{"id":"https://openalex.org/W2109707262","doi":null,"title":"A survey of transformation markers in differentiating epidermal cell lines in culture.","display_name":"A survey of transformation markers in differentiating epidermal cell lines in culture.","publication_year":1980,"publication_date":"1980-12-01","ids":{"openalex":"https://openalex.org/W2109707262","mag":"2109707262","pmid":"https://pubmed.ncbi.nlm.nih.gov/7438101"},"language":"en","primary_location":{"id":"pmid:7438101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7438101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Yuspa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031256332","display_name":"Pamela Hawley\u2010Nelson","orcid":"https://orcid.org/0000-0002-6352-1685","observed_orcids":["https://orcid.org/0000-0002-6352-1685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Hawley-Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B Koehler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Koehler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091892106","display_name":"John R. Stanley","orcid":"https://orcid.org/0000-0002-4922-5820","observed_orcids":["https://orcid.org/0000-0002-4922-5820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Stanley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2664,"has_fulltext":false,"cited_by_count":324,"citation_normalized_percentile":{"value":0.96863982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"40","issue":"12","first_page":"4694","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":0.8059999942779541},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9610000252723694},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/epidermal-antigens","display_name":"epidermal antigens","score":0.7919999957084656},{"id":"https://openalex.org/keywords/keratin","display_name":"keratin","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pemphigus","display_name":"pemphigus","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pemphigoid","display_name":"pemphigoid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/in-vitro-carcinogenesis","display_name":"in vitro carcinogenesis","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.62913978099823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6225641965866089},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6135601997375488},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5640403032302856},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4812152683734894},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.46151918172836304},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43455269932746887},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4320107400417328},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41973596811294556},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4178518056869507},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34698522090911865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31532055139541626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18485328555107117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12053266167640686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06730151176452637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7438101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7438101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2109707262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7438101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1451731626","https://openalex.org/W1486109675","https://openalex.org/W1510895143","https://openalex.org/W1512094340","https://openalex.org/W1520867883","https://openalex.org/W1552544560","https://openalex.org/W1568038050","https://openalex.org/W1633473664","https://openalex.org/W1824925005","https://openalex.org/W1975488871","https://openalex.org/W1976500073","https://openalex.org/W1979580749","https://openalex.org/W1985887257","https://openalex.org/W1993169352","https://openalex.org/W1999439345","https://openalex.org/W2004023258","https://openalex.org/W2011813819","https://openalex.org/W2013704122","https://openalex.org/W2018561627","https://openalex.org/W2023887187","https://openalex.org/W2038085058","https://openalex.org/W2041852399","https://openalex.org/W2046983903","https://openalex.org/W2049403354","https://openalex.org/W2051327342","https://openalex.org/W2056124464","https://openalex.org/W2067531722","https://openalex.org/W2067810661","https://openalex.org/W2093355966","https://openalex.org/W2096424606","https://openalex.org/W2119940076","https://openalex.org/W2123168001","https://openalex.org/W2305433857","https://openalex.org/W2310901142","https://openalex.org/W2339954610","https://openalex.org/W2344412358","https://openalex.org/W2413148796","https://openalex.org/W2444225132","https://openalex.org/W2464393736","https://openalex.org/W4383813188"],"related_works":["https://openalex.org/W7099887382","https://openalex.org/W1990807364","https://openalex.org/W2017839229","https://openalex.org/W2132014297","https://openalex.org/W1968870498","https://openalex.org/W2292480305","https://openalex.org/W2121428853","https://openalex.org/W2444225132","https://openalex.org/W2157783406","https://openalex.org/W2416091944"],"abstract_inverted_index":{"Primary":[0],"mouse":[1],"epidermal":[2,12,35,59,100],"cells":[3,36,101,116,129,161],"underwent":[4],"spontaneous":[5],"malignant":[6,11,94,128,142],"transformation":[7,143],"in":[8,22,37,40,42,144,152,173,190],"culture.":[9],"TWelve":[10],"cell":[13,20,168],"lines":[14,26,55,95],"were":[15,27,89],"established":[16],"which":[17,158,170],"produced":[18],"squamous":[19],"carcinomas":[21],"syngeneic":[23],"hosts.":[24],"These":[25,138],"used":[28],"to":[29,131,162,181],"define":[30],"criteria":[31],"for":[32,49,183],"recognizing":[33],"transformed":[34],"vitro.":[38,191],"Growth":[39],"suspension":[41],"agar,":[43],"agarose,":[44],"or":[45],"Methocel":[46],"was":[47,70,113],"minimal":[48],"11":[50],"of":[51,78,155,188],"the":[52,85,110,124,153,164,186],"lines.":[53,92],"All":[54,93],"tested":[56],"retained":[57],"specific":[58],"antigens":[60],"(pemphigus,":[61],"pemphigoid,":[62],"keratin)":[63],"by":[64,74,84],"indirect":[65],"immunofluorescence,":[66],"but":[67],"keratin":[68],"content":[69],"reduced":[71,105],"when":[72],"quantified":[73],"radioimmunoassay.":[75],"Basal":[76],"activity":[77,82],"ornithine":[79],"decarboxylase":[80],"and":[81,121,167],"induced":[83],"tumor":[86],"promoter":[87],"12-O-tetradecanoylphorbol-13-acetate":[88],"variable":[90],"among":[91],"as":[96,98],"well":[97,103],"normal":[99,115,174],"grew":[102],"at":[104],"extracellular":[106,111],"calcium":[107,112],"concentrations.":[108],"When":[109],"elevated,":[114],"ceased":[117],"proliferation,":[118],"terminally":[119],"differentiated,":[120],"sloughed":[122],"from":[123],"culture":[125],"dish,":[126],"while":[127],"continued":[130],"proliferate":[132],"although":[133],"they":[134],"expressed":[135],"differentiative":[136],"functions.":[137],"results":[139],"indicate":[140],"that":[141],"epidermis":[145],"is":[146],"associated":[147],"with":[148],"a":[149],"fundamental":[150],"alteration":[151,177],"program":[154],"terminal":[156],"differentiation":[157,172],"allows":[159],"some":[160],"escape":[163],"proliferative":[165],"block":[166],"death":[169],"accompanies":[171],"keratinocytes.":[175],"This":[176],"should":[178],"be":[179],"useful":[180],"select":[182],"transformants":[184],"during":[185],"process":[187],"carcinogenesis":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}