{"id":"https://openalex.org/W2110041455","doi":"https://doi.org/10.4161/cbt.6.10.4800","title":"Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells","display_name":"Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2110041455","doi":"https://doi.org/10.4161/cbt.6.10.4800","mag":"2110041455","pmid":"https://pubmed.ncbi.nlm.nih.gov/17921698"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.6.10.4800","doi":"https://doi.org/10.4161/cbt.6.10.4800","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.6.10.4800","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.10.4800?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.10.4800?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066453211","display_name":"Rongcai Jiang","orcid":"https://orcid.org/0000-0002-9119-0115","observed_orcids":["https://orcid.org/0000-0002-9119-0115","https://orcid.org/0009-0004-2257-7668","https://orcid.org/0009-0002-0851-3786","https://orcid.org/0000-0001-9170-9653","https://orcid.org/0000-0001-7827-6128"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongcai Jiang","raw_affiliation_strings":["Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037573167","display_name":"Woonyoung Choi","orcid":"https://orcid.org/0000-0003-1088-9539","observed_orcids":["https://orcid.org/0000-0003-1088-9539"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woonyoung Choi","raw_affiliation_strings":["Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Urology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034443119","display_name":"Limei Hu","orcid":"https://orcid.org/0000-0001-8899-0771","observed_orcids":["https://orcid.org/0000-0001-8899-0771"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limei Hu","raw_affiliation_strings":["Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108364106","display_name":"Eugene W. Gerner","orcid":"https://orcid.org/0000-0002-9906-8501","observed_orcids":["https://orcid.org/0000-0002-9906-8501"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene W. Gerner","raw_affiliation_strings":["Department of Cell Biology and Anatomy ; Arizona Cancer Center ; University of Arizona ; Tucson , Arizona USA","University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy ; Arizona Cancer Center ; University of Arizona ; Tucson , Arizona USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078636533","display_name":"Stanley R. Hamilton","orcid":"https://orcid.org/0000-0002-8331-1052","observed_orcids":["https://orcid.org/0000-0002-8331-1052"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley R. Hamilton","raw_affiliation_strings":["Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology ; The University of Texas ; MD Anderson Cancer Center ; Houston , Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":0.6551,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.63776607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"10","first_page":"1644","last_page":"1648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamine-catabolism","display_name":"polyamine catabolism","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.796999990940094},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5830000042915344},{"id":"https://openalex.org/keywords/anoikis","display_name":"anoikis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-growth-regulation","display_name":"cell growth regulation","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8706692457199097},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7322112321853638},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.7268597483634949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.634078323841095},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.6031838059425354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5558162331581116},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4302043914794922},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.4152109622955322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3214550018310547},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3090047836303711},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.2704077959060669}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.6.10.4800","doi":"https://doi.org/10.4161/cbt.6.10.4800","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.6.10.4800","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.10.4800?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:17921698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17921698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.6.10.4800","doi":"https://doi.org/10.4161/cbt.6.10.4800","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.6.10.4800","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.10.4800?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110041455.pdf","grobid_xml":"https://content.openalex.org/works/W2110041455.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077117832","https://openalex.org/W2374253971","https://openalex.org/W2009575189","https://openalex.org/W3174132709","https://openalex.org/W2001824102","https://openalex.org/W1973856917","https://openalex.org/W2158007263","https://openalex.org/W863867389","https://openalex.org/W2580781468","https://openalex.org/W2953588239"],"abstract_inverted_index":{"N(1),":[0],"N(11)-Diethylnorspermine":[1],"(DENSPM)":[2],"is":[3],"a":[4,49,146,155,160,182],"spermine":[5],"analog":[6],"and":[7,24,68,103,154,176,211],"prototype":[8],"anti-cancer":[9],"drug":[10],"that":[11,75,110,132,167,193],"depletes":[12],"cellular":[13,16,201],"polyamine,":[14],"increases":[15],"oxidative":[17],"stress":[18],"through":[19],"the":[20,26,35,54,80,88,114,137,141,168,194,200,214],"generation":[21],"of":[22,28,31,51,59,83,90,129,140,149,157,170,185,196,203,216],"H(2)O(2)":[23],"induces":[25],"death":[27,215],"multiple":[29],"types":[30],"cancer":[32],"cells.":[33,142,218],"However,":[34],"survival":[36],"pathways":[37,62],"perturbed":[38],"by":[39,122],"DENSPM":[40,76,111,133,186],"are":[41],"uncertain.":[42],"To":[43],"identify":[44],"these":[45,119],"pathways,":[46],"we":[47],"examined":[48],"series":[50],"proteins":[52,172],"in":[53,63,118,136,151,159],"phosphoinositide":[55],"3-kinase":[56],"/AKT/mammalian":[57],"target":[58],"rapamycin":[60],"(PI3K/AKT/mTOR)":[61],"glioblastoma":[64,120,217],"cell":[65,174,177],"lines":[66],"before":[67],"after":[69],"treatment":[70],"with":[71],"DENSPM.":[72],"We":[73,143,164,191],"found":[74],"did":[77,86],"not":[78],"change":[79],"protein":[81,116,125,189,209],"levels":[82,89,169],"PI3K":[84],"but":[85],"reduce":[87],"AKT,":[91,93],"phosphorylated":[92,95,98,101],"mTOR,":[94,96,204],"p70(S6K),":[97,99],"4E-BP1,":[100],"4E-BP1":[102],"eIF-4B":[104],"proteins.":[105],"From":[106],"this":[107],"it":[108],"appears":[109],"directly":[112],"targets":[113],"mTOR":[115,130,135],"level":[117],"cells":[121,153,158],"inhibiting":[123],"mTOR-mediated":[124,188,208],"synthesis.":[126,190],"Immunofluorescence":[127],"analysis":[128],"showed":[131,166],"sequestered":[134],"perinuclear":[138],"region":[139],"also":[144],"detected":[145],"marked":[147],"collapse":[148],"microtubules":[150],"U87":[152],"detachment":[156],"process":[161],"resembling":[162],"anoikis.":[163],"further":[165],"many":[171],"regulating":[173],"growth":[175],"adhesion":[178],"were":[179],"downregulated,":[180],"suggesting":[181],"broad":[183],"effect":[184],"on":[187],"conclude":[192],"activation":[195],"polyamine":[197],"catabolism":[198],"alters":[199],"location":[202],"thus":[205],"negatively":[206],"affecting":[207],"synthesis":[210],"leading":[212],"to":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
