{"id":"https://openalex.org/W2109696752","doi":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","title":"Anti-Inflammatory and Antimicrobial Roles of Secretory Leukocyte Protease Inhibitor","display_name":"Anti-Inflammatory and Antimicrobial Roles of Secretory Leukocyte Protease Inhibitor","publication_year":2005,"publication_date":"2005-02-23","ids":{"openalex":"https://openalex.org/W2109696752","doi":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","mag":"2109696752","pmid":"https://pubmed.ncbi.nlm.nih.gov/15731023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1064911"},"language":"en","primary_location":{"id":"doi:10.1128/iai.73.3.1271-1274.2005","doi":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1064911/pdf/0819-04.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089709339","display_name":"Stergios Doumas","orcid":"https://orcid.org/0000-0001-5423-9250","observed_orcids":["https://orcid.org/0000-0001-5423-9250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stergios Doumas","raw_affiliation_strings":["Private Practice, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice, Manchester, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111528345","display_name":"Alexandros E. Kolokotronis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Kolokotronis","raw_affiliation_strings":["Dental School, Aristotle University of Thessaloniki, Thessaloniki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental School, Aristotle University of Thessaloniki, Thessaloniki","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068506815","display_name":"Panagiotis K. Stefanopoulos","orcid":"https://orcid.org/0000-0002-2733-9923","observed_orcids":["https://orcid.org/0000-0002-2733-9923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panagiotis Stefanopoulos","raw_affiliation_strings":["Hellenic Army, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Army, Athens, Greece","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9524,"has_fulltext":true,"cited_by_count":233,"citation_normalized_percentile":{"value":0.64888889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"73","issue":"3","first_page":"1271","last_page":"1274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.2572999894618988,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-leukocyte-protease-inhibitor","display_name":"secretory leukocyte protease inhibitor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.984000027179718},{"id":"https://openalex.org/keywords/elafin","display_name":"elafin","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cysteine-rich-proteins","display_name":"cysteine-rich proteins","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cationic-proteins","display_name":"cationic proteins","score":0.6700000166893005},{"id":"https://openalex.org/keywords/host-defense-against-pathogens","display_name":"host defense against infection","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7818621397018433},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.7166138887405396},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6097165942192078},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6085331439971924},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5360980033874512},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48667484521865845},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19500550627708435},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11997738480567932},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11320894956588745},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D053491","descriptor_name":"Proteinase Inhibitory Proteins, Secretory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.73.3.1271-1274.2005","doi":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.3.1271-1274.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1064911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1064911","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1064911/pdf/0819-04.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:124343","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1064911","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15731023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15731023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1064911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1064911","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1064911/pdf/0819-04.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109696752.pdf","grobid_xml":"https://content.openalex.org/works/W2109696752.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W183064","https://openalex.org/W10427057","https://openalex.org/W19634248","https://openalex.org/W93884905","https://openalex.org/W1488482313","https://openalex.org/W1494805566","https://openalex.org/W1527008834","https://openalex.org/W1547464441","https://openalex.org/W1609324292","https://openalex.org/W1641338173","https://openalex.org/W1652023268","https://openalex.org/W1764196602","https://openalex.org/W1954606945","https://openalex.org/W1968049903","https://openalex.org/W1968171534","https://openalex.org/W1971049662","https://openalex.org/W1971863732","https://openalex.org/W1981644527","https://openalex.org/W1984179529","https://openalex.org/W1991458846","https://openalex.org/W1991521290","https://openalex.org/W2003718635","https://openalex.org/W2013510929","https://openalex.org/W2018008285","https://openalex.org/W2022810435","https://openalex.org/W2024882709","https://openalex.org/W2025837117","https://openalex.org/W2027203350","https://openalex.org/W2030063068","https://openalex.org/W2058537200","https://openalex.org/W2067538132","https://openalex.org/W2068284474","https://openalex.org/W2070112527","https://openalex.org/W2072996808","https://openalex.org/W2074522344","https://openalex.org/W2076919981","https://openalex.org/W2081935689","https://openalex.org/W2082173481","https://openalex.org/W2087982132","https://openalex.org/W2099982660","https://openalex.org/W2100971299","https://openalex.org/W2106238870","https://openalex.org/W2108806703","https://openalex.org/W2113386659","https://openalex.org/W2125743976","https://openalex.org/W2129945687","https://openalex.org/W2135909713","https://openalex.org/W2136088948","https://openalex.org/W2145268435","https://openalex.org/W2150075152","https://openalex.org/W2158780140","https://openalex.org/W2160892965","https://openalex.org/W2161179716","https://openalex.org/W2164666310","https://openalex.org/W2165572249","https://openalex.org/W2168360736","https://openalex.org/W2168443885","https://openalex.org/W2170927671","https://openalex.org/W2397407438","https://openalex.org/W2991833978"],"related_works":["https://openalex.org/W2090259471","https://openalex.org/W2221450513","https://openalex.org/W2765684393","https://openalex.org/W2168443885","https://openalex.org/W4234715214","https://openalex.org/W1942121673","https://openalex.org/W7098080420","https://openalex.org/W4245336565","https://openalex.org/W102790623","https://openalex.org/W2035645588"],"abstract_inverted_index":{"Human":[0],"secretory":[1],"leukocyte":[2],"protease":[3],"inhibitor":[4],"(SLPI)":[5],"is":[6,20],"an":[7],"11.7-kDa":[8],"cationic":[9],"protein":[10],"and":[11],"a":[12,21],"member":[13],"of":[14],"the":[15,37],"innate":[16],"immunity-associated":[17],"proteins.":[18],"It":[19],"nonglycosylated,":[22],"highly":[23],"basic,":[24],"acid-stable,":[25],"cysteine-rich,":[26],"107-amino":[27],"acid,":[28],"single-chain":[29],"polypeptide":[30],"([50][1]).":[31],"The":[32],"SLPI":[33],"gene,":[34],"along":[35],"with":[36],"elafin":[38]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
