{"id":"https://openalex.org/W2110102374","doi":null,"title":"Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance","display_name":"Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance","publication_year":2013,"publication_date":"2013-05-16","ids":{"openalex":"https://openalex.org/W2110102374","mag":"2110102374"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26899219","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Translational_genomics_of_HIV-1_subtype_C_in_India_molecular_phylogeny_and_drug_resistance/26899219","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/41506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053300883","display_name":"Ujjwal Neogi","orcid":"https://orcid.org/0000-0002-0844-3338","observed_orcids":["https://orcid.org/0000-0002-0844-3338"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ujjwal Neogi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0844-3338","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053300883"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-phylogeny","display_name":"molecular phylogeny","score":0.8870000243186951},{"id":"https://openalex.org/keywords/time-to-the-most-recent-common-ancestor","display_name":"time to most recent common ancestor","score":0.921999990940094},{"id":"https://openalex.org/keywords/hiv-1-recombinant-forms","display_name":"HIV-1 recombinant forms","score":0.7990000247955322},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.6980000138282776},{"id":"https://openalex.org/keywords/antiretroviral-therapy-failure","display_name":"antiretroviral therapy failure","score":0.8960000276565552},{"id":"https://openalex.org/keywords/plasma-viremia","display_name":"plasma viremia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/perinatal-transmission","display_name":"perinatal transmission","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.585440993309021},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.567307710647583},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5589731335639954},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5541780591011047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4515700042247772},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43238240480422974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40249234437942505},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3963189125061035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3274235725402832},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.24777090549468994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21043068170547485}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26899219","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Translational_genomics_of_HIV-1_subtype_C_in_India_molecular_phylogeny_and_drug_resistance/26899219","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41506","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2110102374","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/41506/Neogi_Thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/41506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41506","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":236,"referenced_works":["https://openalex.org/W33778683","https://openalex.org/W65942279","https://openalex.org/W82820957","https://openalex.org/W104886201","https://openalex.org/W128019206","https://openalex.org/W170094209","https://openalex.org/W1040454186","https://openalex.org/W1493172229","https://openalex.org/W1525739154","https://openalex.org/W1612692569","https://openalex.org/W1665723380","https://openalex.org/W1735047172","https://openalex.org/W1963596540","https://openalex.org/W1965655431","https://openalex.org/W1966998384","https://openalex.org/W1967320966","https://openalex.org/W1967974486","https://openalex.org/W1968555621","https://openalex.org/W1969623229","https://openalex.org/W1969795466","https://openalex.org/W1970221582","https://openalex.org/W1970663962","https://openalex.org/W1970736580","https://openalex.org/W1972561651","https://openalex.org/W1973326022","https://openalex.org/W1974449256","https://openalex.org/W1976944433","https://openalex.org/W1977282539","https://openalex.org/W1978977726","https://openalex.org/W1981145791","https://openalex.org/W1981164507","https://openalex.org/W1981273805","https://openalex.org/W1981440980","https://openalex.org/W1981970184","https://openalex.org/W1983683921","https://openalex.org/W1984502945","https://openalex.org/W1986268615","https://openalex.org/W1986351652","https://openalex.org/W1986681262","https://openalex.org/W1988773465","https://openalex.org/W1989468850","https://openalex.org/W1992325700","https://openalex.org/W1994476715","https://openalex.org/W1995515182","https://openalex.org/W1995559092","https://openalex.org/W1996674201","https://openalex.org/W1997038206","https://openalex.org/W1997521026","https://openalex.org/W1998529967","https://openalex.org/W2001214740","https://openalex.org/W2001256818","https://openalex.org/W2001316390","https://openalex.org/W2002842619","https://openalex.org/W2002999238","https://openalex.org/W2003011401","https://openalex.org/W2003310451","https://openalex.org/W2004669329","https://openalex.org/W2007819361","https://openalex.org/W2008340941","https://openalex.org/W2009890799","https://openalex.org/W2010452637","https://openalex.org/W2010561000","https://openalex.org/W2011592728","https://openalex.org/W2011841146","https://openalex.org/W2012816102","https://openalex.org/W2013022909","https://openalex.org/W2013964515","https://openalex.org/W2014490323","https://openalex.org/W2017871159","https://openalex.org/W2018002636","https://openalex.org/W2018341864","https://openalex.org/W2018914739","https://openalex.org/W2019865583","https://openalex.org/W2020096299","https://openalex.org/W2021809965","https://openalex.org/W2021906926","https://openalex.org/W2023718095","https://openalex.org/W2023878269","https://openalex.org/W2024830331","https://openalex.org/W2026787430","https://openalex.org/W2027248144","https://openalex.org/W2028017977","https://openalex.org/W2029246165","https://openalex.org/W2029353650","https://openalex.org/W2029741924","https://openalex.org/W2029911768","https://openalex.org/W2030655849","https://openalex.org/W2031807940","https://openalex.org/W2032136448","https://openalex.org/W2033353520","https://openalex.org/W2033626418","https://openalex.org/W2033702984","https://openalex.org/W2035095394","https://openalex.org/W2035368109","https://openalex.org/W2036926470","https://openalex.org/W2040143211","https://openalex.org/W2041963613","https://openalex.org/W2043966364","https://openalex.org/W2044004371","https://openalex.org/W2045572549","https://openalex.org/W2045949915","https://openalex.org/W2046004980","https://openalex.org/W2049222843","https://openalex.org/W2049579004","https://openalex.org/W2050426237","https://openalex.org/W2051461317","https://openalex.org/W2051470423","https://openalex.org/W2053088580","https://openalex.org/W2053620195","https://openalex.org/W2053906310","https://openalex.org/W2054897050","https://openalex.org/W2056686421","https://openalex.org/W2058171566","https://openalex.org/W2058252938","https://openalex.org/W2060163862","https://openalex.org/W2061751736","https://openalex.org/W2061819014","https://openalex.org/W2062956368","https://openalex.org/W2063739166","https://openalex.org/W2063848583","https://openalex.org/W2065597780","https://openalex.org/W2065860076","https://openalex.org/W2066480278","https://openalex.org/W2068547302","https://openalex.org/W2070676224","https://openalex.org/W2072023931","https://openalex.org/W2072329519","https://openalex.org/W2073705737","https://openalex.org/W2075109825","https://openalex.org/W2075987433","https://openalex.org/W2080615530","https://openalex.org/W2081539383","https://openalex.org/W2082329556","https://openalex.org/W2082595989","https://openalex.org/W2082888620","https://openalex.org/W2084373400","https://openalex.org/W2084400169","https://openalex.org/W2084702672","https://openalex.org/W2085459671","https://openalex.org/W2086448238","https://openalex.org/W2087364590","https://openalex.org/W2089135598","https://openalex.org/W2089479036","https://openalex.org/W2090388486","https://openalex.org/W2091646572","https://openalex.org/W2091793736","https://openalex.org/W2094692623","https://openalex.org/W2097847166","https://openalex.org/W2098406276","https://openalex.org/W2099116831","https://openalex.org/W2100163253","https://openalex.org/W2101359514","https://openalex.org/W2101433593","https://openalex.org/W2102741140","https://openalex.org/W2105013761","https://openalex.org/W2105175831","https://openalex.org/W2105610715","https://openalex.org/W2106720283","https://openalex.org/W2108256128","https://openalex.org/W2108723265","https://openalex.org/W2108939637","https://openalex.org/W2109046728","https://openalex.org/W2109113807","https://openalex.org/W2110482783","https://openalex.org/W2110835349","https://openalex.org/W2112097111","https://openalex.org/W2112375409","https://openalex.org/W2113282092","https://openalex.org/W2114217074","https://openalex.org/W2114903401","https://openalex.org/W2116956383","https://openalex.org/W2118003879","https://openalex.org/W2119366543","https://openalex.org/W2120293408","https://openalex.org/W2120611093","https://openalex.org/W2122581707","https://openalex.org/W2123278408","https://openalex.org/W2123778842","https://openalex.org/W2124409966","https://openalex.org/W2124627199","https://openalex.org/W2126531452","https://openalex.org/W2128260028","https://openalex.org/W2129650377","https://openalex.org/W2131376910","https://openalex.org/W2132632499","https://openalex.org/W2133233128","https://openalex.org/W2140665904","https://openalex.org/W2142683714","https://openalex.org/W2142766084","https://openalex.org/W2144413761","https://openalex.org/W2148026374","https://openalex.org/W2148102806","https://openalex.org/W2148870051","https://openalex.org/W2148970839","https://openalex.org/W2151841601","https://openalex.org/W2152048324","https://openalex.org/W2153000646","https://openalex.org/W2154190260","https://openalex.org/W2154250614","https://openalex.org/W2154963941","https://openalex.org/W2155021935","https://openalex.org/W2155395980","https://openalex.org/W2157713905","https://openalex.org/W2158666214","https://openalex.org/W2159047279","https://openalex.org/W2159271866","https://openalex.org/W2159295367","https://openalex.org/W2161017029","https://openalex.org/W2161920540","https://openalex.org/W2162727140","https://openalex.org/W2162727299","https://openalex.org/W2163315037","https://openalex.org/W2163400707","https://openalex.org/W2165476676","https://openalex.org/W2165895151","https://openalex.org/W2167278859","https://openalex.org/W2169631469","https://openalex.org/W2169736935","https://openalex.org/W2170463669","https://openalex.org/W2172212187","https://openalex.org/W2172274075","https://openalex.org/W2173407000","https://openalex.org/W2181131972","https://openalex.org/W2308294549","https://openalex.org/W2319708874","https://openalex.org/W2323504328","https://openalex.org/W2329155499","https://openalex.org/W2335060193","https://openalex.org/W2339827976","https://openalex.org/W2398313562","https://openalex.org/W2400580124","https://openalex.org/W2404812630","https://openalex.org/W2414698896","https://openalex.org/W2417664277","https://openalex.org/W2621219747","https://openalex.org/W7099781825"],"related_works":["https://openalex.org/W2053469170","https://openalex.org/W2320470711","https://openalex.org/W7096979920","https://openalex.org/W1981970184","https://openalex.org/W2084400169","https://openalex.org/W4220657042","https://openalex.org/W2088742233","https://openalex.org/W2043613093","https://openalex.org/W2104919701","https://openalex.org/W2060163862"],"abstract_inverted_index":{"This":[0],"thesis":[1,65],"describes":[2],"the":[3,18,39,49,76,99,121,126,135,151,173,178,215,220,230,235,250,284,295,425,442,446,511,528,558,615],"translational":[4,521],"genomics":[5,522],"of":[6,42,57,78,83,89,180,206,217,279,297,303,311,325,337,360,377,433,445,489,563,575,605,614,675,716,757],"HIV-1subtype":[7],"C":[8,61,140,202,328,354,372,531,544,689,728],"in":[9,46,71,81,95,120,125,198,219,229,242,265,283,289,415,534,608,648,679,720,729,762],"India":[10,47,535],"from":[11,154,162,386,540],"its":[12,145],"origin":[13,146],"to":[14,20,30,51,150,177,214,271,294,383,388,424,509,514,553,556,566],"therapeutic":[15,26,102],"response":[16,423],"with":[17,193,351,437,459,644,686,725],"aim":[19],"improve":[21],"our":[22,525],"knowledge":[23,526],"for":[24,301,430],"better":[25],"and":[27,48,74,86,91,208,234,257,263,267,286,318,363,379,409,462,470,501,560,571,611,672,684],"preventive":[28],"strategies":[29],"combat":[31],"HIV/AIDS.":[32],"In":[33,113,170,315,347,412,518],"a":[34,130,142,155,322,334,357,416,420,431],"systemic":[35],"approach,":[36],"we":[37,116,320],"identified":[38,321],"molecular":[40],"phylogeny":[41],"HIV-1":[43,59,122,127,138,200,326,352,370,404,529,606,649,687,726,764],"subtypes":[44,607],"circulating":[45,533],"time":[50],"most":[52],"recent":[53],"common":[54],"ancestors":[55],"(tMRCA)":[56],"predominant":[58,616],"subtype":[60,139,201,327,353,371,530,543,617,650,688,727],"strains.":[62,545],"Additionally,":[63],"this":[64,520],"also":[66,111,227,341,394,452],"studied":[67],"drug":[68,84,237,280,304,398,465,502,677],"resistance":[69,238,281,305,399,466,503,678],"mutations":[70,210,239,306,467],"children,":[72,406],"adolescents":[73,407,685],"adults,":[75],"role":[77],"host":[79],"factors":[80],"evolution":[82],"resistance,":[85],"population":[87],"dynamics":[88],"viremia":[90,339,671],"viral":[92,251,439,464,478],"co-receptor":[93,384],"tropism":[94],"perinatal":[96],"transmission.":[97],"Finally,":[98],"long":[100],"term":[101],"responses":[103],"on":[104],"Indian":[105,199,403,426,447,763],"national":[106,427],"first-line":[107,428],"antiretroviral":[108,194,645,760],"therapy":[109,195,429,646,761],"were":[110,211,226,240],"studied.":[112],"Paper":[114,171,413],"I,":[115,582,631],"reported":[117],"an":[118],"increase":[119],"recombinant":[123],"forms":[124],"epidemiology":[128,604],"using":[129,298,549],"robust":[131],"subtyping":[132],"methodology.":[133],"While":[134],"study":[136,451,474,523],"confirmed":[137],"as":[141],"dominant":[143],"subtype,":[144],"was":[147,190],"dated":[148],"back":[149],"early":[152],"1970s":[153],"single":[156],"or":[157],"few":[158],"genetically":[159,538],"related":[160],"strains":[161,366,373,390,532,565,719],"South":[163],"Africa,":[164],"whereafter,":[165],"it":[166,246],"has":[167],"evolved":[168],"independently.":[169],"II,":[172],"lethal":[174],"hypermutations":[175],"due":[176,213],"activity":[179],"human":[181],"apolipoprotein":[182],"B":[183],"mRNA-editing":[184],"enzyme":[185],"catalytic":[186],"polypeptide-like":[187],"3G":[188],"(hA3G)":[189],"significantly":[191],"associated":[192,643],"(ART)":[196],"failure":[197,647],"patients.":[203],"The":[204,276],"presence":[205],"M184I":[207,258],"M230I":[209,260],"observed":[212],"editing":[216],"hA3G":[218],"proviral":[221,287],"compartment":[222],"but":[223,340],"stop":[224],"codons":[225],"found":[228],"open":[231],"reading":[232],"frames":[233],"same":[236],"absent":[241],"plasma":[243,285,338],"virus.":[244],"Therefore,":[245],"is":[247,400,642],"unlikely":[248,270],"that":[249,369,396,454,487],"variants":[252],"which":[253,307,367,536],"exhibit":[254],"hypermutated":[255],"sequences":[256],"and/or":[259],"will":[261],"mature":[262],"expand":[264],"vivo":[266],"hence":[268],"are":[269,537],"have":[272],"any":[273],"clinical":[274],"significance.":[275],"high":[277,335,343,358],"concordance":[278],"genotyping":[282],"compartments":[288],"therapy-na\u00efve":[290,681],"patients,":[291],"gives":[292],"weight":[293],"idea":[296],"whole":[299],"blood":[300],"surveillance":[302],"precludes":[308],"logistic":[309],"challenges":[310],"cold":[312],"chain":[313],"transport.":[314],"Papers":[316],"III":[317],"IV,":[319],"substantial":[323],"proportion":[324],"perinatally-infected":[329,682],"older":[330,349,723],"children":[331,350,683,724],"who":[332],"had":[333,342,476],"burden":[336],"CD4+":[344],"T-cell":[345,496],"counts.":[346],"addition,":[348],"infection":[355,378],"presented":[356],"prevalence":[359,715],"predicted":[361,717],"X4":[362],"R5/X4":[364],"tropic":[365],"indicates":[368],"required":[374],"longer":[375],"duration":[376],"greater":[380],"disease":[381,569],"progression":[382],"transition":[385],"R5-":[387],"X4-tropic":[389,718],"(IV).":[391],"Our":[392,450],"studies":[393],"indicate":[395],"transmitted":[397,676],"low":[401,673],"among":[402],"infected":[405,722,765],"(III)":[408],"adults":[410],"(II).":[411],"V,":[414,591],"longitudinal":[417,768],"cohort":[418,769],"study,":[419],"good":[421],"long-term":[422],"median":[432],"nearly":[434],"four":[435],"years":[436],"2.8%":[438],"failure,":[440],"indicating":[441],"overall":[443],"success":[444],"ART":[448],"program.":[449],"showed":[453],"three":[455],"immunologically":[456],"well":[457],"patients":[458],"virological":[460,498],"rebound":[461],"major":[463],"(M184V,":[468],"K103N":[469],"Y181C)":[471],"during":[472],"one":[473],"visit":[475],"undetectable":[477],"load":[479],"at":[480],"their":[481],"next":[482],"visit.":[483],"These":[484],"findings":[485],"suggest":[486],"use":[488],"multiple":[490],"parameters":[491],"like":[492],"patients\u2019":[493],"immunological":[494],"(CD4+":[495],"count),":[497],"(viral":[499],"load)":[500],"data":[504],"should":[505],"all":[506],"be":[507,554],"used":[508],"optimize":[510],"treatment":[512],"switch":[513],"second":[515],"line":[516,759],"therapy.":[517],"conclusion,":[519],"enhances":[524],"about":[527],"distinct":[539],"prototype":[541],"African":[542],"Considerably":[546],"more":[547],"research":[548],"appropriate":[550],"models":[551],"need":[552],"performed":[555],"understand":[557],"phenotypic":[559],"biological":[561],"characteristics":[562],"these":[564],"guide":[567],"efficient":[568],"intervention":[570],"management":[572],"strategies.":[573],"List":[574],"scientific":[576],"papers":[577],"I.":[578],"Neogi":[579,624,660,700,740],"U,":[580,597,625,661,701,741],"Bontell":[581,630],"Shet":[583,626,667,711,744],"A,":[584,587,595,627,666,707,710,745,751],"De":[585,664,708],"Costa":[586,665,709],"Gupta":[588],"S,":[589,747],"Diwan":[590],"Laishram":[592],"RS,":[593],"Wanchu":[594],"Ranga":[596],"Banerjea":[598,634],"AC,":[599,635],"S\u00f6nnerborg":[600,636,706,750],"A.":[601,637,668,712],"(2012)":[602,669,713],"Molecular":[603],"India:":[609],"Origin":[610],"evolutionary":[612],"history":[613],"C.":[618],"PLoS":[619,771],"ONE.":[620,772],"7(6):e39819.":[621],"https://doi.org/10.1371/journal.pone.0039819":[622],"II.":[623],"Sahoo":[628,662,702],"PN,":[629,663,703],"Ekstrand":[632,752],"ML,":[633],"(2013)":[638,754],"Human":[639],"APOBEC3G-mediated":[640],"hypermutation":[641],"C-infected":[651],"individuals.":[652],"J":[653,731],"Int":[654],"AIDS":[655],"Soc.":[656],"16:18472.":[657],"https://doi.org/10.7448/IAS.16.1.18472":[658],"III.":[659],"High":[670],"level":[674],"anti-retroviral":[680],"infection.":[690],"BMC":[691],"Infec":[692],"Dis.":[693],"Nov":[694],"22;":[695],"12(1):":[696],"317.":[697],"https://doi.org/10.1186/1471-2334-12-317":[698],"IV.":[699],"Arumugam":[704],"K,":[705],"Higher":[714],"perinatally-":[721],"India.":[730],"Acquir":[732],"Immune":[733],"Defic":[734],"Syndr.":[735],"59(4):":[736],"347-53.":[737],"https://doi.org/10.1097/QAI.0b013e3182405c7b":[738],"V.":[739],"Heylen":[742],"E,":[743],"Chandy":[746],"Shamsunder":[748],"R,":[749],"ML.":[753],"Long-term":[755],"efficacy":[756],"first":[758],"patients:":[766],"A":[767],"study.":[770],"8(1):e55421.":[773],"https://doi.org/10.1371/journal.pone.0055421":[774]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}