{"id":"https://openalex.org/W2110034584","doi":"https://doi.org/10.1021/cb800039y","title":"Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity","display_name":"Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2110034584","doi":"https://doi.org/10.1021/cb800039y","mag":"2110034584","pmid":"https://pubmed.ncbi.nlm.nih.gov/18484710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3618672"},"language":"en","primary_location":{"id":"doi:10.1021/cb800039y","doi":"https://doi.org/10.1021/cb800039y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cb800039y","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3618672","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029282098","display_name":"Peng Xie","orcid":"https://orcid.org/0000-0002-7235-3230","observed_orcids":["https://orcid.org/0000-0002-7235-3230"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Xie","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania","The Wistar Institute","Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"The Wistar Institute","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030608620","display_name":"Douglas S. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas S. Williams","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038226828","display_name":"Gunes Ekin Atilla\u2010Gokcumen","orcid":"https://orcid.org/0000-0002-7132-3873","observed_orcids":["https://orcid.org/0000-0002-7132-3873"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Ekin Atilla-Gokcumen","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010283935","display_name":"Leslie Milk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Milk","raw_affiliation_strings":["Graduate Group in Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Group in Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067382998","display_name":"Min Xiao","orcid":"https://orcid.org/0000-0001-9421-6344","observed_orcids":["https://orcid.org/0000-0001-9421-6344"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Xiao","raw_affiliation_strings":["The Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059758317","display_name":"Keiran S.M. Smalley","orcid":"https://orcid.org/0000-0003-1089-9307","observed_orcids":["https://orcid.org/0000-0003-1089-9307"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keiran S. M. Smalley","raw_affiliation_strings":["The Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":["The Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080487872","display_name":"Eric Meggers","orcid":"https://orcid.org/0000-0002-8851-7623","observed_orcids":["https://orcid.org/0000-0002-8851-7623"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Meggers","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061620397","display_name":"Ronen Marmorstein","orcid":"https://orcid.org/0000-0003-4373-4752","observed_orcids":["https://orcid.org/0000-0003-4373-4752","https://orcid.org/0000-0002-9755-7838"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronen Marmorstein","raw_affiliation_strings":["Department of Chemistry, University of Pennsylvania","Graduate Group in Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","The Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Graduate Group in Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"The Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061620397"],"corresponding_institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.576,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.90373658,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"5","first_page":"305","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.847000002861023},{"id":"https://openalex.org/keywords/organoruthenium-compounds","display_name":"organoruthenium compounds","score":0.7789999842643738},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pi3kgamma","display_name":"PI3K\u03b3","score":0.7829999923706055},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.6230000257492065},{"id":"https://openalex.org/keywords/kinase-inhibitor-potency","display_name":"kinase inhibitor potency","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6998819708824158},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.692521333694458},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5788002014160156},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5430334210395813},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.530414879322052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.478863924741745},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4364895224571228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.409223347902298},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3926551938056946},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.38269147276878357},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3826286196708679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3791830539703369},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22728705406188965}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012428","descriptor_name":"Ruthenium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/cb800039y","doi":"https://doi.org/10.1021/cb800039y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cb800039y","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:18484710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18484710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2620215","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3618672","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3618672","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3618672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.581.4849","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.581.4849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.uni-marburg.de/fb15/ag-meggers/publications/Publication_PDF_Files/ACS_ChemBiol_2008_PI3K/","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2620215","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3618672","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1101497901","display_name":"Structure/Function of Human Papillomavirus Oncoproteins","funder_award_id":"R01CA094165","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2668084995","display_name":"Metal Complexes as Protein Kinase Inhibitors","funder_award_id":"R01GM071695","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3033631705","display_name":"Experimental Transformation of Human Melanocytes in Vivo","funder_award_id":"R01CA080999","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G357077679","display_name":null,"funder_award_id":"Y01 GM000080","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4913922740","display_name":null,"funder_award_id":"CA 01015","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6442871445","display_name":"SPORE in Skin Cancer","funder_award_id":"P50CA093372","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G674446306","display_name":null,"funder_award_id":"Y1 GM-0080-03","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000906427","display_name":"Consolidated Basic Cancer Research Program","funder_award_id":"P30CA010815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1529396499","https://openalex.org/W1541596409","https://openalex.org/W1585517331","https://openalex.org/W1969292035","https://openalex.org/W1971333358","https://openalex.org/W1977070803","https://openalex.org/W1984453879","https://openalex.org/W1993133483","https://openalex.org/W1995017064","https://openalex.org/W2001641653","https://openalex.org/W2006632173","https://openalex.org/W2010234097","https://openalex.org/W2013083986","https://openalex.org/W2018567418","https://openalex.org/W2045329873","https://openalex.org/W2045887549","https://openalex.org/W2052750950","https://openalex.org/W2059072734","https://openalex.org/W2059421295","https://openalex.org/W2060146306","https://openalex.org/W2080571148","https://openalex.org/W2085483616","https://openalex.org/W2089090881","https://openalex.org/W2090649030","https://openalex.org/W2090940799","https://openalex.org/W2097493124","https://openalex.org/W2102014488","https://openalex.org/W2103268811","https://openalex.org/W2107614388","https://openalex.org/W2109099165","https://openalex.org/W2111865926","https://openalex.org/W2124593509","https://openalex.org/W2124727390","https://openalex.org/W2129172946","https://openalex.org/W2137705897","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2156876141","https://openalex.org/W2161724145","https://openalex.org/W2171773992","https://openalex.org/W2319433899","https://openalex.org/W2388163742","https://openalex.org/W2949159129","https://openalex.org/W4243559800"],"related_works":["https://openalex.org/W1981811774","https://openalex.org/W2139157948","https://openalex.org/W4404851995","https://openalex.org/W2020486227","https://openalex.org/W3161470636","https://openalex.org/W2614128464","https://openalex.org/W2071114368","https://openalex.org/W4405891438","https://openalex.org/W2115484306","https://openalex.org/W3145046568"],"abstract_inverted_index":{"Mutations":[0],"that":[1,91,140],"constitutively":[2],"activate":[3],"the":[4,25,34,52,77,109,120,133,137,154],"phosphatidyl-inositol-3-kinase":[5],"(PI3K)":[6],"signaling":[7],"pathway,":[8],"including":[9],"alterations":[10],"in":[11,18,76,95,112,125],"PI3K,":[12],"PTEN,":[13],"and":[14,42,80,99,146],"AKT,":[15],"are":[16],"found":[17],"a":[19,55,66,83,106,126,157],"variety":[20],"of":[21,36,54,85,122,132,156,160],"human":[22,96],"cancers,":[23],"implicating":[24],"PI3K":[26,67,110],"lipid":[27,149],"kinase":[28,58],"as":[29],"an":[30,72],"attractive":[31],"target":[32],"for":[33,108,153],"development":[35],"therapeutic":[37],"agents":[38],"to":[39,64,101,143],"treat":[40],"cancer":[41],"other":[43],"related":[44],"diseases.":[45],"In":[46],"this":[47,144],"study,":[48],"we":[49],"report":[50],"on":[51],"combination":[53],"novel":[56],"organometallic":[57,162],"inhibitor":[59],"scaffold":[60],"with":[61,71,105,151],"structure-based":[62],"design":[63,155],"develop":[65],"inhibitor,":[68],"called":[69],"E5E2,":[70],"IC":[73],"50":[74],"potency":[75,145],"mid-low-nanomolar":[78],"range":[79],"selectivity":[81,147],"against":[82],"panel":[84],"protein":[86],"kinases.":[87],"We":[88],"also":[89,118],"show":[90],"E5E2":[92,116],"inhibits":[93,119],"phospho-AKT":[94],"melanoma":[97,123],"cells":[98,124],"leads":[100],"growth":[102],"inhibition.":[103],"Consistent":[104],"role":[107],"pathway":[111],"tumor":[113],"cell":[114],"invasion,":[115],"treatment":[117],"migration":[121],"3D":[127],"spheroid":[128],"assay.":[129],"The":[130],"structure":[131],"PI3Kgamma/E5E2":[134],"complex":[135],"reveals":[136],"molecular":[138],"features":[139],"give":[141],"rise":[142],"toward":[148],"kinases":[150],"implications":[152],"subsequent":[158],"generation":[159],"PI3K-isoform-specific":[161],"inhibitors.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
