{"id":"https://openalex.org/W2109502519","doi":null,"title":"Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease.","display_name":"Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease.","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2109502519","mag":"2109502519","pmid":"https://pubmed.ncbi.nlm.nih.gov/12154061"},"language":"en","primary_location":{"id":"pmid:12154061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006984478","display_name":"\u00c9va Latulippe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva LaTulippe","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036912150","display_name":"Jaya M. Satagopan","orcid":"https://orcid.org/0000-0001-7102-5633","observed_orcids":["https://orcid.org/0000-0001-7102-5633"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaya Satagopan","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111455490","display_name":"Alex Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Smith","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072850546","display_name":"Howard I. Scher","orcid":"https://orcid.org/0000-0002-6791-9324","observed_orcids":["https://orcid.org/0000-0002-6791-9324"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Scher","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012224683","display_name":"Peter T. Scardino","orcid":"https://orcid.org/0000-0002-1601-8411","observed_orcids":["https://orcid.org/0000-0002-1601-8411"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Scardino","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010536553","display_name":"Victor E. Reuter","orcid":"https://orcid.org/0000-0002-7593-1016","observed_orcids":["https://orcid.org/0000-0002-7593-1016"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Reuter","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109979531","display_name":"William L. Gerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L Gerald","raw_affiliation_strings":["Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":8.6745,"has_fulltext":false,"cited_by_count":515,"citation_normalized_percentile":{"value":0.9869253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"62","issue":"15","first_page":"4499","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.796999990940094},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.6949999928474426},{"id":"https://openalex.org/keywords/clinical-heterogeneity","display_name":"clinical heterogeneity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8191511034965515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7423111796379089},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6718085408210754},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.612191915512085},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5024263858795166},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5017902851104736},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4928598403930664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49187302589416504},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.48230934143066406},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.45699188113212585},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4313836991786957},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.42548051476478577},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41220778226852417},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.33229371905326843},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32956957817077637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3263733386993408},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1834372878074646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.173293799161911}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12154061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2109502519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4176058101","display_name":"MOLECULAR CLASSIFICATION OF PROSTATE CANCER","funder_award_id":"U01CA084999","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1579641819","https://openalex.org/W1619256199","https://openalex.org/W1657157395","https://openalex.org/W1963964257","https://openalex.org/W1987572677","https://openalex.org/W1989076816","https://openalex.org/W1994993971","https://openalex.org/W2009905208","https://openalex.org/W2029947874","https://openalex.org/W2036902495","https://openalex.org/W2059972525","https://openalex.org/W2075662817","https://openalex.org/W2085958694","https://openalex.org/W2096252132","https://openalex.org/W2100152672","https://openalex.org/W2118370975","https://openalex.org/W2143650397","https://openalex.org/W2146513771","https://openalex.org/W2150926065","https://openalex.org/W2159400887"],"related_works":["https://openalex.org/W1968445925","https://openalex.org/W2073139956","https://openalex.org/W1811043827","https://openalex.org/W4214860677","https://openalex.org/W2373848675","https://openalex.org/W2980383173","https://openalex.org/W2137820684","https://openalex.org/W2529535171","https://openalex.org/W2732491981","https://openalex.org/W3176328445"],"abstract_inverted_index":{"The":[0,64],"identification":[1],"of":[2,15,33,123,139],"genes":[3,45,71,96,124,142,156],"that":[4,101,125,161],"contribute":[5,103,162],"to":[6,20,43,104,163],"the":[7,78,105],"biological":[8,99],"basis":[9],"for":[10,68],"clinical":[11,106,164],"heterogeneity":[12,165],"and":[13,23,46,51,60,121,133,151,166,169],"progression":[14],"prostate":[16,34,58,62,90],"cancer":[17,35,91],"is":[18],"critical":[19,158],"accurate":[21],"classification":[22],"appropriate":[24],"therapy.":[25],"We":[26],"performed":[27],"a":[28,111],"comprehensive":[29],"gene":[30],"expression":[31,54,66],"analysis":[32],"using":[36],"oligonucleotide":[37],"arrays":[38],"with":[39,49],"63,175":[40],"probe":[41],"sets":[42],"identify":[44],"expressed":[47,95,141,155],"sequences":[48],"strong":[50,112],"uniform":[52],"differential":[53],"between":[55,77,114],"nonrecurrent":[56],"primary":[57],"cancers":[59,120],"metastatic":[61,119],"cancers.":[63],"mean":[65],"value":[67],">3,000":[69],"tumor-intrinsic":[70],"differed":[72],"by":[73],"at":[74],"least":[75],"3-fold":[76],"two":[79],"groups.":[80],"This":[81],"includes":[82],"many":[83],"novel":[84],"ESTs":[85],"not":[86],"previously":[87],"implicated":[88],"in":[89,98,118,127],"progression.":[92],"Many":[93],"differentially":[94,140,154],"participate":[97,126],"processes":[100],"may":[102],"phenotype.":[107],"One":[108],"example":[109],"was":[110],"correlation":[113],"high":[115],"proliferation":[116],"rates":[117],"overexpression":[122],"cell":[128,149],"cycle":[129],"regulation,":[130,145],"DNA":[131,134],"replication,":[132],"repair.":[135],"Other":[136],"functional":[137],"categories":[138],"included":[143],"transcriptional":[144],"signaling,":[146],"signal":[147],"transduction,":[148],"structure,":[150],"motility.":[152],"These":[153],"reflect":[157],"cellular":[159],"activities":[160],"provide":[167],"diagnostic":[168],"therapeutic":[170],"targets.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}