{"id":"https://openalex.org/W2109503570","doi":"https://doi.org/10.1242/jcs.110.6.771","title":"Increased degranulation and phospholipase A2, C, and D activity in RBL cells stimulated through FcepsilonR1 is due to spreading and not simply adhesion","display_name":"Increased degranulation and phospholipase A2, C, and D activity in RBL cells stimulated through FcepsilonR1 is due to spreading and not simply adhesion","publication_year":1997,"publication_date":"1997-03-15","ids":{"openalex":"https://openalex.org/W2109503570","doi":"https://doi.org/10.1242/jcs.110.6.771","mag":"2109503570","pmid":"https://pubmed.ncbi.nlm.nih.gov/9099951"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.110.6.771","doi":"https://doi.org/10.1242/jcs.110.6.771","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.110.6.771","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088736568","display_name":"John R. Apgar","orcid":"https://orcid.org/0000-0003-2974-6968","observed_orcids":["https://orcid.org/0000-0003-2974-6968"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.R. Apgar","raw_affiliation_strings":["Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088736568"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":0.8728,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7436411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"110","issue":"6","first_page":"771","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rbl-cells","display_name":"RBL cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.7689999938011169},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9649999737739563},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.996999979019165},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.4959999918937683},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.953000009059906},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7450000047683716},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/eicosanoid-biosynthesis","display_name":"eicosanoid biosynthesis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.7649999856948853},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/poly-l-lysine","display_name":"poly-L-lysine","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ige-receptor-signaling","display_name":"IgE receptor signaling","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.8031983375549316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6813446283340454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4596862494945526},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4329739511013031},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.4186279773712158},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4131462275981903},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2702975273132324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26197099685668945},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.10565385222434998},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017455","descriptor_name":"Receptors, IgE","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.110.6.771","doi":"https://doi.org/10.1242/jcs.110.6.771","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.110.6.771","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:9099951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9099951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1238580428","display_name":null,"funder_award_id":"R01-GM-42388","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3148875445","display_name":"IGE RECEPTOR INTERACTIONS IN STIMULUS AND SECRETION","funder_award_id":"5r01gm042388-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W22471755","https://openalex.org/W38394178","https://openalex.org/W74169396","https://openalex.org/W1481543280","https://openalex.org/W1511593691","https://openalex.org/W1537493242","https://openalex.org/W1537596069","https://openalex.org/W1557763992","https://openalex.org/W1563458114","https://openalex.org/W1581792908","https://openalex.org/W1751900100","https://openalex.org/W1863780064","https://openalex.org/W1881391726","https://openalex.org/W1889236699","https://openalex.org/W1935292442","https://openalex.org/W1960680499","https://openalex.org/W1990286462","https://openalex.org/W2005226698","https://openalex.org/W2006725651","https://openalex.org/W2007444273","https://openalex.org/W2027186413","https://openalex.org/W2029231027","https://openalex.org/W2035760513","https://openalex.org/W2048345403","https://openalex.org/W2052766715","https://openalex.org/W2057887597","https://openalex.org/W2066367871","https://openalex.org/W2067725687","https://openalex.org/W2084162464","https://openalex.org/W2094861537","https://openalex.org/W2106217238","https://openalex.org/W2112093320","https://openalex.org/W2113396371","https://openalex.org/W2123695711","https://openalex.org/W2135121318","https://openalex.org/W2140152586","https://openalex.org/W2152450698","https://openalex.org/W2155557904","https://openalex.org/W2157952919","https://openalex.org/W2254495044","https://openalex.org/W2258040979","https://openalex.org/W6691512370","https://openalex.org/W6692464770"],"related_works":["https://openalex.org/W2066335296","https://openalex.org/W1557763992","https://openalex.org/W7097776800","https://openalex.org/W2001322216","https://openalex.org/W2081096724","https://openalex.org/W1540338306","https://openalex.org/W1927751645","https://openalex.org/W1965009955","https://openalex.org/W7096794872","https://openalex.org/W2123695711"],"abstract_inverted_index":{"Rat":[0,54],"basophilic":[1,55,178],"leukemia":[2,56,179],"cells":[3,45,57,96,137,167,180,200,209,215,247,257],"will":[4,58,201,210],"adhere":[5,60,102,202],"to":[6,25,61,95,103,124,149,151,203,250],"and":[7,20,34,40,70,90,224,252],"spread":[8,112],"out":[9],"on":[10,22,154],"fibronectin":[11,23,152],"coated":[12,63,205],"surfaces":[13,62],"in":[14,187,248],"an":[15],"integrin":[16],"dependent":[17],"manner.":[18],"Adhesion":[19],"spreading":[21,134,254],"leads":[24],"increased":[26,35,87,170,228],"degranulation,":[27,172],"inositol":[28],"phosphate":[29],"production,":[30],"phospholipase":[31],"D":[32],"activation,":[33],"production":[36,92,231],"of":[37,190,232,245,255],"prostaglandin":[38],"D2":[39],"leukotriene":[41],"C4":[42],"when":[43],"the":[44,49,125,136,142,188,196,246,256,260],"are":[46],"activated":[47,81],"through":[48,119,141],"high":[50],"affinity":[51],"IgE":[52,143],"receptor.":[53,144],"also":[59,111,139,147],"with":[64,222],"anti-rat":[65,105],"class":[66,106],"I":[67,107],"antibodies,":[68],"poly-L-lysine,":[69],"a":[71],"lectin":[72,126],"purified":[73],"from":[74,127],"Tetragonolobus":[75,128],"purpureas.":[76],"In":[77,121],"all":[78],"cases,":[79],"antigen":[80,251],"cells,":[82],"which":[83,97,101,157,192],"were":[84,98,138,146],"adherent,":[85],"displayed":[86],"signaling,":[88,171],"degranulation":[89,229],"eicosanoid":[91,174],"as":[93],"compared":[94],"non-adherent.":[99],"Cells":[100,145],"either":[104],"antibodies":[108],"or":[109,173,230],"poly-L-lysine":[110],"even":[113,219],"though":[114],"this":[115],"is":[116,240],"not":[117,130,162,217,241],"mediated":[118],"integrins.":[120],"contrast,":[122],"adhesion":[123,159,238],"did":[129],"cause":[131],"any":[132],"appreciable":[133],"unless":[135],"triggered":[140],"able":[148],"bind":[150],"immobilized":[153],"polystyrene":[155],"beads":[156],"mimics":[158],"but":[160],"does":[161],"allow":[163],"spreading.":[164],"However,":[165,212],"these":[166,213],"exhibited":[168],"no":[169,227],"production.":[175],"Furthermore,":[176],"rat":[177],"can":[181],"be":[182,259],"modified":[183,199,214],"by":[184],"incubating":[185],"them":[186],"presence":[189],"biotinylated-phosphatidylserine":[191],"becomes":[193],"incorporated":[194],"into":[195],"membrane.":[197],"These":[198,234],"streptavidin":[204],"plates":[206],"while":[207],"unmodified":[208],"not.":[211],"do":[216],"spread,":[218],"after":[220],"activation":[221],"antigen,":[223],"they":[225],"show":[226],"eicosanoids.":[233],"results":[235],"indicate":[236],"that":[237,253],"itself":[239],"sufficient":[242],"for":[243],"upregulation":[244],"response":[249],"may":[258],"critical":[261],"component.":[262]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}