{"id":"https://openalex.org/W2109487389","doi":null,"title":"artigo original Tratamento da Hiperplasia Supra-Renal Cong\u00eanita por Defici\u00eancia da 21-Hidroxilase","display_name":"artigo original Tratamento da Hiperplasia Supra-Renal Cong\u00eanita por Defici\u00eancia da 21-Hidroxilase","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2109487389","mag":"2109487389"},"language":"pt","primary_location":{"id":"mag:2109487389","doi":null,"is_oa":false,"landing_page_url":"http://scielo.br/pdf/abem/v45n1/a10v45n1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110048335","display_name":"Guiomar Madureira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guiomar Madureira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000452786","display_name":"Rosy C. Ueti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosy C. Ueti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103138738","display_name":"Marlene In\u00e1cio","orcid":"https://orcid.org/0000-0001-6424-7465","observed_orcids":["https://orcid.org/0000-0001-6424-7465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marlene In\u00e1cio","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6424-7465","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090018537","display_name":"Frederico A. Queiroz Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederico A. Queiroz Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008550885","display_name":"Berenice Bilharinho Mendonca","orcid":"https://orcid.org/0000-0003-1762-1084","observed_orcids":["https://orcid.org/0000-0003-1762-1084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Berenice B. Mendon\u00e7a","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1762-1084","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17328746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.984000027179718},{"id":"https://openalex.org/keywords/21-hydroxylase-deficiency","display_name":"21-hydroxylase deficiency","score":1.0},{"id":"https://openalex.org/keywords/hydrocortisone-replacement-therapy","display_name":"hydrocortisone replacement","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mineralocorticoid-replacement","display_name":"mineralocorticoid replacement","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fludrocortisone","display_name":"fludrocortisone","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cortisone-acetate","display_name":"cortisone acetate","score":0.8619999885559082},{"id":"https://openalex.org/keywords/adult-height","display_name":"adult height","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.8489999771118164},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.9040466547012329},{"id":"https://openalex.org/C2776899810","wikidata":"https://www.wikidata.org/wiki/Q2697578","display_name":"Fludrocortisone","level":3,"score":0.8858954310417175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7064371109008789},{"id":"https://openalex.org/C2776631543","wikidata":"https://www.wikidata.org/wiki/Q1433654","display_name":"Virilization","level":4,"score":0.6968954801559448},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.56681227684021},{"id":"https://openalex.org/C2911041269","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Adrenogenital syndrome","level":2,"score":0.5205006003379822},{"id":"https://openalex.org/C2777990738","wikidata":"https://www.wikidata.org/wiki/Q1132108","display_name":"Hypospadias","level":2,"score":0.4868602156639099},{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.439653605222702},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4337387979030609},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.41481202840805054},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4107228219509125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4084364175796509},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.326285719871521},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.3190273344516754},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29657864570617676},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.20756039023399353},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.14285176992416382},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.07594096660614014},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2109487389","doi":null,"is_oa":false,"landing_page_url":"http://scielo.br/pdf/abem/v45n1/a10v45n1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1563095952","https://openalex.org/W1964331183","https://openalex.org/W1967028270","https://openalex.org/W1973510392","https://openalex.org/W1979799940","https://openalex.org/W1991352399","https://openalex.org/W1993116465","https://openalex.org/W1997037606","https://openalex.org/W1998294409","https://openalex.org/W2000510142","https://openalex.org/W2037836361","https://openalex.org/W2047107705","https://openalex.org/W2052527544","https://openalex.org/W2059067106","https://openalex.org/W2059566069","https://openalex.org/W2059708085","https://openalex.org/W2062814607","https://openalex.org/W2069402873","https://openalex.org/W2070899628","https://openalex.org/W2077415800","https://openalex.org/W2087015880","https://openalex.org/W2087508700","https://openalex.org/W2090666946","https://openalex.org/W2100016925","https://openalex.org/W2105924023","https://openalex.org/W2116256519","https://openalex.org/W2148614804","https://openalex.org/W2160396079","https://openalex.org/W2304396624","https://openalex.org/W2317239176","https://openalex.org/W2329762064","https://openalex.org/W2398640658"],"related_works":["https://openalex.org/W2050441756","https://openalex.org/W2033340025","https://openalex.org/W2165873915","https://openalex.org/W3009291454","https://openalex.org/W3016903443","https://openalex.org/W2366604416","https://openalex.org/W3013266209","https://openalex.org/W3011079956","https://openalex.org/W2581542024","https://openalex.org/W3031202791"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,22,43,122],"the":[3,23,41,86,120],"treatment":[4,42],"for":[5,89,116],"congenital":[6],"adrenal":[7],"hyperplasia":[8],"due":[9],"to":[10,15,77,107,126,144],"21-hydroxylase":[11],"deficiency":[12],"(CAH-21OH)":[13],"is":[14,48,91,97,142],"replace":[16],"gluco":[17,83],"and":[18,28,30,35,59,84,124,128,130,139],"mineralocorticoids,":[19],"prevent":[20],"virilization":[21],"external":[24],"genitalia,":[25],"salt":[26],"loss":[27],"hyperandrogenism":[29],"preserve":[31],"gonadal":[32],"function,":[33],"fertility":[34],"final":[36,102],"height.":[37,112],"Our":[38],"experience":[39],"in":[40,99],"96":[44],"patients":[45],"with":[46,54,61,71,82],"CAH-21OH":[47,90],"presented.":[49],"Children":[50],"have":[51],"been":[52],"treated":[53],"cortisone":[55],"acetate":[56],"(18-20":[57],"mg/m2/day)":[58],"adults":[60],"dexamethasone":[62],"(0.25-0.75":[63],"mg/day).":[64],"If":[65],"necessary,":[66],"mineralocorticoid":[67],"replacement":[68],"was":[69],"accomplished":[70],"9\u03b1":[72],"-fludrocortisone,":[73],"50-250":[74],"\u00b5g/day,":[75],"according":[76],"chronological":[78],"age.":[79],"Despite":[80],"therapy":[81],"mineralocorticoids":[85],"end":[87],"results":[88],"still":[92,137],"inadequate,":[93],"especially":[94],"when":[95],"growth":[96],"concerned;":[98],"most":[100],"reports":[101],"height":[103],"reaches":[104],"between":[105],"1":[106],"2":[108],"SD":[109],"bellow":[110],"target":[111],"New":[113],"therapeutic":[114],"approaches":[115],"CAH-21OH,":[117],"such":[118],"as":[119],"association":[121],"flutamide":[123],"testolactone":[125],"hydrocortisone":[127],"fludrocortisone,":[129],"even":[131],"surgical":[132],"or":[133],"chemical":[134],"adrenalectomy,":[135],"are":[136],"experimental":[138],"long-term":[140],"follow-up":[141],"necessary":[143],"evaluate":[145],"their":[146],"validity.":[147],"(Arq":[148],"Bras":[149],"Endocrinol":[150],"Metab":[151],"2001;45/1:64-72)":[152]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
