{"id":"https://openalex.org/W2109691994","doi":"https://doi.org/10.2337/db06-1566","title":"Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling","display_name":"Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling","publication_year":2007,"publication_date":"2007-05-26","ids":{"openalex":"https://openalex.org/W2109691994","doi":"https://doi.org/10.2337/db06-1566","mag":"2109691994","pmid":"https://pubmed.ncbi.nlm.nih.gov/17351147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2740742"},"language":"en","primary_location":{"id":"doi:10.2337/db06-1566","doi":"https://doi.org/10.2337/db06-1566","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db06-1566","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/56/6/1615/248463/zdb00607001615.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/56/6/1615/248463/zdb00607001615.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015090983","display_name":"Satoshi Fujita","orcid":"https://orcid.org/0000-0002-2297-1647","observed_orcids":["https://orcid.org/0000-0002-2297-1647"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoshi Fujita","raw_affiliation_strings":["Department Medicine, University of Southern California, Los Angeles, California","Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009813082","display_name":"Blake B. Rasmussen","orcid":"https://orcid.org/0000-0001-7854-5375","observed_orcids":["https://orcid.org/0000-0001-7854-5375"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake B. Rasmussen","raw_affiliation_strings":["Department of Kinesiology and Biological Sciences, University of Southern California, Los Angeles, California","Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Biological Sciences, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087147339","display_name":"Jerson G. Cadenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerson G. Cadenas","raw_affiliation_strings":["Department Medicine, University of Southern California, Los Angeles, California","Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078476145","display_name":"Micah John Drummond","orcid":"https://orcid.org/0000-0001-5961-8890","observed_orcids":["https://orcid.org/0000-0001-5961-8890"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micah J. Drummond","raw_affiliation_strings":["Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089017633","display_name":"Erin L. Glynn","orcid":"https://orcid.org/0000-0002-3578-4939","observed_orcids":["https://orcid.org/0000-0002-3578-4939"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin L. Glynn","raw_affiliation_strings":["Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058875385","display_name":"Fred R. Sattler","orcid":"https://orcid.org/0000-0002-1986-6803","observed_orcids":["https://orcid.org/0000-0002-1986-6803"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred R. Sattler","raw_affiliation_strings":["Department Medicine, University of Southern California, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014318990","display_name":"Elena Volpi","orcid":"https://orcid.org/0000-0001-8776-0384","observed_orcids":["https://orcid.org/0000-0001-8776-0384"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Volpi","raw_affiliation_strings":["Department Medicine, University of Southern California, Los Angeles, California","Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.6756,"has_fulltext":true,"cited_by_count":225,"citation_normalized_percentile":{"value":0.98576632,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"56","issue":"6","first_page":"1615","last_page":"1622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/muscle-protein-metabolism","display_name":"muscle protein metabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.7509999871253967},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/muscle-protein-synthesis","display_name":"muscle protein synthesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.5669999718666077},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.628000020980835},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.8504490852355957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8047623634338379},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7811808586120605},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.700505793094635},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6442423462867737},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6214866042137146},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.535901665687561},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.47582486271858215},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.4662890136241913},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.4586375653743744},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4345264434814453},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.430853933095932},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.42170974612236023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3871697783470154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3671187162399292},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.32312285900115967},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15464097261428833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08751508593559265},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08228263258934021}],"mesh":[{"descriptor_ui":"D000332","descriptor_name":"Aerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2337/db06-1566","doi":"https://doi.org/10.2337/db06-1566","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db06-1566","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/56/6/1615/248463/zdb00607001615.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:17351147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17351147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2740742","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2740742/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"mag:2184459741","doi":null,"is_oa":false,"landing_page_url":"https://diabetes.diabetesjournals.org/content/early/2007/03/09/db06-1566.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.2337/db06-1566","doi":"https://doi.org/10.2337/db06-1566","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db06-1566","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/56/6/1615/248463/zdb00607001615.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2406674694","display_name":"Gas Chromatograph Mass Spectrometer with Combined FID","funder_award_id":"S10RR016650","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G361551701","display_name":"Nutritional and Contractile Regulation of Muscle Growth","funder_award_id":"R01AR049877","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5129310458","display_name":"Insulin and Sarcopenia in the Elderly","funder_award_id":"R01AG018311","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5900184332","display_name":"General Clinical Research Center","funder_award_id":"M01RR000043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8988330972","display_name":"General Clinical Research Center","funder_award_id":"M01RR000073","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000888026","display_name":"UTMB Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG024832","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000913486","display_name":"San Antonio Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG044271","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109691994.pdf","grobid_xml":"https://content.openalex.org/works/W2109691994.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W578069077","https://openalex.org/W1535096557","https://openalex.org/W1837975739","https://openalex.org/W1920416693","https://openalex.org/W1966636463","https://openalex.org/W1989912928","https://openalex.org/W1996129022","https://openalex.org/W2008684260","https://openalex.org/W2010102296","https://openalex.org/W2013160037","https://openalex.org/W2023323317","https://openalex.org/W2025915935","https://openalex.org/W2028767281","https://openalex.org/W2040516838","https://openalex.org/W2051303256","https://openalex.org/W2060855576","https://openalex.org/W2065501573","https://openalex.org/W2071586159","https://openalex.org/W2072998904","https://openalex.org/W2086325585","https://openalex.org/W2094332493","https://openalex.org/W2112396418","https://openalex.org/W2126872284","https://openalex.org/W2127114625","https://openalex.org/W2132683439","https://openalex.org/W2133120527","https://openalex.org/W2137048653","https://openalex.org/W2137789014","https://openalex.org/W2143541002","https://openalex.org/W2145200932","https://openalex.org/W2146603936","https://openalex.org/W2149183386","https://openalex.org/W2149958397","https://openalex.org/W2151185613","https://openalex.org/W2152045320","https://openalex.org/W2153074450","https://openalex.org/W2158389310","https://openalex.org/W2158822657","https://openalex.org/W2160972375","https://openalex.org/W2161239883","https://openalex.org/W2162906405","https://openalex.org/W2166821055","https://openalex.org/W2171329429","https://openalex.org/W2231840105","https://openalex.org/W2281123242","https://openalex.org/W2281167634","https://openalex.org/W2323544099","https://openalex.org/W2328294727","https://openalex.org/W2332951586","https://openalex.org/W2414082932"],"related_works":["https://openalex.org/W2184459741","https://openalex.org/W2109053852","https://openalex.org/W1554327324","https://openalex.org/W2105501226","https://openalex.org/W7101033882","https://openalex.org/W2286494426","https://openalex.org/W3173304720","https://openalex.org/W4412933332","https://openalex.org/W2533768744","https://openalex.org/W1972128335"],"abstract_inverted_index":{"Muscle":[0],"protein":[1,27,52,111,188,230],"metabolism":[2],"is":[3,14],"resistant":[4],"to":[5,31,56,103,152,161,195,204,256],"insulin's":[6],"anabolic":[7,251],"effect":[8],"in":[9,29,36,54,60,106,124,131,143,176,215,235,265],"healthy":[10],"older":[11,37,64,266],"subjects.":[12,38,267],"This":[13],"associated":[15],"with":[16],"reduced":[17],"insulin":[18,32,257],"vasodilation.":[19],"We":[20,39],"hypothesized":[21],"that":[22],"aerobic":[23,70,247],"exercise":[24,71,248],"restores":[25,249],"muscle":[26,51,187,229,254],"anabolism":[28],"response":[30,55,252],"by":[33,258],"improving":[34,259],"vasodilation":[35],"measured":[40],"blood":[41,100,139],"flow,":[42],"endothelin-1,":[43],"Akt/mammalian":[44],"target":[45],"of":[46,63,69,246,253],"rapamycin":[47],"(mTOR)":[48],"signaling,":[49],"and":[50,99,138,180,186,262],"kinetics":[53,112],"physiological":[57],"local":[58],"hyperinsulinemia":[59],"two":[61],"groups":[62],"subjects":[65],"following":[66],"a":[67,244],"bout":[68,245],"(EX":[72,147,190],"group:":[73,89,148,157,191,200],"aged":[74,90],"70":[75],"+/-":[76,92,150,154,159,163,193,197,202,206],"2":[77],"years;":[78],"45-min":[79],"treadmill":[80],"walk,":[81],"70%":[82],"heart":[83],"rate":[84],"max)":[85],"or":[86],"rest":[87],"(CTRL":[88],"68":[91],"1":[93,184],"years).":[94],"Baseline":[95],"endothelin-1":[96,120,128],"was":[97,113],"lower":[98],"flow":[101,140],"tended":[102],"be":[104],"higher":[105,130],"the":[107,132,144,177,216,236,250],"EX":[108,145,178,217,237],"group,":[109],"but":[110,127],"not":[114,226],"different":[115],"between":[116],"groups.":[117],"Insulin":[118,172],"decreased":[119],"(P":[121,135,220,239],"<":[122,136,221,240],"0.05)":[123,137],"both":[125],"groups,":[126],"remained":[129],"CTRL":[133,156,199],"group":[134,146,179,218,238],"increased":[141,181],"only":[142,219,234],"3.8":[149],"0.7":[151],"5.3":[153],"0.8;":[155],"2.5":[158],"0.2":[160,164],"2.6":[162],"ml":[165,170,213],"x":[166,168,209,211],"min(-1)":[167,210],"100":[169,212],"leg(-1)).":[171],"improved":[173],"Akt":[174],"phosphorylation":[175,185],"mTOR/S6":[182],"kinase":[183],"synthesis":[189],"49":[192],"11":[194],"89":[196],"23;":[198],"58":[201],"8":[203],"57":[205],"12":[207],"nmol":[208],"leg(-1))":[214],"0.05).":[222,241],"Because":[223],"breakdown":[224],"did":[225],"change,":[227],"net":[228],"balance":[231],"became":[232],"positive":[233],"In":[242],"conclusion,":[243],"proteins":[255],"endothelial":[260],"function":[261],"Akt/mTOR":[263],"signaling":[264]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}