{"id":"https://openalex.org/W2109862388","doi":"https://doi.org/10.1093/gerona/51a.2.m71","title":"Effect of Age on Body Water and Resting Metabolic Rate","display_name":"Effect of Age on Body Water and Resting Metabolic Rate","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2109862388","doi":"https://doi.org/10.1093/gerona/51a.2.m71","mag":"2109862388","pmid":"https://pubmed.ncbi.nlm.nih.gov/8612106"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/51a.2.m71","doi":"https://doi.org/10.1093/gerona/51a.2.m71","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/51a.2.m71","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011859104","display_name":"Naomi K. Fukagawa","orcid":"https://orcid.org/0000-0001-5954-9039","observed_orcids":["https://orcid.org/0000-0001-5954-9039"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. K. Fukagawa","raw_affiliation_strings":["Charles A. Dana Research Institute, Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02111, USA","Clinical Research Center, Massachusetts Institute of Technology","Department of Pediatrics and Division on Aging, Harvard Medical School","The Charles A. Dana Research Institute and the Harvard Thorndike Laboratory, Department of Medicine, Beth Israel Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles A. Dana Research Institute, Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Pediatrics and Division on Aging, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Charles A. Dana Research Institute and the Harvard Thorndike Laboratory, Department of Medicine, Beth Israel Hospital","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112176578","display_name":"Linda G. Bandini","orcid":"https://orcid.org/0000-0002-6053-1183","observed_orcids":["https://orcid.org/0000-0002-6053-1183"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. G. Bandini","raw_affiliation_strings":["Clinical Research Center, Massachusetts Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046404826","display_name":"William H. Dietz","orcid":"https://orcid.org/0000-0002-6972-0925","observed_orcids":["https://orcid.org/0000-0002-6972-0925"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. H. Dietz","raw_affiliation_strings":["Clinical Research Center, Massachusetts Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688566","display_name":"James B. Young","orcid":"https://orcid.org/0000-0003-2785-1617","observed_orcids":["https://orcid.org/0000-0003-2785-1617"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. Young","raw_affiliation_strings":["The Charles A. Dana Research Institute and the Harvard Thorndike Laboratory, Department of Medicine, Beth Israel Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Charles A. Dana Research Institute and the Harvard Thorndike Laboratory, Department of Medicine, Beth Israel Hospital","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.22759173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"51A","issue":"2","first_page":"M71","last_page":"M73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.843999981880188},{"id":"https://openalex.org/keywords/resting-metabolic-rate","display_name":"resting metabolic rate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/total-body-water","display_name":"total body water","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fat-free-mass","display_name":"fat-free mass","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intracellular-water","display_name":"intracellular water","score":0.8629999756813049},{"id":"https://openalex.org/keywords/extracellular-water","display_name":"extracellular water","score":0.902999997138977},{"id":"https://openalex.org/keywords/18o-labeled-water","display_name":"18O-labeled water","score":0.781000018119812},{"id":"https://openalex.org/keywords/isotope-dilution","display_name":"isotope dilution","score":0.8759999871253967},{"id":"https://openalex.org/keywords/body-composition-assessment","display_name":"body composition assessment","score":0.5170000195503235},{"id":"https://openalex.org/keywords/lean-tissue","display_name":"lean tissue","score":0.6259999871253967},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.5130000114440918},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C82736064","wikidata":"https://www.wikidata.org/wiki/Q623293","display_name":"Basal metabolic rate","level":2,"score":0.652066171169281},{"id":"https://openalex.org/C2992768293","wikidata":"https://www.wikidata.org/wiki/Q623293","display_name":"Metabolic rate","level":2,"score":0.4573078453540802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.363766074180603},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35748472809791565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33605289459228516},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.32411861419677734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29991716146469116}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001481","descriptor_name":"Basal Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/51a.2.m71","doi":"https://doi.org/10.1093/gerona/51a.2.m71","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/51a.2.m71","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmid:8612106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8612106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.907.1859","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.907.1859","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedgerontology.oxfordjournals.org/content/51A/2/M71.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1236666939","display_name":null,"funder_award_id":"RR-00088","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1521345354","display_name":null,"funder_award_id":"RR 01032","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2831195088","display_name":null,"funder_award_id":"AG00599","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2872377240","display_name":"General Clinical Research Center","funder_award_id":"M01RR001032","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1521445923","https://openalex.org/W1808407909","https://openalex.org/W1968575710","https://openalex.org/W1968871753","https://openalex.org/W1983420057","https://openalex.org/W2053608288","https://openalex.org/W2123720115","https://openalex.org/W2150045380","https://openalex.org/W2162185202"],"related_works":["https://openalex.org/W2150045380","https://openalex.org/W2198605773","https://openalex.org/W1985706453","https://openalex.org/W7131657416","https://openalex.org/W366564166","https://openalex.org/W1992399507","https://openalex.org/W1977292290","https://openalex.org/W4249482881","https://openalex.org/W2145565310","https://openalex.org/W1912439589"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,137],"previously":[2],"reported":[3],"that":[4,139],"differences":[5],"in":[6,27,35,42,58,100,118,128,145,157],"fat-free":[7],"mass":[8],"(FFM)":[9],"estimated":[10,107],"by":[11,155],"isotope":[12],"dilution":[13],"of":[14,45,56],"18O-labeled":[15],"water":[16,46,72,109,159,175],"could":[17,52],"not":[18,127],"fully":[19,153],"account":[20],"for":[21,67,106],"lower":[22],"resting":[23],"metabolic":[24],"rates":[25],"(RMR)":[26],"old":[28,129],"men":[29,130],"and":[30,49,70,74,81,87,120,131,170],"women":[31,132],"compared":[32],"to":[33,54,172],"RMR":[34,101,116,144],"young":[36],"men.":[37],"METHODS:":[38],"Since":[39],"age-related":[40,98],"changes":[41,156],"the":[43,59,97],"distribution":[44],"between":[47],"extracellular":[48],"intracellular":[50,71],"spaces":[51],"lead":[53],"overestimation":[55],"FFM":[57],"old,":[60],"we":[61],"reanalyzed":[62],"our":[63],"data":[64,83],"using":[65],"estimates":[66],"total":[68],"body":[69,108,158,174],"(TBW":[73],"ICW,":[75],"respectively)":[76],"derived":[77],"from":[78,84],"published":[79],"equations":[80,171],"included":[82],"adolescent":[85],"boys":[86,119],"girls":[88,121],"studied":[89],"under":[90],"similar":[91],"conditions.":[92],"RESULTS:":[93],"In":[94],"both":[95],"sexes,":[96],"reduction":[99],"remained":[102],"significant":[103],"after":[104],"adjustment":[105],"compartments":[110],"(p":[111,122,133],"<":[112,123],".05).":[113],"While":[114],"adjusted":[115],"differed":[117],".0001),":[124],"it":[125],"did":[126],"=":[134],".15).":[135],"CONCLUSION:":[136],"conclude":[138],"aging":[140],"per":[141],"se":[142],"reduces":[143],"lean":[146],"tissue,":[147],"a":[148],"difference":[149],"which":[150],"cannot":[151],"be":[152,165],"explained":[154],"or":[160],"its":[161],"distribution.":[162],"Investigators":[163],"should":[164],"cautious":[166],"when":[167],"selecting":[168],"models":[169],"estimate":[173],"compartments.":[176]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}