{"id":"https://openalex.org/W2109814767","doi":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","title":"Large-scale gene-expression studies and the challenge of multiple sclerosis.","display_name":"Large-scale gene-expression studies and the challenge of multiple sclerosis.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2109814767","doi":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","mag":"2109814767","pmid":"https://pubmed.ncbi.nlm.nih.gov/12372148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/244911"},"language":"en","primary_location":{"id":"doi:10.1186/gb-2002-3-10-reviews1027","doi":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2002-3-10-reviews1027","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2002-3-10-reviews1027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014721690","display_name":"Sergio E. Baranzini","orcid":"https://orcid.org/0000-0003-0067-194X","observed_orcids":["https://orcid.org/0000-0003-0067-194X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergio E Baranzini","raw_affiliation_strings":["Department of Neurology, University of California San Francisco, San Francisco, CA 94143-0435, USA. sebaran@cgl.ucsf.edu","University of California\u2014San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, San Francisco, CA 94143-0435, USA. sebaran@cgl.ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California\u2014San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104805489","display_name":"Stephen L. Hauser","orcid":"https://orcid.org/0000-0002-4932-4001","observed_orcids":["https://orcid.org/0000-0002-4932-4001"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L Hauser","raw_affiliation_strings":["Department of Neurology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143-0435, USA","University of California\u2014San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143-0435, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California\u2014San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014721690"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":1.2748,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80177116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"10","first_page":"reviews1027.1","last_page":"reviews1027.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/myelin-damage","display_name":"myelin damage","score":0.9039999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.7329999804496765},{"id":"https://openalex.org/keywords/genetic-and-environmental-risk-factors","display_name":"genetic and environmental risk factors","score":0.7200000286102295},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7281213998794556},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.500124454498291},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.48262152075767517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45903280377388},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43671730160713196},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43280351161956787},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3998068571090698},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3415190279483795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3276529908180237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29057493805885315},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2321000099182129},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2182714343070984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18885120749473572},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1397567093372345}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/gb-2002-3-10-reviews1027","doi":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2002-3-10-reviews1027","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:244911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/244911","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:12372148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12372148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Comparative Study"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5774g4nc","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5774g4nc","pdf_url":"https://escholarship.org/uc/item/5774g4nc","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, vol 3, iss 10","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5774g4nc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5774g4nc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome biology, vol 3, iss 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/gb-2002-3-10-reviews1027","doi":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2002-3-10-reviews1027","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2002-3-10-reviews1027","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1102822278","display_name":null,"funder_award_id":"NS26799","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6133376561","display_name":"Gene linkage study of multiple sclerosis sibling pairs","funder_award_id":"R01NS026799","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109814767.pdf","grobid_xml":"https://content.openalex.org/works/W2109814767.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W62276965","https://openalex.org/W1605353467","https://openalex.org/W1968663827","https://openalex.org/W1970156673","https://openalex.org/W2001526641","https://openalex.org/W2010888033","https://openalex.org/W2019926860","https://openalex.org/W2050163545","https://openalex.org/W2054568222","https://openalex.org/W2064580314","https://openalex.org/W2086080135","https://openalex.org/W2088407304","https://openalex.org/W2090348783","https://openalex.org/W2136059495","https://openalex.org/W2147062889","https://openalex.org/W2150926065","https://openalex.org/W2150989762","https://openalex.org/W2166686431","https://openalex.org/W2332018470","https://openalex.org/W4213111919","https://openalex.org/W4213387068"],"related_works":["https://openalex.org/W2052738976","https://openalex.org/W2049058158","https://openalex.org/W1489322456","https://openalex.org/W2076322837","https://openalex.org/W2076355210","https://openalex.org/W2163700096","https://openalex.org/W3195292970","https://openalex.org/W2118525500","https://openalex.org/W2162658393","https://openalex.org/W2732131604"],"abstract_inverted_index":{"In":[0],"multiple":[1,44],"sclerosis,":[2],"a":[3,7],"complex":[4],"neurodegenerative":[5],"disorder,":[6],"combination":[8],"of":[9,37],"genetic":[10],"and":[11,17,46],"environmental":[12],"factors":[13],"results":[14],"in":[15,28],"inflammation":[16],"myelin":[18],"damage.":[19],"Recent":[20],"transcription-profiling":[21],"studies":[22,33],"have":[23],"found":[24],"distinct":[25],"gene-expression":[26],"patterns":[27],"diseased":[29],"tissue;":[30],"such":[31],"large-scale":[32],"at":[34],"different":[35],"stages":[36],"the":[38],"disease":[39],"are":[40],"contributing":[41],"to":[42],"understanding":[43],"sclerosis":[45],"developing":[47],"effective":[48],"therapy.":[49]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
