{"id":"https://openalex.org/W2110170256","doi":"https://doi.org/10.1186/1471-2091-12-1","title":"Characterization of a core fragment of the rhesus monkey TRIM5\u03b1 protein","display_name":"Characterization of a core fragment of the rhesus monkey TRIM5\u03b1 protein","publication_year":2011,"publication_date":"2011-01-04","ids":{"openalex":"https://openalex.org/W2110170256","doi":"https://doi.org/10.1186/1471-2091-12-1","mag":"2110170256","pmid":"https://pubmed.ncbi.nlm.nih.gov/21205312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3025952"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2091-12-1","doi":"https://doi.org/10.1186/1471-2091-12-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2091-12-1","pdf_url":"https://bmcbiochem.biomedcentral.com/counter/pdf/10.1186/1471-2091-12-1","source":{"id":"https://openalex.org/S120371716","display_name":"BMC Biochemistry","issn_l":"1471-2091","issn":["1471-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmcbiochem.biomedcentral.com/counter/pdf/10.1186/1471-2091-12-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006224216","display_name":"Alak Kanti Kar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alak K Kar","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA","Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031375126","display_name":"Youdong Mao","orcid":"https://orcid.org/0000-0001-9302-2257","observed_orcids":["https://orcid.org/0000-0001-9302-2257"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youdong Mao","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA, USA, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058880979","display_name":"Gregory H. Bird","orcid":"https://orcid.org/0000-0002-6853-643X","observed_orcids":["https://orcid.org/0000-0002-6853-643X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Bird","raw_affiliation_strings":["Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020222350","display_name":"Loren D. Walensky","orcid":"https://orcid.org/0000-0002-0869-2334","observed_orcids":["https://orcid.org/0000-0002-0869-2334"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loren Walensky","raw_affiliation_strings":["Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071476197","display_name":"Joseph Sodroski","orcid":"https://orcid.org/0000-0002-9750-1615","observed_orcids":["https://orcid.org/0000-0002-9750-1615"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph Sodroski","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA, 02115","Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA, USA, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA, USA, 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071476197"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":1.6593,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.82299574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.329800009727478,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim5alpha","display_name":"TRIM5\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tripartite-motif-proteins","display_name":"tripartite motif proteins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/retroviral-restriction-factors","display_name":"retroviral restriction factors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/coiled-coil-domain","display_name":"coiled-coil domain","score":0.9490000009536743},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7870000004768372},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8169999718666077},{"id":"https://openalex.org/keywords/alpha-helical-content","display_name":"alpha-helical content","score":0.8610000014305115},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.8690000176429749},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.6790000200271606},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.8056187629699707},{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.687332034111023},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5272825360298157},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5059942603111267},{"id":"https://openalex.org/C88611116","wikidata":"https://www.wikidata.org/wiki/Q957004","display_name":"Trim","level":2,"score":0.4991722106933594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.465562105178833},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45425087213516235},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3953530192375183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3213156759738922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2963258624076843},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2091-12-1","doi":"https://doi.org/10.1186/1471-2091-12-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2091-12-1","pdf_url":"https://bmcbiochem.biomedcentral.com/counter/pdf/10.1186/1471-2091-12-1","source":{"id":"https://openalex.org/S120371716","display_name":"BMC Biochemistry","issn_l":"1471-2091","issn":["1471-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biochemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3025952","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3025952","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biochem","raw_type":"Text"},{"id":"pmid:21205312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21205312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.804.3547","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.804.3547","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/79/bb/1471-2091-12-1.PMC3025952.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1471-2091-12-1","doi":"https://doi.org/10.1186/1471-2091-12-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2091-12-1","pdf_url":"https://bmcbiochem.biomedcentral.com/counter/pdf/10.1186/1471-2091-12-1","source":{"id":"https://openalex.org/S120371716","display_name":"BMC Biochemistry","issn_l":"1471-2091","issn":["1471-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G109081360","display_name":"Structure of the Retroviral Restriction Factor, TRIM5alpha","funder_award_id":"R21AI076094","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4012745225","display_name":"Antiretroviral activity of TRIM5alpha","funder_award_id":"R01AI063987","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5517451199","display_name":"Stapled Antigens for HIV-1 Vaccination","funder_award_id":"R01AI084102","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6516918191","display_name":null,"funder_award_id":"AI 06354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110170256.pdf","grobid_xml":"https://content.openalex.org/works/W2110170256.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1497066157","https://openalex.org/W1599334180","https://openalex.org/W1963507800","https://openalex.org/W1965150816","https://openalex.org/W1965849042","https://openalex.org/W1969108300","https://openalex.org/W1975032534","https://openalex.org/W1976617857","https://openalex.org/W1986075897","https://openalex.org/W1989887938","https://openalex.org/W1993016006","https://openalex.org/W1997318570","https://openalex.org/W1998130142","https://openalex.org/W2003002450","https://openalex.org/W2011068404","https://openalex.org/W2013556374","https://openalex.org/W2019500431","https://openalex.org/W2020927386","https://openalex.org/W2022754521","https://openalex.org/W2023559737","https://openalex.org/W2024645073","https://openalex.org/W2026727321","https://openalex.org/W2032538087","https://openalex.org/W2033388772","https://openalex.org/W2039111207","https://openalex.org/W2043953762","https://openalex.org/W2048682843","https://openalex.org/W2049054781","https://openalex.org/W2050400345","https://openalex.org/W2051777873","https://openalex.org/W2059091401","https://openalex.org/W2060027591","https://openalex.org/W2060956856","https://openalex.org/W2066803746","https://openalex.org/W2068196085","https://openalex.org/W2068902686","https://openalex.org/W2073251642","https://openalex.org/W2073532837","https://openalex.org/W2078365430","https://openalex.org/W2082314789","https://openalex.org/W2091340735","https://openalex.org/W2097660625","https://openalex.org/W2098339028","https://openalex.org/W2102679105","https://openalex.org/W2114859237","https://openalex.org/W2116773729","https://openalex.org/W2119875571","https://openalex.org/W2120072271","https://openalex.org/W2123451102","https://openalex.org/W2125275092","https://openalex.org/W2126098576","https://openalex.org/W2131037087","https://openalex.org/W2132278469","https://openalex.org/W2136372912","https://openalex.org/W2138446538","https://openalex.org/W2138468602","https://openalex.org/W2142660310","https://openalex.org/W2147703962","https://openalex.org/W2150860726","https://openalex.org/W2151766144","https://openalex.org/W2152806961","https://openalex.org/W2153524396","https://openalex.org/W2155584359","https://openalex.org/W2156829363","https://openalex.org/W2161823195","https://openalex.org/W2163135670","https://openalex.org/W2168607622","https://openalex.org/W2242165656","https://openalex.org/W2402421550","https://openalex.org/W2624936342","https://openalex.org/W2978248397"],"related_works":["https://openalex.org/W7099265092","https://openalex.org/W2102679105","https://openalex.org/W1976617857","https://openalex.org/W2023559737","https://openalex.org/W2473050198","https://openalex.org/W2114859237","https://openalex.org/W2151766144","https://openalex.org/W2149489038","https://openalex.org/W2724532922","https://openalex.org/W7009461252"],"abstract_inverted_index":{"BACKGROUND:":[0],"Like":[1],"all":[2],"tripartite":[3],"motif":[4,130],"(TRIM)":[5],"proteins,":[6],"the":[7,35,56,81,102,116],"retroviral":[8],"restriction":[9],"factor":[10],"TRIM5\u03b1":[11,125],"consists":[12],"of":[13,37,66,80,86,91,96,124,136],"RING,":[14],"B-box":[15,57,117],"2":[16,122],"and":[17,48,61,73,94,120],"coiled-coil":[18,119],"domains,":[19,34],"with":[20,101],"a":[21,50,127,133],"C-terminal":[22],"B30.2(SPRY)":[23],"domain.":[24],"Although":[25],"structures":[26],"have":[27],"been":[28],"determined":[29],"for":[30],"some":[31],"individual":[32],"TRIM":[33,40],"structure":[36,84],"an":[38],"intact":[39],"protein":[41,70],"is":[42],"unknown.":[43],"RESULTS:":[44],"Here,":[45],"we":[46],"express":[47],"characterize":[49],"protease-resistant":[51],"29-kD":[52],"core":[53,128],"fragment":[54],"containing":[55],"2,":[58,118],"coiled":[59],"coil":[60],"adjacent":[62],"linker":[63,121],"(L2)":[64],"region":[65],"TRIM5\u03b1.":[67],"This":[68],"BCCL2":[69,82],"formed":[71],"dimers":[72,97],"higher-order":[74],"oligomers":[75],"in":[76],"solution.":[77],"Approximately":[78],"40%":[79],"secondary":[83],"consisted":[85],"alpha":[87,104],"helices.":[88],"Partial":[89],"loss":[90],"alpha-helical":[92,137],"content":[93],"dissociation":[95],"occurred":[98],"at":[99],"42\u00b0C,":[100],"residual":[103],"helices":[105],"remaining":[106],"stable":[107],"up":[108],"to":[109],"80\u00b0C.":[110],"CONCLUSIONS:":[111],"These":[112],"results":[113],"indicate":[114],"that":[115,131],"regions":[123],"form":[126],"dimerization":[129],"exhibits":[132],"high":[134],"level":[135],"content.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
