{"id":"https://openalex.org/W2109411976","doi":"https://doi.org/10.2217/pme.14.19","title":"Recent Advances in Personalized Lung Cancer Medicine","display_name":"Recent Advances in Personalized Lung Cancer Medicine","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2109411976","doi":"https://doi.org/10.2217/pme.14.19","mag":"2109411976","pmid":"https://pubmed.ncbi.nlm.nih.gov/25506379"},"language":"en","primary_location":{"id":"doi:10.2217/pme.14.19","doi":"https://doi.org/10.2217/pme.14.19","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pme.14.19","pdf_url":null,"source":{"id":"https://openalex.org/S134466978","display_name":"Personalized Medicine","issn_l":"1741-0541","issn":["1741-0541","1744-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263209","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004579069","display_name":"Ross A. Okimoto","orcid":"https://orcid.org/0000-0002-4467-8476","observed_orcids":["https://orcid.org/0000-0002-4467-8476"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross A Okimoto","raw_affiliation_strings":["Division of Hematology &amp; Medical Oncology, University of California San\u00a0Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology &amp; Medical Oncology, University of California San\u00a0Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004509086","display_name":"Trever Grant Bivona","orcid":"https://orcid.org/0000-0001-5734-4128","observed_orcids":["https://orcid.org/0000-0001-5734-4128"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trever\u00a0G Bivona","raw_affiliation_strings":["Division of Hematology &amp; Medical Oncology, University of California San\u00a0Francisco, San Francisco, CA, USA","Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA","Division of Hematology and Medical Oncology; University of California San Francisco; San Francisco, CA USA ; Helen Diller Family Comprehensive Cancer Center; University of California San Francisco; San Francisco, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology &amp; Medical Oncology, University of California San\u00a0Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"Division of Hematology and Medical Oncology; University of California San Francisco; San Francisco, CA USA ; Helen Diller Family Comprehensive Cancer Center; University of California San Francisco; San Francisco, CA USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6328,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92984742,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"309","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.699999988079071},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6859999895095825},{"id":"https://openalex.org/keywords/multiplex-genotyping","display_name":"multiplex genotyping","score":0.843999981880188},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.996999979019165},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.7067152857780457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6808041930198669},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6729253530502319},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6587719321250916},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.48085862398147583},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.47461453080177307},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4634629786014557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4416845440864563},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.42376306653022766},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4210614562034607},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.338774710893631},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3354652225971222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29315996170043945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15693750977516174},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.1554582417011261},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1525794267654419},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13507679104804993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1280398666858673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10484182834625244},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2217/pme.14.19","doi":"https://doi.org/10.2217/pme.14.19","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pme.14.19","pdf_url":null,"source":{"id":"https://openalex.org/S134466978","display_name":"Personalized Medicine","issn_l":"1741-0541","issn":["1741-0541","1744-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized Medicine","raw_type":"journal-article"},{"id":"pmid:25506379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25506379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4263209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Per Med","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7j12480k","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7j12480k","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Personalized Medicine, vol 11, iss 3","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4263209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Per Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5899999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1402578135","display_name":null,"funder_award_id":"DP2CA174497","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G248810425","display_name":"Rational Combined Inhibition of NF-kB and EGFR to Optimize Lung Cancer Treatment","funder_award_id":"R01CA169338","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6011500327","display_name":"Genetic Modifiers such as Fas Regulate Tumor-Cell Dependence on Mutant EGFR","funder_award_id":"K08CA154787","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W70527475","https://openalex.org/W1516354149","https://openalex.org/W1676439699","https://openalex.org/W1814699096","https://openalex.org/W1819015028","https://openalex.org/W1965451568","https://openalex.org/W1967394241","https://openalex.org/W1978236936","https://openalex.org/W1979840428","https://openalex.org/W1980497534","https://openalex.org/W1981083257","https://openalex.org/W1987370132","https://openalex.org/W1997134098","https://openalex.org/W2001999652","https://openalex.org/W2007661090","https://openalex.org/W2016692297","https://openalex.org/W2018178643","https://openalex.org/W2018336040","https://openalex.org/W2021876472","https://openalex.org/W2028015151","https://openalex.org/W2031159738","https://openalex.org/W2033780390","https://openalex.org/W2040657105","https://openalex.org/W2043696829","https://openalex.org/W2047004048","https://openalex.org/W2048500586","https://openalex.org/W2049449785","https://openalex.org/W2050249255","https://openalex.org/W2055402151","https://openalex.org/W2061020371","https://openalex.org/W2061278019","https://openalex.org/W2065799563","https://openalex.org/W2072521670","https://openalex.org/W2096198395","https://openalex.org/W2100794900","https://openalex.org/W2102348612","https://openalex.org/W2103447891","https://openalex.org/W2104830962","https://openalex.org/W2110338679","https://openalex.org/W2110835998","https://openalex.org/W2112854176","https://openalex.org/W2116265446","https://openalex.org/W2116720928","https://openalex.org/W2124662474","https://openalex.org/W2125744030","https://openalex.org/W2127101185","https://openalex.org/W2127919472","https://openalex.org/W2128542677","https://openalex.org/W2129172946","https://openalex.org/W2129360604","https://openalex.org/W2130488043","https://openalex.org/W2132157071","https://openalex.org/W2132578211","https://openalex.org/W2133867160","https://openalex.org/W2134607826","https://openalex.org/W2136549983","https://openalex.org/W2149372853","https://openalex.org/W2159480044","https://openalex.org/W2160982674","https://openalex.org/W2161650275","https://openalex.org/W2161821474","https://openalex.org/W2162724777","https://openalex.org/W2163188200","https://openalex.org/W2163798887","https://openalex.org/W2166084034","https://openalex.org/W2167010784","https://openalex.org/W2168691181","https://openalex.org/W2168930905","https://openalex.org/W2169276102","https://openalex.org/W2171342019","https://openalex.org/W2240169541","https://openalex.org/W2242848604","https://openalex.org/W2318605753","https://openalex.org/W2998961111"],"related_works":["https://openalex.org/W3024984103","https://openalex.org/W2594116300","https://openalex.org/W1989579159","https://openalex.org/W2903335149","https://openalex.org/W2045309793","https://openalex.org/W2980826365","https://openalex.org/W2172208023","https://openalex.org/W3115588838","https://openalex.org/W1957032760","https://openalex.org/W2507860857"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,5,14,25,65,89,104,118],"molecular":[3,123],"subtypes":[4],"non-small-cell":[6],"lung":[7,119,136],"cancer":[8,63,120,137],"has":[9,111],"transformed":[10],"the":[11,22,27,36,62,84,102,112,116],"clinical":[12,23,109,132],"management":[13,117],"this":[15],"disease.":[16],"This":[17],"is":[18],"best":[19],"exemplified":[20],"by":[21],"success":[24],"targeting":[26],"EGFR":[28],"or":[29],"ALK":[30],"with":[31,46,86],"tyrosine":[32],"kinase":[33],"inhibitors":[34],"in":[35],"front-line":[37],"setting.":[38],"Our":[39],"ability":[40],"to":[41,100,114],"further":[42],"improve":[43],"patient":[44,125],"outcomes":[45,133],"biomarker-based":[47],"targeted":[48],"therapies":[49],"will":[50,81],"depend":[51],"on":[52],"a":[53,87],"more":[54],"comprehensive":[55],"genetic":[56,90,106],"platform":[57],"that":[58],"can":[59],"rationally":[60],"interrogate":[61],"genome":[64],"an":[66],"individual":[67],"patient.":[68,94],"Novel":[69],"technologies,":[70],"including":[71],"multiplex":[72],"genotyping":[73],"and":[74,80,127],"next-generation":[75],"sequencing":[76],"are":[77,97],"rapidly":[78],"evolving":[79],"soon":[82],"challenge":[83],"oncologist":[85],"wealth":[88],"information":[91],"for":[92],"each":[93],"Although":[95],"there":[96],"many":[98],"barriers":[99],"overcome,":[101],"integration":[103],"these":[105],"platforms":[107],"into":[108],"care":[110],"potential":[113],"transform":[115],"through":[121,134],"improved":[122],"categorization,":[124],"stratification,":[126],"drug":[128],"development,":[129],"thereby,":[130],"improving":[131],"personalized":[135],"medicine.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
