{"id":"https://openalex.org/W2109648403","doi":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","title":"Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice","display_name":"Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2109648403","doi":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","mag":"2109648403","pmid":"https://pubmed.ncbi.nlm.nih.gov/9529043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/108050"},"language":"en","primary_location":{"id":"doi:10.1128/iai.66.4.1282-1286.1998","doi":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080605949","display_name":"Joseph U. Igietseme","orcid":"https://orcid.org/0000-0001-7135-1260","observed_orcids":["https://orcid.org/0000-0001-7135-1260"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph U. Igietseme","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103340764","display_name":"Linda L. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L. Perry","raw_affiliation_strings":["<!--label omitted: 2-->Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]},{"raw_affiliation_string":"Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","institution_ids":["https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004696864","display_name":"Godwin A. Ananaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118458328","display_name":"Spelman College","ror":"https://ror.org/02fvaj957","country_code":"US","type":"education","lineage":["https://openalex.org/I118458328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Godwin A. Ananaba","raw_affiliation_strings":["<!--label omitted: 3-->Department of Biology, Spelman College, Atlanta, Georgia 303143; and","Department of Biology, Spelman College, Atlanta, Georgia 303143; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Department of Biology, Spelman College, Atlanta, Georgia 303143; and","institution_ids":["https://openalex.org/I118458328"]},{"raw_affiliation_string":"Department of Biology, Spelman College, Atlanta, Georgia 303143; and","institution_ids":["https://openalex.org/I118458328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048905209","display_name":"Ijindah M. Uriri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ijindah M. Uriri","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067470341","display_name":"Omegbhai O. Ojior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omegbhai O. Ojior","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058942403","display_name":"Shantha N. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shantha N. Kumar","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 303101;","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078176047","display_name":"Harlan D. Caldwell","orcid":"https://orcid.org/0000-0002-2018-8106","observed_orcids":["https://orcid.org/0000-0002-2018-8106"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harlan D. Caldwell","raw_affiliation_strings":["<!--label omitted: 2-->Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]},{"raw_affiliation_string":"Laboratory of Intracellular Parasites, The Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana 598402","institution_ids":["https://openalex.org/I4405287673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1396,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.9573423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"4","first_page":"1282","last_page":"1286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia-trachomatis","display_name":"Chlamydia trachomatis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/genital-tract-infection","display_name":"genital tract infection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/macrophage-susceptibility","display_name":"macrophage susceptibility","score":0.628000020980835},{"id":"https://openalex.org/keywords/dissemination","display_name":"dissemination","score":0.5170000195503235},{"id":"https://openalex.org/keywords/inos-knockout-mice","display_name":"iNOS knockout mice","score":0.7979999780654907},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8195835947990417},{"id":"https://openalex.org/C2777391075","wikidata":"https://www.wikidata.org/wiki/Q131065","display_name":"Chlamydia trachomatis","level":2,"score":0.8163925409317017},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7590675950050354},{"id":"https://openalex.org/C2780122209","wikidata":"https://www.wikidata.org/wiki/Q153356","display_name":"Chlamydia","level":2,"score":0.6977521181106567},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5710640549659729},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.530113935470581},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5105537176132202},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.49637895822525024},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4560241401195526},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.43062758445739746},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4059099853038788},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11422237753868103}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002692","descriptor_name":"Chlamydia trachomatis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005831","descriptor_name":"Genital Diseases, Female","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.66.4.1282-1286.1998","doi":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.66.4.1282-1286.1998","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1782420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:108050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:9529043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9529043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1782420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1054627411","display_name":null,"funder_award_id":"AI 41231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G172738272","display_name":null,"funder_award_id":"RR 03034","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3093997161","display_name":null,"funder_award_id":"RR115598","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4658142325","display_name":"Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center","funder_award_id":"G12RR003034","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5997856825","display_name":"INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA","funder_award_id":"R01AI041231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W51164297","https://openalex.org/W1489855050","https://openalex.org/W1540820582","https://openalex.org/W1592104297","https://openalex.org/W1816225120","https://openalex.org/W1834041853","https://openalex.org/W1853964654","https://openalex.org/W1892959235","https://openalex.org/W1897722863","https://openalex.org/W1905860555","https://openalex.org/W1944133880","https://openalex.org/W1969289450","https://openalex.org/W1976183542","https://openalex.org/W1984022297","https://openalex.org/W1991484350","https://openalex.org/W1992491174","https://openalex.org/W2007318579","https://openalex.org/W2020722849","https://openalex.org/W2052596336","https://openalex.org/W2065623957","https://openalex.org/W2102890176","https://openalex.org/W2103336793","https://openalex.org/W2109206608","https://openalex.org/W2117079340","https://openalex.org/W2122515902","https://openalex.org/W2123752343","https://openalex.org/W2128429564","https://openalex.org/W2131999220","https://openalex.org/W2134768631","https://openalex.org/W2137838799","https://openalex.org/W2149200346","https://openalex.org/W2158890206","https://openalex.org/W2162624157","https://openalex.org/W2164407992","https://openalex.org/W2169989761","https://openalex.org/W2172010129","https://openalex.org/W2221890604","https://openalex.org/W2237320181","https://openalex.org/W2399407447","https://openalex.org/W2412095377","https://openalex.org/W2416433109","https://openalex.org/W2462730741","https://openalex.org/W4297584900","https://openalex.org/W4313343430"],"related_works":["https://openalex.org/W1963372442","https://openalex.org/W2105883725","https://openalex.org/W4297584900","https://openalex.org/W2148499789","https://openalex.org/W2065623957","https://openalex.org/W2138405179","https://openalex.org/W2127391524","https://openalex.org/W2103336793","https://openalex.org/W2399407447","https://openalex.org/W2074064949"],"abstract_inverted_index":{"Type":[0],"1":[1],"CD4+-T-cell-mediated":[2,24,203],"immunity":[3],"is":[4,235],"crucial":[5],"for":[6,42,238],"the":[7,13,43,50,59,64,69,86,103,130,152,191,197,231,246,257],"resolution":[8],"of":[9,12,26,34,52,66,72,105,118,127,154,177,181,190,200,205,219,240,250,259,261],"chlamydial":[10,27,107,160,206],"infection":[11,161],"murine":[14],"female":[15,247],"genital":[16,55,106,123,248],"tract.":[17],"Previous":[18],"studies":[19],"demonstrating":[20],"a":[21,39,136,148],"correlation":[22],"between":[23],"inhibition":[25],"growth":[28,70,207],"and":[29,80,111,132,215],"gamma":[30],"interferon":[31],"(IFN-gamma)-mediated":[32],"induction":[33],"nitric":[35,44,88],"oxide":[36,45,89],"synthase":[37,90],"suggested":[38,187],"potential":[40],"role":[41,65],"(NO)":[46],"effector":[47,193,233],"pathway":[48,194,234],"in":[49,76,81,102,109,139,142,151,162,184,208,221],"clearance":[51],"Chlamydia":[53,73,119,128,220,241],"from":[54,122,156,169,242],"epithelial":[56,124,243],"cells":[57,244],"by":[58,116,264],"immune":[60],"system.":[61],"To":[62],"clarify":[63],"this":[67],"pathway,":[68],"levels":[71],"trachomatis":[74,263],"organisms":[75,120],"normal":[77],"(iNOS+/+)":[78],"mice":[79,84,113,158,186,222,251],"genetically":[82],"engineered":[83],"lacking":[85,223],"inducible":[87],"(iNOS)":[91],"gene":[92],"(iNOS-/-":[93],"mice)":[94],"were":[95,166],"compared.":[96],"There":[97],"was":[98,195],"no":[99,174],"significant":[100],"difference":[101],"course":[104],"infections":[108,165],"iNOS+/+":[110,143],"iNOS-/-":[112,140,157,185],"as":[114],"determined":[115],"recovery":[117],"shed":[121],"cells.":[125],"Dissemination":[126],"to":[129,135,159,256],"spleen":[131],"lungs":[133],"occurred":[134],"greater":[137],"extent":[138],"than":[141],"mice,":[144],"which":[145],"correlated":[146],"with":[147,173],"marginal":[149],"increase":[150],"susceptibility":[153],"macrophages":[155,209],"vitro.":[163],"However,":[164],"rapidly":[167],"cleared":[168],"all":[170],"affected":[171],"tissues,":[172],"clinical":[175],"signs":[176],"disease.":[178],"The":[179],"finding":[180],"minimal":[182],"dissemination":[183,218,260],"that":[188,230],"activation":[189],"iNOS":[192,232],"not":[196,236],"primary":[198],"target":[199],"IFN-gamma":[201],"during":[202],"control":[204,258],"because":[210],"previous":[211],"reports":[212],"demonstrated":[213],"extensive":[214],"often":[216],"fatal":[217],"IFN-gamma.":[224],"In":[225],"summary,":[226],"these":[227],"results":[228],"indicate":[229],"required":[237],"elimination":[239],"lining":[245],"tract":[249],"although":[252],"it":[253],"may":[254],"contribute":[255],"C.":[262],"infected":[265],"macrophages.":[266]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
