{"id":"https://openalex.org/W2109848680","doi":"https://doi.org/10.1186/2052-0492-1-4","title":"Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock","display_name":"Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock","publication_year":2013,"publication_date":"2013-10-23","ids":{"openalex":"https://openalex.org/W2109848680","doi":"https://doi.org/10.1186/2052-0492-1-4","mag":"2109848680","pmid":"https://pubmed.ncbi.nlm.nih.gov/25705399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4336264"},"language":"en","primary_location":{"id":"doi:10.1186/2052-0492-1-4","doi":"https://doi.org/10.1186/2052-0492-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2052-0492-1-4","pdf_url":"https://jintensivecare.biomedcentral.com/track/pdf/10.1186/2052-0492-1-4","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jintensivecare.biomedcentral.com/track/pdf/10.1186/2052-0492-1-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008716590","display_name":"Nobuyuki Hamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobuyuki Hamano","raw_affiliation_strings":["General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025284070","display_name":"Kenichiro Nishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Nishi","raw_affiliation_strings":["General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075088790","display_name":"Aki Onose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Onose","raw_affiliation_strings":["Division of Anesthesiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655 Japan","Division of Anesthesiology, National Center for Global Health and Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anesthesiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655 Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Division of Anesthesiology, National Center for Global Health and Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059234587","display_name":"Akihisa Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihisa Okamoto","raw_affiliation_strings":["General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"General Intensive Care Unit, Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032463292","display_name":"Takeshi Umegaki","orcid":"https://orcid.org/0000-0001-6113-6444","observed_orcids":["https://orcid.org/0000-0001-6113-6444"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Umegaki","raw_affiliation_strings":["Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Etsuko Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Etsuko Yamazaki","raw_affiliation_strings":["Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012061869","display_name":"Kiichi Hirota","orcid":"https://orcid.org/0000-0003-1110-0827","observed_orcids":["https://orcid.org/0000-0003-1110-0827"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiichi Hirota","raw_affiliation_strings":["Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018326525","display_name":"Hiroe Ookura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroe Ookura","raw_affiliation_strings":["Department of Clinical Laboratory, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Clinical Laboratory,Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Clinical Laboratory,Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025161261","display_name":"Hakuo Takahashi","orcid":"https://orcid.org/0000-0002-6860-8691","observed_orcids":["https://orcid.org/0000-0002-6860-8691"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hakuo Takahashi","raw_affiliation_strings":["Department of Clinical Sciences and Laboratory Medicine, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Clinical Sciences and Laboratory Medicine, Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences and Laboratory Medicine, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Clinical Sciences and Laboratory Medicine, Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108752483","display_name":"Koh Shingu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koh Shingu","raw_affiliation_strings":["Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191 Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Anesthesiology,Hirakata Hospital, Kansai Medical University, Hirakata, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008716590"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":2577,"currency":"USD","value_usd":2577},"apc_paid":{"value":2577,"currency":"USD","value_usd":2577},"fwci":0.6574,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72079309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/severe-sepsis","display_name":"severe sepsis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":1.0},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.7260000109672546},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9729999899864197},{"id":"https://openalex.org/keywords/blood-lactate","display_name":"blood lactate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.8090000152587891},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.8830000162124634},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.703000009059906},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9442018866539001},{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.8671516180038452},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7501541972160339},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7023432850837708},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.566493809223175},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5519659519195557},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5211898684501648},{"id":"https://openalex.org/C2777465075","wikidata":"https://www.wikidata.org/wiki/Q7392039","display_name":"SOFA score","level":3,"score":0.5106156468391418},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.5086184740066528},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.48555824160575867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45020806789398193},{"id":"https://openalex.org/C2776914243","wikidata":"https://www.wikidata.org/wiki/Q7647235","display_name":"Surviving Sepsis Campaign","level":5,"score":0.4170157313346863},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3296125531196594},{"id":"https://openalex.org/C2994086866","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Severe sepsis","level":4,"score":0.14326083660125732}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/2052-0492-1-4","doi":"https://doi.org/10.1186/2052-0492-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2052-0492-1-4","pdf_url":"https://jintensivecare.biomedcentral.com/track/pdf/10.1186/2052-0492-1-4","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3300064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4336264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4336264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4336264","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Intensive Care","raw_type":"Text"},{"id":"pmid:25705399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25705399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of intensive care","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/2052-0492-1-4","doi":"https://doi.org/10.1186/2052-0492-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2052-0492-1-4","pdf_url":"https://jintensivecare.biomedcentral.com/track/pdf/10.1186/2052-0492-1-4","source":{"id":"https://openalex.org/S2764383928","display_name":"Journal of Intensive Care","issn_l":"2052-0492","issn":["2052-0492"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Intensive Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109848680.pdf","grobid_xml":"https://content.openalex.org/works/W2109848680.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W372520013","https://openalex.org/W1486737843","https://openalex.org/W1565989699","https://openalex.org/W1977502717","https://openalex.org/W1990935230","https://openalex.org/W1993942101","https://openalex.org/W2006558163","https://openalex.org/W2013760221","https://openalex.org/W2024874252","https://openalex.org/W2024958381","https://openalex.org/W2039145048","https://openalex.org/W2044142824","https://openalex.org/W2047796424","https://openalex.org/W2049927822","https://openalex.org/W2057924704","https://openalex.org/W2060819666","https://openalex.org/W2084516448","https://openalex.org/W2086476972","https://openalex.org/W2104951444","https://openalex.org/W2107247772","https://openalex.org/W2111883268","https://openalex.org/W2118858814","https://openalex.org/W2129921286","https://openalex.org/W2136732030","https://openalex.org/W2145577370","https://openalex.org/W2160691650","https://openalex.org/W2163517004","https://openalex.org/W2163814324","https://openalex.org/W2167766152","https://openalex.org/W2442246762","https://openalex.org/W2581605534","https://openalex.org/W2768146862","https://openalex.org/W3023757607","https://openalex.org/W3216465316","https://openalex.org/W4245690870"],"related_works":["https://openalex.org/W2915603440","https://openalex.org/W4281865807","https://openalex.org/W2606319324","https://openalex.org/W2979648018","https://openalex.org/W2368380453","https://openalex.org/W2412974538","https://openalex.org/W4282919705","https://openalex.org/W2326796590","https://openalex.org/W1981481784","https://openalex.org/W2350057178"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1,323],"some":[2],"studies":[3,292],"conducted":[4],"outside":[5],"of":[6,12,38,41,60,85,106,124,224,227,239,279,288,300,311],"Japan":[7,26,282],"have":[8],"addressed":[9],"the":[10,19,36,55,93,192,198,204,216,225,231,252,261,276,285,309],"effectiveness":[11,37,310],"intravenous":[13],"immunoglobulins":[14],"(IVIG)":[15],"in":[16,25,43,46,179,197,203,215,230,255,264,281,315],"treating":[17],"infections,":[18],"dosing":[20],"regimens":[21,299],"and":[22,147,168,187,211,260,271,346],"amounts":[23],"used":[24],"are":[27,244,293],"very":[28],"different":[29],"from":[30],"those":[31],"reported.":[32],"Here,":[33],"we":[34,307],"investigate":[35],"single-dose":[39,301,312,336],"administration":[40],"IVIG":[42,86,107,118,220,228,280,313,337],"sepsis":[44,68,319],"patients":[45,52,196,316,332],"Japan.":[47],"METHODS:":[48],"We":[49,155],"analyzed":[50],"79":[51],"admitted":[53],"to":[54,66,295],"intensive":[56],"care":[57,63],"unit":[58],"(ICU)":[59],"a":[61,77,97,102],"tertiary":[62],"institution":[64],"due":[65],"severe":[67,318],"or":[69,96,320],"septic":[70,321],"shock.":[71,322],"Patients":[72],"were":[73,325,334],"randomly":[74],"divided":[75,83],"into":[76],"group":[78,98,200],"that":[79,99],"was":[80,100,119,153],"administered":[81,101,335],"standard":[82,103],"doses":[84],"(5":[87],"g/day":[88,109],"for":[89,110,251],"3":[90],"days,":[91],"designated":[92],"S":[94],"group)":[95],"single":[104],"dose":[105],"(15":[108],"1":[111],"day,":[112],"H":[113,199],"group);":[114],"freeze-dried":[115],"sulfonated":[116],"human":[117],"used.":[120],"The":[121,173],"longitudinal":[122],"assessment":[123],"procalcitonin":[125],"(PCT)":[126],"levels,":[127,131,138,140,181,183,210,342,345],"C-reactive":[128],"protein":[129],"(CRP)":[130],"white":[132],"blood":[133,136,212,268,343],"cell":[134],"count,":[135],"lactate":[137,213,269,344],"IL-6":[139,209,256,341],"Sequential":[141],"Organ":[142],"Failure":[143],"Assessment":[144],"(SOFA)":[145],"score,":[146],"Systemic":[148],"Inflammatory":[149],"Response":[150],"Syndrome":[151],"(SIRS)":[152],"conducted.":[154],"also":[156],"assessed":[157],"mechanical":[158],"ventilation":[159],"duration":[160],"(days),":[161,164],"ICU":[162],"stay":[163],"28-day":[165,184],"survival":[166,170,185,189],"rate,":[167,186],"90-day":[169,188],"rate.":[171],"RESULTS:":[172],"study":[174],"showed":[175,201,338],"no":[176,326],"significant":[177,240,327],"differences":[178],"PCT":[180],"CRP":[182],"rate":[190],"between":[191],"two":[193],"groups.":[194],"However,":[195,275],"improvements":[202,243,263],"various":[205],"SIRS":[206],"diagnostic":[207],"criteria,":[208],"levels":[214,257,270],"early":[217,241,253],"stages":[218],"after":[219,258],"administration.":[221],"In":[222,304],"light":[223],"non-recommendation":[226],"therapy":[229],"Surviving":[232],"Sepsis":[233],"Campaign":[234],"Guidelines":[235],"2012,":[236],"our":[237],"findings":[238],"post-administration":[242],"noteworthy.":[245],"IVIG's":[246],"anti-inflammatory":[247],"effects":[248,287,328],"may":[249,266,283],"account":[250],"reduction":[254],"treatment,":[259],"accompanying":[262],"microcirculation":[265],"improve":[267],"reduce":[272],"SOFA":[273],"scores.":[274,349],"low":[277],"dosages":[278],"limit":[284],"anti-cytokine":[286],"this":[289,305],"treatment.":[290],"Further":[291],"needed":[294],"determine":[296],"appropriate":[297],"treatment":[298,314],"IVIG.":[302],"CONCLUSIONS:":[303],"study,":[306],"investigated":[308],"with":[317],"there":[324],"on":[329],"patient":[330],"prognoses,":[331],"who":[333],"significantly":[339],"improved":[340],"disease":[347],"severity":[348]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}