{"id":"https://openalex.org/W2109836718","doi":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","title":"Nevirapine Significantly Reduces the Levels of Racemic Methadone and (R)-Methadone in Human Immunodeficiency Virus-Infected Patients","display_name":"Nevirapine Significantly Reduces the Levels of Racemic Methadone and (R)-Methadone in Human Immunodeficiency Virus-Infected Patients","publication_year":2004,"publication_date":"2004-10-25","ids":{"openalex":"https://openalex.org/W2109836718","doi":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","mag":"2109836718","pmid":"https://pubmed.ncbi.nlm.nih.gov/15504834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/525438"},"language":"en","primary_location":{"id":"doi:10.1128/aac.48.11.4148-4153.2004","doi":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC525438","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042403757","display_name":"Hartmut Stocker","orcid":"https://orcid.org/0000-0001-9656-8474","observed_orcids":["https://orcid.org/0000-0001-9656-8474"]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hartmut Stocker","raw_affiliation_strings":["Kompetenznetz HIV/AIDS, Berlin, Germany","Vivantes Auguste-Viktoria-Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kompetenznetz HIV/AIDS, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"Vivantes Auguste-Viktoria-Klinikum","institution_ids":["https://openalex.org/I4210094075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081871937","display_name":"Guido Kruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Kruse","raw_affiliation_strings":["HIV-Lab, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV-Lab, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087103946","display_name":"Peter Kreckel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Kreckel","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078455366","display_name":"Christian Herzmann","orcid":"https://orcid.org/0000-0002-2421-3495","observed_orcids":["https://orcid.org/0000-0002-2421-3495"]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Herzmann","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108344991","display_name":"Keikawus Arast\u00e9h","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Keikawus Araste\u0301h","raw_affiliation_strings":["Kompetenznetz HIV/AIDS, Berlin, Germany","Vivantes Auguste-Viktoria-Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kompetenznetz HIV/AIDS, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"Vivantes Auguste-Viktoria-Klinikum","institution_ids":["https://openalex.org/I4210094075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039226888","display_name":"J\u00f6rg A. Claus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jo\u0308rg Claus","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057375934","display_name":"Heiko K. Jessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko Jessen","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109279035","display_name":"Christiane Cordes","orcid":"https://orcid.org/0009-0001-1926-2081","observed_orcids":["https://orcid.org/0009-0001-1926-2081"]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Cordes","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075231376","display_name":"Bettina Hintsche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bettina Hintsche","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016311815","display_name":"Frank Schlote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Schlote","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074280519","display_name":"Lothar Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lothar Schneider","raw_affiliation_strings":["EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPIMED GmbH, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022918770","display_name":"Michael Kurowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094075","display_name":"Auguste-Viktoria-Klinik","ror":"https://ror.org/00mznnx78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094075"]},{"id":"https://openalex.org/I4210109729","display_name":"Vivantes Klinikum","ror":"https://ror.org/01x29t295","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109729"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Kurowski","raw_affiliation_strings":["HIV-Lab, c/o Vivantes Auguste-Viktoria Klinikum","Kompetenznetz HIV/AIDS, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV-Lab, c/o Vivantes Auguste-Viktoria Klinikum","institution_ids":["https://openalex.org/I4210094075","https://openalex.org/I4210109729"]},{"raw_affiliation_string":"Kompetenznetz HIV/AIDS, Berlin, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042403757"],"corresponding_institution_ids":["https://openalex.org/I4210094075"],"apc_list":null,"apc_paid":null,"fwci":1.7697,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.81610914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"11","first_page":"4148","last_page":"4153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":0.996999979019165},{"id":"https://openalex.org/keywords/methadone","display_name":"methadone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.6729999780654907},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7279999852180481},{"id":"https://openalex.org/keywords/eddp","display_name":"EDDP","score":0.75},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.5139999985694885},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.9297057390213013},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.7713230848312378},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6614969968795776},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6201481819152832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5984712243080139},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34398341178894043},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.12090793251991272},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.10123443603515625}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006556","descriptor_name":"Heroin Dependence","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006556","descriptor_name":"Heroin Dependence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006556","descriptor_name":"Heroin Dependence","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019829","descriptor_name":"Nevirapine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019829","descriptor_name":"Nevirapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.48.11.4148-4153.2004","doi":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.48.11.4148-4153.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:122339","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC525438","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15504834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15504834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:525438","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC525438/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:122339","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC525438","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1497037168","https://openalex.org/W1499815876","https://openalex.org/W1898849923","https://openalex.org/W1982888213","https://openalex.org/W1983278543","https://openalex.org/W1992398275","https://openalex.org/W2005125553","https://openalex.org/W2007504551","https://openalex.org/W2012776104","https://openalex.org/W2019939029","https://openalex.org/W2029906878","https://openalex.org/W2037296208","https://openalex.org/W2042467292","https://openalex.org/W2042672025","https://openalex.org/W2059124286","https://openalex.org/W2062789155","https://openalex.org/W2062829031","https://openalex.org/W2064961024","https://openalex.org/W2069854160","https://openalex.org/W2083568105","https://openalex.org/W2089852018","https://openalex.org/W2105540175","https://openalex.org/W2131828698","https://openalex.org/W2134294082","https://openalex.org/W2138266957","https://openalex.org/W2142306898","https://openalex.org/W2150306849","https://openalex.org/W2151288869","https://openalex.org/W2161212077","https://openalex.org/W2167392727","https://openalex.org/W2329526205","https://openalex.org/W2333750047","https://openalex.org/W2411764984"],"related_works":["https://openalex.org/W1970115874","https://openalex.org/W1898849923","https://openalex.org/W2002809044","https://openalex.org/W4385843556","https://openalex.org/W2138266957","https://openalex.org/W2069854160","https://openalex.org/W2029983415","https://openalex.org/W3035466508","https://openalex.org/W2042467292","https://openalex.org/W2051194122"],"abstract_inverted_index":{"Methadone":[0,237],"is":[1,244],"metabolized":[2],"by":[3,15,139,160,235],"various":[4],"isoforms":[5],"of":[6,22,31,33,46,60,81,121,127,150,158,192,197,231],"the":[7,23,29,38,42,73,119,145,154,208,226,252,258],"cytochrome":[8],"P450":[9],"family,":[10],"which":[11,215,220],"can":[12],"be":[13,255],"induced":[14],"many":[16],"drugs,":[17],"including":[18],"nevirapine.":[19,247],"The":[20,124,229],"objective":[21],"present":[24],"study":[25],"was":[26,76,212,216],"to":[27,94,190,194,204,249,257],"determine":[28],"effects":[30],"coadministration":[32,149],"nevirapine":[34,75,122,151],"and":[35,48,115,129,175],"methadone":[36,62,103,128,159,170,202,243],"on":[37],"dose-adjusted":[39,156],"areas":[40],"under":[41],"concentration-time":[43],"curves":[44],"(AUCs)":[45],"racemic":[47,61,169],"(R)-methadone.":[49],"Twenty-five":[50],"human":[51],"immunodeficiency":[52],"virus-infected":[53],"subjects":[54],"taking":[55,168],"stable":[56],"single":[57],"daily":[58],"doses":[59,104],"or":[63,92],"(R)-methadone":[64,176],"were":[65,112,137,164],"included":[66],"in":[67,135,187],"this":[68],"prospective,":[69],"single-crossover":[70],"trial.":[71],"At":[72],"baseline,":[74],"either":[77],"started":[78],"as":[79],"part":[80],"a":[82],"new":[83],"regimen":[84],"containing":[85],"two":[86],"nucleoside":[87],"reverse":[88],"transcriptase":[89],"inhibitors":[90],"(NRTIs)":[91],"added":[93],"an":[95],"ongoing":[96],"NRTI":[97],"regimen.":[98],"Patients":[99],"could":[100],"increase":[101,211],"their":[102],"if":[105],"withdrawal":[106,205],"symptoms":[107],"developed.":[108],"Twelve-hour":[109],"pharmacokinetic":[110,227],"profiles":[111],"obtained":[113],"before":[114],"28":[116],"days":[117],"after":[118],"start":[120],"treatment.":[123],"total":[125],"concentrations":[126],"its":[130],"inactive":[131],"metabolite,":[132],"2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine":[133],"(EDDP),":[134],"serum":[136],"determined":[138],"liquid":[140],"chromatography-tandem":[141],"mass":[142],"spectrometry.":[143],"Among":[144],"20":[146,198],"evaluable":[147],"patients,":[148],"significantly":[152],"decreased":[153],"mean":[155],"AUC":[157,162,181,230],"41%.":[161],"reductions":[163],"similar":[165],"for":[166],"patients":[167,189,199],"(37%;":[171],"n":[172,178],"=":[173,179],"11)":[174],"(44%;":[177],"9).":[180],"changes":[182],"ranged":[183],"from":[184,225],"mild":[185],"increases":[186],"three":[188],"decreases":[191],"up":[193],"70%.":[195],"Fourteen":[196],"required":[200],"additional":[201],"due":[203],"symptoms.":[206],"However,":[207],"median":[209],"dose":[210,238],"only":[213],"15%,":[214],"less":[217],"than":[218],"that":[219],"would":[221],"have":[222],"been":[223],"expected":[224],"data.":[228],"EDDP":[232],"increased":[233],"significantly,":[234],"35%.":[236],"adjustments":[239,253],"are":[240],"justified":[241],"when":[242],"coadministered":[245],"with":[246],"Due":[248],"extensive":[250],"variability,":[251],"must":[254],"tailored":[256],"individual":[259],"patient's":[260],"needs.":[261]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
