{"id":"https://openalex.org/W2109852871","doi":"https://doi.org/10.1152/ajpregu.00021.2005","title":"Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats","display_name":"Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats","publication_year":2005,"publication_date":"2005-06-09","ids":{"openalex":"https://openalex.org/W2109852871","doi":"https://doi.org/10.1152/ajpregu.00021.2005","mag":"2109852871","pmid":"https://pubmed.ncbi.nlm.nih.gov/15947073"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00021.2005","doi":"https://doi.org/10.1152/ajpregu.00021.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00021.2005","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024428595","display_name":"Carol A. Everson","orcid":"https://orcid.org/0000-0002-6903-5581","observed_orcids":["https://orcid.org/0000-0002-6903-5581"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol A. Everson","raw_affiliation_strings":["Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave., Milwaukee WI 53295, USA. ceverson@mcw.edu","Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave., Milwaukee WI 53295, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave., Milwaukee WI 53295, USA. ceverson@mcw.edu","institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave., Milwaukee WI 53295, USA","institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4210101863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024428595"],"corresponding_institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4210101863"],"apc_list":null,"apc_paid":null,"fwci":7.7597,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.96731892,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"289","issue":"4","first_page":"R1054","last_page":"R1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.45579999685287476,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":1.0},{"id":"https://openalex.org/keywords/differential-leukocyte-count","display_name":"differential leukocyte count","score":0.414000004529953},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.8629999756813049},{"id":"https://openalex.org/keywords/serum-immunoglobulins","display_name":"serum immunoglobulins","score":0.8339999914169312},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neutrophilia","display_name":"neutrophilia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/monocytosis","display_name":"monocytosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/septicemia","display_name":"septicemia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.6700000166893005},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6940000057220459},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6750137805938721},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.6416530609130859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5860872864723206},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5710145235061646},{"id":"https://openalex.org/C2994136372","wikidata":"https://www.wikidata.org/wiki/Q110084","display_name":"Blood serum","level":2,"score":0.43713539838790894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31511491537094116},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.14695855975151062}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.00021.2005","doi":"https://doi.org/10.1152/ajpregu.00021.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00021.2005","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:15947073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15947073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1002192329","display_name":"NEUROENDOCRINE ABNORMALITIES INDUCED BY SLEEP DEPRIVATIO","funder_award_id":"5r01ns038733-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3382612778","display_name":null,"funder_award_id":"NS-38733","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5567531015","display_name":null,"funder_award_id":"HL59271","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8074009770","display_name":"NEUROBIOLOGY OF SLEEP DEPRIVATION--IMPAIRED HOST DEFENSE","funder_award_id":"7r29hl059271-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W802254","https://openalex.org/W38148246","https://openalex.org/W49116051","https://openalex.org/W76526392","https://openalex.org/W279100446","https://openalex.org/W318954921","https://openalex.org/W353969420","https://openalex.org/W614161177","https://openalex.org/W1472040153","https://openalex.org/W1485180169","https://openalex.org/W1511475277","https://openalex.org/W1529783563","https://openalex.org/W1532190041","https://openalex.org/W1543139337","https://openalex.org/W1550711362","https://openalex.org/W1568315239","https://openalex.org/W1569179190","https://openalex.org/W1577346123","https://openalex.org/W1580305011","https://openalex.org/W1592968073","https://openalex.org/W1594816032","https://openalex.org/W1596295539","https://openalex.org/W1615793553","https://openalex.org/W1664641772","https://openalex.org/W1804360235","https://openalex.org/W1863724130","https://openalex.org/W1892344960","https://openalex.org/W1913747285","https://openalex.org/W1950796414","https://openalex.org/W1963992117","https://openalex.org/W1965011825","https://openalex.org/W1969640104","https://openalex.org/W1975319022","https://openalex.org/W1978156269","https://openalex.org/W1984285433","https://openalex.org/W1988162831","https://openalex.org/W1993191293","https://openalex.org/W1993483422","https://openalex.org/W2000772013","https://openalex.org/W2001724939","https://openalex.org/W2002116366","https://openalex.org/W2003652884","https://openalex.org/W2005810962","https://openalex.org/W2006034152","https://openalex.org/W2008780577","https://openalex.org/W2011381578","https://openalex.org/W2020287085","https://openalex.org/W2026050411","https://openalex.org/W2027223222","https://openalex.org/W2031855484","https://openalex.org/W2038876934","https://openalex.org/W2039486873","https://openalex.org/W2065478782","https://openalex.org/W2074111720","https://openalex.org/W2083826377","https://openalex.org/W2086495219","https://openalex.org/W2098572726","https://openalex.org/W2100138491","https://openalex.org/W2101843129","https://openalex.org/W2106715395","https://openalex.org/W2124292257","https://openalex.org/W2150444494","https://openalex.org/W2176519822","https://openalex.org/W2314246994","https://openalex.org/W2328605528","https://openalex.org/W2335289703","https://openalex.org/W2411715653","https://openalex.org/W2414473156","https://openalex.org/W2415521750","https://openalex.org/W2441644216","https://openalex.org/W2500696431","https://openalex.org/W2896560395","https://openalex.org/W3179533778"],"related_works":["https://openalex.org/W4221120102","https://openalex.org/W2384059707","https://openalex.org/W2942995828","https://openalex.org/W2027223222","https://openalex.org/W3033656792","https://openalex.org/W2011381578","https://openalex.org/W2024940102","https://openalex.org/W2070284059","https://openalex.org/W2422841511","https://openalex.org/W7095575674"],"abstract_inverted_index":{"The":[0,47,115,133],"specific":[1],"systems":[2],"and":[3,43,55,79,93,103,109,111,129,152,189,229],"mechanisms":[4],"affected":[5],"by":[6,29,73,126,131,144,168,233],"sleep":[7,23,67,169,202,215,235],"deprivation":[8,24,68,170,216,236],"that":[9,35,59,82,210],"may":[10,60,230,243],"perpetuate":[11],"disease":[12,227,242],"processes":[13,194,228],"in":[14,37,52,71,121,225,241],"humans":[15],"still":[16],"are":[17],"speculative.":[18],"In":[19,160],"laboratory":[20],"rats,":[21,123],"prolonged":[22],"induces":[25],"a":[26,77,238],"state":[27],"marked":[28],"abnormal":[30],"control":[31],"over":[32],"indigenous":[33],"bacteria":[34,188],"results":[36,116],"transient":[38],"infections":[39],"of":[40,147,174,206],"internal":[41],"tissues":[42],"eventual":[44],"lethal":[45],"septicemia.":[46],"present":[48],"studies":[49],"investigated":[50],"changes":[51],"blood,":[53],"serum,":[54],"bone":[56,92],"marrow":[57],"parameters":[58],"provide":[61,231],"diagnostic":[62],"clues":[63],"to":[64,185,214],"immunopathology.":[65],"Prolonged":[66],"was":[69,183],"produced":[70],"rats":[72],"the":[74,207],"disk-over-water":[75],"method,":[76],"well-established":[78],"selective":[80],"means":[81,232],"does":[83],"not":[84],"interfere":[85],"with":[86,197],"normal":[87],"waking":[88],"behaviors.":[89],"Measurements":[90],"included":[91],"blood":[94,97],"differential":[95],"white":[96],"cell":[98],"counts,":[99],"multiple":[100,162],"serum":[101,112,135,163],"cytokines":[102],"chemokines,":[104],"several":[105],"major":[106],"Ig":[107,164],"classes":[108,165],"subclasses,":[110],"endotoxin":[113],"concentrations.":[114],"indicated":[117],"mild,":[118],"regenerative":[119],"neutrophilia":[120],"sleep-deprived":[122],"initially":[124],"accompanied":[125],"immature":[127],"neutrophils":[128],"later":[130],"monocytosis.":[132],"corresponding":[134],"cytokine":[136],"profile":[137],"revealed":[138],"an":[139,175],"evolving":[140],"proinflammatory":[141],"state,":[142],"particularly":[143],"high":[145],"incidence":[146],"interleukin-1beta,":[148],"implicating":[149],"mononuclear":[150],"phagocytes":[151],"resident":[153],"tissue":[154],"cells":[155],"as":[156,212,220,237],"main":[157],"intermediary":[158],"sources.":[159],"addition,":[161],"were":[166],"increased":[167],"without":[171],"experimental":[172],"administration":[173],"exogenous":[176],"antigen.":[177],"Despite":[178],"this":[179],"immune":[180,198],"activation,":[181],"there":[182],"failure":[184],"eradicate":[186],"invading":[187],"toxins,":[190],"suggesting":[191],"competing":[192],"anti-inflammatory":[193],"or":[195,222],"interference":[196],"effector":[199],"functions":[200],"during":[201],"deprivation.":[203],"Nearly":[204],"all":[205],"immune-related":[208],"events":[209],"emerged":[211],"responses":[213],"have":[217],"been":[218],"implicated":[219],"etiological":[221],"provocative":[223],"factors":[224],"other":[226],"which":[234],"risk":[239],"factor":[240],"become":[244],"understood.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}