{"id":"https://openalex.org/W2109999650","doi":null,"title":"A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.","display_name":"A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.","publication_year":1999,"publication_date":"1999-08-15","ids":{"openalex":"https://openalex.org/W2109999650","mag":"2109999650","pmid":"https://pubmed.ncbi.nlm.nih.gov/10463613"},"language":"en","primary_location":{"id":"pmid:10463613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10463613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043076766","display_name":"Joseph Leo Wiemels","orcid":"https://orcid.org/0000-0003-4838-9951","observed_orcids":["https://orcid.org/0000-0003-4838-9951"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J L Wiemels","raw_affiliation_strings":["Leukaemia Research Fund Centre, Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukaemia Research Fund Centre, Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052845737","display_name":"Alistair T. Pagnamenta","orcid":"https://orcid.org/0000-0001-7334-0602","observed_orcids":["https://orcid.org/0000-0001-7334-0602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pagnamenta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016036121","display_name":"G. Malcolm Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110344281","display_name":"Osborn B. Eden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O B Eden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111420708","display_name":"F E Alexander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F E Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111607029","display_name":"Melvyn F. Greaves","orcid":"https://orcid.org/0000-0002-7239-1384","observed_orcids":["https://orcid.org/0000-0002-7239-1384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Greaves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.183,"has_fulltext":false,"cited_by_count":215,"citation_normalized_percentile":{"value":0.9787618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"16","first_page":"4095","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.1656000018119812,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1","display_name":"NAD(P)H:quinone oxidoreductase 1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nqo1-polymorphism","display_name":"NQO1 polymorphism","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mll-af4-fusion","display_name":"MLL-AF4 fusion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/infant-leukemia","display_name":"infant leukemia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/quinone-detoxification","display_name":"quinone detoxification","score":0.8980000019073486},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.4309999942779541},{"id":"https://openalex.org/keywords/tel-aml1-fusion-gene","display_name":"TEL-AML1 fusion","score":0.906000018119812},{"id":"https://openalex.org/keywords/hyperdiploidy","display_name":"hyperdiploidy","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5802591443061829},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5454561710357666},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5079501271247864},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4952453672885895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43916499614715576},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32721972465515137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32492494583129883}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051788","descriptor_name":"Myeloid-Lymphoid Leukemia Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10463613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10463613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.3636","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.3636","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/59/16/4095.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/31d3aad2-416e-4631-baf5-31f7c2e53bfd","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/31d3aad2-416e-4631-baf5-31f7c2e53bfd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wiemels, JL, Pagnamenta, A, Taylor, GM, Eden, OB, Alexander, FE & Greaves, MF 1999, 'A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with paediatric leukaemias that have MLL fusions', Cancer Research, vol. 59.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2109999650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10463613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W4908868","https://openalex.org/W28658331","https://openalex.org/W36679969","https://openalex.org/W51523625","https://openalex.org/W166666086","https://openalex.org/W217174247","https://openalex.org/W1492157159","https://openalex.org/W1556870191","https://openalex.org/W1578196675","https://openalex.org/W1586451492","https://openalex.org/W1595656597","https://openalex.org/W1750225402","https://openalex.org/W1842901255","https://openalex.org/W1846542962","https://openalex.org/W1906310597","https://openalex.org/W1930427755","https://openalex.org/W1974176317","https://openalex.org/W1976717526","https://openalex.org/W1980022601","https://openalex.org/W1980790707","https://openalex.org/W1982805396","https://openalex.org/W1988376306","https://openalex.org/W1988708581","https://openalex.org/W1990780198","https://openalex.org/W1990863885","https://openalex.org/W1992003696","https://openalex.org/W1994029494","https://openalex.org/W1994547803","https://openalex.org/W1997885761","https://openalex.org/W2001886943","https://openalex.org/W2005140181","https://openalex.org/W2008018118","https://openalex.org/W2026206582","https://openalex.org/W2050800108","https://openalex.org/W2053831323","https://openalex.org/W2058536932","https://openalex.org/W2066785941","https://openalex.org/W2072467180","https://openalex.org/W2084444653","https://openalex.org/W2085110243","https://openalex.org/W2087542439","https://openalex.org/W2095405591","https://openalex.org/W2101085659","https://openalex.org/W2124093763","https://openalex.org/W2128279248","https://openalex.org/W2130714065","https://openalex.org/W2133615399","https://openalex.org/W2133955203","https://openalex.org/W2137810538","https://openalex.org/W2154215238","https://openalex.org/W2163819445","https://openalex.org/W2168881809","https://openalex.org/W2242790540","https://openalex.org/W2253470886","https://openalex.org/W2294291334","https://openalex.org/W2407641423","https://openalex.org/W2411581624","https://openalex.org/W2413750325","https://openalex.org/W3143569680"],"related_works":["https://openalex.org/W7099426511","https://openalex.org/W2047028713","https://openalex.org/W7135928245","https://openalex.org/W2089450195","https://openalex.org/W7000758506","https://openalex.org/W2124643798","https://openalex.org/W7097681399","https://openalex.org/W7097126653","https://openalex.org/W7096782212","https://openalex.org/W2144433333"],"abstract_inverted_index":{"Rearrangements":[0],"and":[1,19,66,83,230],"fusion":[2,188],"of":[3,16,70,112,165,182,217,232],"the":[4,43,71,87,180,193,215],"MLL":[5,28,72,116],"gene":[6,29,238],"with":[7,63,115,134,168],"various":[8],"alternative":[9],"partner":[10],"genes":[11,189],"occur":[12,32],"in":[13,25,33,97,106,162,196,222,228,247],"approximately":[14],"80%":[15],"infant":[17,47,113,183,223],"leukemias":[18,114,127,167,184],"are":[20],"acquired":[21],"during":[22,55],"fetal":[23,53],"hemopoiesis":[24],"utero.":[26],"Similar":[27],"recombinants":[30],"also":[31],"topoisomerase":[34,64,80],"II-inhibiting":[35,81],"drug-induced":[36],"leukemias.":[37],"These":[38,212],"data":[39,213],"have":[40,132],"led":[41],"to":[42,57,131],"suggestion":[44],"that":[45,59,100,185],"some":[46],"leukemia":[48,224],"may":[49],"arise":[50],"via":[51],"transplacental":[52],"exposures":[54],"pregnancy":[56],"substances":[58],"form":[60],"cleavable":[61],"complexes":[62],"II":[65],"induce":[67],"illegitimate":[68],"recombination":[69],"gene.":[73],"A":[74],"structural":[75],"feature":[76],"shared":[77],"by":[78,92,239],"many":[79],"drugs":[82],"other":[84,163],"chemicals":[85],"is":[86],"quinone":[88],"moiety.":[89],"We":[90],"assayed,":[91],"PCR-RFLP,":[93],"for":[94],"a":[95,107,218,235,244,248],"polymorphism":[96],"an":[98,240],"enzyme":[99],"detoxifies":[101],"quinones,":[102],"NAD(P)H:quinone":[103],"oxidoreductase":[104],"(NQO1),":[105],"series":[108],"(n":[109,123,171,176,190],"=":[110,124,152,172,177,191,210],"36)":[111],"rearrangements":[117],"versus":[118],"unselected":[119],"cord":[120],"blood":[121],"controls":[122,147],"100).":[125],"MLL-rearranged":[126],"were":[128],"more":[129,204],"likely":[130],"genotypes":[133,202],"low":[135,197],"NQO1":[136,201],"function":[137,200],"(heterozygous":[138],"CT":[139],"or":[140,174,198],"homozygous":[141],"TT":[142],"at":[143],"nucleotide":[144],"609)":[145],"than":[146],"(odds":[148,206],"ratio,":[149,207],"2.5;":[150],"P":[151,209],"0.015).":[153],"In":[154,179],"contrast,":[155],"no":[156],"significant":[157],"allele":[158,242],"bias":[159,194],"was":[160,203],"seen":[161],"groups":[164],"pediatric":[166],"TEL-AML1":[169],"fusions":[170],"50)":[173],"hyperdiploidy":[175],"29).":[178],"subset":[181],"had":[186],"MLL-AF4":[187],"21),":[192],"increase":[195],"null":[199],"pronounced":[205],"8.12;":[208],"0.00013).":[211],"support":[214],"idea":[216],"novel":[219],"causal":[220],"mechanism":[221],"involving":[225],"genotoxic":[226],"exposure":[227],"utero":[229],"modulation":[231],"impact":[233],"on":[234],"selective":[236],"target":[237],"inherited":[241],"encoding":[243],"rate-limiting":[245],"step":[246],"carcinogen":[249],"detoxification":[250],"pathway.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
