{"id":"https://openalex.org/W2109854832","doi":null,"title":"PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.","display_name":"PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2109854832","mag":"2109854832","pmid":"https://pubmed.ncbi.nlm.nih.gov/12839945"},"language":"en","primary_location":{"id":"pmid:12839945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12839945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086855070","display_name":"Jing Dong Su","orcid":"https://orcid.org/0000-0001-5389-734X","observed_orcids":["https://orcid.org/0000-0001-5389-734X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Dong Su","raw_affiliation_strings":["Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46204, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46204, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087593134","display_name":"Lindsey D. Mayo","orcid":"https://orcid.org/0000-0002-5997-5166","observed_orcids":["https://orcid.org/0000-0002-5997-5166"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey D Mayo","raw_affiliation_strings":["Indiana University. Bloomington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University. Bloomington","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003360187","display_name":"David B. Donner","orcid":"https://orcid.org/0000-0001-8523-1497","observed_orcids":["https://orcid.org/0000-0001-8523-1497"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B Donner","raw_affiliation_strings":["Indiana Univ.-Purdue Univ. Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Univ.-Purdue Univ. Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025976004","display_name":"Donald L. Durden","orcid":"https://orcid.org/0000-0001-5386-1427","observed_orcids":["https://orcid.org/0000-0001-5386-1427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald L Durden","raw_affiliation_strings":["Computational Chemistry & Innovative Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Chemistry & Innovative Therapeutics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2999,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.93635332,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"13","first_page":"3585","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/p21-waf-1","display_name":"p21WAF-1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9760000109672546},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/u373mg-cells","display_name":"U373 cells","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9063591361045837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7542182207107544},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7499129772186279},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6611472964286804},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5830271244049072},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5721324682235718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4911811053752899},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.46295031905174255},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.4523792862892151},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4498596787452698},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3369305729866028},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22776010632514954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1499653160572052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12839945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12839945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2109854832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12839945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2841975085","display_name":"Biology and Therapy of High Risk Neuroblastoma","funder_award_id":"P01CA081403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G94590247","display_name":"VASCULAR ENDOTHELIAL CELL GROWTH FACTOR IN PATHOLOGY","funder_award_id":"R01CA073023","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W2320996","https://openalex.org/W1509669696","https://openalex.org/W1522549867","https://openalex.org/W1617532721","https://openalex.org/W1625966995","https://openalex.org/W1630547983","https://openalex.org/W1673025041","https://openalex.org/W1830258850","https://openalex.org/W1939083266","https://openalex.org/W1965173366","https://openalex.org/W1969820174","https://openalex.org/W1970339836","https://openalex.org/W1982085952","https://openalex.org/W1984418041","https://openalex.org/W1988607142","https://openalex.org/W1997306286","https://openalex.org/W2009011863","https://openalex.org/W2010677999","https://openalex.org/W2015519364","https://openalex.org/W2020891498","https://openalex.org/W2024306318","https://openalex.org/W2024885545","https://openalex.org/W2030573603","https://openalex.org/W2033791403","https://openalex.org/W2048141128","https://openalex.org/W2053185662","https://openalex.org/W2056530510","https://openalex.org/W2067751798","https://openalex.org/W2068345721","https://openalex.org/W2068427129","https://openalex.org/W2068912983","https://openalex.org/W2071870489","https://openalex.org/W2082979850","https://openalex.org/W2091151265","https://openalex.org/W2114098415","https://openalex.org/W2125497603","https://openalex.org/W2125649123","https://openalex.org/W2128585726","https://openalex.org/W2128761168","https://openalex.org/W2129873928","https://openalex.org/W2132279561","https://openalex.org/W2132482143","https://openalex.org/W2137035181","https://openalex.org/W2141820814","https://openalex.org/W2152988906","https://openalex.org/W2155140015","https://openalex.org/W2155737059","https://openalex.org/W2161810908","https://openalex.org/W2167761137","https://openalex.org/W2168772856","https://openalex.org/W2319962899","https://openalex.org/W2320297010","https://openalex.org/W2329341179","https://openalex.org/W2408915816"],"related_works":["https://openalex.org/W2132482143","https://openalex.org/W2083977617","https://openalex.org/W1964305994","https://openalex.org/W1959848155","https://openalex.org/W1983704814","https://openalex.org/W2387074970","https://openalex.org/W2015291255","https://openalex.org/W2606037364","https://openalex.org/W2102509984","https://openalex.org/W2009972187"],"abstract_inverted_index":{"Previous":[0],"work":[1],"from":[2],"our":[3],"laboratory":[4],"demonstrated":[5,20],"that":[6,24,44,89,163,184],"PTEN":[7,45,77,90,111,165,190],"regulates":[8],"tumor-induced":[9,151],"angiogenesis":[10],"and":[11,37,58,67,78,91,105,112,127,148,166,172,177,191],"thrombospondin":[12],"1":[13],"expression":[14,61],"in":[15,40,74,83,123,137,157,174,199,210,215],"malignant":[16,219],"glioma.":[17],"Herein,":[18],"we":[19],"the":[21,25,52,60,96,143,150,185,204,209,216],"first":[22,205],"evidence":[23,162,183,207],"systemic":[26],"administration":[27],"of":[28,49,54,62,98,110,145,154,218],"a":[29],"phosphatidylinositol":[30],"3'-kinase":[31],"(PI3K)":[32],"inhibitor":[33],"(LY294002)":[34],"has":[35],"antitumor":[36,178],"antiangiogenic":[38,176],"activity":[39,82],"vivo.":[41,158,200],"We":[42],"show":[43],"reconstitution":[46],"diminished":[47],"phosphorylation":[48],"AKT,":[50],"induced":[51,80,139],"transactivation":[53],"p53":[55,63,81,170],"(7.5-fold":[56],"induction)":[57],"increased":[59],"target":[64],"genes,":[65,189],"p21(waf-1)":[66],"insulin-like":[68],"growth":[69,120,136],"factor":[70],"binding":[71],"protein":[72],"3":[73],"glioma":[75,119,134],"cells.":[76,107],"LY294002":[79,113,132,214],"human":[84],"brain":[85,129,146],"endothelial":[86,106],"cells,":[87],"suggesting":[88],"PI3K":[92,167],"pathways":[93],"can":[94],"suppress":[95],"progression":[97,198],"cancer":[99],"through":[100],"direct":[101],"actions":[102],"on":[103],"tumor":[104,130,135,140,187,197],"The":[108],"capacity":[109],"to":[114,195],"inhibit":[115],"U87MG":[116,155],"or":[117],"U373MG":[118],"was":[121],"tested":[122],"an":[124],"ectopic":[125],"skin":[126],"orthotopic":[128],"model.":[131],"inhibited":[133],"vivo,":[138],"regression,":[141],"decreased":[142],"incidence":[144],"tumors,":[147],"blocked":[149],"angiogenic":[152],"response":[153],"cells":[156],"These":[159,180],"data":[160,202],"provide":[161,182,203],"both":[164],"inhibitors":[168],"regulate":[169],"function":[171],"display":[173],"vivo":[175,211],"activity.":[179],"results":[181],"two":[186],"suppressor":[188],"p53,":[192],"act":[193],"together":[194],"block":[196],"Our":[201],"preclinical":[206],"for":[208,213],"efficacy":[212],"treatment":[217],"gliomas.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
