{"id":"https://openalex.org/W2109282175","doi":"https://doi.org/10.1073/pnas.0506405103","title":"Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans","display_name":"Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans","publication_year":2006,"publication_date":"2006-01-10","ids":{"openalex":"https://openalex.org/W2109282175","doi":"https://doi.org/10.1073/pnas.0506405103","mag":"2109282175","pmid":"https://pubmed.ncbi.nlm.nih.gov/16407097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1334641"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0506405103","doi":"https://doi.org/10.1073/pnas.0506405103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0506405103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0506405103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0506405103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrew J. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew J. Phillips","raw_affiliation_strings":["Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086320110","display_name":"Jonathan D. Crowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan D. Crowe","raw_affiliation_strings":["Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013034771","display_name":"Mark Ramsdale","orcid":"https://orcid.org/0009-0009-0746-4127","observed_orcids":["https://orcid.org/0009-0009-0746-4127"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark Ramsdale","raw_affiliation_strings":["Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013034771"],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":null,"apc_paid":null,"fwci":4.9404,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.96840461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"103","issue":"3","first_page":"726","last_page":"731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8799999952316284},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6840000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/secondary-necrosis","display_name":"secondary necrosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.6850000023841858},{"id":"https://openalex.org/keywords/fungal-stress-response","display_name":"fungal stress response","score":0.5360000133514404},{"id":"https://openalex.org/keywords/ras1","display_name":"Ras1","score":0.531000018119812},{"id":"https://openalex.org/keywords/tpk1","display_name":"TPK1","score":0.800000011920929},{"id":"https://openalex.org/keywords/tpk2","display_name":"Tpk2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pde2","display_name":"PDE2","score":0.8519999980926514},{"id":"https://openalex.org/keywords/acetic-acid-stress","display_name":"acetic acid stress","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hydrogen-peroxide-induced-oxidative-stress","display_name":"hydrogen peroxide stress","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8077479600906372},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7467409372329712},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.701856791973114},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5974118113517761},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5852967500686646},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.5843147039413452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5806897282600403},{"id":"https://openalex.org/C2775839086","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Pathogenic fungus","level":3,"score":0.5406314134597778},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.45960572361946106},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4284099340438843},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4127245545387268},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.41197073459625244},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.41149672865867615},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3655049204826355},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.359397292137146},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.312467098236084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2517653703689575},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0506405103","doi":"https://doi.org/10.1073/pnas.0506405103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0506405103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0506405103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:295090","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1334641","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1334641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1334641","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:16407097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16407097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.0506405103","doi":"https://doi.org/10.1073/pnas.0506405103","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0506405103","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0506405103","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109282175.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1487958751","https://openalex.org/W1496714497","https://openalex.org/W1580707289","https://openalex.org/W1858702144","https://openalex.org/W1975115559","https://openalex.org/W1975940974","https://openalex.org/W1978684735","https://openalex.org/W1980103713","https://openalex.org/W1986387700","https://openalex.org/W1987929315","https://openalex.org/W2010482423","https://openalex.org/W2013027370","https://openalex.org/W2014656185","https://openalex.org/W2027284709","https://openalex.org/W2033341831","https://openalex.org/W2042360184","https://openalex.org/W2055841310","https://openalex.org/W2067820742","https://openalex.org/W2081108932","https://openalex.org/W2081490071","https://openalex.org/W2098657730","https://openalex.org/W2099364953","https://openalex.org/W2107013040","https://openalex.org/W2107039058","https://openalex.org/W2109500897","https://openalex.org/W2110643694","https://openalex.org/W2114725487","https://openalex.org/W2115256513","https://openalex.org/W2115444314","https://openalex.org/W2117061686","https://openalex.org/W2119570364","https://openalex.org/W2120706631","https://openalex.org/W2121702473","https://openalex.org/W2126774514","https://openalex.org/W2127142654","https://openalex.org/W2132092226","https://openalex.org/W2134607537","https://openalex.org/W2135707527","https://openalex.org/W2140006865","https://openalex.org/W2140935709","https://openalex.org/W2143712580","https://openalex.org/W2144236385","https://openalex.org/W2145923257","https://openalex.org/W2146126669","https://openalex.org/W2162062509","https://openalex.org/W2162566576","https://openalex.org/W2163110564","https://openalex.org/W2167376998","https://openalex.org/W2317721149","https://openalex.org/W6600862553"],"related_works":["https://openalex.org/W854939898","https://openalex.org/W2896091232","https://openalex.org/W2127142654","https://openalex.org/W2107039058","https://openalex.org/W4319318052","https://openalex.org/W2150023843","https://openalex.org/W1896176881","https://openalex.org/W2096110497","https://openalex.org/W2104253511","https://openalex.org/W2143188153"],"abstract_inverted_index":{"A":[0],"better":[1],"understanding":[2],"of":[3,7,23,85,127,129,137,163,166,176,182],"the":[4,21,48,73,83,86,92,113,125,161,167],"molecular":[5],"basis":[6],"programmed":[8],"cell":[9],"death":[10],"(PCD)":[11],"in":[12,20,47,145,160],"fungi":[13],"could":[14],"provide":[15],"information":[16],"that":[17,26,58,72,91,101,118,151],"is":[18,80,95],"useful":[19],"design":[22],"antifungal":[24],"drugs":[25],"combat":[27],"life-threatening":[28],"fungal":[29],"infections.":[30],"Harsh":[31],"environmental":[32],"stresses,":[33],"such":[34],"as":[35,191],"acetic":[36],"acid":[37],"or":[38,111,135,194],"hydrogen":[39],"peroxide,":[40],"have":[41],"been":[42],"shown":[43],"to":[44,66,82],"induce":[45],"PCD":[46,181],"pathogenic":[49],"fungus":[50],"Candida":[51],"albicans.":[52],"In":[53],"this":[54,77],"study,":[55],"we":[56,89],"show":[57],"dying":[59],"cells":[60,130],"progress":[61],"from":[62],"an":[63],"apoptotic":[64,114],"state":[65,70],"a":[67],"secondary":[68],"necrotic":[69],"and":[71,108,122],"rate":[74,126],"at":[75],"which":[76],"change":[78],"occurs":[79],"proportional":[81],"intensity":[84],"stimulus.":[87],"Also,":[88],"found":[90],"temporal":[93],"response":[94],"modulated":[96],"by":[97,186,195],"Ras-cAMP-PKA":[98,103],"signals.":[99],"Mutations":[100],"block":[102],"signaling":[104,120,139],"(ras1Delta,":[105],"cdc35Delta,":[106],"tpk1Delta,":[107],"tpk2Delta)":[109],"suppress":[110],"delay":[112],"response,":[115],"whereas":[116],"mutations":[117],"stimulate":[119,152],"(RAS1(val13)":[121],"pde2Delta)":[123],"accelerate":[124],"entry":[128],"into":[131],"apoptosis.":[132],"Pharmacological":[133],"stimulation":[134],"inhibition":[136],"Ras":[138,177],"reinforces":[140],"these":[141],"findings.":[142],"Transient":[143],"increases":[144],"endogenous":[146],"cAMP":[147],"occur":[148],"under":[149],"conditions":[150],"apoptosis":[153],"but":[154],"not":[155],"growth":[156],"arrest.":[157],"Death-specific":[158],"changes":[159],"abundance":[162],"different":[164],"isoforms":[165],"PKA":[168],"regulatory":[169],"subunit,":[170],"Bcy1p,":[171],"are":[172],"also":[173],"observed.":[174],"Activation":[175],"signals":[178],"may":[179],"regulate":[180],"C.":[183],"albicans,":[184],"either":[185],"inhibiting":[187],"antiapoptotic":[188],"functions":[189],"(such":[190],"stress":[192],"responses)":[193],"activating":[196],"proapoptotic":[197],"functions.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
