{"id":"https://openalex.org/W2109835167","doi":"https://doi.org/10.1039/b810817j","title":"Synthesis and conformational studies of peptides from new C-linked carbo-\u03b2-amino acids (\u03b2-Caas) with anomeric methylamino- and difluorophenyl moieties","display_name":"Synthesis and conformational studies of peptides from new C-linked carbo-\u03b2-amino acids (\u03b2-Caas) with anomeric methylamino- and difluorophenyl moieties","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2109835167","doi":"https://doi.org/10.1039/b810817j","mag":"2109835167","pmid":"https://pubmed.ncbi.nlm.nih.gov/18972045"},"language":"en","primary_location":{"id":"doi:10.1039/b810817j","doi":"https://doi.org/10.1039/b810817j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b810817j","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103853104","display_name":"Gangavaram V. M. Sharma","orcid":"https://orcid.org/0000-0001-5638-788X","observed_orcids":["https://orcid.org/0000-0001-5638-788X"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gangavaram V. M. Sharma","raw_affiliation_strings":["D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, 500 007, India. esmvee@iict.res.in","D-211, Discovery Laboratory, Organic Chemistry Division III,Hyderabad,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, 500 007, India. esmvee@iict.res.in","institution_ids":["https://openalex.org/I55664587"]},{"raw_affiliation_string":"D-211, Discovery Laboratory, Organic Chemistry Division III,Hyderabad,India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008869021","display_name":"Velaparthi Subash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Velaparthi Subash","raw_affiliation_strings":["D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107398674","display_name":"Yella Reddy Nelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelli Yella Reddy","raw_affiliation_strings":["D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020975568","display_name":"Kongari Narsimulu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kongari Narsimulu","raw_affiliation_strings":["Centre for Nuclear Magnetic Resonance, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Nuclear Magnetic Resonance, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002172866","display_name":"Rapolu Ravi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rapolu Ravi","raw_affiliation_strings":["Centre for Nuclear Magnetic Resonance, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Nuclear Magnetic Resonance, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065567147","display_name":"Vivekanand B. Jadhav","orcid":"https://orcid.org/0000-0002-2840-8126","observed_orcids":["https://orcid.org/0000-0002-2840-8126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivekanand B. Jadhav","raw_affiliation_strings":["D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D-211, Discovery Laboratory, Organic Chemistry Division III, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069368405","display_name":"Upadhyayula Suryanarayana Murthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Upadhyayula S. N. Murthy","raw_affiliation_strings":["Biology Group, Indian Institute of Chemical Technology, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Group, Indian Institute of Chemical Technology, Hyderabad, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089197955","display_name":"Kankipati Hara Kishore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kankipati Hara Kishore","raw_affiliation_strings":["Biology Group, Indian Institute of Chemical Technology, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Group, Indian Institute of Chemical Technology, Hyderabad, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108613859","display_name":"Ajit Chand Kunwar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ajit C. Kunwar","raw_affiliation_strings":["Centre for Nuclear Magnetic Resonance, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Nuclear Magnetic Resonance, Hyderabad, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103853104","https://openalex.org/A5108613859"],"corresponding_institution_ids":["https://openalex.org/I55664587"],"apc_list":null,"apc_paid":null,"fwci":0.7842,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68288232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"22","first_page":"4142","last_page":"4142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.44209998846054077,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-peptides","display_name":"\u03b2-peptides","score":0.7429999709129333},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9478141069412231},{"id":"https://openalex.org/C7947691","wikidata":"https://www.wikidata.org/wiki/Q567575","display_name":"Anomer","level":2,"score":0.7757916450500488},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6302539110183716},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46295222640037537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20414674282073975}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005461","descriptor_name":"Fluorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/b810817j","doi":"https://doi.org/10.1039/b810817j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b810817j","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:18972045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18972045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W46404907","https://openalex.org/W169053664","https://openalex.org/W1501359805","https://openalex.org/W1692871424","https://openalex.org/W1969141061","https://openalex.org/W1974070925","https://openalex.org/W1980679185","https://openalex.org/W1981989090","https://openalex.org/W1982845463","https://openalex.org/W1983521156","https://openalex.org/W1986326797","https://openalex.org/W1986447658","https://openalex.org/W1990319821","https://openalex.org/W1990871455","https://openalex.org/W1991402320","https://openalex.org/W1991877201","https://openalex.org/W1997536573","https://openalex.org/W2001006255","https://openalex.org/W2001392646","https://openalex.org/W2002021814","https://openalex.org/W2008907698","https://openalex.org/W2010087060","https://openalex.org/W2011045591","https://openalex.org/W2013875027","https://openalex.org/W2015706105","https://openalex.org/W2019682754","https://openalex.org/W2020267788","https://openalex.org/W2021198082","https://openalex.org/W2026564408","https://openalex.org/W2034134871","https://openalex.org/W2035637405","https://openalex.org/W2036628662","https://openalex.org/W2040885207","https://openalex.org/W2041130141","https://openalex.org/W2042584758","https://openalex.org/W2046738285","https://openalex.org/W2046961604","https://openalex.org/W2047843512","https://openalex.org/W2050653286","https://openalex.org/W2052252427","https://openalex.org/W2053227889","https://openalex.org/W2054808758","https://openalex.org/W2059960222","https://openalex.org/W2065316476","https://openalex.org/W2065526492","https://openalex.org/W2071373488","https://openalex.org/W2071783339","https://openalex.org/W2072304084","https://openalex.org/W2078154140","https://openalex.org/W2078830012","https://openalex.org/W2081277508","https://openalex.org/W2086885624","https://openalex.org/W2087043215","https://openalex.org/W2093512095","https://openalex.org/W2094999440","https://openalex.org/W2096649736","https://openalex.org/W2099164065","https://openalex.org/W2108918515","https://openalex.org/W2111115066","https://openalex.org/W2112878090","https://openalex.org/W2113301225","https://openalex.org/W2115792147","https://openalex.org/W2119682743","https://openalex.org/W2123868168","https://openalex.org/W2128203459","https://openalex.org/W2130974803","https://openalex.org/W2132762304","https://openalex.org/W2135175432","https://openalex.org/W2139320411","https://openalex.org/W2147937771","https://openalex.org/W2148332170","https://openalex.org/W2154050644","https://openalex.org/W2157221253","https://openalex.org/W2164415338","https://openalex.org/W2168519444","https://openalex.org/W2310328055","https://openalex.org/W2338266679","https://openalex.org/W2497559450","https://openalex.org/W2949097172","https://openalex.org/W2949442262","https://openalex.org/W2949469436","https://openalex.org/W2950205068","https://openalex.org/W2952481049","https://openalex.org/W2952567892","https://openalex.org/W2953039651","https://openalex.org/W4252505159","https://openalex.org/W4285719527","https://openalex.org/W4297193213","https://openalex.org/W4297193224"],"related_works":["https://openalex.org/W2888093540","https://openalex.org/W2088255029","https://openalex.org/W2045852270","https://openalex.org/W2169866059","https://openalex.org/W2012860621","https://openalex.org/W1978052412","https://openalex.org/W2038602336","https://openalex.org/W3805002","https://openalex.org/W2113098752","https://openalex.org/W2318476606"],"abstract_inverted_index":{"New":[0],"C-linked":[1],"carbo-beta-amino":[2],"acids":[3],"(beta-Caas),":[4],"Cbz-(S)-beta-Caa-(NHBoc)-OMe":[5],"(1)":[6],"and":[7,28,31,54,82,118,131,149,159],"Cbz-(R)-beta-Caa-(NHBoc)-OMe":[8],"(2),":[9],"with":[10,34],"an":[11,95],"additional":[12,96],"amine":[13,64,97],"group":[14,16,98],"(methylamino":[15],"of":[17,23,43,70,94,116],"NHBoc)":[18],"at":[19,39],"the":[20,24,40,44,63,68,85,92,107,112,124],"C-1":[21],"position":[22,42],"lyxofuranoside":[25,45],"side":[26,46],"chain":[27,47],"Boc-(S)-beta-Caa-(diFP)-OMe":[29],"(3)":[30],"Boc-(R)-beta-Caa-(diFP)-OMe":[32],"(4),":[33],"a":[35],"C-difluorophenyl":[36,113],"(diFP)":[37,114],"moiety":[38,115],"anomeric":[41],"were":[48,56],"prepared":[49,156],"from":[50,58,157],"D-mannose.":[51],"Beta-peptides":[52],"[tetra-":[53],"hexapeptides]":[55],"synthesized":[57],"these":[59],"beta-Caas,":[60],"'epimeric'":[61],"[at":[62],"stereocentre":[65],"(C(beta))],":[66],"using":[67],"concept":[69],"'alternating":[71],"chirality'":[72],"to":[73,122],"carry":[74],"out":[75],"their":[76,137],"conformational":[77],"studies":[78],"[NMR":[79],"(CDCl(3)),":[80],"CD":[81],"MD].":[83],"In":[84],"monomer":[86],"design,":[87],"it":[88],"was":[89],"envisaged":[90],"that":[91],"presence":[93],"in":[99,105,109,140],"1":[100,130],"or":[101],"2":[102],"would":[103],"help":[104],"solubilizing":[106],"peptides":[108,128,155],"water,":[110,141],"while,":[111],"3":[117,158],"4":[119],"is":[120],"expected":[121],"enhance":[123],"biological":[125,169],"activity.":[126,170],"The":[127,154],"having":[129],"2,":[132],"though":[133],"could":[134],"not":[135,166],"retain":[136],"12-10-mixed":[138],"helices":[139],"have":[142],"shown":[143],"moderate":[144],"activity":[145],"against":[146,162],"gram":[147,150],"positive":[148],"negative":[151],"bacterial":[152],"strains.":[153],"4,":[160],"much":[161],"our":[163],"expectations,":[164],"did":[165],"display":[167],"any":[168]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}