{"id":"https://openalex.org/W2109988147","doi":"https://doi.org/10.1177/0269881109359100","title":"Age-dependent effects of methylphenidate in the prefrontal cortex: evidence from electrophysiological and Arc gene expression measurements","display_name":"Age-dependent effects of methylphenidate in the prefrontal cortex: evidence from electrophysiological and Arc gene expression measurements","publication_year":2010,"publication_date":"2010-02-08","ids":{"openalex":"https://openalex.org/W2109988147","doi":"https://doi.org/10.1177/0269881109359100","mag":"2109988147","pmid":"https://pubmed.ncbi.nlm.nih.gov/20142300"},"language":"en","primary_location":{"id":"doi:10.1177/0269881109359100","doi":"https://doi.org/10.1177/0269881109359100","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881109359100","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052726489","display_name":"B. Gronier","orcid":"https://orcid.org/0000-0001-8107-2070","observed_orcids":["https://orcid.org/0000-0001-8107-2070"]},"institutions":[{"id":"https://openalex.org/I66943878","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83","country_code":"GB","type":"education","lineage":["https://openalex.org/I66943878"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gronier Benjamin","raw_affiliation_strings":["Leicester School of Pharmacy, De Montfort University, UK,","Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, UK. bgronier@dmu.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester School of Pharmacy, De Montfort University, UK,","institution_ids":["https://openalex.org/I66943878"]},{"raw_affiliation_string":"Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, UK. bgronier@dmu.ac.uk","institution_ids":["https://openalex.org/I66943878"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aston James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66943878","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83","country_code":"GB","type":"education","lineage":["https://openalex.org/I66943878"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aston James","raw_affiliation_strings":["Leicester School of Pharmacy, De Montfort University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester School of Pharmacy, De Montfort University, UK","institution_ids":["https://openalex.org/I66943878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087847641","display_name":"C. Liauzun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66943878","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83","country_code":"GB","type":"education","lineage":["https://openalex.org/I66943878"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liauzun Claire","raw_affiliation_strings":["Leicester School of Pharmacy, De Montfort University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester School of Pharmacy, De Montfort University, UK","institution_ids":["https://openalex.org/I66943878"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077084941","display_name":"Tyra Zetterstr\u00f6m","orcid":"https://orcid.org/0000-0002-9838-7711","observed_orcids":["https://orcid.org/0000-0002-9838-7711"]},"institutions":[{"id":"https://openalex.org/I66943878","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83","country_code":"GB","type":"education","lineage":["https://openalex.org/I66943878"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tyra Zetterstr\u00f6m","raw_affiliation_strings":["Leicester School of Pharmacy, De Montfort University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester School of Pharmacy, De Montfort University, UK","institution_ids":["https://openalex.org/I66943878"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052726489"],"corresponding_institution_ids":["https://openalex.org/I66943878"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.1511,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77831936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"12","first_page":"1819","last_page":"1827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylphenidate","display_name":"methylphenidate","score":1.0},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9750000238418579},{"id":"https://openalex.org/keywords/age-dependent-effects","display_name":"age-dependent effects","score":0.7590000033378601},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuronal-firing-rate","display_name":"neuronal firing rate","score":0.7099999785423279},{"id":"https://openalex.org/keywords/single-unit-activity","display_name":"single-unit activity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/juvenile-rats","display_name":"young rats","score":0.7049999833106995},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cingulate-cortex","display_name":"cingulate cortex","score":0.8019999861717224},{"id":"https://openalex.org/keywords/orbital-cortex","display_name":"orbital cortex","score":0.9679999947547913},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.7598980665206909},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7434098720550537},{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.742483377456665},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.6189711689949036},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.590247392654419},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5131168961524963},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.24827799201011658},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.23719695210456848},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.15497830510139465},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/0269881109359100","doi":"https://doi.org/10.1177/0269881109359100","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881109359100","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:20142300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20142300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychopharmacology (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:dora.dmu.ac.uk:2086/4496","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2086/4496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400394","display_name":"DMU Open Research Archive (De Montfort University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66943878","host_organization_name":"De Montfort University","host_organization_lineage":["https://openalex.org/I66943878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.dora.dmu.ac.uk:2086/4496","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2086/4496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400394","display_name":"DMU Open Research Archive (De Montfort University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66943878","host_organization_name":"De Montfort University","host_organization_lineage":["https://openalex.org/I66943878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2187476025","doi":null,"is_oa":false,"landing_page_url":"http://adhdnet.com/wp/papers10/Gronier_2010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1916743044","https://openalex.org/W1964751335","https://openalex.org/W1968571803","https://openalex.org/W1970448316","https://openalex.org/W1975376465","https://openalex.org/W1975431871","https://openalex.org/W1978275630","https://openalex.org/W1980494785","https://openalex.org/W1981703394","https://openalex.org/W1982093125","https://openalex.org/W1983906828","https://openalex.org/W1985645068","https://openalex.org/W1989057449","https://openalex.org/W1995992264","https://openalex.org/W1996885013","https://openalex.org/W1997765732","https://openalex.org/W2003615600","https://openalex.org/W2018140929","https://openalex.org/W2018418849","https://openalex.org/W2030508131","https://openalex.org/W2036572502","https://openalex.org/W2043509245","https://openalex.org/W2044451720","https://openalex.org/W2056268429","https://openalex.org/W2057377674","https://openalex.org/W2072402975","https://openalex.org/W2078434415","https://openalex.org/W2079634519","https://openalex.org/W2087379206","https://openalex.org/W2091628557","https://openalex.org/W2093622479","https://openalex.org/W2128508619","https://openalex.org/W2137587432","https://openalex.org/W2140736710","https://openalex.org/W2159875740","https://openalex.org/W2163815564","https://openalex.org/W2289733791","https://openalex.org/W2296487620"],"related_works":["https://openalex.org/W2187476025","https://openalex.org/W1990944689","https://openalex.org/W2055542607","https://openalex.org/W4400181332","https://openalex.org/W2903039893","https://openalex.org/W2618921436","https://openalex.org/W4388363120","https://openalex.org/W2103073726","https://openalex.org/W2149085698","https://openalex.org/W2088072152"],"abstract_inverted_index":{"Methylphenidate,":[0,85],"a":[1,27,104],"drug":[2],"widely":[3],"used":[4],"for":[5,169],"attention":[6],"deficit":[7],"hyperactivity":[8],"disorder":[9],"in":[10,17,23,68,72,123,149,161,196],"children,":[11],"may":[12],"affect":[13],"neuronal":[14],"function":[15],"differently":[16],"young":[18],"and":[19,53,79,159,163,177,198],"adult":[20,73,91,199],"subjects,":[21],"particularly":[22],"the":[24,39,44,57,69,124,134,170,186],"prefrontal":[25,70,110,189],"cortex,":[26,165],"brain":[28],"structure":[29],"that":[30,185],"does":[31],"not":[32],"fully":[33],"develop":[34],"until":[35],"adulthood.":[36],"We":[37],"compared":[38,153],"impact":[40],"of":[41,46,56,107,109,130,188],"development":[42],"on":[43,48],"effects":[45],"methylphenidate":[47,67,142,193],"single":[49],"unit":[50],"electrical":[51],"activity":[52],"mRNA":[54,151],"expression":[55],"effector":[58],"immediate":[59],"early":[60],"gene":[61],"activity-regulated":[62],"cytoskeletal-associated":[63],"protein":[64],"(Arc)":[65],"following":[66],"cortex":[71,111,190],"(more":[74],"than":[75],"60":[76],"days":[77,82],"old)":[78,83],"juvenile":[80,125,171,197],"(25-35":[81],"rats.":[84,200],"administered":[86],"under":[87],"urethane":[88],"anaesthesia":[89],"to":[90,99,114,192],"rats,":[92,126],"at":[93,133],"doses":[94],"ranging":[95],"from":[96,116],"1":[97],"mg/kg":[98,101,144],"3":[100],"intravenously,":[102],"exerts":[103],"progressive":[105],"activation":[106,119],"firing":[108],"neurones":[112,191],"(30%":[113],"84%":[115],"baseline).":[117],"This":[118],"was":[120],"significantly":[121,174],"lower":[122,175],"reaching":[127],"only":[128],"37%":[129],"baseline":[131],"levels":[132,152],"highest":[135],"dose":[136],"(3":[137],"mg/kg,":[138],"intravenous).":[139],"In":[140,179],"adults,":[141],"(4":[143],"intraperitoneal)":[145],"produced":[146],"marked":[147],"increases":[148],"Arc":[150],"with":[154],"saline":[155],"controls":[156],"by":[157],"123%":[158],"164%":[160],"cingulated":[162],"orbital":[164],"respectively.":[166],"Corresponding":[167],"values":[168],"rats":[172],"were":[173],"(42%":[176],"79%).":[178],"summary,":[180],"this":[181],"multi-approach":[182],"investigation":[183],"showed":[184],"reactivity":[187],"differs":[194],"markedly":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
