{"id":"https://openalex.org/W2109580321","doi":"https://doi.org/10.1002/gcc.2870030411","title":"Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction","display_name":"Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W2109580321","doi":"https://doi.org/10.1002/gcc.2870030411","mag":"2109580321","pmid":"https://pubmed.ncbi.nlm.nih.gov/1958596"},"language":"en","primary_location":{"id":"doi:10.1002/gcc.2870030411","doi":"https://doi.org/10.1002/gcc.2870030411","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870030411","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109229151","display_name":"Eun\u2010Soo Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun\u2010Soo Han","raw_affiliation_strings":["Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038210500","display_name":"Mary Pat Moyer","orcid":"https://orcid.org/0000-0002-0297-8921","observed_orcids":["https://orcid.org/0000-0002-0297-8921"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Pat Moyer","raw_affiliation_strings":["Department of Surgery, University of Texas Health Science Center, San Antonio, Texas","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109932346","display_name":"Susan L. Naylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Naylor","raw_affiliation_strings":["Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013505896","display_name":"Alan Y. Sakaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Y. Sakaguchi","raw_affiliation_strings":["Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013505896"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":4810,"currency":"USD","value_usd":4810},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.18324955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"3","issue":"4","first_page":"313","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.18729999661445618,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-gene","display_name":"TP53 gene","score":0.8550000190734863},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.7269999980926514},{"id":"https://openalex.org/keywords/exon-5","display_name":"exon 5","score":0.6769999861717224},{"id":"https://openalex.org/keywords/frameshift-mutation","display_name":"frameshift mutation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/in-frame-stop-codon","display_name":"in-frame stop codon","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8400821685791016},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7588484287261963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.643319845199585},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5989570021629333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5947760939598083},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5280438661575317},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.4867148697376251},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4832952320575714},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.479331374168396},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.43652960658073425},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.4306025505065918},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4297918379306793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41482013463974}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016368","descriptor_name":"Frameshift Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gcc.2870030411","doi":"https://doi.org/10.1002/gcc.2870030411","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870030411","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},{"id":"pmid:1958596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1958596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, chromosomes & cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4714266043","display_name":"MOLECULAR GENETIC MECHANISMS OF AGING","funder_award_id":"P01AG006872","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306184","display_name":"Meadows Foundation","ror":"https://ror.org/03ay6m507"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1859397449","https://openalex.org/W1986684060","https://openalex.org/W1989887575","https://openalex.org/W1995095999","https://openalex.org/W2001914931","https://openalex.org/W2004429299","https://openalex.org/W2038861485","https://openalex.org/W2054549064","https://openalex.org/W2075300416","https://openalex.org/W2085295693","https://openalex.org/W2113954582","https://openalex.org/W2163565167","https://openalex.org/W2258553975"],"related_works":["https://openalex.org/W2188394403","https://openalex.org/W2002667571","https://openalex.org/W2025429202","https://openalex.org/W1546975510","https://openalex.org/W2310512112","https://openalex.org/W4317663846","https://openalex.org/W4400088039","https://openalex.org/W4236363974","https://openalex.org/W1997768403","https://openalex.org/W2502602507"],"abstract_inverted_index":{"The":[0],"human":[1],"TP53":[2,10,49,73,112,127],"gene":[3,11,50,113],"is":[4],"a":[5,33,72,117],"possible":[6],"tumor":[7],"suppressor":[8],"since":[9],"mutations":[12],"are":[13],"observed":[14],"in":[15,81],"greater":[16],"than":[17],"70%":[18],"of":[19,47,86,124],"sporadic":[20],"colorectal":[21],"carcinoma":[22],"DNAs.":[23],"In":[24],"genomic":[25],"DNAs":[26],"from":[27],"seven":[28],"colon":[29,64],"cancer":[30,65],"cell":[31],"samples,":[32],"405":[34],"base":[35],"pair":[36],"DNA":[37],"fragment":[38],"containing":[39],"exon":[40,45,82],"5,":[41,43],"intron":[42],"and":[44,57,96],"6":[46],"the":[48,76,97,110,121],"was":[51,68],"amplified":[52],"by":[53],"polymerase":[54],"chain":[55],"reaction":[56],"analyzed":[58],"for":[59],"mutations.":[60],"One":[61],"sample":[62],"[human":[63],"(HCC)":[66],"278]":[67],"found":[69],"to":[70,93,116],"have":[71],"mutation":[74],"altering":[75],"amino":[77,106],"acid":[78,107],"glutamine":[79,90],"167":[80,91],"5.":[83],"A":[84],"deletion":[85],"2":[87],"bases":[88],"changed":[89],"(CAG)":[92],"alanine":[94],"(GCA)":[95],"resulting":[98],"frame-shift":[99],"produced":[100],"an":[101],"in-frame":[102],"stop":[103],"codon":[104],"at":[105],"179.":[108],"While":[109],"normal":[111],"gives":[114],"rise":[115],"53":[118],"kD":[119],"protein,":[120],"estimated":[122],"size":[123],"this":[125],"mutant":[126],"protein":[128],"if":[129],"expressed":[130],"would":[131],"be":[132],"approximately":[133],"20":[134],"kD.":[135]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
