[169],"(Hp-\u03b12)":[170],"vitamin":[172],"D-binding":[173],"(VDBP)":[175],"found":[177],"be":[179,212],"significantly":[180,195,215],"upregulated":[181],"responder":[183,220],"sera":[184,230],"(P\u22640.02)":[185],"at":[186,214],"entry.":[188],"contrast,":[190],"apolipoprotein":[191],"C-III":[192],"(ApoC-III)":[193],"showed":[194],"higher":[196,216],"levels":[197,217],"(P=0.0162).":[200],"At":[201],"end":[203],"ApoA-II,":[204],"Hp-\u03b11,":[205,240],"Hp-\u03b12":[206],"VDBP":[208,242],"identified":[210],"expressed":[213],"(P<0.05)":[218],"sera.":[221],"CONCLUSIONS:":[222],"By":[223],"application":[224],"proteomics":[227],"immunodepleted":[229],"we":[231],"could":[232],"validate":[235],"for":[236,248],"first":[238],"time":[239],"-\u03b12,":[241],"ApoC-III":[244],"as":[245],"potential":[246],"biomarkers":[247],"prediction":[249],"drug":[252],"RA.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}