{"id":"https://openalex.org/W2109728135","doi":null,"title":"PROTEINS IN NUCLEOCYTOPLASMIC INTERACTIONS : II. Turnover and Changes in Nuclear Protein Distribution with Time and Growth.","display_name":"PROTEINS IN NUCLEOCYTOPLASMIC INTERACTIONS : II. Turnover and Changes in Nuclear Protein Distribution with Time and Growth.","publication_year":1968,"publication_date":"1968-01-01","ids":{"openalex":"https://openalex.org/W2109728135","mag":"2109728135","pmid":"https://pubmed.ncbi.nlm.nih.gov/19806693"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2107328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2107328","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2107328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111441501","display_name":"Lester Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Goldstein","raw_affiliation_strings":["Institute for Developmental Biology, University of Colorado, Boulder, Colorado 80302"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Developmental Biology, University of Colorado, Boulder, Colorado 80302","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111750361","display_name":"David M. Prescott","orcid":"https://orcid.org/0000-0002-9798-9526","observed_orcids":["https://orcid.org/0000-0002-9798-9526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Prescott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.818,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.90613471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"1","first_page":"53","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amoeba-proteus","display_name":"Amoeba proteus","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nuclear-proteins","display_name":"nuclear proteins","score":0.800000011920929},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nucleocytoplasmic-shuttling","display_name":"nucleocytoplasmic shuttling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.828000009059906},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nuclear-transplantation","display_name":"nuclear transplantation","score":0.722000002861023},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.8985503911972046},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.794436514377594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7449613809585571},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.7259200215339661},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.6333741545677185},{"id":"https://openalex.org/C2780467534","wikidata":"https://www.wikidata.org/wiki/Q1190338","display_name":"Amoeba proteus","level":3,"score":0.6139720678329468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6076017618179321},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.5708096623420715},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5413231253623962},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5161905884742737},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.44224032759666443},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.43428274989128113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32225683331489563},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.24659159779548645},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11529159545898438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000656","descriptor_name":"Amoeba","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000656","descriptor_name":"Amoeba","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D000656","descriptor_name":"Amoeba","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2107328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2107328","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:19806693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmid:19866726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19866726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"mag:2109728135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2107328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2107328","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W169893763","https://openalex.org/W1134451578","https://openalex.org/W2014038211","https://openalex.org/W2027951917","https://openalex.org/W2030799269","https://openalex.org/W2049919168","https://openalex.org/W2054746696","https://openalex.org/W2059527163","https://openalex.org/W2496135136"],"related_works":["https://openalex.org/W4323285551","https://openalex.org/W7073956737","https://openalex.org/W169893763","https://openalex.org/W7098011837","https://openalex.org/W7094030826","https://openalex.org/W2023869698","https://openalex.org/W2150945532","https://openalex.org/W2504105780","https://openalex.org/W2006920843","https://openalex.org/W1967703920"],"abstract_inverted_index":{"In":[0,53],"previous":[1],"studies,":[2],"we":[3,56],"showed":[4],"that":[5,233],"essentially":[6,278],"all":[7,50,282],"the":[8,11,59,64,113,146,149,183,190,198,210,224,265,274],"proteins":[9,96],"of":[10,63,66,69,76,85,105,115,126,148,206,209,231,262,264,281],"Amoeba":[12],"proteus":[13],"nucleus":[14,27,169,174,199],"could":[15],"be":[16,286],"classified":[17],"either":[18],"as":[19,39,71,73],"Rapidly":[20],"Migrating":[21],"Proteins":[22,42],"(RMP),":[23],"which":[24,44],"shuttle":[25],"between":[26,165],"and":[28,61,80,90,111,119,131,155,170,200,250],"cytoplasm":[29,118,127,225],"continuously":[30],"at":[31,49,203,219],"a":[32,166,204,229,260],"relatively":[33],"rapid":[34],"rate":[35,114,205],"during":[36,51],"interphase,":[37],"or":[38],"Slow":[40],"Turnover":[41],"(STP),":[43],"seem":[45],"to":[46,117,227,236],"move":[47],"hardly":[48],"interphase.":[52],"this":[54],"paper,":[55],"report":[57],"on":[58,74,141],"kinetics":[60],"direction":[62],"movement":[65],"both":[67],"classes":[68,152],"protein,":[70],"well":[72],"aspects":[75],"their":[77],"localization,":[78],"with":[79,89,269],"without":[81,91,132],"growth.":[82],"The":[83,158],"effects":[84],"growth":[86,154],"were":[87],"observed":[88],"cell":[92,121,156,214],"division.":[93,157],"These":[94],"nuclear":[95,211,266,283],"have":[97,228,248],"been":[98],"studied":[99],"in":[100,175,182],"several":[101],"ways:":[102],"by":[103,123,139,144],"transplantation":[104],"labeled":[106,129,134,162,168,240],"nuclei":[107],"into":[108],"unlabeled":[109,142,172,253],"cells":[110,241],"noting":[112,145],"distribution":[116],"host":[120,173],"nuclei;":[122],"repeated":[124],"amputation":[125,136],"from":[128],"cells-with":[130],"initially":[133],"cytoplasm-each":[135],"being":[137],"followed":[138],"refeeding":[140],"food;":[143],"redistribution":[147],"various":[150],"protein":[151,267,284],"following":[153],"data":[159],"show":[160],"(a)":[161],"RMP":[163],"equilibrate":[164],"grafted":[167],"an":[171,277],"ca.":[176,207],"3":[177],"hr,":[178],"but":[179],"are":[180,242,251],"detectable":[181],"latter":[184,275],"less":[185],"than":[186],"30":[187],"min":[188],"after":[189,255],"operation;":[191],"(b)":[192],"STP":[193],"label":[194,268],"does,":[195],"indeed,":[196],"leave":[197],"does":[201],"so":[202],"25%":[208],"total":[212],"per":[213],"generation":[215],"(ca.":[216],"36-40":[217],"hr":[218],"23":[220],"degrees":[221],"C);":[222],"(c)":[223],"appears":[226],"reserve":[230],"material":[232],"is":[234,259],"converted":[235],"RMP;":[237],"(d)":[238],"when":[239],"amputated":[243],"just":[244],"before":[245],"they":[246],"would":[247],"divided":[249],"refed":[252],"food":[254],"each":[256,270],"amputation,":[257],"there":[258],"loss":[261],"20-25%":[263],"amputation;":[271],"(e)":[272],"under":[273],"circumstances,":[276],"complete":[279],"turnover":[280],"can":[285],"demonstrated.":[287]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
