{"id":"https://openalex.org/W2109918753","doi":"https://doi.org/10.1093/jb/mvj195","title":"Lipid Phosphate Phosphatases 1 and 3 Are Localized in Distinct Lipid Rafts","display_name":"Lipid Phosphate Phosphatases 1 and 3 Are Localized in Distinct Lipid Rafts","publication_year":2006,"publication_date":"2006-09-27","ids":{"openalex":"https://openalex.org/W2109918753","doi":"https://doi.org/10.1093/jb/mvj195","mag":"2109918753","pmid":"https://pubmed.ncbi.nlm.nih.gov/17005594"},"language":"en","primary_location":{"id":"doi:10.1093/jb/mvj195","doi":"https://doi.org/10.1093/jb/mvj195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvj195","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100868439","display_name":"Masahiro Kai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Kai","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052438029","display_name":"Fumio Sakane","orcid":"https://orcid.org/0000-0003-0857-0377","observed_orcids":["https://orcid.org/0000-0003-0857-0377"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumio Sakane","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112619207","display_name":"Yanjun Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yan-Jun Jia","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100855424","display_name":"Shin-ichi Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi Imai","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039759180","display_name":"Satoshi Yasuda","orcid":"https://orcid.org/0000-0002-1011-0815","observed_orcids":["https://orcid.org/0000-0002-1011-0815"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yasuda","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071531810","display_name":"Hideo Kanoh","orcid":"https://orcid.org/0000-0002-8765-1249","observed_orcids":["https://orcid.org/0000-0002-8765-1249"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Kanoh","raw_affiliation_strings":["Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sapporo Medical University School of Medicine, West-17, South-1, Sapporo 060-8556","institution_ids":["https://openalex.org/I141882310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100868439"],"corresponding_institution_ids":["https://openalex.org/I141882310"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":1.0131,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.71222612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"140","issue":"5","first_page":"677","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9829999804496765},{"id":"https://openalex.org/keywords/membrane-protein-localization","display_name":"membrane protein localization","score":0.5090000033378601},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cytochalasin-d","display_name":"cytochalasin D","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cholera-toxin-b-subunit","display_name":"cholera toxin B subunit","score":0.8109999895095825},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.7770000100135803},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.656000018119812},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.7935471534729004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6015459895133972},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.5003623962402344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4889892339706421},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4768292009830475},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.47458434104919434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44636744260787964},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4329507648944855},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4159998893737793},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4148518443107605},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3844279646873474},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.31298118829727173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28475332260131836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10240823030471802},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0771729052066803},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002793","descriptor_name":"Cholic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010711","descriptor_name":"Phosphatidate Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017830","descriptor_name":"Octoxynol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jb/mvj195","doi":"https://doi.org/10.1093/jb/mvj195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvj195","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:17005594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17005594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jbiochem:mvj195v1","doi":null,"is_oa":false,"landing_page_url":"http://jb.oxfordjournals.org/cgi/content/short/mvj195v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W61835041","https://openalex.org/W1564861448","https://openalex.org/W1935489497","https://openalex.org/W1963977396","https://openalex.org/W1965966865","https://openalex.org/W1967256311","https://openalex.org/W1968956158","https://openalex.org/W1969653816","https://openalex.org/W1979000612","https://openalex.org/W1987898211","https://openalex.org/W1988049211","https://openalex.org/W1995252640","https://openalex.org/W1995673366","https://openalex.org/W1996284698","https://openalex.org/W2006485553","https://openalex.org/W2013063326","https://openalex.org/W2016165171","https://openalex.org/W2018175015","https://openalex.org/W2027628801","https://openalex.org/W2028811272","https://openalex.org/W2032122936","https://openalex.org/W2035450414","https://openalex.org/W2045263227","https://openalex.org/W2051437293","https://openalex.org/W2057475017","https://openalex.org/W2057680304","https://openalex.org/W2064754325","https://openalex.org/W2070182516","https://openalex.org/W2080494149","https://openalex.org/W2085955396","https://openalex.org/W2086358590","https://openalex.org/W2098880330","https://openalex.org/W2121936687","https://openalex.org/W2127792983","https://openalex.org/W2132095774","https://openalex.org/W2132202643","https://openalex.org/W2133388060","https://openalex.org/W2137940220","https://openalex.org/W2139675058","https://openalex.org/W2139846514","https://openalex.org/W2141367941","https://openalex.org/W2156850039","https://openalex.org/W2158784355","https://openalex.org/W2163266343"],"related_works":["https://openalex.org/W2008046104","https://openalex.org/W2092111186","https://openalex.org/W2097729517","https://openalex.org/W2169712438","https://openalex.org/W12316912","https://openalex.org/W2298155206","https://openalex.org/W1995252640","https://openalex.org/W6989907437","https://openalex.org/W2127792983","https://openalex.org/W2065522237"],"abstract_inverted_index":{"Lipid":[0],"phosphate":[1],"phosphatases":[2],"(LPPs),":[3],"integral":[4],"membrane":[5,148],"proteins":[6,83],"with":[7,37,128],"six":[8],"transmembrane":[9],"domains,":[10],"dephosphorylate":[11],"a":[12,131],"variety":[13],"of":[14,111,124,130,153],"extracellular":[15,164],"lipid":[16,38,183],"phosphates.":[17],"Although":[18],"LPP3":[19,178],"is":[20,34],"already":[21],"known":[22],"to":[23,25,70,91,147],"bind":[24],"Triton":[26,50,169],"X-100-insoluble":[27],"rafts,":[28],"we":[29],"here":[30],"report":[31],"that":[32,47,129,143,161,175,185],"LPP1":[33,48,59,62,75,100,112,125,144,176],"also":[35],"associated":[36],"rafts":[39,184],"distinct":[40,150,182],"from":[41,151],"those":[42,152],"harboring":[43],"LPP3.":[44,154],"We":[45],"found":[46],"was":[49,89,113,145],"X-100-soluble,":[51],"but":[52],"CHAPS-insoluble":[53,99],"in":[54,102,181],"LNCaP":[55],"cells":[56,64],"endogenously":[57],"expressing":[58],"and":[60,118,177],"several":[61,78],"cDNA-transfected":[63],"including":[65],"NIH3T3":[66],"fibroblasts.":[67],"In":[68],"addition":[69],"the":[71,87,92,98,108,120,167],"non-ionic":[72],"detergent":[73],"insolubility,":[74],"further":[76],"possessed":[77],"properties":[79],"formulated":[80],"for":[81],"raft-localizing":[82],"as":[84],"follows:":[85],"first,":[86],"CHAPS-insolubility":[88],"resistant":[90],"actin-disrupting":[93],"drug":[94],"cytochalasin":[95],"D;":[96],"second,":[97],"floated":[101],"an":[103],"Optiprep":[104],"density":[105],"gradient;":[106],"third,":[107],"CHAPS":[109],"insolubility":[110],"lost":[114],"by":[115],"cholesterol":[116],"depletion;":[117],"finally,":[119],"subcellular":[121],"distribution":[122],"pattern":[123],"exclusively":[126],"overlapped":[127],"raft":[132],"marker,":[133],"cholera":[134],"toxin":[135],"B":[136],"subunit.":[137],"Interestingly,":[138],"confocal":[139],"microscopic":[140],"analysis":[141],"showed":[142],"distributed":[146,180],"compartments":[149],"Analysis":[155],"using":[156],"various":[157],"LPP1/LPP3":[158],"chimeras":[159],"revealed":[160],"their":[162,191],"first":[163],"regions":[165],"determine":[166],"different":[168],"X-100":[170],"solubilities.":[171],"These":[172],"results":[173],"indicate":[174],"are":[179],"may":[186],"provide":[187],"unique":[188],"microenvironments":[189],"defining":[190],"non-redundant":[192],"physiological":[193],"functions.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
