{"id":"https://openalex.org/W2109879947","doi":"https://doi.org/10.1146/annurev-genet-051710-150955","title":"Regulation of Homologous Recombination in Eukaryotes","display_name":"Regulation of Homologous Recombination in Eukaryotes","publication_year":2010,"publication_date":"2010-11-03","ids":{"openalex":"https://openalex.org/W2109879947","doi":"https://doi.org/10.1146/annurev-genet-051710-150955","mag":"2109879947","pmid":"https://pubmed.ncbi.nlm.nih.gov/20690856","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114321"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-genet-051710-150955","doi":"https://doi.org/10.1146/annurev-genet-051710-150955","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-genet-051710-150955","pdf_url":null,"source":{"id":"https://openalex.org/S92134727","display_name":"Annual Review of Genetics","issn_l":"0066-4197","issn":["0066-4197","1545-2948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114321","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051968023","display_name":"Wolf\u2010Dietrich Heyer","orcid":"https://orcid.org/0000-0002-7774-1953","observed_orcids":["https://orcid.org/0000-0002-7774-1953"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolf-Dietrich Heyer","raw_affiliation_strings":["Department of Microbiology, University of California, Davis, Davis, California 95616-8665;","Department of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616-8665","Department of Microbiology, University of California, Davis, Davis, California 95616-8665, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of California, Davis, Davis, California 95616-8665;","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616-8665","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Microbiology, University of California, Davis, Davis, California 95616-8665, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051850739","display_name":"Kirk Tevebaugh Ehmsen","orcid":"https://orcid.org/0000-0003-1376-2592","observed_orcids":["https://orcid.org/0000-0003-1376-2592"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk T. Ehmsen","raw_affiliation_strings":["Department of Microbiology, University of California, Davis, Davis, California 95616-8665;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of California, Davis, Davis, California 95616-8665;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038712886","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0001-5817-9144","observed_orcids":["https://orcid.org/0000-0001-5817-9144"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Department of Microbiology, University of California, Davis, Davis, California 95616-8665;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of California, Davis, Davis, California 95616-8665;","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":4.5601,"has_fulltext":false,"cited_by_count":1128,"citation_normalized_percentile":{"value":0.9758848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"44","issue":"1","first_page":"113","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recombination-regulation","display_name":"recombination regulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.796999990940094},{"id":"https://openalex.org/keywords/meiotic-chromosome-segregation","display_name":"meiotic chromosome segregation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dna-damage-tolerance","display_name":"DNA damage tolerance","score":0.5429999828338623},{"id":"https://openalex.org/keywords/replication-fork-recovery","display_name":"replication fork recovery","score":0.6740000247955322},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.8510000109672546},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.9380000233650208},{"id":"https://openalex.org/keywords/translocation","display_name":"translocation","score":0.656000018119812},{"id":"https://openalex.org/keywords/recombination-intermediates","display_name":"recombination intermediates","score":0.9100000262260437},{"id":"https://openalex.org/keywords/metastable-intermediates","display_name":"metastable intermediates","score":0.6209999918937683},{"id":"https://openalex.org/keywords/eukaryotic-cells","display_name":"eukaryotic cells","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.8105611801147461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7483183741569519},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.7266673445701599},{"id":"https://openalex.org/C82040048","wikidata":"https://www.wikidata.org/wiki/Q7049125","display_name":"Non-allelic homologous recombination","level":5,"score":0.723273754119873},{"id":"https://openalex.org/C135300049","wikidata":"https://www.wikidata.org/wiki/Q5426559","display_name":"FLP-FRT recombination","level":5,"score":0.7187305092811584},{"id":"https://openalex.org/C50919411","wikidata":"https://www.wikidata.org/wiki/Q5334294","display_name":"Ectopic recombination","level":5,"score":0.6155999898910522},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.589816689491272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.584872841835022},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.5681132674217224},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.5657232999801636},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5586411356925964},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.49527159333229065},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45537859201431274},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41278648376464844},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.4122558534145355},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2855859696865082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20899927616119385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-genet-051710-150955","doi":"https://doi.org/10.1146/annurev-genet-051710-150955","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-genet-051710-150955","pdf_url":null,"source":{"id":"https://openalex.org/S92134727","display_name":"Annual Review of Genetics","issn_l":"0066-4197","issn":["0066-4197","1545-2948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genetics","raw_type":"journal-article"},{"id":"pmid:20690856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20690856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4114321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114321","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Genet","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4114321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114321","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Genet","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7248776272","display_name":"Regulation of Recombinational DNA Repair","funder_award_id":"R01CA092276","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909931","display_name":"Recombinational Mechanisms of DNA Repair","funder_award_id":"R01GM058015","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G988704721","display_name":"Hormones, DNA Repair, BRCA1/2 and Ovarian Cancer Preven*","funder_award_id":"R03CA092776","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":176,"referenced_works":["https://openalex.org/W1523619671","https://openalex.org/W1565890429","https://openalex.org/W1667638673","https://openalex.org/W1864762190","https://openalex.org/W1868205825","https://openalex.org/W1880623221","https://openalex.org/W1888032283","https://openalex.org/W1936192069","https://openalex.org/W1946191948","https://openalex.org/W1965546838","https://openalex.org/W1965818711","https://openalex.org/W1967435033","https://openalex.org/W1969499298","https://openalex.org/W1971201699","https://openalex.org/W1971240706","https://openalex.org/W1973495504","https://openalex.org/W1973507920","https://openalex.org/W1973674463","https://openalex.org/W1973721031","https://openalex.org/W1974706661","https://openalex.org/W1977088495","https://openalex.org/W1978054036","https://openalex.org/W1978411020","https://openalex.org/W1979385111","https://openalex.org/W1980623630","https://openalex.org/W1984320346","https://openalex.org/W1984919526","https://openalex.org/W1985018899","https://openalex.org/W1988805210","https://openalex.org/W1989136612","https://openalex.org/W1989575399","https://openalex.org/W1989643386","https://openalex.org/W1992632955","https://openalex.org/W1993026474","https://openalex.org/W1993567700","https://openalex.org/W1994242043","https://openalex.org/W1995992980","https://openalex.org/W2000531777","https://openalex.org/W2000826427","https://openalex.org/W2000950365","https://openalex.org/W2001680897","https://openalex.org/W2002131406","https://openalex.org/W2003755228","https://openalex.org/W2004511634","https://openalex.org/W2005665415","https://openalex.org/W2006268714","https://openalex.org/W2006364890","https://openalex.org/W2006575165","https://openalex.org/W2007429193","https://openalex.org/W2009167909","https://openalex.org/W2010278736","https://openalex.org/W2010711320","https://openalex.org/W2012457691","https://openalex.org/W2012838063","https://openalex.org/W2017297714","https://openalex.org/W2018011810","https://openalex.org/W2019239618","https://openalex.org/W2021044341","https://openalex.org/W2026959390","https://openalex.org/W2028767678","https://openalex.org/W2029271814","https://openalex.org/W2031202740","https://openalex.org/W2031292590","https://openalex.org/W2031515662","https://openalex.org/W2032640722","https://openalex.org/W2033651349","https://openalex.org/W2035194468","https://openalex.org/W2035692319","https://openalex.org/W2037233550","https://openalex.org/W2038195538","https://openalex.org/W2041731996","https://openalex.org/W2043004358","https://openalex.org/W2043689293","https://openalex.org/W2045069136","https://openalex.org/W2048839078","https://openalex.org/W2051816955","https://openalex.org/W2052547134","https://openalex.org/W2053417989","https://openalex.org/W2054782539","https://openalex.org/W2055667487","https://openalex.org/W2056254686","https://openalex.org/W2057072455","https://openalex.org/W2061737909","https://openalex.org/W2064693320","https://openalex.org/W2064965689","https://openalex.org/W2067463001","https://openalex.org/W2069757035","https://openalex.org/W2069839388","https://openalex.org/W2070271970","https://openalex.org/W2070400998","https://openalex.org/W2072155586","https://openalex.org/W2072668354","https://openalex.org/W2073234328","https://openalex.org/W2075152619","https://openalex.org/W2077706229","https://openalex.org/W2078519341","https://openalex.org/W2079659589","https://openalex.org/W2079664271","https://openalex.org/W2082447947","https://openalex.org/W2084624885","https://openalex.org/W2085866527","https://openalex.org/W2086449675","https://openalex.org/W2089260242","https://openalex.org/W2091350790","https://openalex.org/W2093814864","https://openalex.org/W2094020226","https://openalex.org/W2094981589","https://openalex.org/W2096136751","https://openalex.org/W2098126099","https://openalex.org/W2098245314","https://openalex.org/W2098271823","https://openalex.org/W2100770435","https://openalex.org/W2100929591","https://openalex.org/W2101665191","https://openalex.org/W2102107922","https://openalex.org/W2102321696","https://openalex.org/W2102923747","https://openalex.org/W2104161593","https://openalex.org/W2104566573","https://openalex.org/W2106975638","https://openalex.org/W2107991933","https://openalex.org/W2108077889","https://openalex.org/W2108572433","https://openalex.org/W2110691960","https://openalex.org/W2112664493","https://openalex.org/W2115626825","https://openalex.org/W2116471216","https://openalex.org/W2117502397","https://openalex.org/W2118064322","https://openalex.org/W2121218667","https://openalex.org/W2121708201","https://openalex.org/W2123235480","https://openalex.org/W2124837740","https://openalex.org/W2125678927","https://openalex.org/W2126492332","https://openalex.org/W2126552646","https://openalex.org/W2127392515","https://openalex.org/W2128202064","https://openalex.org/W2128365753","https://openalex.org/W2128761982","https://openalex.org/W2129308592","https://openalex.org/W2129707839","https://openalex.org/W2130742597","https://openalex.org/W2131081117","https://openalex.org/W2131280401","https://openalex.org/W2133643647","https://openalex.org/W2135453449","https://openalex.org/W2137627491","https://openalex.org/W2140336382","https://openalex.org/W2142182986","https://openalex.org/W2143064529","https://openalex.org/W2144386534","https://openalex.org/W2144550200","https://openalex.org/W2146554642","https://openalex.org/W2146578290","https://openalex.org/W2149156322","https://openalex.org/W2149390987","https://openalex.org/W2149795092","https://openalex.org/W2153560282","https://openalex.org/W2154074565","https://openalex.org/W2156709395","https://openalex.org/W2158151897","https://openalex.org/W2159487855","https://openalex.org/W2159656070","https://openalex.org/W2161608278","https://openalex.org/W2162378349","https://openalex.org/W2164540979","https://openalex.org/W2167844213","https://openalex.org/W2168149052","https://openalex.org/W2169741450","https://openalex.org/W2212043371","https://openalex.org/W4210950111","https://openalex.org/W4210999313","https://openalex.org/W6989611305","https://openalex.org/W7000769061","https://openalex.org/W7036526416"],"related_works":["https://openalex.org/W2339179566","https://openalex.org/W104792544","https://openalex.org/W3047087686","https://openalex.org/W3186015424","https://openalex.org/W2512717426","https://openalex.org/W2925673664","https://openalex.org/W2126404651","https://openalex.org/W2034527116","https://openalex.org/W1544336383","https://openalex.org/W2228001583"],"abstract_inverted_index":{"Homologous":[0],"recombination":[1,37,44,59,76,84,96,118,127],"(HR)":[2],"is":[3],"required":[4],"for":[5,22,73],"accurate":[6],"chromosome":[7],"segregation":[8],"during":[9],"the":[10,52,92,112],"first":[11],"meiotic":[12],"division":[13],"and":[14,19,32,38,47,64,91,114,124,130],"constitutes":[15],"a":[16,69],"key":[17],"repair":[18],"tolerance":[20],"pathway":[21],"complex":[23],"DNA":[24,27,33],"damage,":[25],"including":[26],"double-strand":[28],"breaks,":[29],"interstrand":[30],"crosslinks,":[31],"gaps.":[34],"In":[35],"addition,":[36],"replication":[39,49],"are":[40,120],"inextricably":[41],"linked,":[42],"as":[43],"recovers":[45],"stalled":[46],"broken":[48],"forks,":[50],"enabling":[51],"evolution":[53],"of":[54,94,117],"larger":[55],"genomes/replicons.":[56],"Defects":[57],"in":[58],"lead":[60,79],"to":[61,80,104,122],"genomic":[62],"instability":[63],"elevated":[65],"cancer":[66],"predisposition,":[67],"demonstrating":[68],"clear":[70],"cellular":[71,107],"need":[72],"recombination.":[74],"However,":[75],"can":[77],"also":[78],"genome":[81],"rearrangements.":[82],"Unrestrained":[83],"causes":[85],"undesired":[86],"endpoints":[87],"(translocation,":[88],"deletion,":[89],"inversion)":[90],"accumulation":[93],"toxic":[95],"intermediates.":[97,137],"Evidently,":[98],"HR":[99],"must":[100],"be":[101],"carefully":[102],"regulated":[103],"match":[105],"specific":[106],"needs.":[108],"Here,":[109],"we":[110],"review":[111],"factors":[113],"mechanistic":[115],"stages":[116],"that":[119,126],"subject":[121],"regulation":[123],"suggest":[125],"achieves":[128],"flexibility":[129],"robustness":[131],"by":[132],"proceeding":[133],"through":[134],"metastable,":[135],"reversible":[136]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":49},{"year":2024,"cited_by_count":61},{"year":2023,"cited_by_count":65},{"year":2022,"cited_by_count":74},{"year":2021,"cited_by_count":89},{"year":2020,"cited_by_count":95},{"year":2019,"cited_by_count":82},{"year":2018,"cited_by_count":82},{"year":2017,"cited_by_count":95},{"year":2016,"cited_by_count":85},{"year":2015,"cited_by_count":77},{"year":2014,"cited_by_count":72},{"year":2013,"cited_by_count":69},{"year":2012,"cited_by_count":61}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}