{"id":"https://openalex.org/W2109973479","doi":"https://doi.org/10.1093/hmg/1.1.19","title":"Reconstruction of the 204 Mb human DMD-gene bhy homologous YAC recombination","display_name":"Reconstruction of the 204 Mb human DMD-gene bhy homologous YAC recombination","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2109973479","doi":"https://doi.org/10.1093/hmg/1.1.19","mag":"2109973479","pmid":"https://pubmed.ncbi.nlm.nih.gov/1301131"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/1.1.19","doi":"https://doi.org/10.1093/hmg/1.1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/1.1.19","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040120668","display_name":"Johan T. den Dunnen","orcid":"https://orcid.org/0000-0002-6304-1710","observed_orcids":["https://orcid.org/0000-0002-6304-1710"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.T.Den Dunnen","raw_affiliation_strings":["Department of Human Genetics, Leiden University, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007927714","display_name":"Petra M. Grootscholten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.M. Grootscholten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112165477","display_name":"JG Dauwerse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.G. Dauwerse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003348266","display_name":"Ann P. Walker","orcid":"https://orcid.org/0000-0002-8485-3494","observed_orcids":["https://orcid.org/0000-0002-8485-3494"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.P. Walker","raw_affiliation_strings":["ICRF, University of Oxford, Institute of Molecular Medicine Headington, Oxford OX3 9DU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICRF, University of Oxford, Institute of Molecular Medicine Headington, Oxford OX3 9DU","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.P. Monaco","raw_affiliation_strings":["ICRF, University of Oxford, Institute of Molecular Medicine Headington, Oxford OX3 9DU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICRF, University of Oxford, Institute of Molecular Medicine Headington, Oxford OX3 9DU","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073227025","display_name":"Robin J. Butler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Butler","raw_affiliation_strings":["Biotechnology Department, ICI Pharmaceuticals Alderly Park, Macclesfield, Cheshire SK10 4TG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Department, ICI Pharmaceuticals Alderly Park, Macclesfield, Cheshire SK10 4TG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113724228","display_name":"Rakesh Anand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Anand","raw_affiliation_strings":["Biotechnology Department, ICI Pharmaceuticals Alderly Park, Macclesfield, Cheshire SK10 4TG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Department, ICI Pharmaceuticals Alderly Park, Macclesfield, Cheshire SK10 4TG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044975213","display_name":"Alison J. Coffey","orcid":"https://orcid.org/0000-0002-1338-8513","observed_orcids":["https://orcid.org/0000-0002-1338-8513"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.J. Coffey","raw_affiliation_strings":["Paediatric Research Unit, Division of Medical and Molecular Genetics, Guy's Hospital London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Research Unit, Division of Medical and Molecular Genetics, Guy's Hospital London SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109099554","display_name":"D. R. Bentley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.R. Bentley","raw_affiliation_strings":["Paediatric Research Unit, Division of Medical and Molecular Genetics, Guy's Hospital London SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Research Unit, Division of Medical and Molecular Genetics, Guy's Hospital London SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010372182","display_name":"H. Yde Steensma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.Y. Steensma","raw_affiliation_strings":["Department of Cell Biology and Genetics, Leiden University Wassenaarseweg 64, 233 AL Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Genetics, Leiden University Wassenaarseweg 64, 233 AL Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055691889","display_name":"Gert\u2010Jan B. van Ommen","orcid":"https://orcid.org/0000-0002-8603-218X","observed_orcids":["https://orcid.org/0000-0002-8603-218X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G.J.B.Van ommen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.4116,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.9008976,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"19","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dmd-gene","display_name":"dystrophin gene","score":0.9589999914169312},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/becker-muscular-dystrophy","display_name":"Becker muscular dystrophy","score":1.0},{"id":"https://openalex.org/keywords/yeast-artificial-chromosomes","display_name":"yeast artificial chromosomes","score":0.8090000152587891},{"id":"https://openalex.org/keywords/in-vivo-recombination","display_name":"in vivo recombination","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitotic-instability","display_name":"mitotic instability","score":0.7070000171661377},{"id":"https://openalex.org/keywords/meiotic-instability","display_name":"meiotic instability","score":0.843999981880188},{"id":"https://openalex.org/keywords/nondisjunction","display_name":"nondisjunction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/xp21","display_name":"Xp21","score":0.7350000143051147},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9169510006904602},{"id":"https://openalex.org/C6970260","wikidata":"https://www.wikidata.org/wiki/Q420895","display_name":"Yeast artificial chromosome","level":5,"score":0.7239441871643066},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6842296123504639},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6804957389831543},{"id":"https://openalex.org/C132144397","wikidata":"https://www.wikidata.org/wiki/Q2966744","display_name":"Human artificial chromosome","level":4,"score":0.6707274913787842},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.5448725819587708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49184107780456543},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.467591255903244},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.4125611186027527},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39167678356170654},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3339705765247345},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.26745396852493286}],"mesh":[{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009136","descriptor_name":"Muscular Dystrophies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016189","descriptor_name":"Dystrophin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/hmg/1.1.19","doi":"https://doi.org/10.1093/hmg/1.1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/1.1.19","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:1301131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1301131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.969.4858","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.969.4858","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hmg.oxfordjournals.org/content/1/1/19.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:75084","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/75084/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HUMAN MOLECULAR GENETICS , 1 (1) pp. 19-28. (1992)","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:hmg:1/1/19","doi":null,"is_oa":false,"landing_page_url":"http://hmg.oxfordjournals.org/cgi/content/short/1/1/19","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098776145","https://openalex.org/W2124891931","https://openalex.org/W2088054672","https://openalex.org/W1968089129","https://openalex.org/W2076295812","https://openalex.org/W2054950080","https://openalex.org/W2424701999","https://openalex.org/W2086962712","https://openalex.org/W1572652076","https://openalex.org/W249510709"],"abstract_inverted_index":{"The":[0,49,147],"human":[1,226],"dystrophin":[2,47,227],"gene,":[3],"mutations":[4],"of":[5,65,87,116,137,165,191],"which":[6,113],"cause":[7],"Duchenne":[8],"and":[9,27,71,127,185,208],"Becker":[10],"muscular":[11],"dystrophy,":[12],"measures":[13,124],"2.4":[14],"Mb.":[15],"This":[16],"size":[17],"seriously":[18],"limits":[19],"its":[20],"cloning":[21],"as":[22,166],"a":[23,68,99,104,138,151,187,205],"single":[24],"DNA":[25],"fragment":[26],"subsequent":[28],"in-vitro":[29],"expression":[30],"studies.":[31,235],"We":[32,93,198],"have":[33,94],"used":[34],"stepwise":[35],"in-vivo":[36],"recombination":[37,101],"between":[38,108],"overlapping":[39,81,219],"yeast":[40,59,202],"artificial":[41],"chromosomes":[42],"(YACs)":[43],"to":[44,102,154,162,212,224],"reconstruct":[45,213],"the":[46,129,135,143,163,177,192,201,225],"gene.":[48],"recombinant":[50,122],"YACs":[51,66,111],"are":[52],"mitotically":[53],"stable":[54],"upon":[55,85],"propagation":[56],"in":[57,74,98,157,172,194],"haploid":[58],"cells.":[60,76],"In":[61],"contrast,":[62],"specific":[63,132],"combinations":[64],"display":[67],"remarkable":[69],"mitotic":[70],"meiotic":[72],"instability":[73],"diploid":[75,88],"Non-disjunction":[77],"is":[78,204],"rare":[79],"for":[80,112,233],"YACs,":[82],"but":[83],"increases":[84],"sporulation":[86],"cells":[89],"containing":[90,142],"non-overlapping":[91,110],"molecules.":[92],"exploited":[95],"this":[96],"feature":[97],"three-point":[100],"bridge":[103],"280":[105],"kb":[106,140],"gap":[107],"two":[109],"no":[114],"YAC":[115,123,181,220],"proper":[117],"polarity":[118],"existed.":[119],"Our":[120],"largest":[121],"2.3":[125,178],"Mb":[126,179],"contains":[128],"entire":[130],"muscle":[131],"DMD-gene":[133,193],"with":[134],"exception":[136],"100":[139],"region":[141],"in-frame":[144],"exon":[145],"60.":[146],"latter":[148],"segment":[149],"has":[150,229],"high":[152],"tendency":[153],"undergo":[155],"deletions":[156],"multi-molecular":[158],"interactions,":[159],"probably":[160],"due":[161],"presence":[164],"yet":[167],"unidentified":[168],"instability-enhancing":[169],"sequences.":[170],"Fluorescent":[171],"situ":[173],"hybridizations":[174],"confirmed":[175],"that":[176,200],"DMD":[180],"contained":[182],"Xp21-sequences":[183],"only":[184],"indicated":[186],"compact":[188],"tertiary":[189],"structure":[190],"interphase":[195],"lymphocyte":[196],"nuclei.":[197],"conclude":[199],"system":[203],"flexible,":[206],"efficient":[207],"generally":[209],"applicable":[210],"tool":[211],"or":[214],"build":[215],"genomic":[216],"regions":[217],"from":[218],"constituents.":[221],"Its":[222],"application":[223],"gene":[228],"provided":[230],"many":[231],"possibilities":[232],"future":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}