{"id":"https://openalex.org/W2109401985","doi":null,"title":"Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.","display_name":"Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.","publication_year":2001,"publication_date":"2001-09-15","ids":{"openalex":"https://openalex.org/W2109401985","mag":"2109401985","pmid":"https://pubmed.ncbi.nlm.nih.gov/11559570"},"language":"en","primary_location":{"id":"pmid:11559570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11559570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101535366","display_name":"Ying Huang","orcid":"https://orcid.org/0000-0002-3517-5527","observed_orcids":["https://orcid.org/0000-0002-3517-5527"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Huang","raw_affiliation_strings":["Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037193816","display_name":"Marilyn J. Hillman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Hillman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060881656","display_name":"Ruiming Rong","orcid":"https://orcid.org/0000-0003-0537-7045","observed_orcids":["https://orcid.org/0000-0003-0537-7045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103263069","display_name":"M. Saeed Sheikh","orcid":"https://orcid.org/0000-0002-9058-0170","observed_orcids":["https://orcid.org/0000-0002-9058-0170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Sheikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3082,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.88675787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"61","issue":"18","first_page":"6918","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulindac-sulfide","display_name":"sulindac sulfide","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.9739999771118164},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9649999737739563},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.8740000128746033},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mitochondrial-pathway","display_name":"mitochondrial pathway","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.9711785316467285},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7826269865036011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5920093655586243},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5321492552757263},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4721653163433075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.428910493850708},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.41138312220573425},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3228352963924408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2966916561126709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29660630226135254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2680199146270752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1665518581867218},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053220","descriptor_name":"Receptors, TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11559570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11559570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2109401985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11559570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8073759610","display_name":"Death receptors in prostate cancer biology and apoptosis","funder_award_id":"R21CA089043","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1484817497","https://openalex.org/W1519516598","https://openalex.org/W1538959208","https://openalex.org/W1549386419","https://openalex.org/W1599806854","https://openalex.org/W1614077614","https://openalex.org/W1924121791","https://openalex.org/W1977394772","https://openalex.org/W1980235624","https://openalex.org/W1980919524","https://openalex.org/W1984709119","https://openalex.org/W2004457956","https://openalex.org/W2009085926","https://openalex.org/W2015103955","https://openalex.org/W2017578232","https://openalex.org/W2026307857","https://openalex.org/W2035768602","https://openalex.org/W2038114873","https://openalex.org/W2039267077","https://openalex.org/W2043944220","https://openalex.org/W2049312704","https://openalex.org/W2055580039","https://openalex.org/W2058118671","https://openalex.org/W2062853648","https://openalex.org/W2084733813","https://openalex.org/W2085552591","https://openalex.org/W2089476060","https://openalex.org/W2092508425","https://openalex.org/W2101721166","https://openalex.org/W2111640802","https://openalex.org/W2113505777","https://openalex.org/W2122482353","https://openalex.org/W2132411546","https://openalex.org/W2151501496","https://openalex.org/W2162560719","https://openalex.org/W2170720047","https://openalex.org/W2315629023","https://openalex.org/W2336215030"],"related_works":["https://openalex.org/W2024441078","https://openalex.org/W7099654989","https://openalex.org/W2334572212","https://openalex.org/W2091165828","https://openalex.org/W1976516830","https://openalex.org/W2129193589","https://openalex.org/W1876192519","https://openalex.org/W2249782933","https://openalex.org/W2125062544","https://openalex.org/W7035448186"],"abstract_inverted_index":{"Sulindac":[0,12,81,100],"is":[1,14,23],"the":[2,17,40,72,87,104,112,129,177,184,199,220,232,239,256],"most":[3],"extensively":[4],"investigated":[5],"clinically":[6],"relevant":[7],"chemopreventive":[8],"nonsteroidal":[9],"anti-inflammatory":[10],"drug.":[11],"sulfide":[13,38,69,82,101,253],"one":[15],"of":[16,20,114,131,179,231,241],"major":[18],"metabolites":[19],"sulindac":[21,37,68,134,188,210,226,244,252],"that":[22,36,67,143,196,251],"believed":[24],"to":[25,48,78,175,266],"mediate":[26,49,79],"its":[27,50],"antitumorigenic":[28],"effects":[29,52],"by":[30,197],"inducing":[31],"apoptosis.":[32,80,164,212,246,268],"Recent":[33],"evidence":[34],"suggests":[35],"engages":[39,255],"mitochondrial":[41],"pathway":[42,77,259],"involving":[43,260],"caspase":[44,89,264],"9":[45],"and":[46,85,95,120,150,187,262],"Bax":[47],"apoptotic":[51,156,180,201],"[Zhang":[53],"et":[54],"al.,":[55],"Science":[56],"(Wash.":[57],"DC),":[58],"290:":[59],"989-992,":[60],"2000].":[61],"In":[62],"this":[63],"report,":[64],"we":[65,137],"demonstrate":[66,250],"also":[70,224,254],"engaged":[71],"membrane":[73,257],"death":[74,173,205],"receptor":[75,124,154],"(DR)":[76],"up-regulated":[83,103],"DR5":[84,105,132,242,261],"activated":[86],"proximal":[88,263],"8":[90,265],"in":[91,133,146,161,229,243],"various":[92],"different":[93],"colon":[94],"prostate":[96,140],"cancer":[97,141],"cell":[98,233],"lines.":[99],"specifically":[102],"levels":[106,113],"but":[107,158],"had":[108],"no":[109],"effect":[110],"on":[111],"other":[115],"DRs":[116],"including":[117],"DR4,":[118],"Fas,":[119],"tumor":[121,151,215],"necrosis":[122,152,216],"factor":[123,153],"1.":[125],"To":[126],"further":[127,237],"delineate":[128],"role":[130],"sulfide-induced":[135,189,211,227,245],"apoptosis,":[136],"used":[138],"JCA-1":[139,165],"cells":[142,166],"are":[144,159],"deficient":[145],"mounting":[147],"a":[148],"Fas":[149],"1-dependent":[155],"response":[157],"proficient":[160],"mediating":[162],"DR5-dependent":[163,200],"were":[167],"stably":[168],"transfected":[169],"with":[170],"dominant-negative":[171,203],"Fas-associated":[172,204],"domain":[174,206],"block":[176],"flow":[178],"signals":[181],"originating":[182],"from":[183],"endogenous":[185],"DR5,":[186,223],"apoptosis":[190,228],"was":[191],"investigated.":[192],"Our":[193],"results":[194,249],"indicated":[195],"blocking":[198],"pathway,":[202],"did":[207],"indeed":[208],"inhibit":[209],"Furthermore,":[213],"exogenous":[214],"factor-related":[217],"apoptosis-inducing":[218],"ligand,":[219],"ligand":[221],"for":[222],"potentiated":[225],"all":[230],"lines":[234],"tested,":[235],"thereby":[236],"supporting":[238],"involvement":[240],"Thus,":[247],"our":[248],"DR":[258],"induce":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
