{"id":"https://openalex.org/W2109696502","doi":null,"title":"Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects.","display_name":"Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2109696502","mag":"2109696502","pmid":"https://pubmed.ncbi.nlm.nih.gov/8455074"},"language":"en","primary_location":{"id":"pmid:8455074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8455074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028366515","display_name":"Michela A.L. Edelbroek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M A Edelbroek","raw_affiliation_strings":["Department of Surgery, University Hospital Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Hospital Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069463167","display_name":"Michael Horowitz","orcid":"https://orcid.org/0000-0002-0942-0306","observed_orcids":["https://orcid.org/0000-0002-0942-0306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Horowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J M Wishart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Wishart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108764265","display_name":"Louis M. A. Akkermans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Akkermans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4421,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92410137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"4","first_page":"582","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.9169999957084656},{"id":"https://openalex.org/keywords/alcohol-absorption","display_name":"alcohol absorption","score":0.9509999752044678},{"id":"https://openalex.org/keywords/small-intestinal-transit","display_name":"small intestinal transit","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lactobionate","display_name":"lactobionate","score":0.8349999785423279},{"id":"https://openalex.org/keywords/peak-blood-alcohol-concentration","display_name":"peak blood alcohol concentration","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":0.6729999780654907},{"id":"https://openalex.org/keywords/drug-effects-on-digestion","display_name":"drug effects on digestion","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.8765746355056763},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.7982774972915649},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.634908139705658},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5875163078308105},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.5428365468978882},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5350929498672485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5117999911308289},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4906295835971832},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.45005133748054504},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.41876932978630066},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40302708745002747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2769204080104828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18851226568222046},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.17359906435012817},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12386411428451538},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004369","descriptor_name":"Pentetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013671","descriptor_name":"Technetium Tc 99m Sulfur Colloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8455074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8455074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Clinical Trial"},{"id":"mag:2109696502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8455074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1777965105","https://openalex.org/W1854773125","https://openalex.org/W1857381806","https://openalex.org/W1872461297","https://openalex.org/W1989900973","https://openalex.org/W1991340659","https://openalex.org/W2029552964","https://openalex.org/W2046117078","https://openalex.org/W2048836704","https://openalex.org/W2068473290","https://openalex.org/W2080881783","https://openalex.org/W2087802945","https://openalex.org/W2095671448","https://openalex.org/W2118639623","https://openalex.org/W2155626591","https://openalex.org/W2164057422","https://openalex.org/W2168540099","https://openalex.org/W2263714146","https://openalex.org/W2274724535","https://openalex.org/W2327122843","https://openalex.org/W2328097473","https://openalex.org/W2437898944","https://openalex.org/W2955761657"],"related_works":["https://openalex.org/W41727850","https://openalex.org/W2409624085","https://openalex.org/W2414486627","https://openalex.org/W2225332843","https://openalex.org/W2415094823","https://openalex.org/W1982415967","https://openalex.org/W1965101960","https://openalex.org/W2781270313","https://openalex.org/W2078650052","https://openalex.org/W1988771604"],"abstract_inverted_index":{"The":[0,171],"effects":[1,236],"of":[2,10,51,59,67,84,92,99,128,150,223,231,244,253],"erythromycin":[3,35,164,211,218],"on":[4],"gastric":[5,206,257],"emptying":[6,87,91,144,197,207],"and":[7,17,64,76,88,96,141,216,250],"intragastric":[8],"distribution":[9],"a":[11,52,125,132],"mixed":[12],"solid/liquid":[13],"meal,":[14,56],"alcohol":[15,115,139,178,224,232,245,254],"absorption":[16],"small":[18,107,213,248],"intestinal":[19,108,214],"transit":[20,109,215],"were":[21,120],"examined":[22],"in":[23,30],"eight":[24],"male":[25],"volunteers.":[26],"Each":[27],"subject":[28],"received,":[29],"double-blind":[31],"randomized":[32],"order,":[33],"either":[34],"as":[36,226,228],"the":[37,49,82,94,100,142,147,151,175,199,220,229,247,256],"lactobionate":[38],"(3":[39],"mg.kg-1":[40],"i.v.":[41],"over":[42],"20":[43],"min)":[44],"or":[45],"saline":[46,154],"immediately":[47],"before":[48],"consumption":[50],"radioisotopically":[53],"labeled":[54],"test":[55],"which":[57],"consisted":[58],"330":[60],"g":[61,78],"minced":[62],"beef":[63],"400":[65],"ml":[66],"orange":[68],"juice":[69],"containing":[70],"ethanol":[71],"(0.5":[72],"g.kg-1":[73],"body":[74],"weight)":[75],"10":[77],"lactulose.":[79],"Erythromycin":[80],"increased":[81],"rate":[83,230],"total":[85,172,183,221],"stomach":[86,90,201],"proximal":[89,200],"both":[93],"solid":[95],"liquid":[97,148],"components":[98],"meal":[101,152],"(p":[102,110,117,187],"<":[103,111,118,159,169,188],"0.001),":[104],"but":[105,161],"slowed":[106],"0.01).":[112],"Peak":[113],"blood":[114,138,177],"concentrations":[116,140],"0.01)":[119,189],"higher":[121],"after":[122,153,163,190],"erythromycin,":[123,210],"with":[124],"mean":[126],"increase":[127],"40%.":[129],"There":[130],"was":[131,185],"significant":[133],"inverse":[134],"relationship":[135],"between":[136],"peak":[137],"50%":[143],"time":[145,180],"for":[146],"component":[149],"(r":[155,165],"=":[156,166],"-0.70,":[157],"p":[158,168],"0.05),":[160],"not":[162],"-0.57,":[167],"0.1).":[170],"area":[173],"under":[174],"venous":[176],"concentration":[179],"curve":[181],"(i.e.,":[182],"absorption)":[184],"greater":[186],"erythromycin.":[191],"These":[192,234],"results":[193],"suggest":[194],"that:":[195],"faster":[196],"from":[198],"contributes":[202],"to":[203,239,246],"more":[204,241],"rapid":[205,242],"induced":[208],"by":[209,255],"retards":[212],"that":[217],"increases":[219],"amount":[222],"absorbed":[225],"well":[227],"absorption.":[233],"latter":[235],"are":[237],"likely":[238],"reflect":[240],"delivery":[243],"intestine":[249],"reduced":[251],"metabolism":[252],"mucosa.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
