{"id":"https://openalex.org/W2109901776","doi":"https://doi.org/10.4269/ajtmh.2004.71.639","title":"CONSTRUCTION OF YELLOW FEVER/ST. LOUIS ENCEPHALITIS CHIMERIC VIRUS AND THE USE OF CHIMERAS AS A DIAGNOSTIC TOOL","display_name":"CONSTRUCTION OF YELLOW FEVER/ST. LOUIS ENCEPHALITIS CHIMERIC VIRUS AND THE USE OF CHIMERAS AS A DIAGNOSTIC TOOL","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W2109901776","doi":"https://doi.org/10.4269/ajtmh.2004.71.639","mag":"2109901776","pmid":"https://pubmed.ncbi.nlm.nih.gov/15569798"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.2004.71.639","doi":"https://doi.org/10.4269/ajtmh.2004.71.639","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2004.71.639","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"KONSTANTIN V. PUGACHEV","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KONSTANTIN V. PUGACHEV","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012170482","display_name":"Farshad Guirakhoo","orcid":"https://orcid.org/0000-0003-0124-013X","observed_orcids":["https://orcid.org/0000-0003-0124-013X","https://orcid.org/0000-0002-0903-1765"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FARSHAD GUIRAKHOO","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029881937","display_name":"Fred Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FRED MITCHELL","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834128","display_name":"S. Ocran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SIMEON W. OCRAN","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089908072","display_name":"M. Angela Parsons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MEGAN PARSONS","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108207900","display_name":"Barbara Wilmot Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BARBARA W. JOHNSON","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087451306","display_name":"Olga L. Kosoy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"OLGA L. KOSOY","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052474853","display_name":"Robert S. Lanciotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT S. LANCIOTTI","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039295142","display_name":"John T. Roehrig","orcid":"https://orcid.org/0000-0001-7581-0479","observed_orcids":["https://orcid.org/0000-0001-7581-0479"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN T. ROEHRIG","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109054812","display_name":"Dennis W. Trent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DENNIS W. TRENT","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","Microbiology And Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]},{"raw_affiliation_string":"Microbiology And Immunology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055066987","display_name":"Thomas P. C. Monath","orcid":"https://orcid.org/0000-0001-7509-4599","observed_orcids":["https://orcid.org/0000-0001-7509-4599"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THOMAS P. MONATH","raw_affiliation_strings":["Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acambis Inc., Cambridge, Massachusetts; Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210160401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.698,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84963287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"71","issue":"5","first_page":"639","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/st-louis-encephalitis-virus","display_name":"St. Louis encephalitis virus","score":0.9330000281333923},{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/yellow-fever-virus","display_name":"yellow fever virus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chimeric-viruses","display_name":"chimeric viruses","score":0.7770000100135803},{"id":"https://openalex.org/keywords/virus-neutralization-test","display_name":"virus neutralization test","score":0.7649999856948853},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/attenuated-vaccine-candidate","display_name":"attenuated vaccine candidate","score":0.5820000171661377},{"id":"https://openalex.org/keywords/diagnostic-reagents","display_name":"diagnostic reagents","score":0.8009999990463257},{"id":"https://openalex.org/keywords/biocontainment","display_name":"biocontainment","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8662922382354736},{"id":"https://openalex.org/C2779131611","wikidata":"https://www.wikidata.org/wiki/Q154874","display_name":"Yellow fever","level":3,"score":0.7912816405296326},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6550711989402771},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.643978476524353},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.623490571975708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5723215341567993},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5361824631690979},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5305806994438171},{"id":"https://openalex.org/C2779141303","wikidata":"https://www.wikidata.org/wiki/Q738292","display_name":"Japanese encephalitis","level":4,"score":0.5003304481506348},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.4384792149066925},{"id":"https://openalex.org/C2779734145","wikidata":"https://www.wikidata.org/wiki/Q3053951","display_name":"Viral encephalitis","level":4,"score":0.4317009449005127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23311880230903625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09123697876930237}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001118","descriptor_name":"Argentina","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003465","descriptor_name":"Culex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004665","descriptor_name":"Encephalitis Virus, St. Louis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004665","descriptor_name":"Encephalitis Virus, St. Louis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004665","descriptor_name":"Encephalitis Virus, St. Louis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004674","descriptor_name":"Encephalitis, St. Louis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004674","descriptor_name":"Encephalitis, St. Louis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004674","descriptor_name":"Encephalitis, St. Louis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015004","descriptor_name":"Yellow Fever","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015004","descriptor_name":"Yellow Fever","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015004","descriptor_name":"Yellow Fever","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4269/ajtmh.2004.71.639","doi":"https://doi.org/10.4269/ajtmh.2004.71.639","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2004.71.639","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Tropical Medicine and Hygiene","raw_type":"journal-article"},{"id":"pmid:15569798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15569798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.5418","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.5418","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intl.ajtmh.org/content/71/5/639.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W119464451","https://openalex.org/W1565923748","https://openalex.org/W1906136187","https://openalex.org/W1915221427","https://openalex.org/W1971099200","https://openalex.org/W1981895261","https://openalex.org/W2004331253","https://openalex.org/W2004531540","https://openalex.org/W2004688624","https://openalex.org/W2005845823","https://openalex.org/W2017633496","https://openalex.org/W2025944484","https://openalex.org/W2046147584","https://openalex.org/W2055452844","https://openalex.org/W2069040057","https://openalex.org/W2096638210","https://openalex.org/W2109100918","https://openalex.org/W2130049797","https://openalex.org/W2140630012","https://openalex.org/W2155660565","https://openalex.org/W2161290006","https://openalex.org/W2168953627"],"related_works":["https://openalex.org/W7095220270","https://openalex.org/W2162744638","https://openalex.org/W2474046713","https://openalex.org/W2994634657","https://openalex.org/W4300869333","https://openalex.org/W2888367998","https://openalex.org/W4412845275","https://openalex.org/W1986220070","https://openalex.org/W3016400661","https://openalex.org/W2103575839"],"abstract_inverted_index":{"St.":[0],"Louis":[1],"encephalitis":[2],"(SLE)":[3],"and":[4,13,39,91,106,127,131],"West":[5],"Nile":[6],"(WN)":[7],"flaviviruses":[8],"are":[9],"genetically":[10],"closely":[11],"related":[12],"cocirculate":[14],"in":[15,74,109],"the":[16,23,49,64,70,75,79,92,120],"United":[17,76],"States.":[18],"Virus":[19],"neutralization":[20,112],"tests":[21],"provide":[22],"most":[24],"specific":[25],"means":[26],"for":[27,43,122],"serodiagnosis":[28],"of":[29,36],"infections":[30],"with":[31],"these":[32],"viruses.":[33],"However,":[34],"use":[35,123],"wild-type":[37],"SLE":[38,84,105,130],"WN":[40,107],"viral":[41],"strains":[42],"laboratory":[44],"testing":[45],"is":[46],"constrained":[47],"by":[48],"biocontainment":[50],"requirements.":[51],"We":[52],"constructed":[53,94],"two":[54],"highly":[55],"attenuated":[56,81],"yellow":[57],"fever":[58],"(YF)":[59],"virus":[60,90,111],"chimeras":[61,118],"that":[62],"contain":[63],"premembrane-envelope":[65],"(prM-E)":[66],"protein":[67],"genes":[68],"from":[69],"virulent":[71],"MSI-7":[72],"(isolated":[73],"States)":[77],"or":[78],"naturally":[80],"CorAn9124":[82],"(Argentina)":[83],"strains.":[85],"The":[86],"YF/SLE":[87],"(CorAn":[88],"version)":[89],"previously":[93],"YF/WN":[95],"chimera":[96],"were":[97],"shown":[98],"to":[99],"specifically":[100],"distinguish":[101],"between":[102],"confirmed":[103],"human":[104],"cases":[108],"a":[110],"test":[113],"using":[114],"patient":[115],"sera.":[116],"These":[117],"have":[119],"potential":[121],"as":[124],"diagnostic":[125],"reagents":[126],"vaccines":[128],"against":[129],"WN.":[132]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}