{"id":"https://openalex.org/W2109828337","doi":"https://doi.org/10.1158/1078-0432.ccr-07-1265","title":"Differential Effects of Combined Ad5-\u039424RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma","display_name":"Differential Effects of Combined Ad5-\u039424RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma","publication_year":2007,"publication_date":"2007-12-15","ids":{"openalex":"https://openalex.org/W2109828337","doi":"https://doi.org/10.1158/1078-0432.ccr-07-1265","mag":"2109828337","pmid":"https://pubmed.ncbi.nlm.nih.gov/18094429"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-07-1265","doi":"https://doi.org/10.1158/1078-0432.ccr-07-1265","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-07-1265","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042649357","display_name":"Martine L.M. Lamfers","orcid":"https://orcid.org/0000-0001-7745-9029","observed_orcids":["https://orcid.org/0000-0001-7745-9029"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martine L.M. Lamfers","raw_affiliation_strings":["1Neurosurgery, Departments of","6Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, the Netherlands","Department of Neurosurgery, VU University Medical Center, Amsterdam, the Netherlands. M.Lamfers@erasmusmc.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"6Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Neurosurgery, VU University Medical Center, Amsterdam, the Netherlands. M.Lamfers@erasmusmc.nl","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053305431","display_name":"Sander Idema","orcid":"https://orcid.org/0000-0001-7267-0255","observed_orcids":["https://orcid.org/0000-0001-7267-0255"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sander Idema","raw_affiliation_strings":["1Neurosurgery, Departments of","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089979813","display_name":"Lisette Bosscher","orcid":"https://orcid.org/0000-0001-8532-8846","observed_orcids":["https://orcid.org/0000-0001-8532-8846"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lisette Bosscher","raw_affiliation_strings":["1Neurosurgery, Departments of","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041750646","display_name":"Stan Heukelom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stan Heukelom","raw_affiliation_strings":["2Radiotherapy,","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Radiotherapy,","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005028209","display_name":"Sharif Moeniralm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sharif Moeniralm","raw_affiliation_strings":["1Neurosurgery, Departments of","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026264825","display_name":"Ida H. van der Meulen\u2010Muileman","orcid":"https://orcid.org/0000-0002-3821-9927","observed_orcids":["https://orcid.org/0000-0002-3821-9927"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ida H. van der Meulen-Muileman","raw_affiliation_strings":["3Medical Oncology, and","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Oncology, and","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992784","display_name":"Ren\u00e9e M. Overmeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rene\u0301e M. Overmeer","raw_affiliation_strings":["3Medical Oncology, and","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Oncology, and","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252713","display_name":"Paul van der Valk","orcid":"https://orcid.org/0000-0002-0983-1607","observed_orcids":["https://orcid.org/0000-0002-0983-1607"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul van der Valk","raw_affiliation_strings":["4Pathology, and","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pathology, and","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108504728","display_name":"Victor W. van Beusechem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Victor W. van Beusechem","raw_affiliation_strings":["3Medical Oncology, and","Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Oncology, and","institution_ids":[]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039709555","display_name":"Winald R. Gerritsen","orcid":"https://orcid.org/0000-0003-1110-9119","observed_orcids":["https://orcid.org/0000-0003-1110-9119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Winald R. Gerritsen","raw_affiliation_strings":["3Medical Oncology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Medical Oncology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004632162","display_name":"William Peter Vandertop","orcid":"https://orcid.org/0000-0001-5417-0265","observed_orcids":["https://orcid.org/0000-0001-5417-0265"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. Peter Vandertop","raw_affiliation_strings":["1Neurosurgery, Departments of","5Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"5Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; and","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063092847","display_name":"Clemens M.F. Dirven","orcid":"https://orcid.org/0000-0002-0713-2722","observed_orcids":["https://orcid.org/0000-0002-0713-2722"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Clemens M.F. Dirven","raw_affiliation_strings":["1Neurosurgery, Departments of","6Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, the Netherlands","Vrije Universiteit Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Neurosurgery, Departments of","institution_ids":[]},{"raw_affiliation_string":"6Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Vrije Universiteit Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8355,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.86080858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"24","first_page":"7451","last_page":"7458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/integrin-targeted-therapy","display_name":"integrin-targeted therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/orthotopic-glioma-model","display_name":"orthotopic glioma model","score":0.8109999895095825},{"id":"https://openalex.org/keywords/intracranial-tumors","display_name":"intracranial tumors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7200000286102295},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.818413496017456},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.808441162109375},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6462298035621643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6450284123420715},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.595946192741394},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.511277437210083},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.4986257553100586},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4365476965904236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38824763894081116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36002111434936523},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3328273594379425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1258014440536499},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.07273876667022705},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1158/1078-0432.ccr-07-1265","doi":"https://doi.org/10.1158/1078-0432.ccr-07-1265","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-07-1265","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:18094429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18094429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/158e73b4-bc3d-4c5f-b5db-b01dcb9faa75","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/158e73b4-bc3d-4c5f-b5db-b01dcb9faa75","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lamfers, M L M, Idema, S, Bosscher, L, Heukelom, S, Moeniralm, S, van der Meulen-Muileman, I H, Overmeer, R M, van der Valk, P, van Beusechem, V W, Gerritsen, W R, Vandertop, W P & Dirven, C M F 2007, 'Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma', Clinical cancer research, vol. 13, no. 24, pp. 7451-8. https://doi.org/10.1158/1078-0432.CCR-07-1265","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/4e5c5ee4-7c1f-476d-a917-bc2807ae2061","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/4e5c5ee4-7c1f-476d-a917-bc2807ae2061","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lamfers, M L M, Idema, S, Bosscher, L, Heukelom, S, Moeniralm, S, van der Meulen-Muileman, I H, Overmeer, R M, van der Valk, P, van Beusechem, V W, Gerritsen, W R, Vandertop, W P & Dirven, C M F 2007, 'Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma', Clinical cancer research, vol. 13, no. 24, pp. 7451-7458. https://doi.org/10.1158/1078-0432.CCR-07-1265","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/6eadd278-92ab-4cd5-943c-2ccbeb51ef32","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/6eadd278-92ab-4cd5-943c-2ccbeb51ef32","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lamfers, M, Idema, S, Bosscher, L, Heukelom, S, Moeniralm, S, van der Meulen-Muileman, IH, Overmeer, RM, Valk, P, van Beusechem, VW, Gerritsen, WR, Vandertop, WP & Dirven, C 2007, 'Differential effects of combined Ad5-Delta 24RGD and radiation therapy in In vitro versus In vivo models of malignant glioma', Clinical Cancer Research, vol. 13, no. 24, pp. 7451-7458. https://doi.org/10.1158/1078-0432.CCR-07-1265","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e4864735-27d1-4fd9-82f0-cbb30683445e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/differential-effects-of-combined-ad5-delta-24rgd-and-radiation-therapy-in-in-vitro-versus-in-vivo-models-of-malignant-glioma(e4864735-27d1-4fd9-82f0-cbb30683445e).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical cancer research, 13(24), 7451 - 7458. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/6eadd278-92ab-4cd5-943c-2ccbeb51ef32","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/6eadd278-92ab-4cd5-943c-2ccbeb51ef32","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, 13(24), 7451 - 7458. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/df28ce65-4740-4ddc-abf1-6a665d3b708f","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/df28ce65-4740-4ddc-abf1-6a665d3b708f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, 13(24), 7451 - 8. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W117192623","https://openalex.org/W1491631791","https://openalex.org/W1531166036","https://openalex.org/W1781724529","https://openalex.org/W1796073242","https://openalex.org/W1808107661","https://openalex.org/W1809188197","https://openalex.org/W1968377494","https://openalex.org/W1968436602","https://openalex.org/W1998128870","https://openalex.org/W2040276875","https://openalex.org/W2044700629","https://openalex.org/W2045575161","https://openalex.org/W2048604915","https://openalex.org/W2058854040","https://openalex.org/W2103810198","https://openalex.org/W2107985871","https://openalex.org/W2110592777","https://openalex.org/W2112136138","https://openalex.org/W2112259520","https://openalex.org/W2117210608","https://openalex.org/W2130641534","https://openalex.org/W2135875837","https://openalex.org/W2147961945","https://openalex.org/W2148104215","https://openalex.org/W2150110662","https://openalex.org/W2154369685","https://openalex.org/W2330752334","https://openalex.org/W2410852615"],"related_works":["https://openalex.org/W1781724529","https://openalex.org/W7014695318","https://openalex.org/W2144142256","https://openalex.org/W4256016249","https://openalex.org/W2592330014","https://openalex.org/W2057540983","https://openalex.org/W4200525233","https://openalex.org/W1985396267","https://openalex.org/W2132532698","https://openalex.org/W2005156579"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"integrin-targeted":[2],"conditionally":[3],"replicating":[4],"adenovirus":[5],"Ad5-delta":[6,42,97,148,176,219,225],"24RGD":[7,43,98,149,177,226],"has":[8],"been":[9],"shown":[10],"to":[11,47,64,101,118,162,197],"possess":[12],"strong":[13],"oncolytic":[14,104,265],"activity":[15,50,232],"in":[16,51,77,88,133,136,199,205,233,236,241,257],"experimental":[17],"tumors":[18,171],"and":[19,32,69,202,227,235],"is":[20],"currently":[21],"being":[22],"developed":[23],"toward":[24],"phase":[25],"I":[26],"clinical":[27],"evaluation":[28],"for":[29],"ovarian":[30],"cancer":[31],"malignant":[33],"glioma.":[34],"Previously,":[35],"we":[36],"reported":[37,203],"that":[38,92],"combination":[39,142,174,262],"therapy":[40,74,143],"of":[41,62,72,94,154,160,165,175,209,218,252,261],"with":[44,178,187,224,264],"irradiation":[45,95,151,185,228],"led":[46,100],"synergistic":[48],"antitumor":[49,216,231],"s.c.":[52,206,237],"glioma":[53,80,244],"xenografts.":[54],"In":[55,139,195],"the":[56,59,70,163,198,215,250,253,259],"current":[57],"study,":[58],"underlying":[60],"mechanism":[61],"action":[63],"this":[65],"synergy":[66],"was":[67,115,144],"studied":[68],"effects":[71,260],"combined":[73],"were":[75],"assessed":[76],"an":[78,242],"orthotopic":[79,243],"model.":[81,245],"EXPERIMENTAL":[82],"DESIGN":[83],"AND":[84],"RESULTS:":[85],"Sequencing":[86],"studies":[87],"U-87":[89],"monolayers":[90],"showed":[91,157],"delivery":[93,108],"before":[96,111],"infection":[99,110],"a":[102,126,130,173],"greater":[103],"effect":[105,114,217],"than":[106,147],"simultaneous":[107],"or":[109,122,150,186],"irradiation.":[112,194],"This":[113],"not":[116,212,240],"due":[117],"enhanced":[119,230],"virus":[120,161],"production":[121],"release.":[123],"Experiments":[124],"using":[125],"luciferase-encoding":[127],"vector":[128],"revealed":[129],"small":[131],"increase":[132],"transgene":[134],"expression":[135],"irradiated":[137,166],"cells.":[138],"tumor":[140,255],"spheroids,":[141],"more":[145],"effective":[146],"alone.":[152],"Staining":[153],"spheroid":[155],"sections":[156],"improved":[158],"penetration":[159],"core":[164],"spheroids.":[167],"Mice":[168],"bearing":[169],"intracranial":[170],"received":[172],"1":[179],"x":[180,189],"5":[181],"Gy":[182,191],"total":[183],"body":[184],"2":[188],"6":[190],"whole":[192],"brain":[193],"contrast":[196],"vitro":[200,234],"data":[201],"results":[204,248],"tumors,":[207,238],"addition":[208],"radiotherapy":[210],"did":[211],"significantly":[213],"enhance":[214],"24RGD.":[220],"CONCLUSIONS:":[221],"Combined":[222],"treatment":[223],"shows":[229],"but":[239],"These":[246],"differential":[247],"underscore":[249],"significance":[251],"selected":[254],"model":[256],"assessing":[258],"therapies":[263],"adenoviruses.":[266]},"counts_by_year":[{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
