{"id":"https://openalex.org/W2109985221","doi":null,"title":"Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.","display_name":"Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2109985221","mag":"2109985221","pmid":"https://pubmed.ncbi.nlm.nih.gov/11585742"},"language":"en","primary_location":{"id":"pmid:11585742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11585742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052834632","display_name":"Jung\u2010Hoon Yoon","orcid":"https://orcid.org/0000-0002-3009-0962","observed_orcids":["https://orcid.org/0000-0002-3009-0962"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Yoon","raw_affiliation_strings":["Department of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L E Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L E Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024550359","display_name":"Zhide Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078231565","display_name":"Chong-Soon Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048312997","display_name":"Gerd P. Pfeifer","orcid":"https://orcid.org/0000-0002-5080-9604","observed_orcids":["https://orcid.org/0000-0002-5080-9604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G P Pfeifer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0164,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.91996558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"61","issue":"19","first_page":"7110","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/g-to-t-transversions","display_name":"G to T transversions","score":0.9559999704360962},{"id":"https://openalex.org/keywords/benzo-a-pyrene-diol-epoxide","display_name":"benzo[a]pyrene diol epoxide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7059999704360962},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7239999771118164},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C64872895","wikidata":"https://www.wikidata.org/wiki/Q1361360","display_name":"Transversion","level":4,"score":0.9331161975860596},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6810489296913147},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6375739574432373},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5879643559455872},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4848159849643707},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.48168858885765076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4536549150943756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45216336846351624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4507454037666321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4294228255748749},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.4189884662628174},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.40565428137779236},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.343122661113739},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1529383361339569}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015123","descriptor_name":"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015123","descriptor_name":"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016153","descriptor_name":"Genes, Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056968","descriptor_name":"Lac Repressors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11585742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11585742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:2109985221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11585742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1470395870","display_name":"2 FORMS OF UVRC AND THEIR ROLES IN REPAIR OF DNA DAMAGE","funder_award_id":"R01ES008389","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6425677983","display_name":"CpG methylation and mutation","funder_award_id":"R01CA084469","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W158760893","https://openalex.org/W1552426876","https://openalex.org/W1557886108","https://openalex.org/W1588528213","https://openalex.org/W1635060344","https://openalex.org/W1640635403","https://openalex.org/W1771276563","https://openalex.org/W1966497102","https://openalex.org/W1967221425","https://openalex.org/W1967446284","https://openalex.org/W1968246855","https://openalex.org/W1974218448","https://openalex.org/W1976056213","https://openalex.org/W1978880592","https://openalex.org/W1979909696","https://openalex.org/W1982878027","https://openalex.org/W1983437978","https://openalex.org/W1984128578","https://openalex.org/W1995646116","https://openalex.org/W2002446851","https://openalex.org/W2004722288","https://openalex.org/W2006060399","https://openalex.org/W2014375283","https://openalex.org/W2015315533","https://openalex.org/W2028528554","https://openalex.org/W2033410478","https://openalex.org/W2039067014","https://openalex.org/W2040900367","https://openalex.org/W2042316019","https://openalex.org/W2048716837","https://openalex.org/W2055070789","https://openalex.org/W2060716471","https://openalex.org/W2065317391","https://openalex.org/W2066190225","https://openalex.org/W2079781652","https://openalex.org/W2086046963","https://openalex.org/W2086498123","https://openalex.org/W2087200114","https://openalex.org/W2092067928","https://openalex.org/W2101324933","https://openalex.org/W2112224924","https://openalex.org/W2131910049","https://openalex.org/W2135718122","https://openalex.org/W2135911067","https://openalex.org/W2138100316","https://openalex.org/W2139688106","https://openalex.org/W2150367351","https://openalex.org/W2156882408","https://openalex.org/W2158409998","https://openalex.org/W2164542791","https://openalex.org/W2167286171","https://openalex.org/W2169238431","https://openalex.org/W2329646608","https://openalex.org/W2416518335"],"related_works":["https://openalex.org/W2137315428","https://openalex.org/W1976056213","https://openalex.org/W2091781283","https://openalex.org/W2016455125","https://openalex.org/W2158043407","https://openalex.org/W2135911067","https://openalex.org/W1978880592","https://openalex.org/W1934474142","https://openalex.org/W2138100316","https://openalex.org/W2114704467"],"abstract_inverted_index":{"A":[0],"large":[1],"fraction":[2],"of":[3,17,50,53,73,83,88,118,127,154,157,167,169,184,186,195,198,207,217,240,243],"the":[4,59,81,107,119,142,158,179,187,227,230,244],"p53":[5,60,62,231],"mutations":[6,89,160,189,269,280],"in":[7,22,28,45,86,96,112,138,151,229,233,263],"lung":[8,23,46,234,267],"cancers":[9,24,47,235],"from":[10,25,236],"smokers":[11,237],"are":[12,68],"G-to-T":[13,42,129,162,171,191,245],"transversions,":[14,163],"a":[15,102,256],"type":[16],"mutation":[18],"that":[19,36,273],"is":[20,38,146],"infrequent":[21],"nonsmokers":[26],"and":[27,48,106,109,164,193,266,270],"most":[29],"other":[30,276],"tumors.":[31],"Previous":[32],"studies":[33],"have":[34],"indicated":[35],"there":[37],"an":[39],"association":[40],"between":[41,258],"transversion":[43,208],"hotspots":[44,209],"sites":[49,134],"preferential":[51,69],"formation":[52,72],"polycyclic":[54,259],"aromatic":[55,260],"hydrocarbon":[56],"adducts":[57,74,219],"along":[58],"gene.":[61],"codons":[63],"containing":[64],"methylated":[65,99,147,175,202,211,249,285],"CpG":[66,84,98,124,133,149,176,203,250,286],"sequences":[67,150],"targets":[70],"for":[71],"by":[75,90],"(+/-)":[76],"anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene":[77],"(BPDE).":[78],"To":[79],"assess":[80],"role":[82],"methylation":[85,117],"induction":[87],"BPDE,":[91],"we":[92],"analyzed":[93],"BPDE":[94,218],"mutagenesis":[95],"three":[97],"target":[100],"genes:":[101],"supF":[103],"shuttle":[104,120],"vector":[105,121],"cII":[108,143],"lacI":[110,180],"transgenes":[111],"embryonic":[113],"mouse":[114],"fibroblasts.":[115],"After":[116],"at":[122,132,148,174,201,210,221,248,284],"all":[123,128,170],"sequences,":[125],"42%":[126],"transversions":[130,172,246],"were":[131,161,190],"compared":[135],"with":[136,214],"23%":[137],"unmethylated":[139],"DNA.":[140],"In":[141,178],"transgene,":[144],"which":[145],"vivo,":[152],"83":[153],"147":[155],"(56%)":[156],"BPDE-induced":[159,188],"58%":[165],"(48":[166],"83)":[168],"occurred":[173,200,247],"sequences.":[177,204,287],"gene,":[181],"68%":[182],"(75":[183],"111)":[185],"events,":[192],"58":[194],"75":[196],"(77%)":[197],"these":[199],"The":[205],"occurrence":[206],"CpGs":[212],"correlated":[213],"high":[215],"levels":[216],"formed":[220],"such":[222],"sites.":[223,251],"This":[224],"situation":[225],"mirrors":[226],"one":[228],"gene":[232],"where":[238],"236":[239],"465":[241],"(51%)":[242],"These":[252],"findings":[253],"further":[254],"strengthen":[255],"link":[257],"hydrocarbons":[261],"present":[262],"cigarette":[264],"smoke":[265],"cancer":[268],"provide":[271],"evidence":[272],"mutational":[274],"processes":[275],"than":[277],"C-to-T":[278],"transition":[279],"can":[281],"occur":[282],"selectively":[283]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
