{"id":"https://openalex.org/W2109462976","doi":"https://doi.org/10.1128/jvi.00921-09","title":"Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection","display_name":"Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection","publication_year":2009,"publication_date":"2009-07-16","ids":{"openalex":"https://openalex.org/W2109462976","doi":"https://doi.org/10.1128/jvi.00921-09","mag":"2109462976","pmid":"https://pubmed.ncbi.nlm.nih.gov/19605475","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748050"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00921-09","doi":"https://doi.org/10.1128/jvi.00921-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00921-09","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081656476","display_name":"Christina Thobakgale","orcid":"https://orcid.org/0000-0001-5619-8894","observed_orcids":["https://orcid.org/0000-0001-5619-8894"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Christina F. Thobakgale","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041072379","display_name":"Andrew J. Prendergast","orcid":"https://orcid.org/0000-0001-7904-7992","observed_orcids":["https://orcid.org/0000-0001-7904-7992"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Prendergast","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hayley Crawford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hayley Crawford","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019060933","display_name":"Nompumelelo Prudence Mkhwanazi","orcid":"https://orcid.org/0000-0002-0808-9201","observed_orcids":["https://orcid.org/0000-0002-0808-9201"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nompumelelo Mkhwanazi","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024469055","display_name":"Danni Ramduth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Danni Ramduth","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103554711","display_name":"Sharon Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Sharon Reddy","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Claudia Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Molina","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109334808","display_name":"Zenele Mncube","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Zenele Mncube","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073126768","display_name":"Alasdair J. Leslie","orcid":"https://orcid.org/0000-0003-2538-6467","observed_orcids":["https://orcid.org/0000-0003-2538-6467"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair Leslie","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056187765","display_name":"J\u00falia G. Prado","orcid":"https://orcid.org/0000-0002-5439-4645","observed_orcids":["https://orcid.org/0000-0002-5439-4645"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia Prado","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109877","display_name":"Fundisiwe Chonco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Fundi Chonco","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065861817","display_name":"Wendy Mphatswe","orcid":"https://orcid.org/0000-0002-1520-8635","observed_orcids":["https://orcid.org/0000-0002-1520-8635"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Wendy Mphatshwe","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042081819","display_name":"Gareth Tudor\u2010Williams","orcid":"https://orcid.org/0000-0002-4488-849X","observed_orcids":["https://orcid.org/0000-0002-4488-849X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Tudor-Williams","raw_affiliation_strings":["Department of Paediatrics, Division of Medicine, Imperial College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Division of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083327866","display_name":"Prakash Mohan Jeena","orcid":"https://orcid.org/0000-0001-9244-6285","observed_orcids":["https://orcid.org/0000-0001-9244-6285"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Prakash Jeena","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047375243","display_name":"Natasha Blanckenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Natasha Blanckenberg","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088371341","display_name":"Krista L. Dong","orcid":"https://orcid.org/0000-0002-2038-3518","observed_orcids":["https://orcid.org/0000-0002-2038-3518"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Krista Dong","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085152597","display_name":"Photini Kiepiela","orcid":"https://orcid.org/0000-0003-2563-7617","observed_orcids":["https://orcid.org/0000-0003-2563-7617"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Photini Kiepiela","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110880287","display_name":"Hoosen Mohamed Coovadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Hoosen Coovadia","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040954811","display_name":"Thumbi Ndung\u2019u","orcid":"https://orcid.org/0000-0003-2962-3992","observed_orcids":["https://orcid.org/0000-0003-2962-3992"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Thumbi Ndung'u","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Bruce D. Walker","raw_affiliation_strings":["HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","Howard Hughes Medical Institute, Chevy Chase, Maryland 20185","Ragon Institute, Massachusetts General Hospital, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland 20185","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Ragon Institute, Massachusetts General Hospital, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043346206","display_name":"Philip Goulder","orcid":"https://orcid.org/0000-0002-9842-4674","observed_orcids":["https://orcid.org/0000-0002-9842-4674"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["GB","ZA"],"is_corresponding":false,"raw_author_name":"Philip J. R. Goulder","raw_affiliation_strings":["Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9781,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.92235205,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"83","issue":"19","first_page":"10234","last_page":"10244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-b-57","display_name":"HLA-B*57","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hla-b-58-01","display_name":"HLA-B*58:01","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hla-class-i-alleles","display_name":"HLA class I alleles","score":0.7329999804496765},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.7599999904632568},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gag-epitopes","display_name":"Gag epitopes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.7419999837875366},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.6639999747276306},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8782945871353149},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6320441961288452},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5402197241783142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5360738635063171},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5198295712471008},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5147557258605957},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4197397232055664},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4177815020084381},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.17349475622177124},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15170586109161377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09773269295692444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07649490237236023}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.00921-09","doi":"https://doi.org/10.1128/jvi.00921-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00921-09","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2748050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:19605475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19605475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2748050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306134","display_name":"Doris Duke Charitable Foundation","ror":"https://ror.org/04n65rp89"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1606271020","https://openalex.org/W1964646310","https://openalex.org/W1976168729","https://openalex.org/W1980929359","https://openalex.org/W1990105675","https://openalex.org/W2008152684","https://openalex.org/W2035084589","https://openalex.org/W2045551237","https://openalex.org/W2053695022","https://openalex.org/W2054980981","https://openalex.org/W2066100904","https://openalex.org/W2069926681","https://openalex.org/W2076225720","https://openalex.org/W2087484510","https://openalex.org/W2089034023","https://openalex.org/W2096015577","https://openalex.org/W2109356424","https://openalex.org/W2112475246","https://openalex.org/W2113708505","https://openalex.org/W2116129118","https://openalex.org/W2116296845","https://openalex.org/W2116360856","https://openalex.org/W2118115182","https://openalex.org/W2125377484","https://openalex.org/W2129665077","https://openalex.org/W2131397181","https://openalex.org/W2138594667","https://openalex.org/W2143430982","https://openalex.org/W2147134928","https://openalex.org/W2151326236","https://openalex.org/W2159859837","https://openalex.org/W2169951364","https://openalex.org/W2170947401"],"related_works":["https://openalex.org/W2134847258","https://openalex.org/W2156096572","https://openalex.org/W2509192869","https://openalex.org/W1990741334","https://openalex.org/W1783283619","https://openalex.org/W2054637007","https://openalex.org/W1956443538","https://openalex.org/W2330868763","https://openalex.org/W2033788989","https://openalex.org/W2000049931"],"abstract_inverted_index":{"A":[0],"broad":[1],"Gag-specific":[2],"CD8(+)":[3,127,187,287],"T-cell":[4,128,188,288],"response":[5,53],"is":[6,35],"associated":[7,151],"with":[8,32,152],"effective":[9],"control":[10,34],"of":[11,20,62,81,102,112,159,247,285,298],"adult":[12,76,279],"human":[13],"immunodeficiency":[14],"virus":[15,119],"(HIV)":[16],"infection.":[17],"The":[18],"association":[19],"certain":[21],"HLA":[22,125,267],"class":[23,268],"I":[24,269],"molecules,":[25],"such":[26,63],"as":[27,276,278,282],"HLA-B*57,":[28],"-B*5801,":[29],"and":[30,130,164,177,294],"-B*8101,":[31],"immune":[33,52],"linked":[36],"to":[37,49,92,120,185,190,201,222],"mutations":[38,66,250],"within":[39,67,226],"Gag":[40,68,191,228],"epitopes":[41,69,192,229],"presented":[42,193,230],"by":[43,175,194,231,301],"these":[44,113],"alleles":[45,106,206,217,233,239,270],"that":[46,55,88,266],"allow":[47],"HIV":[48],"evade":[50],"the":[51,86,103,108,121,153,160,169,195,204,215,227,286,292,296,302],"but":[54],"also":[56],"reduce":[57],"viral":[58,73,131],"replicative":[59],"capacity.":[60],"Transmission":[61],"viruses":[64,300],"containing":[65],"results":[70],"in":[71,75,199,253,274,291],"lower":[72],"loads":[74],"recipients.":[77],"In":[78],"this":[79],"study":[80],"pediatric":[82,275],"infection,":[83,280],"we":[84],"tested":[85],"hypothesis":[87],"children":[89,256],"may":[90],"tend":[91],"progress":[93],"relatively":[94],"slowly":[95],"if":[96],"either":[97],"they":[98],"themselves":[99],"possess":[100],"one":[101,111,158],"protective":[104,161,170,196,216,260],"HLA-B":[105,162,197,261],"or":[107,155],"mother":[109,154,176],"possesses":[110],"alleles,":[114,163,198],"thereby":[115],"transmitting":[116],"a":[117,283],"low-fitness":[118,299],"child.":[122],"We":[123],"analyzed":[124],"type,":[126],"responses,":[129],"sequence":[132],"changes":[133],"for":[134],"61":[135],"mother-child":[136],"pairs":[137],"from":[138,145],"Durban,":[139],"South":[140],"Africa,":[141],"who":[142],"were":[143,218],"monitored":[144],"birth.":[146],"Slow":[147,182],"progression":[148,273],"was":[149,172,251],"significantly":[150,166,219],"child":[156,178,293],"possessing":[157],"more":[165,220],"so":[167],"when":[168],"allele":[171],"not":[173,236],"shared":[174],"(P":[179,207],"=":[180,208,244],"0.007).":[181],"progressors":[183,202],"tended":[184],"make":[186],"responses":[189,289],"contrast":[200],"expressing":[203,214,237],"same":[205],"0.07;":[209],"Fisher's":[210],"exact":[211],"test).":[212],"Mothers":[213],"likely":[221],"transmit":[223],"escape":[224,249],"variants":[225],"those":[232,238],"than":[234],"mothers":[235,258],"(75%":[240],"versus":[241],"21%;":[242],"P":[243],"0.001).":[245],"Reversion":[246],"transmitted":[248],"observed":[252],"all":[254],"slow-progressing":[255],"whose":[257],"possessed":[259],"alleles.":[262],"These":[263],"data":[264],"show":[265],"influence":[271],"disease":[272],"well":[277],"both":[281],"result":[284],"generated":[290],"through":[295],"transmission":[297],"mother.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}